KEGG    Network variation - Cadherin signaling
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ENTRYnt06549
NameCadherin signaling
CategoryPathway view; Cellular process
Pathwayhsa04519 Cadherin signaling
Display drug-target relation   disease type
N01999    CDH=CDHCTNNBCTNNA(ACTB,ACTG1)
N02000    CDH=CDHCTNNBCTNNA(WWC1+NF2)((MST1/2+SAV1)+(LA..(YAP/TAZ+TEAD)
N02012    CDH=CDHCTNNDARHGAP35RHOA
N02001    CDH=CDHCTNNB(TCF/LEF+CBP)
    DGLBC/EC/OC/BCDS1   CDH1*
    ARVD14/ADHD8/ACOGS   CDH2*
    EEMS/HJMD   CDH3*
    TBHS2/ESWS   CDH11*
    MRD3   CDH15*
    BCDS2     CTNND1*
    OC/HCC/PTR/MDB     CTNNB1*
    EVR7/MRD19     CTNNB1*
    MDPT2       CTNNA1*
    CDCBM9       CTNNA2*
    ARVD13       CTNNA3*
    T2DM       TCF7L2*
    ECTD17       LEF1*
    RSTS1/MKHK1       CREBBP*
    CRC/RSTS2/MKHK2       EP300*
    BNS         ACTB*
    BRWS1/DDS1         ACTB*
    BRWS2/DFNA20/26         ACTG1*
    IMD110           STK4*
    COB             YAP1*
    SCRA             TEAD1*
 
N02008    DSC/DSG=DSC/DSG(PKP+JUP)DSP(KRT1/2,DES,VIM)
N02009    DSC/DSG=DSC/DSGJUPCTNNB(TCF/LEF+CBP)
N02023      DSG1ERBINSHOC2RASRAFMEKERK
    ARVD11   DSC2*
    HYPTSV   DSC3*
    PPKS1/EPKHE   DSG1*
    ARVD10/CMD1BB   DSG2*
    ABOLM   DSG3*
    LAH1   DSG4*
    EDSFS     PKP1*
    ARVD9     PKP2*
    ARVD12/NXD     JUP*
    ARVD8/PPKS2/DCWHKTA/EBLA/DCWHK       DSP*
    NSLH1       SHOC2*
 
N02004    cPCDH=cPCDH(NCKAP1+ABI2+CYFIP..ARP2/3(ACTB,ACTG1)
    NEDGS   PCDHGC4*
    IMD72     NCKAP1L*
    DEE65     CYFIP2*
    NEDALVS     WASF1*
    IMD113       ARPC5*
    DEVLO       ARPC4*
    IMD71       ARPC1B*
N02002      PCDHD1PPP1CA
N02003      PCDH8/10/18/20(GSK3B+APC+CSNK1A1..CTNNB(TCF/LEF+CBP)
N02005      PCDH19GABRA1
    DEE9   PCDH19*
    DEE19/EIG13/ECA4/EJM5     GABRA1*
N02007    PCDH15=CDH23(USH1C,USH1G)(MYO7A,MYO1C)
    DFNB12/USH1D/1F/PITA5   CDH23*
    DFNB18A/USH1C     USH1C*
    USH1G     USH1G*
    DFNA11/DFNB2/USH1B       MYO7A*
N02006    CDH23=PCDH15(TMC1/2+LHFPL5+TMI..
    DFNB23/USH1D/1F   PCDH15*
    DFNA36/DFNB7/11     TMC1*
    DFNB67     LHFPL5*
    DFNB6     TMIE*
    DFNB48     CIB2*
 
N02011    DCHS1/2=FAT4(ATN1,MUPP1+PALS1)
    VMLDS1/MVP2 DCHS1*
    VMLDS2/HKLLS2   FAT4*
    DRPLA     ATN1*
    CHEDDA     ATN1*
    HYC2     MPDZ*
 
N02010    WNT5/11(FZD3/6+CELSR)(DVL+ANKRD6)((DAAM1,RHOA,ROCK)..
    LMPHM9/YNS   CELSR1*
    NDNC1   FZD6*
    DRS2     DVL1*
    DRS3     DVL3*
    EDFAOB       RHOA*
    MRD48       RAC1*
    IMD73A/C       RAC2*
    IMD73B       RAC2*
    NEDBAF       RAC3*

Disease nameDisease category
DGLBC/EC/OC/BCDS1H00018Gastric cancerCancer
H00026Endometrial cancerCancer
H00027Ovarian cancerCancer
H02474Blepharocheilodontic syndromeCongenital malformation
ARVD14/ADHD8/ACOGSH00293Arrhythmogenic right ventricular cardiomyopathyCardiovascular disease
H01895Attention deficit hyperactivity disorder (ADHD)Mental and behavioural disorder
H02508Agenesis of corpus callosum, cardiac, ocular, and genital syndromeCongenital malformation
EEMS/HJMDH00639Ectodermal dysplasia, ectrodactyly, and macular dystrophyCongenital malformation
H00785Congenital hypotrichosis with juvenile macular dystrophyCongenital malformation
TBHS2/ESWSH02853Teebi hypertelorism syndromeCongenital malformation
H02926Elsahy-Waters syndromeCongenital malformation
MRD3H00773Autosomal dominant intellectual developmental disorderMental and behavioural disorder
BCDS2H02474Blepharocheilodontic syndromeCongenital malformation
OC/HCC/PTR/MDBH00027Ovarian cancerCancer
H00048Hepatocellular carcinomaCancer
H00947PilomatricomaNeoplasm
H01667MedulloblastomaCancer
EVR7/MRD19H00589Familial exudative vitreoretinopathyNervous system disease
H00773Autosomal dominant intellectual developmental disorderMental and behavioural disorder
MDPT2H01890Pattern dystrophies of the retinal pigment epitheliumNervous system disease
CDCBM9H01881Complex cortical dysplasia with other brain malformationsCongenital malformation
ARVD13H00293Arrhythmogenic right ventricular cardiomyopathyCardiovascular disease
T2DMH00409Type 2 diabetes mellitusEndocrine and metabolic disease
ECTD17H00651Hypohidrotic ectodermal dysplasiaCongenital malformation
RSTS1/MKHK1H00504Rubinstein-Taybi syndromeCongenital malformation
H02650Menke-Hennekam syndromeCongenital malformation
CRC/RSTS2/MKHK2H00020Colorectal cancerCancer
H00504Rubinstein-Taybi syndromeCongenital malformation
H02650Menke-Hennekam syndromeCongenital malformation
BNSH02716Becker nevus syndromeCongenital malformation
BRWS1/DDS1H02023Baraitser-Winter syndromeCongenital malformation
H01255Juvenile-onset dystoniaCongenital malformation
BRWS2/DFNA20/26H02023Baraitser-Winter syndromeCongenital malformation
H00604Deafness, autosomal dominantNervous system disease
IMD110H00093Combined immunodeficiencyPrimary immunodeficiency
COBH01114Ocular colobomaCongenital malformation
SCRAH01180Sveinsson chorioretinal atrophy (SCRA)Nervous system disease
ARVD11H00293Arrhythmogenic right ventricular cardiomyopathyCardiovascular disease
HYPTSVH00782Hypotrichosis and recurrent skin vesiclesSkin disease
PPKS1/EPKHEH00717Striate palmoplantar keratodermaCongenital malformation
H03008Congenital erythroderma with palmoplantar keratoderma, hypotrichosis, and hyper-IgECongenital malformation
ARVD10/CMD1BBH00293Arrhythmogenic right ventricular cardiomyopathyCardiovascular disease
H00294Dilated cardiomyopathyCardiovascular disease
ABOLMH02648Acantholytic blistering of the oral and laryngeal mucosaDigestive system disease
LAH1H00784Localized autosomal recessive hypotrichosisSkin disease
EDSFSH00644Ectodermal dysplasia/skin fragility syndromeCongenital malformation
ARVD9H00293Arrhythmogenic right ventricular cardiomyopathyCardiovascular disease
ARVD12/NXDH00293Arrhythmogenic right ventricular cardiomyopathyCardiovascular disease
H00669Naxos diseaseCongenital malformation
ARVD8/PPKS2/DCWHKTA/EBLA/DCWHKH00293Arrhythmogenic right ventricular cardiomyopathyCardiovascular disease
H00717Striate palmoplantar keratodermaCongenital malformation
H00893Dilated cardiomyopathy with woolly hair, keratoderma, and tooth agenesisCongenital malformation
H01737Epidermolysis bullosaCongenital malformation
H02094Carvajal syndromeCongenital malformation
NSLH1H02191Noonan-like syndrome with loose anagen hairCongenital malformation
NEDGSH03041Neurodevelopmental disorder with poor growth and skeletal anomaliesCongenital malformation
IMD72H02526Disorders of adaptive immunityImmune system disease
DEE65H00606Early infantile epileptic encephalopathyNervous system disease
NEDALVSH03010Neurodevelopmental disorder with absent language and variable seizuresCongenital malformation
IMD113H01725Primary immunodeficiency diseaseImmune system disease
DEVLOH03042Developmental delay, language impairment, and ocular abnormalitiesCongenital malformation
IMD71H00093Combined immunodeficiencyPrimary immunodeficiency
DEE9H00606Early infantile epileptic encephalopathyNervous system disease
DEE19/EIG13/ECA4/EJM5H00606Early infantile epileptic encephalopathyNervous system disease
H00808Idiopathic generalized epilepsiesNervous system disease
H02215Childhood absence epilepsyNervous system disease
H02217Juvenile myoclonic epilepsyNervous system disease
DFNB12/USH1D/1F/PITA5H00605Deafness, autosomal recessiveNervous system disease
H00779Usher syndromeNervous system disease
H01102Pituitary adenomasNeoplasm
DFNB18A/USH1CH00605Deafness, autosomal recessiveNervous system disease
H00779Usher syndromeNervous system disease
USH1GH00779Usher syndromeNervous system disease
DFNA11/DFNB2/USH1BH00604Deafness, autosomal dominantNervous system disease
H00605Deafness, autosomal recessiveNervous system disease
H00779Usher syndromeNervous system disease
DFNB23/USH1D/1FH00605Deafness, autosomal recessiveNervous system disease
H00779Usher syndromeNervous system disease
DFNA36/DFNB7/11H00604Deafness, autosomal dominantNervous system disease
H00605Deafness, autosomal recessiveNervous system disease
DFNB67H00605Deafness, autosomal recessiveNervous system disease
DFNB6H00605Deafness, autosomal recessiveNervous system disease
DFNB48H00605Deafness, autosomal recessiveNervous system disease
VMLDS1/MVP2H01393Van Maldergem syndromeCongenital malformation
H01868Mitral valve prolapseCardiovascular disease
VMLDS2/HKLLS2H01393Van Maldergem syndromeCongenital malformation
H02169Hennekam lymphangiectasia-lymphedema syndromeCongenital malformation
DRPLAH00060Dentatorubropallidoluysian atrophy (DRPLA)Neurodegenerative disease
CHEDDAH03011Congenital hypotonia, epilepsy, developmental delay, and digital anomaliesCongenital malformation
HYC2H01677Congenital hydrocephalusCongenital malformation
LMPHM9/YNSH00535Lymphatic malformationCongenital malformation
H03009Yellow nail syndromeSkin disease
NDNC1H01307Nonsyndromic congenital nail disorderSkin disease
DRS2H00485Robinow syndromeCongenital malformation
DRS3H00485Robinow syndromeCongenital malformation
EDFAOBH02456Ectodermal dysplasiaCongenital malformation
MRD48H00773Autosomal dominant intellectual developmental disorderMental and behavioural disorder
IMD73A/CH01725Primary immunodeficiency diseaseImmune system disease
IMD73BH01725Primary immunodeficiency diseaseImmune system disease
NEDBAFH03043Neurodevelopmental disorder with structural brain anomalies and dysmorphic faciesCongenital malformation