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ENTRY	nt06324
Name	GHRH-GH-IGF signaling
Category	Pathway view; Endocrine system
Disease	H02035 Isolated growth hormone deficiency (IGHD)
Display	drug-target relation   disease type

D7  |                             N00910    GHRH → GHRHR → GNAS → ADCY → cAMP → PKA → CREB ⇒ POU1F1 ⇒ (GH1,GH2)     IGHD4     GHRHR*     Acromegaly         GNAS*↗     CPHD1                             POU1F1*         D1,D2,D3,D4,D5,D6  |             N00907    GH → GHR → JAK2 → STAT5 ⇒ IGF1     IGHD1 GH*     Laron syndrome     GHR*         D2  |                         N00233    IGF → IGF1R → GRB2 → SOS → RAS → RAF → MEK → ERK     IGF-I deficiency IGF*     IGF1RES     IGF1R*   N01782    GHRL → (GHSR,MRAP2) → (GNA11,GNAQ)     Genetic obesity GHRL*     GHDP     GHSR*     Genetic obesity     MRAP2*

		Disease name	Disease category
IGHD4	H02035	Isolated growth hormone deficiency	Endocrine and metabolic disease
Acromegaly	H01483	Acromegaly	Endocrine and metabolic disease
CPHD1	H02036	Combined pituitary hormone deficiency	Endocrine and metabolic disease
	H00254	Growth hormone deficiency	Endocrine and metabolic disease
IGHD1	H02035	Isolated growth hormone deficiency	Endocrine and metabolic disease
Laron syndrome	H02037	Laron syndrome	Endocrine and metabolic disease
IGF-I deficiency	H02040	Insulin-like growth factor I deficiency	Endocrine and metabolic disease
IGF1RES	H01274	Growth delay due to insulin-like growth factor I resistance	Endocrine and metabolic disease
Genetic obesity	H02106	Genetic obesity	Endocrine and metabolic disease
GHDP	H00254	Growth hormone deficiency	Endocrine and metabolic disease

		Drug name
D1	D02691	Somatropin (USP/INN)
D2	D03297	Mecasermin (USAN/INN)
D3	D05394	Pegvisomant (USAN/INN)
D4	D10990	Somatrogon (USAN/INN)
D5	D11194	Somapacitan (USAN/INN)
D6	D11486	Lonapegsomatropin (USAN/INN)
D7	D09015	Tesamorelin acetate (USAN)