KEGG   PATHWAY: acat04145
Entry
acat04145                   Pathway                                
Name
Phagosome - Aquarana catesbeiana (American bullfrog)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
acat04145  Phagosome
acat04145

Other DBs
GO: 0045335
Organism
Aquarana catesbeiana (American bullfrog) [GN:acat]
Gene
141101732  [KO:K04392]
141101733  [KO:K04392]
141101734  [KO:K04392]
141102565  [KO:K08057]
141102829  RAB7A; ras-related protein Rab-7a [KO:K07897]
141102866  SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956]
141103174  NCF4; neutrophil cytosol factor 4 [KO:K08012]
141103318  SEC22B; vesicle-trafficking protein SEC22b [KO:K08517]
141103412  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
141103600  NCF2; neutrophil cytosol factor 2 [KO:K08010]
141103901  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661]
141104530  [KO:K07375]
141104642  [KO:K10068]
141105220  [KO:K08763]
141105222  [KO:K10074]
141105226  [KO:K06563]
141105548  [KO:K01330] [EC:3.4.21.41]
141105610  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
141105860  [KO:K10089]
141105914  COMP; cartilage oligomeric matrix protein [KO:K04659]
141106237  [KO:K03991]
141106238  [KO:K10068]
141106239  [KO:K10068]
141106240  [KO:K10068]
141106242  [KO:K10068]
141106243  [KO:K10068]
141106245  [KO:K10068]
141106247  [KO:K10067]
141106364  TCIRG1; V-type proton ATPase 116 kDa subunit a 3 isoform X1 [KO:K02154]
141106424  [KO:K10068]
141106429  [KO:K10068]
141106439  [KO:K03991]
141106440  [KO:K03991]
141106470  [KO:K10068]
141107149  [KO:K06752]
141107150  [KO:K06751]
141107154  [KO:K06751]
141107476  [KO:K06752]
141107478  [KO:K06752]
141107479  [KO:K06752]
141107480  [KO:K06752]
141107481  [KO:K06752]
141107483  [KO:K06752]
141107485  [KO:K06752]
141107490  [KO:K06751]
141107491  [KO:K06751]
141107492  [KO:K06751]
141107494  [KO:K06751]
141107496  [KO:K06751]
141107501  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
141107502  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
141107503  [KO:K06751]
141107508  [KO:K06751]
141107512  [KO:K06751]
141107515  [KO:K06751]
141107518  [KO:K06751]
141107519  [KO:K06751]
141107520  [KO:K06751]
141107521  [KO:K06751]
141107522  [KO:K06751]
141107523  [KO:K06751]
141107525  [KO:K06751]
141107526  [KO:K06751]
141107527  [KO:K06751]
141107529  [KO:K06751]
141107533  [KO:K06751]
141107537  [KO:K06751]
141107538  [KO:K06751]
141107544  [KO:K06751]
141107545  [KO:K06751]
141107600  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
141107881  TUBB; tubulin beta chain [KO:K07375]
141108146  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
141108309  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
141108324  [KO:K07375]
141108325  [KO:K07375]
141108513  ITGAV; integrin alpha-V [KO:K06487]
141108549  [KO:K07897]
141108554  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
141108898  [KO:K06752]
141108899  [KO:K06752]
141108902  [KO:K06751]
141111370  VAMP3; vesicle-associated membrane protein 3 [KO:K13505]
141112485  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
141112518  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
141112699  CYBA; cytochrome b-245 light chain [KO:K08009]
141112867  TUBB3; tubulin beta-3 chain [KO:K07375]
141112876  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
141113178  RAB5C; ras-related protein Rab-5C [KO:K07889]
141113556  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
141113637  ACTG1; actin, cytoplasmic 2 [KO:K05692]
141114087  TUBB1; tubulin beta-1 chain [KO:K07375]
141114148  ITGB3; integrin beta-3 [KO:K06493]
141114155  MRC2; C-type mannose receptor 2 [KO:K06560]
141114512  MSR1; macrophage scavenger receptor types I and II [KO:K06558]
141114593  ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 isoform X1 [KO:K02154]
141116423  STX7; syntaxin-7 [KO:K08488]
141116455  THBS3; thrombospondin-3 [KO:K04659]
141116456  [KO:K10169]
141116492  [KO:K02145] [EC:7.1.2.2]
141116619  [KO:K01368] [EC:3.4.22.27]
141116691  [KO:K12560]
141116692  [KO:K12560]
141116694  [KO:K12560]
141116695  [KO:K12560]
141116863  [KO:K10159]
141116864  THBS1; thrombospondin-1 [KO:K16857]
141116874  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
141116882  [KO:K10159]
141116941  [KO:K12560]
141117052  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
141117378  STX18; syntaxin-18 [KO:K08492]
141117401  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
141117509  [KO:K01368] [EC:3.4.22.27]
141117545  [KO:K12560]
141117582  [KO:K01368] [EC:3.4.22.27]
141117624  [KO:K01368] [EC:3.4.22.27]
141120848  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
141126994  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
141127321  ITGA5; integrin alpha-5 [KO:K06484]
141127470  RAB5B; ras-related protein Rab-5B [KO:K07888]
141127513  [KO:K07374]
141127516  [KO:K07374]
141127517  TUBA1B; tubulin alpha-1B chain [KO:K07374]
141127720  [KO:K02155]
141127772  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
141127926  CYBB; NADPH oxidase 2 [KO:K21421] [EC:1.-.-.-]
141128006  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
141128320  STX12; syntaxin-12 [KO:K13813]
141128585  [KO:K01368] [EC:3.4.22.27]
141128652  [KO:K07374]
141128897  [KO:K10789] [EC:1.11.2.2]
141128967  RILP; rab-interacting lysosomal protein [KO:K13883]
141129023  [KO:K10789] [EC:1.11.2.2]
141129025  [KO:K10789] [EC:1.11.2.2]
141129422  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
141131446  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
141131538  [KO:K01365] [EC:3.4.22.15]
141131539  [KO:K01365] [EC:3.4.22.15]
141131540  [KO:K01365] [EC:3.4.22.15]
141131671  [KO:K01365] [EC:3.4.22.15]
141131726  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
141131759  [KO:K07374]
141131761  [KO:K07374]
141131941  [KO:K03662]
141132043  [KO:K09481]
141132124  [KO:K12478]
141132471  CD14; monocyte differentiation antigen CD14 [KO:K10159]
141132514  CANX; calnexin isoform X1 [KO:K08054]
141132719  ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 [KO:K02154]
141132748  TUBA8; tubulin alpha-8 chain [KO:K07374]
141132757  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
141133110  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
141133137  ITGA2; integrin alpha-2 [KO:K06481]
141133200  [KO:K06563]
141133201  [KO:K06563]
141133202  [KO:K06563]
141133251  [KO:K06563]
141133256  [KO:K06563]
141133333  CALR; calreticulin [KO:K08057]
141133425  TUBB4A; tubulin beta-4A chain isoform X1 [KO:K07375]
141133427  C3; complement C3 [KO:K03990]
141133428  [KO:K03990]
141133429  [KO:K03990]
141133431  [KO:K03990]
141133433  [KO:K03990]
141133434  [KO:K03990]
141133435  [KO:K03990]
141133436  [KO:K03990]
141133437  [KO:K03990]
141133447  [KO:K03990]
141134494  CD36; platelet glycoprotein 4 [KO:K06259]
141139364  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
141139392  COLEC11; collectin-11 isoform X1 [KO:K10066]
141139500  NOS1; nitric oxide synthase 1 isoform X1 [KO:K13240] [EC:1.14.13.39]
141139891  TFRC; transferrin receptor protein 1 [KO:K06503]
141140431  ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 isoform X1 [KO:K02154]
141140537  SCARB1; scavenger receptor class B member 1 isoform X1 [KO:K13885]
141140549  THBS2; thrombospondin-2 [KO:K04659]
141144158  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
141144246  [KO:K06560]
141144247  [KO:K06560]
141144314  [KO:K05719]
141144315  [KO:K05719]
141144316  [KO:K05719]
141144317  [KO:K05719]
141144483  RAB5A; ras-related protein Rab-5A [KO:K07887]
141144523  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
141144604  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
141144708  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
141144885  [KO:K07375]
141145046  TUBB6; tubulin beta-6 chain [KO:K07375]
141145097  COLEC12; collectin-12 isoform X1 [KO:K10062]
141145168  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
141145328  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
141145417  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
141146076  [KO:K02148]
141146683  ACTB; actin, cytoplasmic 1 [KO:K05692]
141146744  [KO:K01365] [EC:3.4.22.15]
141146753  [KO:K01365] [EC:3.4.22.15]
141146765  [KO:K01365] [EC:3.4.22.15]
141146767  [KO:K01365] [EC:3.4.22.15]
141146810  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
141146825  [KO:K07888]
141146835  ITGB2; integrin beta-2 [KO:K06464]
141146996  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
141147057  PLA2R1; secretory phospholipase A2 receptor isoform X1 [KO:K06560]
141147168  [KO:K07374]
141147173  [KO:K07374]
141147174  [KO:K07374]
141147175  [KO:K07374]
141147176  [KO:K07374]
141147177  [KO:K07374]
141147284  [KO:K13884]
141147285  [KO:K13884]
141147286  [KO:K13884]
141147290  [KO:K06588]
141148135  [KO:K06461]
141148136  [KO:K06461]
141148137  [KO:K06461]
141148490  CORO1A; coronin-1A [KO:K13882]
141148846  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
acat04142  Lysosome biogenesis
acat04144  Endocytosis
acat04620  Toll-like receptor signaling pathway
KO pathway
ko04145   

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