KEGG   PATHWAY: pon05200
Entry
pon05200                    Pathway                                
Name
Pathways in cancer - Pongo abelii (Sumatran orangutan)
Class
Human Diseases; Cancer: overview
Pathway map
pon05200  Pathways in cancer
pon05200

Organism
Pongo abelii (Sumatran orangutan) [GN:pon]
Gene
100442362  DCC; netrin receptor DCC [KO:K06765]
100435491  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100460459  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
100442490  APPL1; DCC-interacting protein 13-alpha isoform X1 [KO:K08733]
100174439  CDH1; cadherin-1 precursor [KO:K05689]
100173739  CTNNB1; catenin beta-1 [KO:K02105]
100174076  CTNNA2; catenin alpha-2 [KO:K05691]
100453792  CTNNA1; catenin alpha-1 isoform X1 [KO:K05691]
100434225  AXIN1; axin-1 isoform X1 [KO:K02157]
100431721  AXIN2; axin-2 isoform X1 [KO:K04385]
100431482  APC; adenomatous polyposis coli protein isoform X2 [KO:K02085]
100435472  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
100447772  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100461234  TCF7; transcription factor 7 isoform X1 [KO:K02620]
100436197  TCF7L1; transcription factor 7-like 1 [KO:K04490]
100434811  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
100447785  LEF1; lymphoid enhancer-binding factor 1 isoform X2 [KO:K04492]
100172652  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
100456735  MYC; myc proto-oncogene protein [KO:K04377]
100171625  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100441356  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100137034  WNT2; protein Wnt-2 precursor [KO:K00182]
100460815  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
100431449  WNT3; proto-oncogene Wnt-3 [KO:K00312]
100448240  WNT3A; protein Wnt-3a isoform X1 [KO:K00312]
100436330  WNT4; protein Wnt-4 [KO:K00408]
100174132  WNT5B; protein Wnt-5b precursor [KO:K00444]
100447525  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
100440643  WNT6; protein Wnt-6 [KO:K00445]
100451196  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
100441147  WNT7A; protein Wnt-7a [KO:K00572]
100450268  WNT8B; protein Wnt-8b [KO:K00714]
100448766  WNT8A; protein Wnt-8a isoform X1 [KO:K00714]
100462535  WNT9B; protein Wnt-9b isoform X1 [KO:K01064]
100452135  WNT9A; protein Wnt-9a [KO:K01064]
100440744  WNT10B; protein Wnt-10b [KO:K01357]
100441013  WNT10A; protein Wnt-10a [KO:K01357]
100443554  WNT11; protein Wnt-11 [KO:K01384]
100452466  WNT16; protein Wnt-16 [KO:K01558]
100437467  FZD7; frizzled-7 [KO:K02432]
100444369  FZD1; frizzled-1 [KO:K02432]
100452043  FZD2; frizzled-2 [KO:K02235]
100457942  FZD3; frizzled-3 [KO:K02329]
100447615  FZD4; frizzled-4 [KO:K02354]
100458618  FZD5; frizzled-5 [KO:K02375]
112135184  FZD8; frizzled-8 [KO:K02375]
100172142  FZD6; frizzled-6 precursor [KO:K02376]
100442825  FZD10; frizzled-10 [KO:K02842]
100438736  FZD9; frizzled-9 [KO:K02842]
100449188  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
100452008  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
100448038  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
100454488  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
100454011  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X2 [KO:K02353]
100461775  FRAT1; proto-oncogene FRAT1 [KO:K03069]
100462141  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
100173859  F2; prothrombin precursor [KO:K01313] [EC:3.4.21.5]
100458106  AGT; angiotensinogen [KO:K09821]
100447792  F2R; proteinase-activated receptor 1 [KO:K03914]
100447897  F2RL3; proteinase-activated receptor 4 [KO:K04236]
100458931  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
100458628  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
100448001  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
100459511  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
100444153  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
100432438  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
100461588  AGTR1; type-1 angiotensin II receptor [KO:K04166]
100173387  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
100461065  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
100457621  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
100450531  ARHGEF11; rho guanine nucleotide exchange factor 11 isoform X2 [KO:K12331]
100438951  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
100453517  PLEKHG5; pleckstrin homology domain-containing family G member 5 isoform X1 [KO:K19464]
100171605  RHOA; transforming protein RhoA precursor [KO:K04513]
100432582  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
100461801  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
100173045  CXCL12; stromal cell-derived factor 1 precursor [KO:K10031]
100451032  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
100456074  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
100172679  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100458137  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
100438451  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
100440992  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
100447375  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X5 [KO:K04260]
100445063  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
100442753  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X3 [KO:K04632]
103888841  neuroendocrine secretory protein 55 [KO:K04632]
100449504  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
100445431  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
100431221  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
100460806  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100454138  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
100438178  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
100436577  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
100461383  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
103889530  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
100174748  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform 2 [KO:K04345] [EC:2.7.11.11]
100431906  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma isoform X1 [KO:K04345] [EC:2.7.11.11]
100437102  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100173664  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
100458183  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1 [KO:K04537]
100453483  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X2 [KO:K07825]
100455858  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
100171833  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
100172647  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor [KO:K07826]
100453366  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100190818  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 precursor [KO:K04541]
100171710  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 precursor [KO:K04542]
100453407  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
112130221  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
100433177  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
100439475  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 isoform X2 [KO:K04546]
100173039  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 precursor [KO:K04347]
112130240  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
112129369  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100439849  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X3 [KO:K04548]
100452739  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
100457450  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
100457807  COL4A5; collagen alpha-5(IV) chain isoform X3 [KO:K06237]
100444160  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
100444523  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
100443710  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
100444077  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
100438698  LAMA1; laminin subunit alpha-1 [KO:K05637]
100458901  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
100439539  LAMA3; laminin subunit alpha-3 [KO:K06240]
100456580  LOW QUALITY PROTEIN: laminin subunit alpha-5-like [KO:K06240]
100458670  LAMB1; laminin subunit beta-1 [KO:K05636]
100441641  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
100434204  LAMB3; laminin subunit beta-3 [KO:K06244]
100461994  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
100446999  LAMC1; laminin subunit gamma-1 [KO:K05635]
100446634  LAMC2; laminin subunit gamma-2 [KO:K06246]
100441462  LAMC3; laminin subunit gamma-3 [KO:K06247]
100449704  FN1; fibronectin isoform X1 [KO:K05717]
100452800  ITGA2B; integrin alpha-IIb [KO:K06476]
100459915  ITGA3; integrin alpha-3 [KO:K06482]
100442478  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
100451792  ITGAV; integrin alpha-V [KO:K06487]
100172223  ITGB1; integrin beta-1 precursor [KO:K05719]
100447959  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
100432846  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100453779  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103889133  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100174298  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100173589  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
100437617  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100171828  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100436271  NKX3-1; homeobox protein Nkx-3.1 [KO:K09348]
100454279  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100448114  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100442100  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100174735  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
100440586  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X3 [KO:K07209] [EC:2.7.11.10]
100449496  IKBKG; NF-kappa-B essential modulator isoform X5 [KO:K07210]
100459445  NF-kappa-B inhibitor alpha [KO:K04734]
100461595  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100462387  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
100456049  RELA; transcription factor p65 [KO:K04735]
100436566  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100436584  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
100938429  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
100457858  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
100457249  BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
100449741  XIAP; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
100937717  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
100432733  BIRC7; baculoviral IAP repeat-containing protein 7 isoform X2 [KO:K16061]
100453051  BCL2L1; bcl-2-like protein 1 [KO:K04570]
100172676  TRAF1; TNF receptor-associated factor 1 [KO:K03172]
100458089  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100460079  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100431446  TRAF4; TNF receptor-associated factor 4 [KO:K09848]
100453867  TRAF5; TNF receptor-associated factor 5 isoform X2 [KO:K09849]
100449432  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100456786  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100462008  LOW QUALITY PROTEIN: ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
100459428  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
100456988  RPS6KB1; LOW QUALITY PROTEIN: ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
100454097  BAD; bcl2-associated agonist of cell death [KO:K02158]
100460676  FOXO1; forkhead box protein O1 [KO:K07201]
100171532  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
100435218  TP53; cellular tumor antigen p53 [KO:K04451]
100449905  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100453682  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100431481  BCR; breakpoint cluster region protein [KO:K08878] [EC:2.7.11.1]
100453216  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
100452410  CRK; adapter molecule crk isoform X1 [KO:K04438]
100443298  CRKL; crk-like protein [KO:K04438]
100462634  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
100461695  STAT5A; signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
100462537  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
100461844  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
100456126  PIM2; serine/threonine-protein kinase pim-2 [KO:K08806] [EC:2.7.11.1]
100432100  KNG1; kininogen-1 isoform X1 [KO:K03898]
100457204  EDN1; endothelin-1 [KO:K16366]
100434593  BDKRB1; B1 bradykinin receptor isoform X2 [KO:K03915]
100434213  BDKRB2; B2 bradykinin receptor isoform X1 [KO:K03916]
100439448  EDNRA; endothelin-1 receptor isoform X2 [KO:K04197]
100452014  EDNRB; endothelin receptor type B isoform X2 [KO:K04198]
100458686  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
100460338  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
100458716  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100460060  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
100434502  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100461961  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100434355  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100439900  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100451563  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100455248  IL2; interleukin-2 [KO:K05429]
100447057  IL3; interleukin-3 [KO:K04736]
100451705  IL4; interleukin-4 isoform X1 [KO:K05430]
100450694  IL5; interleukin-5 [KO:K05428]
100453941  IL6; interleukin-6 isoform X2 [KO:K05405]
100447454  IL7; interleukin-7 isoform X1 [KO:K05431]
100444807  IL12A; interleukin-12 subunit alpha [KO:K05406]
100435254  IL12B; interleukin-12 subunit beta [KO:K05425]
100451066  IL13; interleukin-13 isoform X1 [KO:K05435]
100456813  IL15; interleukin-15 [KO:K05433]
100452384  IL23A; interleukin-23 subunit alpha [KO:K05426]
100459890  EPO; erythropoietin isoform X1 [KO:K05437]
100459543  interferon alpha-10 [KO:K05414]
100432532  IFNA8; interferon alpha-8 [KO:K05414]
100432906  IFNA2; interferon alpha-2 [KO:K05414]
100434036  IFNA6; interferon alpha-6 [KO:K05414]
100434796  interferon alpha-5 [KO:K05414]
100435169  interferon alpha-14 [KO:K05414]
100438871  interferon alpha-17-like [KO:K05414]
100439978  IFNA21; interferon alpha-21 [KO:K05414]
100432153  interferon alpha-1/13 [KO:K05414]
100445711  interferon alpha-10-like [KO:K05414]
100438149  interferon alpha-4-like [KO:K05414]
100437034  interferon alpha-4-like [KO:K05414]
100433301  interferon alpha-1/13-like [KO:K05414]
112134962  interferon alpha-10-like [KO:K05414]
100443523  interferon alpha-4-like [KO:K05414]
100444043  IFNG; interferon gamma [KO:K04687]
100440118  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
100460977  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
100454903  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
100462256  interleukin-3 receptor subunit alpha [KO:K04737]
100449812  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
100457063  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
100450437  IL5RA; interleukin-5 receptor subunit alpha isoform X2 [KO:K05067]
100459702  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
100451191  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
100461835  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
100435478  IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063]
100456779  IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
100457694  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
100439247  IL15RA; interleukin-15 receptor subunit alpha isoform X6 [KO:K05074]
100458963  IL23R; interleukin-23 receptor [KO:K05065]
100452294  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
100443118  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100441293  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
100171593  IFNGR1; interferon gamma receptor 1 precursor [KO:K05132]
100442383  IFNGR2; interferon gamma receptor 2 [KO:K05133]
100453034  EML4; echinoderm microtubule-associated protein-like 4 isoform X1 [KO:K15420]
100458012  ALK; ALK tyrosine kinase receptor isoform X1 [KO:K05119] [EC:2.7.10.1]
100451529  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
100447844  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
100171706  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
100444206  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
100433477  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100172517  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
100433988  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
100171541  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
100173683  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100452011  STAT2; signal transducer and activator of transcription 2 isoform X3 [KO:K11221]
100436344  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
100173709  STAT6; signal transducer and activator of transcription 6 [KO:K11225]
100448769  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
100456050  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
100440872  PGF; placenta growth factor isoform X1 [KO:K16859]
100453191  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
100433743  VEGFD; vascular endothelial growth factor D [KO:K05449]
100172994  TGFA; protransforming growth factor alpha precursor [KO:K08774]
100455021  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100459280  EGFR; epidermal growth factor receptor isoform X2 [KO:K04361] [EC:2.7.10.1]
100450307  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
100440212  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100460243  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
100431735  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100460001  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
100444645  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
100453365  IGF2; insulin-like growth factor II [KO:K13769]
100172156  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100459690  KITLG; kit ligand isoform X1 [KO:K05461]
100437110  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
100439816  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
100454731  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
100462115  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
100137030  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100174103  FGF1; fibroblast growth factor 1 [KO:K18496]
100459751  FGF2; fibroblast growth factor 2 [KO:K18497]
100454905  FGF16; fibroblast growth factor 16 [KO:K04358]
100448388  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
100454475  FGF9; fibroblast growth factor 9 [KO:K04358]
100460891  FGF20; fibroblast growth factor 20 [KO:K04358]
100450364  FGF17; fibroblast growth factor 17 isoform X2 [KO:K04358]
100440363  FGF3; fibroblast growth factor 3 [KO:K04358]
100440732  FGF4; fibroblast growth factor 4 [KO:K04358]
100459069  FGF6; fibroblast growth factor 6 [KO:K04358]
100432789  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
100437858  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
100460498  FGF18; fibroblast growth factor 18 [KO:K04358]
100172539  FGF7; fibroblast growth factor 7 precursor [KO:K04358]
100431992  FGF10; fibroblast growth factor 10 [KO:K04358]
100441475  FGF19; fibroblast growth factor 19 [KO:K22603]
100447289  FGF21; fibroblast growth factor 21 [KO:K22429]
100439010  FGF23; fibroblast growth factor 23 [KO:K22428]
100174545  FGFR1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
100171540  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
100433126  FGFR3; LOW QUALITY PROTEIN: fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
100461105  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
100173972  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100434331  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100458733  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100459427  HRAS; GTPase HRas [KO:K02833]
100462513  KRAS; GTPase KRas isoform X1 [KO:K07827]
100174317  NRAS; GTPase NRas precursor [KO:K07828]
100431871  ARAF; serine/threonine-protein kinase A-Raf isoform X4 [KO:K08845] [EC:2.7.11.1]
100442288  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100173732  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
100446021  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100450988  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100169740  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100431824  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100450292  JUN; transcription factor AP-1 [KO:K04448]
100462290  FOS; proto-oncogene c-Fos [KO:K04379]
100444400  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
100459931  MMP1; interstitial collagenase [KO:K01388] [EC:3.4.24.7]
100451667  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
100455867  MMP9; LOW QUALITY PROTEIN: matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
100437111  interleukin-8 isoform X1 [KO:K10030]
100437488  LOW QUALITY PROTEIN: interleukin-8 [KO:K10030]
112128505  interleukin-8 [KO:K10030]
100443314  CDK4; cyclin-dependent kinase 4 isoform X2 [KO:K02089] [EC:2.7.11.22]
100173967  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
100442682  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
100457000  CCDC6; coiled-coil domain-containing protein 6 [KO:K09288]
100172727  NCOA4; nuclear receptor coactivator 4 [KO:K09289]
100452269  NTRK1; high affinity nerve growth factor receptor isoform X2 [KO:K03176] [EC:2.7.10.1]
100174017  TPM3; tropomyosin alpha-3 chain [KO:K09290]
100444048  TPR; nucleoprotein TPR [KO:K09291]
100461706  TFG; protein TFG isoform X1 [KO:K09292]
103888520  RASSF1; ras association domain-containing protein 1 isoform X3 [KO:K09850]
100450890  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
100438713  STK4; serine/threonine-protein kinase 4 [KO:K04411]
100448934  DAPK1; death-associated protein kinase 1 [KO:K08803] [EC:2.7.11.1]
100440287  DAPK3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
100455827  DAPK2; death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
100450941  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
100457650  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100432611  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
100436432  CALML5; calmodulin-like protein 5 [KO:K02183]
100436811  CALML3; calmodulin-like protein 3 [KO:K02183]
100444426  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
100172680  CALM1; calmodulin [KO:K02183]
100173214  CALM2; calmodulin [KO:K02183]
100172890  CALM3; calmodulin [KO:K02183]
100451658  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
100455662  calmodulin-alpha-like [KO:K02183]
103892390  calmodulin-like [KO:K02183]
100433531  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
100172212  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
100462386  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
100436747  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
100451493  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
100434751  LOW QUALITY PROTEIN: ral-GDS-related protein [KO:K08732]
100441438  RALA; ras-related protein Ral-A [KO:K07834]
100174018  RALB; ras-related protein Ral-B precursor [KO:K07835]
100431225  RALBP1; ralA-binding protein 1 isoform X1 [KO:K08773]
100438199  CDC42; cell division control protein 42 homolog [KO:K04393]
100443271  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100431483  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
112129584  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100439813  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
100457163  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
100174482  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
100459133  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100437424  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100189903  PAX8; paired box protein Pax-8 isoform 1 [KO:K09293]
100171496  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
100460920  RXRB; retinoic acid receptor RXR-beta isoform X2 [KO:K08525]
100171682  RXRG; retinoic acid receptor RXR-gamma [KO:K08526]
100439439  RARB; retinoic acid receptor beta isoform X3 [KO:K08528]
100441912  ESR1; estrogen receptor isoform X2 [KO:K08550]
100459579  ESR2; estrogen receptor beta isoform X1 [KO:K08551]
100432710  NCOA1; nuclear receptor coactivator 1 isoform X1 [KO:K09101] [EC:2.3.1.48]
100432859  NCOA3; nuclear receptor coactivator 3 isoform X1 [KO:K11256] [EC:2.3.1.48]
100440745  SP1; transcription factor Sp1 isoform X1 [KO:K04684]
100444721  PPARD; peroxisome proliferator-activated receptor delta [KO:K04504]
100440279  junction plakoglobin [KO:K10056]
100451883  ZBTB16; zinc finger and BTB domain-containing protein 16 isoform X1 [KO:K10055]
100439672  RARA; retinoic acid receptor alpha isoform X1 [KO:K08527]
100449200  CCNA1; cyclin-A1 isoform X2 [KO:K06627]
100453784  CCNA2; cyclin-A2 [KO:K06627]
100445630  PML; LOW QUALITY PROTEIN: protein PML [KO:K10054] [EC:2.3.2.-]
100449725  RUNX1; LOW QUALITY PROTEIN: runt-related transcription factor 1 [KO:K08367]
100456274  RUNX1T1; LOW QUALITY PROTEIN: protein CBFA2T1 [KO:K10053]
100449540  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
100442871  CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055]
100452697  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1 [KO:K05066]
100452320  LOW QUALITY PROTEIN: granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
100433338  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
100433386  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
100461015  cyclin-dependent kinase inhibitor 2A [KO:K06621]
100435851  E2F1; transcription factor E2F1 [KO:K17454]
100458002  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
100448297  E2F3; transcription factor E2F3 isoform X3 [KO:K06620]
100436950  MAX; protein max isoform X4 [KO:K04453]
100454123  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
100459175  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
100454924  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100457978  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100452570  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100454367  CKS1B; cyclin-dependent kinases regulatory subunit 1 [KO:K02219]
100462374  CKS2; cyclin-dependent kinases regulatory subunit 2 [KO:K02219]
100174716  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
112135798  S-phase kinase-associated protein 1-like [KO:K03094]
100441665  RBX1; E3 ubiquitin-protein ligase RBX1 isoform X2 [KO:K03868] [EC:2.3.2.32]
100432371  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
100446748  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
100438282  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
100461587  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
100462155  RB1; retinoblastoma-associated protein [KO:K06618]
100436665  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100452809  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100456437  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
100450682  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
100460189  bcl-2 homologous antagonist/killer [KO:K14021]
100432001  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
100454099  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
100443121  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
100936787  LOW QUALITY PROTEIN: telomerase reverse transcriptase-like [KO:K11126] [EC:2.7.7.49]
100936620  TERT; LOW QUALITY PROTEIN: telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
100172074  MITF; microphthalmia-associated transcription factor isoform X3 [KO:K09455]
100459982  TGFB1; transforming growth factor beta-1 [KO:K13375]
100461291  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
100433208  TGFB3; transforming growth factor beta-3 [KO:K13377]
100450864  TGFBR1; TGF-beta receptor type-1 isoform X2 [KO:K04674] [EC:2.7.11.30]
100459236  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
100173357  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
100448249  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
100439171  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
100431606  MECOM; MDS1 and EVI1 complex locus protein EVI1 [KO:K04462] [EC:2.1.1.367]
100461333  CTBP1; C-terminal-binding protein 1 isoform X2 [KO:K04496] [EC:1.1.1.428]
100452123  CTBP2; C-terminal-binding protein 2 isoform X1 [KO:K04496] [EC:1.1.1.428]
100172663  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
100294534  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
100436876  MLH1; DNA mismatch repair protein Mlh1 isoform X1 [KO:K08734]
100431828  MSH2; DNA mismatch repair protein Msh2 isoform X1 [KO:K08735]
100171924  MSH3; DNA mismatch repair protein Msh3 [KO:K08736]
100458732  MSH6; DNA mismatch repair protein Msh6 [KO:K08737]
100435800  BRCA2; breast cancer type 2 susceptibility protein [KO:K08775]
100432066  RAD51; DNA repair protein RAD51 homolog 1 isoform X2 [KO:K04482]
100461418  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
100439256  FADD; FAS-associated death domain protein [KO:K02373]
100172115  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100173269  BID; BH3-interacting domain death agonist [KO:K04726]
100457415  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
100452429  BBC3; bcl-2-binding component 3 isoform X1 [KO:K10132]
100443209  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
100171479  CYCS; cytochrome c [KO:K08738]
100462404  cytochrome c-like [KO:K08738]
112128551  cytochrome c-like [KO:K08738]
100445149  cytochrome c-like [KO:K08738]
112128607  cytochrome c-like [KO:K08738]
112130824  cytochrome c-like [KO:K08738]
112132396  LOW QUALITY PROTEIN: cytochrome c 2-like [KO:K08738]
112133797  cytochrome c-like [KO:K08738]
112134675  cytochrome c-like [KO:K08738]
112134685  cytochrome c-like [KO:K08738]
112134371  cytochrome c-like [KO:K08738]
112134960  cytochrome c-like [KO:K08738]
112135506  cytochrome c-like [KO:K08738]
100459074  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
100435918  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
100173389  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
100172480  NFE2L2; nuclear factor erythroid 2-related factor 2 [KO:K05638]
100173339  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
100172039  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
100174562  GSTM2; glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
100437206  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
100437569  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
100439198  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
100445078  glutathione S-transferase A2 isoform X1 [KO:K00799] [EC:2.5.1.18]
100445448  GSTA1; glutathione S-transferase A1 isoform X1 [KO:K00799] [EC:2.5.1.18]
100446578  glutathione S-transferase A3 isoform X1 [KO:K00799] [EC:2.5.1.18]
100447725  GSTO1; glutathione S-transferase omega-1 isoform X2 [KO:K00799] [EC:2.5.1.18]
100448103  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
100450689  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
100450954  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
100452892  GSTM3; glutathione S-transferase Mu 3 isoform X1 [KO:K00799] [EC:2.5.1.18]
100453263  glutathione S-transferase Mu 5 [KO:K00799] [EC:2.5.1.18]
100453622  glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
100454483  glutathione S-transferase Mu 1 isoform X5 [KO:K00799] [EC:2.5.1.18]
100461022  glutathione S-transferase theta-2B [KO:K00799] [EC:2.5.1.18]
100445831  LOW QUALITY PROTEIN: glutathione S-transferase A5 [KO:K00799] [EC:2.5.1.18]
100439941  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
100450224  LOW QUALITY PROTEIN: glutathione S-transferase A3 [KO:K00799] [EC:2.5.1.18]
100451109  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
100449856  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
100442886  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
100450378  LOW QUALITY PROTEIN: glutathione S-transferase theta-2-like [KO:K00799] [EC:2.5.1.18]
100432722  glutathione S-transferase omega-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
112133809  glutathione S-transferase A5-like [KO:K00799] [EC:2.5.1.18]
100449495  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
100174544  GSTP1; glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
100174180  TXNRD1; thioredoxin reductase 1, cytoplasmic [KO:K22182] [EC:1.8.1.9]
100440283  TXNRD3; thioredoxin reductase 3 [KO:K22182] [EC:1.8.1.9]
100455257  TXNRD2; thioredoxin reductase 2, mitochondrial [KO:K22182] [EC:1.8.1.9]
100173372  VHL; von Hippel-Lindau disease tumor suppressor [KO:K03871]
100431947  VHLL; LOW QUALITY PROTEIN: von Hippel-Lindau-like protein [KO:K03871]
100439601  ELOC; elongin-C isoform X1 [KO:K03872]
100445769  elongin-C-like [KO:K03872]
100441119  elongin-C-like [KO:K03872]
112130159  elongin-C-like [KO:K03872]
100456083  ELOB; elongin-B [KO:K03873]
100174361  CUL2; cullin-2 [KO:K03870]
100172704  EGLN2; egl nine homolog 2 [KO:K09592] [EC:1.14.11.29]
100451138  EGLN3; egl nine homolog 3 [KO:K09592] [EC:1.14.11.29]
100454843  EGLN1; egl nine homolog 1 [KO:K09592] [EC:1.14.11.29]
100172452  FH; fumarate hydratase, mitochondrial [KO:K01679] [EC:4.2.1.2]
100173994  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
100439667  EPAS1; endothelial PAS domain-containing protein 1 isoform X1 [KO:K09095]
100172172  ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
100440880  ARNT2; aryl hydrocarbon receptor nuclear translocator 2 isoform X1 [KO:K15589]
100455260  EP300; histone acetyltransferase p300 isoform X2 [KO:K04498] [EC:2.3.1.48]
100445634  CREBBP; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
100173447  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
100431986  JAG1; protein jagged-1 [KO:K06052]
100447370  JAG2; protein jagged-2 isoform X1 [KO:K21635]
100437589  DLL4; delta-like protein 4 [KO:K06051]
100436112  DLL3; delta-like protein 3 isoform X2 [KO:K06051]
100436254  DLL1; delta-like protein 1 [KO:K06051]
100449179  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
100447628  NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
100454773  NOTCH3; neurogenic locus notch homolog protein 3 [KO:K20995]
100436768  NOTCH4; neurogenic locus notch homolog protein 4 [KO:K20996]
100455979  HES1; transcription factor HES-1 [KO:K06054]
112129124  HES5; transcription factor HES-5 [KO:K06055]
100448422  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 isoform X1 [KO:K09091]
100172222  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
100444303  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
100462098  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100461003  SHH; sonic hedgehog protein isoform X1 [KO:K11988]
100452966  SMO; smoothened homolog [KO:K06226]
100440029  KIF7; kinesin-like protein KIF7 isoform X1 [KO:K18806]
100438531  GLI1; zinc finger protein GLI1 isoform X1 [KO:K16797]
100461064  GLI2; zinc finger protein GLI2 isoform X1 [KO:K16798]
100438626  GLI3; transcriptional activator GLI3 isoform X1 [KO:K06230]
100460853  BMP2; bone morphogenetic protein 2 [KO:K21283]
100449444  BMP4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
100434376  HHIP; hedgehog-interacting protein [KO:K06231]
100460320  PTCH2; protein patched homolog 2 isoform X1 [KO:K11101]
100171490  AR; androgen receptor [KO:K08557]
100173428  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
100173221  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
100445801  LOW QUALITY PROTEIN: putative heat shock protein HSP 90-alpha A5 [KO:K04079]
100447247  heat shock protein HSP 90-beta-like [KO:K04079]
100174651  HSP90B1; endoplasmin precursor [KO:K09487]
100432364  KLK3; prostate-specific antigen isoform X1 [KO:K01351] [EC:3.4.21.77]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00122  Fumarate
C00149  (S)-Malate
C00165  Diacylglycerol
C00187  Cholesterol
C00280  Androstenedione
C00410  Progesterone
C00416  Phosphatidate
C00533  Nitric oxide
C00535  Testosterone
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00681  1-Acyl-sn-glycerol 3-phosphate
C00704  Superoxide
C00735  Cortisol
C00762  Cortisone
C00777  Retinoate
C00951  Estradiol-17beta
C01227  Dehydroepiandrosterone
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01471  Acrolein
C03917  Dihydrotestosterone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07653  Flutamide
C15493  9-cis-Retinoic acid
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16844  Hydroxyl radical
C21641  Hydroperoxyl radical
C21642  4-Hydroxynonenal
Reference
  Authors
Weinberg RA.
  Title
The biology of cancer
  Journal
Garland Science, Taylor & Francis Group, LLC (2007)
Reference
PMID:10647931
  Authors
Hanahan D, Weinberg RA
  Title
The hallmarks of cancer.
  Journal
Cell 100:57-70 (2000)
DOI:10.1016/S0092-8674(00)81683-9
Reference
PMID:15000146
  Authors
Grady WM.
  Title
Genomic instability and colon cancer.
  Journal
Cancer Metastasis Rev 23:11-27 (2004)
DOI:10.1023/A:1025861527711
Reference
PMID:16555243
  Authors
Soreide K, Janssen EA, Soiland H, Korner H, Baak JP.
  Title
Microsatellite instability in colorectal cancer.
  Journal
Br J Surg 93:395-406 (2006)
DOI:10.1002/bjs.5328
Reference
PMID:11078609
  Authors
Anwar S, Hall C, White J, Deakin M, Farrell W, Elder JB.
  Title
Hereditary non-polyposis colorectal cancer: an updated review.
  Journal
Eur J Surg Oncol 26:635-45 (2000)
DOI:10.1053/ejso.2000.0974
Reference
PMID:16699851
  Authors
Takayama T, Miyanishi K, Hayashi T, Sato Y, Niitsu Y.
  Title
Colorectal cancer: genetics of development and metastasis.
  Journal
J Gastroenterol 41:185-92 (2006)
DOI:10.1007/s00535-006-1801-6
Reference
PMID:12621137
  Authors
Lynch HT, de la Chapelle A.
  Title
Hereditary colorectal cancer.
  Journal
N Engl J Med 348:919-32 (2003)
DOI:10.1056/NEJMra012242
Reference
PMID:12951588
  Authors
Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C.
  Title
The significance of unstable chromosomes in colorectal cancer.
  Journal
Nat Rev Cancer 3:695-701 (2003)
DOI:10.1038/nrc1165
Reference
PMID:10505543
  Authors
Behrens J.
  Title
Cadherins and catenins: role in signal transduction and tumor progression.
  Journal
Cancer Metastasis Rev 18:15-30 (1999)
DOI:10.1023/A:1006200102166
Reference
PMID:16042571
  Authors
Behrens J.
  Title
The role of the Wnt signalling pathway in colorectal tumorigenesis.
  Journal
Biochem Soc Trans 33:672-5 (2005)
DOI:10.1042/BST0330672
Reference
PMID:15349822
  Authors
Behrens J, Lustig B.
  Title
The Wnt connection to tumorigenesis.
  Journal
Int J Dev Biol 48:477-87 (2004)
DOI:10.1387/ijdb.041815jb
Reference
PMID:9196022
  Authors
Polakis P.
  Title
The adenomatous polyposis coli (APC) tumor suppressor.
  Journal
Biochim Biophys Acta 1332:F127-47 (1997)
DOI:10.1016/S0304-419X(97)00008-5
Reference
PMID:12737309
  Authors
Janssen KP.
  Title
Murine models of colorectal cancer: studying the role of oncogenic K-ras.
  Journal
Cell Mol Life Sci 60:495-506 (2003)
DOI:10.1007/s000180300041
Reference
PMID:11459867
  Authors
Adjei AA.
  Title
Blocking oncogenic Ras signaling for cancer therapy.
  Journal
J Natl Cancer Inst 93:1062-74 (2001)
DOI:10.1093/jnci/93.14.1062
Reference
PMID:15573119
  Authors
Arakawa H.
  Title
Netrin-1 and its receptors in tumorigenesis.
  Journal
Nat Rev Cancer 4:978-87 (2004)
DOI:10.1038/nrc1504
Reference
PMID:15310786
  Authors
Mehlen P, Fearon ER.
  Title
Role of the dependence receptor DCC in colorectal cancer pathogenesis.
  Journal
J Clin Oncol 22:3420-8 (2004)
DOI:10.1200/JCO.2004.02.019
Reference
PMID:11223406
  Authors
Peltomaki P.
  Title
DNA mismatch repair and cancer.
  Journal
Mutat Res 488:77-85 (2001)
DOI:10.1016/S1383-5742(00)00058-2
Reference
PMID:15711891
  Authors
Li F, Cao Y, Townsend CM Jr, Ko TC.
  Title
TGF-beta signaling in colon cancer cells.
  Journal
World J Surg 29:306-11 (2005)
DOI:10.1007/s00268-004-7813-6
Reference
PMID:11170304
  Authors
Roman C, Saha D, Beauchamp R.
  Title
TGF-beta and colorectal carcinogenesis.
  Journal
Microsc Res Tech 52:450-7 (2001)
DOI:10.1002/1097-0029(20010215)52:4<450::AID-JEMT1030>3.0.CO;2-O
Reference
PMID:16326109
  Authors
Watson AJ.
  Title
An overview of apoptosis and the prevention of colorectal cancer.
  Journal
Crit Rev Oncol Hematol 57:107-21 (2006)
DOI:10.1016/j.critrevonc.2005.06.005
Reference
PMID:15479695
  Authors
Watson AJ.
  Title
Apoptosis and colorectal cancer.
  Journal
Gut 53:1701-9 (2004)
DOI:10.1136/gut.2004.052704
Reference
PMID:11477132
  Authors
Houlston RS.
  Title
What we could do now: molecular pathology of colorectal cancer.
  Journal
Mol Pathol 54:206-14 (2001)
DOI:10.1136/mp.54.4.206
Reference
  Authors
Von Hoff D, Evans D, Hruban R (ed).
  Title
Pancreatic cancer
  Journal
Jones and Bartlett publishers (2005)
Reference
  Authors
Niitsu Y, Yokota J (ed).
  Title
[Oncogenes and Tumor Suppressor Genes for Medical Oncologist] (In Japanese)
  Journal
Nankodo (1999)
Reference
PMID:12459728
  Authors
Bardeesy N, DePinho RA.
  Title
Pancreatic cancer biology and genetics.
  Journal
Nat Rev Cancer 2:897-909 (2002)
DOI:10.1038/nrc949
Reference
PMID:11407945
  Authors
Bardeesy N, Sharpless NE, DePinho RA, Merlino G.
  Title
The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model.
  Journal
Semin Cancer Biol 11:201-18 (2001)
DOI:10.1006/scbi.2000.0371
Reference
PMID:12946833
  Authors
Cowgill SM, Muscarella P.
  Title
The genetics of pancreatic cancer.
  Journal
Am J Surg 186:279-86 (2003)
DOI:10.1016/S0002-9610(03)00226-5
Reference
PMID:16702400
  Authors
Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA.
  Title
Genetics and biology of pancreatic ductal adenocarcinoma.
  Journal
Genes Dev 20:1218-49 (2006)
DOI:10.1101/gad.1415606
Reference
PMID:10740269
  Authors
Shields JM, Pruitt K, McFall A, Shaub A, Der CJ.
  Title
Understanding Ras: 'it ain't over 'til it's over'.
  Journal
Trends Cell Biol 10:147-54 (2000)
DOI:10.1016/S0962-8924(00)01740-2
Reference
PMID:12648469
  Authors
Holbro T, Civenni G, Hynes NE.
  Title
The ErbB receptors and their role in cancer progression.
  Journal
Exp Cell Res 284:99-110 (2003)
DOI:10.1016/S0014-4827(02)00099-X
Reference
PMID:14967450
  Authors
Marmor MD, Skaria KB, Yarden Y.
  Title
Signal transduction and oncogenesis by ErbB/HER receptors.
  Journal
Int J Radiat Oncol Biol Phys 58:903-13 (2004)
DOI:10.1016/j.ijrobp.2003.06.002
Reference
PMID:14586404
  Authors
DeArmond D, Brattain MG, Jessup JM, Kreisberg J, Malik S, Zhao S, Freeman JW.
  Title
Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines.
  Journal
Oncogene 22:7781-95 (2003)
DOI:10.1038/sj.onc.1206966
Reference
PMID:12545153
  Authors
Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K.
  Title
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis.
  Journal
Oncogene 22:319-29 (2003)
DOI:10.1038/sj.onc.1206122
Reference
PMID:14580692
  Authors
Toyonaga T, Nakano K, Nagano M, Zhao G, Yamaguchi K, Kuroki S, Eguchi T, Chijiiwa K, Tsuneyoshi M, Tanaka M.
  Title
Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer.
  Journal
Cancer Lett 201:107-16 (2003)
DOI:10.1016/S0304-3835(03)00482-8
Reference
PMID:12079267
  Authors
Schmid RM.
  Title
Genetic basis of pancreatic cancer.
  Journal
Best Pract Res Clin Gastroenterol 16:421-33 (2002)
DOI:10.1053/bega.2002.0316
Reference
PMID:15774796
  Authors
Elliott RL, Blobe GC.
  Title
Role of transforming growth factor Beta in human cancer.
  Journal
J Clin Oncol 23:2078-93 (2005)
DOI:10.1200/JCO.2005.02.047
Reference
PMID:15823750
  Authors
Rudkin TM, Foulkes WD.
  Title
BRCA2: breaks, mistakes and failed separations.
  Journal
Trends Mol Med 11:145-8 (2005)
DOI:10.1016/j.molmed.2005.02.003
Reference
PMID:11707511
  Authors
Venkitaraman AR.
  Title
Functions of BRCA1 and BRCA2 in the biological response to DNA damage.
  Journal
J Cell Sci 114:3591-8 (2001)
Reference
PMID:15639402
  Authors
Soni D, King JA, Kaye AH, Hovens CM.
  Title
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge.
  Journal
J Clin Neurosci 12:1-5 (2005)
DOI:10.1016/j.jocn.2004.04.001
Reference
PMID:12154354
  Authors
Zhu Y, Parada LF.
  Title
The molecular and genetic basis of neurological tumours.
  Journal
Nat Rev Cancer 2:616-26 (2002)
DOI:10.1038/nrc866
Reference
PMID:11253051
  Authors
Holland EC.
  Title
Gliomagenesis: genetic alterations and mouse models.
  Journal
Nat Rev Genet 2:120-9 (2001)
DOI:10.1038/35052535
Reference
PMID:16700615
  Authors
Bansal K, Liang ML, Rutka JT.
  Title
Molecular biology of human gliomas.
  Journal
Technol Cancer Res Treat 5:185-94 (2006)
DOI:10.1177/153303460600500302
Reference
  Authors
Tabuchi K (ed).
  Title
[Gliomas: Research and therapy] (In Japanese)
  Journal
Springer-Verlag Tokyo (2006)
Reference
PMID:12762887
  Authors
Kapoor GS, O'Rourke DM.
  Title
Mitogenic signaling cascades in glial tumors.
  Journal
Neurosurgery 52:1425-34; discussion 1434-5 (2003)
DOI:10.1227/01.NEU.0000065135.28143.39
Reference
PMID:16095998
  Authors
Hulleman E, Helin K.
  Title
Molecular mechanisms in gliomagenesis.
  Journal
Adv Cancer Res 94:1-27 (2005)
DOI:10.1016/S0065-230X(05)94001-3
Reference
PMID:11057895
  Authors
Schlessinger J.
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 103:211-25 (2000)
DOI:10.1016/S0092-8674(00)00114-8
Reference
PMID:9643506
  Authors
Ng HK, Lam PY.
  Title
The molecular genetics of central nervous system tumors.
  Journal
Pathology 30:196-202 (1998)
DOI:10.1080/00313029800169236
Reference
PMID:12084351
  Authors
Knobbe CB, Merlo A, Reifenberger G.
  Title
Pten signaling in gliomas.
  Journal
Neuro-oncol 4:196-211 (2002)
DOI:10.1093/neuonc/4.3.196
Reference
PMID:16557281
  Authors
Kondo T, Ezzat S, Asa SL.
  Title
Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
  Journal
Nat Rev Cancer 6:292-306 (2006)
DOI:10.1038/nrc1836
Reference
PMID:16551846
  Authors
Chiloeches A, Marais R.
  Title
Is BRAF the Achilles' Heel of thyroid cancer?
  Journal
Clin Cancer Res 12:1661-4 (2006)
DOI:10.1158/1078-0432.CCR-06-0051
Reference
PMID:16946003
  Authors
Reddi HV, McIver B, Grebe SK, Eberhardt NL
  Title
The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
  Journal
Endocrinology 148:932-5 (2007)
DOI:10.1210/en.2006-0926
Reference
PMID:17062879
  Authors
Santoro M, Melillo RM, Fusco A.
  Title
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
  Journal
Eur J Endocrinol 155:645-653 (2006)
DOI:10.1530/eje.1.02289
Reference
PMID:16242838
  Authors
Pierotti MA, Greco A.
  Title
Oncogenic rearrangements of the NTRK1/NGF receptor.
  Journal
Cancer Lett 232:90-8 (2006)
DOI:10.1016/j.canlet.2005.07.043
Reference
PMID:16189702
  Authors
Sobrinho-Simoes M, Preto A, Rocha AS, Castro P, Maximo V, Fonseca E, Soares P.
  Title
Molecular pathology of well-differentiated thyroid carcinomas.
  Journal
Virchows Arch 447:787-93 (2005)
DOI:10.1007/s00428-005-0065-5
Reference
PMID:11165748
  Authors
Gimm O.
  Title
Thyroid cancer.
  Journal
Cancer Lett 163:143-56 (2001)
DOI:10.1016/S0304-3835(00)00697-2
Reference
PMID:12094241
  Authors
Williams D.
  Title
Cancer after nuclear fallout: lessons from the Chernobyl accident.
  Journal
Nat Rev Cancer 2:543-9 (2002)
DOI:10.1038/nrc845
Reference
PMID:16236521
  Authors
Steffen B, Muller-Tidow C, Schwable J, Berdel WE, Serve H.
  Title
The molecular pathogenesis of acute myeloid leukemia.
  Journal
Crit Rev Oncol Hematol 56:195-221 (2005)
DOI:10.1016/j.critrevonc.2004.10.012
Reference
PMID:12563308
  Authors
Tenen DG.
  Title
Disruption of differentiation in human cancer: AML shows the way.
  Journal
Nat Rev Cancer 3:89-101 (2003)
DOI:10.1038/nrc989
Reference
PMID:16146838
  Authors
Choudhary C, Muller-Tidow C, Berdel WE, Serve H.
  Title
Signal transduction of oncogenic Flt3.
  Journal
Int J Hematol 82:93-9 (2005)
DOI:10.1532/IJH97.05090
Reference
PMID:12951584
  Authors
Stirewalt DL, Radich JP.
  Title
The role of FLT3 in haematopoietic malignancies.
  Journal
Nat Rev Cancer 3:650-65 (2003)
DOI:10.1038/nrc1169
Reference
PMID:16642045
  Authors
Martelli AM, Nyakern M, Tabellini G, Bortul R, Tazzari PL, Evangelisti C, Cocco L.
  Title
Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.
  Journal
Leukemia 20:911-28 (2006)
DOI:10.1038/sj.leu.2404245
Reference
PMID:15625120
  Authors
Lennartsson J, Jelacic T, Linnekin D, Shivakrupa R.
  Title
Normal and oncogenic forms of the receptor tyrosine kinase kit.
  Journal
Stem Cells 23:16-43 (2005)
DOI:10.1634/stemcells.2004-0117
Reference
PMID:11721960
  Authors
Lorsbach RB, Downing JR.
  Title
The role of the AML1 transcription factor in leukemogenesis.
  Journal
Int J Hematol 74:258-65 (2001)
DOI:10.1007/BF02982058
Reference
PMID:12468433
  Authors
Mizuki M, Schwable J, Steur C, Choudhary C, Agrawal S, Sargin B, Steffen B, Matsumura I, Kanakura Y, Bohmer FD, Muller-Tidow C, Berdel WE, Serve H.
  Title
Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations.
  Journal
Blood 101:3164-73 (2003)
DOI:10.1182/blood-2002-06-1677
Reference
PMID:17554387
  Authors
Mikesch JH, Steffen B, Berdel WE, Serve H, Muller-Tidow C.
  Title
The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia.
  Journal
Leukemia 21:1638-47 (2007)
DOI:10.1038/sj.leu.2404732
Reference
PMID:16352814
  Authors
Mueller BU, Pabst T, Fos J, Petkovic V, Fey MF, Asou N, Buergi U, Tenen DG.
  Title
ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression.
  Journal
Blood 107:3330-8 (2006)
DOI:10.1182/blood-2005-07-3068
Reference
PMID:15719031
  Authors
Ren R.
  Title
Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia.
  Journal
Nat Rev Cancer 5:172-83 (2005)
DOI:10.1038/nrc1567
Reference
PMID:11071626
  Authors
Deininger MW, Goldman JM, Melo JV.
  Title
The molecular biology of chronic myeloid leukemia.
  Journal
Blood 96:3343-56 (2000)
Reference
PMID:14982876
  Authors
Calabretta B, Perrotti D.
  Title
The biology of CML blast crisis.
  Journal
Blood 103:4010-22 (2004)
DOI:10.1182/blood-2003-12-4111
Reference
PMID:10403855
  Authors
Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM.
  Title
The biology of chronic myeloid leukemia.
  Journal
N Engl J Med 341:164-72 (1999)
DOI:10.1056/NEJM199907153410306
Reference
PMID:15156182
  Authors
Mitani K.
  Title
Molecular mechanisms of leukemogenesis by AML1/EVI-1.
  Journal
Oncogene 23:4263-9 (2004)
DOI:10.1038/sj.onc.1207777
Reference
PMID:16484590
  Authors
Dong M, Blobe GC.
  Title
Role of transforming growth factor-beta in hematologic malignancies.
  Journal
Blood 107:4589-96 (2006)
DOI:10.1182/blood-2005-10-4169
Reference
PMID:9834202
  Authors
Kurokawa M, Mitani K, Imai Y, Ogawa S, Yazaki Y, Hirai H.
  Title
The t(3;21) fusion product, AML1/Evi-1, interacts with Smad3 and blocks transforming growth factor-beta-mediated growth inhibition of myeloid cells.
  Journal
Blood 92:4003-12 (1998)
Reference
PMID:12801837
  Authors
Brusa G, Benvenuti M, Mazzacurati L, Mancini M, Pattacini L, Martinelli G, Barbieri E, Greenberger JS, Baccarani M, Santucci MA.
  Title
p53 loss of function enhances genomic instability and accelerates clonal evolution of murine myeloid progenitors expressing the p(210)BCR-ABL tyrosine kinase.
  Journal
Haematologica 88:622-30 (2003)
Reference
PMID:11160144
  Authors
Baldwin AS.
  Title
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.
  Journal
J Clin Invest 107:241-6 (2001)
DOI:10.1172/JCI11991
Reference
PMID:12244301
  Authors
Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, Arteaga CL.
  Title
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.
  Journal
Nat Med 8:1145-52 (2002)
DOI:10.1038/nm759
Reference
PMID:15948971
  Authors
Tilli CM, Van Steensel MA, Krekels GA, Neumann HA, Ramaekers FC.
  Title
Molecular aetiology and pathogenesis of basal cell carcinoma.
  Journal
Br J Dermatol 152:1108-24 (2005)
DOI:10.1111/j.1365-2133.2005.06587.x
Reference
PMID:12588368
  Authors
Saldanha G, Fletcher A, Slater DN.
  Title
Basal cell carcinoma: a dermatopathological and molecular biological update.
  Journal
Br J Dermatol 148:195-202 (2003)
DOI:10.1046/j.1365-2133.2003.05151.x
Reference
PMID:15978322
  Authors
Daya-Grosjean L, Couve-Privat S.
  Title
Sonic hedgehog signaling in basal cell carcinomas.
  Journal
Cancer Lett 225:181-92 (2005)
DOI:10.1016/j.canlet.2004.10.003
Reference
PMID:15468170
  Authors
Tsai KY, Tsao H.
  Title
The genetics of skin cancer.
  Journal
Am J Med Genet C Semin Med Genet 131C:82-92 (2004)
DOI:10.1002/ajmg.c.30037
Reference
PMID:16881963
  Authors
Athar M, Tang X, Lee JL, Kopelovich L, Kim AL.
  Title
Hedgehog signalling in skin development and cancer.
  Journal
Exp Dermatol 15:667-77 (2006)
DOI:10.1111/j.1600-0625.2006.00473.x
Reference
PMID:16306523
  Authors
Rubin AI, Chen EH, Ratner D.
  Title
Basal-cell carcinoma.
  Journal
N Engl J Med 353:2262-9 (2005)
DOI:10.1056/NEJMra044151
Reference
PMID:11276000
  Authors
Saldanha G.
  Title
The Hedgehog signalling pathway and cancer.
  Journal
J Pathol 193:427-32 (2001)
DOI:10.1002/1096-9896(2000)9999:9999<::AID-PATH815>3.0.CO;2-N
Reference
PMID:15270885
  Authors
Saldanha G, Ghura V, Potter L, Fletcher A.
  Title
Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation.
  Journal
Br J Dermatol 151:157-64 (2004)
DOI:10.1111/j.1365-2133.2004.06048.x
Reference
PMID:14737121
  Authors
Pasca di Magliano M, Hebrok M.
  Title
Hedgehog signalling in cancer formation and maintenance.
  Journal
Nat Rev Cancer 3:903-11 (2003)
DOI:10.1038/nrc1229
Reference
PMID:15656799
  Authors
Reifenberger J, Wolter M, Knobbe CB, Kohler B, Schonicke A, Scharwachter C, Kumar K, Blaschke B, Ruzicka T, Reifenberger G.
  Title
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas.
  Journal
Br J Dermatol 152:43-51 (2005)
DOI:10.1111/j.1365-2133.2005.06353.x
Reference
PMID:14556242
  Authors
Cohen MM Jr.
  Title
The hedgehog signaling network.
  Journal
Am J Med Genet A 123:5-28 (2003)
DOI:10.1002/ajmg.a.20495
Reference
PMID:11736900
  Authors
Yamazaki F, Aragane Y, Kawada A, Tezuka T.
  Title
Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma.
  Journal
Br J Dermatol 145:771-7 (2001)
DOI:10.1046/j.1365-2133.2001.04468.x
Reference
PMID:16054233
  Authors
Erb P, Ji J, Wernli M, Kump E, Glaser A, Buchner SA.
  Title
Role of apoptosis in basal cell and squamous cell carcinoma formation.
  Journal
Immunol Lett 100:68-72 (2005)
DOI:10.1016/j.imlet.2005.06.008
Reference
PMID:11130178
  Authors
Toftgard R.
  Title
Hedgehog signalling in cancer.
  Journal
Cell Mol Life Sci 57:1720-31 (2000)
DOI:10.1007/PL00000654
Reference
PMID:16822996
  Authors
Miller AJ, Mihm MC Jr.
  Title
Melanoma.
  Journal
N Engl J Med 355:51-65 (2006)
DOI:10.1056/NEJMra052166
Reference
PMID:12894244
  Authors
Chin L.
  Title
The genetics of malignant melanoma: lessons from mouse and man.
  Journal
Nat Rev Cancer 3:559-70 (2003)
DOI:10.1038/nrc1145
Reference
PMID:16750612
  Authors
Takata M, Saida T.
  Title
Genetic alterations in melanocytic tumors.
  Journal
J Dermatol Sci 43:1-10 (2006)
DOI:10.1016/j.jdermsci.2006.05.002
Reference
PMID:15841168
  Authors
Chudnovsky Y, Khavari PA, Adams AE.
  Title
Melanoma genetics and the development of rational therapeutics.
  Journal
J Clin Invest 115:813-24 (2005)
DOI:10.1172/JCI24808
Reference
PMID:16001050
  Authors
Merlino G.
  Title
Cancer biology: the weakest link?
  Journal
Nature 436:33-5 (2005)
DOI:10.1038/436033a
Reference
PMID:16001072
  Authors
Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S, Beroukhim R, Milner DA, Granter SR, Du J, Lee C, Wagner SN, Li C, Golub TR, Rimm DL, Meyerson ML, Fisher DE, Sellers WR.
  Title
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.
  Journal
Nature 436:117-22 (2005)
DOI:10.1038/nature03664
Reference
PMID:16899407
  Authors
Levy C, Khaled M, Fisher DE.
  Title
MITF: master regulator of melanocyte development and melanoma oncogene.
  Journal
Trends Mol Med 12:406-14 (2006)
DOI:10.1016/j.molmed.2006.07.008
Reference
PMID:15009714
  Authors
Tsao H, Goel V, Wu H, Yang G, Haluska FG.
  Title
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.
  Journal
J Invest Dermatol 122:337-41 (2004)
DOI:10.1046/j.0022-202X.2004.22243.x
Reference
PMID:11224709
  Authors
Gruss C, Herlyn M.
  Title
Role of cadherins and matrixins in melanoma.
  Journal
Curr Opin Oncol 13:117-23 (2001)
DOI:10.1097/00001622-200103000-00006
Reference
PMID:15721476
  Authors
Thompson JF, Scolyer RA, Kefford RF.
  Title
Cutaneous melanoma.
  Journal
Lancet 365:687-701 (2005)
DOI:10.1016/S0140-6736(05)17951-3
Reference
PMID:14695152
  Authors
Omholt K, Platz A, Kanter L, Ringborg U, Hansson J.
  Title
NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression.
  Journal
Clin Cancer Res 9:6483-8 (2003)
Reference
PMID:15557758
  Authors
Hussein MR.
  Title
The TP53 tumor suppressor gene and melanoma tumorigenesis: is there a relationship?
  Journal
Tumour Biol 25:200-7 (2004)
DOI:10.1159/000081103
Reference
PMID:10843728
  Authors
Lazar-Molnar E, Hegyesi H, Toth S, Falus A.
  Title
Autocrine and paracrine regulation by cytokines and growth factors in melanoma.
  Journal
Cytokine 12:547-54 (2000)
DOI:10.1006/cyto.1999.0614
Reference
PMID:16339096
  Authors
Cohen HT, McGovern FJ.
  Title
Renal-cell carcinoma.
  Journal
N Engl J Med 353:2477-90 (2005)
DOI:10.1056/NEJMra043172
Reference
PMID:15122209
  Authors
Pavlovich CP, Schmidt LS.
  Title
Searching for the hereditary causes of renal-cell carcinoma.
  Journal
Nat Rev Cancer 4:381-93 (2004)
DOI:10.1038/nrc1364
Reference
PMID:14634372
  Authors
Linehan WM, Walther MM, Zbar B.
  Title
The genetic basis of cancer of the kidney.
  Journal
J Urol 170:2163-72 (2003)
DOI:10.1097/01.ju.0000096060.92397.ed
Reference
PMID:14685170
  Authors
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF.
  Title
Met, metastasis, motility and more.
  Journal
Nat Rev Mol Cell Biol 4:915-25 (2003)
DOI:10.1038/nrm1261
Reference
PMID:15611513
  Authors
Kim WY, Kaelin WG.
  Title
Role of VHL gene mutation in human cancer.
  Journal
J Clin Oncol 22:4991-5004 (2004)
DOI:10.1200/JCO.2004.05.061
Reference
PMID:17211469
  Authors
Sudarshan S, Linehan WM, Neckers L.
  Title
HIF and fumarate hydratase in renal cancer.
  Journal
Br J Cancer 96:403-7 (2007)
DOI:10.1038/sj.bjc.6603547
Reference
PMID:17287871
  Authors
Sudarshan S, Pinto PA, Neckers L, Linehan WM.
  Title
Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer.
  Journal
Nat Clin Pract Urol 4:104-10 (2007)
DOI:10.1038/ncpuro0711
Reference
PMID:12351585
  Authors
Bodmer D, van den Hurk W, van Groningen JJ, Eleveld MJ, Martens GJ, Weterman MA, van Kessel AG.
  Title
Understanding familial and non-familial renal cell cancer.
  Journal
Hum Mol Genet 11:2489-98 (2002)
DOI:10.1093/hmg/11.20.2489
Reference
PMID:17158541
  Authors
Mitra AP, Datar RH, Cote RJ.
  Title
Molecular pathways in invasive bladder cancer: new insights into mechanisms, progression, and target identification.
  Journal
J Clin Oncol 24:5552-64 (2006)
DOI:10.1200/JCO.2006.08.2073
Reference
PMID:16474624
  Authors
Wolff EM, Liang G, Jones PA.
  Title
Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.
  Journal
Nat Clin Pract Urol 2:502-10 (2005)
DOI:10.1038/ncpuro0318
Reference
PMID:16110317
  Authors
Wu XR.
  Title
Urothelial tumorigenesis: a tale of divergent pathways.
  Journal
Nat Rev Cancer 5:713-25 (2005)
DOI:10.1038/nrc1697
Reference
PMID:11103787
  Authors
Brown NS, Jones A, Fujiyama C, Harris AL, Bicknell R.
  Title
Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors.
  Journal
Cancer Res 60:6298-302 (2000)
Reference
PMID:12850530
  Authors
Bellmunt J, Hussain M, Dinney CP.
  Title
Novel approaches with targeted therapies in bladder cancer. Therapy of bladder cancer by blockade of the epidermal growth factor receptor family.
  Journal
Crit Rev Oncol Hematol 46 Suppl:S85-104 (2003)
DOI:10.1016/S1040-8428(03)00067-2
Reference
PMID:17149381
  Authors
Sugano K, Kakizoe T.
  Title
Genetic alterations in bladder cancer and their clinical applications in molecular tumor staging.
  Journal
Nat Clin Pract Urol 3:642-52 (2006)
DOI:10.1038/ncpuro0649
Reference
PMID:15746962
  Authors
Dunn KL, Espino PS, Drobic B, He S, Davie JR.
  Title
The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling.
  Journal
Biochem Cell Biol 83:1-14 (2005)
DOI:10.1139/o04-121
Reference
PMID:15551095
  Authors
Williams SG, Stein JP.
  Title
Molecular pathways in bladder cancer.
  Journal
Urol Res 32:373-85 (2004)
DOI:10.1007/s00240-003-0345-y
Reference
PMID:12878745
  Authors
Nelson WG, De Marzo AM, Isaacs WB.
  Title
Prostate cancer.
  Journal
N Engl J Med 349:366-81 (2003)
DOI:10.1056/NEJMra021562
Reference
PMID:15724144
  Authors
Li L, Ittmann MM, Ayala G, Tsai MJ, Amato RJ, Wheeler TM, Miles BJ, Kadmon D, Thompson TC.
  Title
The emerging role of the PI3-K-Akt pathway in prostate cancer progression.
  Journal
Prostate Cancer Prostatic Dis 8:108-18 (2005)
DOI:10.1038/sj.pcan.4500776
Reference
PMID:16551847
  Authors
Pienta KJ, Bradley D.
  Title
Mechanisms underlying the development of androgen-independent prostate cancer.
  Journal
Clin Cancer Res 12:1665-71 (2006)
DOI:10.1158/1078-0432.CCR-06-0067
Reference
PMID:11900250
  Authors
Feldman BJ, Feldman D.
  Title
The development of androgen-independent prostate cancer.
  Journal
Nat Rev Cancer 1:34-45 (2001)
DOI:10.1038/35094009
Reference
PMID:15082523
  Authors
Heinlein CA, Chang C.
  Title
Androgen receptor in prostate cancer.
  Journal
Endocr Rev 25:276-308 (2004)
DOI:10.1210/er.2002-0032
Reference
PMID:9422516
  Authors
Koivisto P, Kolmer M, Visakorpi T, Kallioniemi OP.
  Title
Androgen receptor gene and hormonal therapy failure of prostate cancer.
  Journal
Am J Pathol 152:1-9 (1998)
Reference
PMID:10835690
  Authors
Zhao XY, Malloy PJ, Krishnan AV, Swami S, Navone NM, Peehl DM, Feldman D.
  Title
Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor.
  Journal
Nat Med 6:703-6 (2000)
DOI:10.1038/76287
Reference
PMID:10453277
  Authors
Macri E, Loda M.
  Title
Role of p27 in prostate carcinogenesis.
  Journal
Cancer Metastasis Rev 17:337-44 (1998)
DOI:10.1023/A:1006133620914
Reference
PMID:11750244
  Authors
Steers WD.
  Title
5alpha-reductase activity in the prostate.
  Journal
Urology 58:17-24; discussion 24 (2001)
DOI:10.1016/S0090-4295(01)01299-7
Reference
PMID:8069858
  Authors
Lin D, Meyer DJ, Ketterer B, Lang NP, Kadlubar FF.
  Title
Effects of human and rat glutathione S-transferases on the covalent DNA binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro: a possible mechanism of organ specificity in their carcinogenesis.
  Journal
Cancer Res 54:4920-6 (1994)
Reference
PMID:11527574
  Authors
Grimes CA, Jope RS.
  Title
The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling.
  Journal
Prog Neurobiol 65:391-426 (2001)
DOI:10.1016/S0301-0082(01)00011-9
Reference
PMID:15947972
  Authors
Ryan AJ, Susil B, Jobling TW, Oehler MK.
  Title
Endometrial cancer.
  Journal
Cell Tissue Res 322:53-61 (2005)
DOI:10.1007/s00441-005-1109-5
Reference
PMID:14747944
  Authors
Lax SF.
  Title
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
  Journal
Virchows Arch 444:213-23 (2004)
DOI:10.1007/s00428-003-0947-3
Reference
PMID:16508724
  Authors
Shiozawa T, Konishi I.
  Title
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
  Journal
Int J Clin Oncol 11:13-21 (2006)
DOI:10.1007/s10147-005-0546-1
Reference
PMID:17028294
  Authors
Hecht JL, Mutter GL.
  Title
Molecular and pathologic aspects of endometrial carcinogenesis.
  Journal
J Clin Oncol 24:4783-91 (2006)
DOI:10.1200/JCO.2006.06.7173
Reference
PMID:11431710
  Authors
Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J.
  Title
Molecular pathology of endometrial hyperplasia and carcinoma.
  Journal
Hum Pathol 32:569-77 (2001)
DOI:10.1053/hupa.2001.25929
Reference
PMID:15284264
  Authors
Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH.
  Title
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
  Journal
J Clin Oncol 22:3126-32 (2004)
DOI:10.1200/JCO.2004.11.154
Reference
PMID:7585656
  Authors
Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF.
  Title
Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.
  Journal
Cancer Res 55:5693-8 (1995)
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12711111
  Authors
Sanchez-Cespedes M.
  Title
Dissecting the genetic alterations involved in lung carcinogenesis.
  Journal
Lung Cancer 40:111-21 (2003)
DOI:10.1016/S0169-5002(03)00033-3
Reference
PMID:11720739
  Authors
Kaye FJ.
  Title
Molecular biology of lung cancer.
  Journal
Lung Cancer 34 Suppl 2:S35-41 (2001)
DOI:10.1016/S0169-5002(01)00342-7
Reference
PMID:12616528
  Authors
Shivapurkar N, Reddy J, Chaudhary PM, Gazdar AF.
  Title
Apoptosis and lung cancer: a review.
  Journal
J Cell Biochem 88:885-98 (2003)
DOI:10.1002/jcb.10440
Reference
PMID:11807782
  Authors
Sartorius UA, Krammer PH.
  Title
Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines.
  Journal
Int J Cancer 97:584-92 (2002)
DOI:10.1002/ijc.10096
Reference
PMID:16064138
  Authors
Adhikary S, Eilers M.
  Title
Transcriptional regulation and transformation by Myc proteins.
  Journal
Nat Rev Mol Cell Biol 6:635-45 (2005)
DOI:10.1038/nrm1703
Reference
PMID:11463388
  Authors
Spruck C, Strohmaier H, Watson M, Smith AP, Ryan A, Krek TW, Reed SI.
  Title
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.
  Journal
Mol Cell 7:639-50 (2001)
DOI:10.1016/S1097-2765(01)00210-6
Reference
PMID:15109562
  Authors
Buttery RC, Rintoul RC, Sethi T.
  Title
Small cell lung cancer: the importance of the extracellular matrix.
  Journal
Int J Biochem Cell Biol 36:1154-60 (2004)
DOI:10.1016/S1357-2725(03)00261-9
Reference
PMID:11559746
  Authors
Yamada KM, Araki M.
  Title
Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis.
  Journal
J Cell Sci 114:2375-82 (2001)
Reference
PMID:11905738
  Authors
Rintoul RC, Sethi T.
  Title
The role of extracellular matrix in small-cell lung cancer.
  Journal
Lancet Oncol 2:437-42 (2001)
DOI:10.1016/S1470-2045(00)00421-6
Reference
PMID:12243753
  Authors
Ekedahl J, Joseph B, Grigoriev MY, Muller M, Magnusson C, Lewensohn R, Zhivotovsky B.
  Title
Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells.
  Journal
Exp Cell Res 279:277-90 (2002)
DOI:10.1006/excr.2002.5608
Reference
PMID:12379883
  Authors
Osada H, Takahashi T.
  Title
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.
  Journal
Oncogene 21:7421-34 (2002)
DOI:10.1038/sj.onc.1205802
Reference
PMID:12741677
  Authors
Yokota J, Nishioka M, Tani M, Kohno T.
  Title
Genetic alterations responsible for metastatic phenotypes of lung cancer cells.
  Journal
Clin Exp Metastasis 20:189-93 (2003)
DOI:10.1023/a:1022978932215
Reference
PMID:16870043
  Authors
Aviel-Ronen S, Blackhall FH, Shepherd FA, Tsao MS.
  Title
K-ras mutations in non-small-cell lung carcinoma: a review.
  Journal
Clin Lung Cancer 8:30-8 (2006)
DOI:10.3816/CLC.2006.n.030
Reference
PMID:15948711
  Authors
Pfeifer GP, Dammann R.
  Title
Methylation of the tumor suppressor gene RASSF1A in human tumors.
  Journal
Biochemistry (Mosc) 70:576-83 (2005)
DOI:10.1007/s10541-005-0151-y
Reference
PMID:11902573
  Authors
Altucci L, Gronemeyer H.
  Title
The promise of retinoids to fight against cancer.
  Journal
Nat Rev Cancer 1:181-93 (2001)
DOI:10.1038/35106036
Reference
PMID:10944551
  Authors
Virmani AK, Rathi A, Zochbauer-Muller S, Sacchi N, Fukuyama Y, Bryant D, Maitra A, Heda S, Fong KM, Thunnissen F, Minna JD, Gazdar AF.
  Title
Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas.
  Journal
J Natl Cancer Inst 92:1303-7 (2000)
DOI:10.1093/jnci/92.16.1303
Reference
PMID:12867060
  Authors
Hirsch FR, Scagliotti GV, Langer CJ, Varella-Garcia M, Franklin WA.
  Title
Epidermal growth factor family of receptors in preneoplasia and lung cancer: perspectives for targeted therapies.
  Journal
Lung Cancer 41 Suppl 1:S29-42 (2003)
DOI:10.1016/S0169-5002(03)00137-5
Reference
PMID:16112428
  Authors
Panani AD, Roussos C.
  Title
Cytogenetic and molecular aspects of lung cancer.
  Journal
Cancer Lett 239:1-9 (2006)
DOI:10.1016/j.canlet.2005.06.030
Reference
PMID:12407699
  Authors
Mitsuuchi Y, Testa JR.
  Title
Cytogenetics and molecular genetics of lung cancer.
  Journal
Am J Med Genet 115:183-8 (2002)
DOI:10.1002/ajmg.10692
Reference
PMID:15942304
  Authors
Breuer RH, Postmus PE, Smit EF.
  Title
Molecular pathology of non-small-cell lung cancer.
  Journal
Respiration 72:313-30 (2005)
DOI:10.1159/000085376
Reference
PMID:11895903
  Authors
Piyathilake CJ, Frost AR, Manne U, Weiss H, Bell WC, Heimburger DC, Grizzle WE.
  Title
Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lung.
  Journal
Clin Cancer Res 8:734-44 (2002)
Reference
PMID:16189154
  Authors
Awaya H, Takeshima Y, Furonaka O, Kohno N, Inai K.
  Title
Gene amplification and protein expression of EGFR and HER2 by chromogenic in situ hybridisation and immunohistochemistry in atypical adenomatous hyperplasia and adenocarcinoma of the lung.
  Journal
J Clin Pathol 58:1076-80 (2005)
DOI:10.1136/jcp.2004.025585
Reference
PMID:21193867
  Authors
Lappano R, Maggiolini M
  Title
G protein-coupled receptors: novel targets for drug discovery in cancer.
  Journal
Nat Rev Drug Discov 10:47-60 (2011)
DOI:10.1038/nrd3320
Reference
PMID:24508914
  Authors
O'Hayre M, Degese MS, Gutkind JS
  Title
Novel insights into G protein and G protein-coupled receptor signaling in cancer.
  Journal
Curr Opin Cell Biol 27:126-35 (2014)
DOI:10.1016/j.ceb.2014.01.005
Reference
PMID:17251915
  Authors
Dorsam RT, Gutkind JS
  Title
G-protein-coupled receptors and cancer.
  Journal
Nat Rev Cancer 7:79-94 (2007)
DOI:10.1038/nrc2069
Related
pathway
pon03320  PPAR signaling pathway
pon04010  MAPK signaling pathway
pon04020  Calcium signaling pathway
pon04024  cAMP signaling pathway
pon04060  Cytokine-cytokine receptor interaction
pon04066  HIF-1 signaling pathway
pon04110  Cell cycle
pon04115  p53 signaling pathway
pon04150  mTOR signaling pathway
pon04151  PI3K-Akt signaling pathway
pon04210  Apoptosis
pon04310  Wnt signaling pathway
pon04330  Notch signaling pathway
pon04340  Hedgehog signaling pathway
pon04350  TGF-beta signaling pathway
pon04370  VEGF signaling pathway
pon04510  Focal adhesion
pon04512  ECM-receptor interaction
pon04520  Adherens junction
pon04630  JAK-STAT signaling pathway
pon04915  Estrogen signaling pathway
KO pathway
ko05200   
LinkDB

DBGET integrated database retrieval system