KEGG   PATHWAY: acat04142
Entry
acat04142                   Pathway                                
Name
Lysosome biogenesis - Aquarana catesbeiana (American bullfrog)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
acat04142  Lysosome biogenesis
acat04142

Other DBs
GO: 0005764
Organism
Aquarana catesbeiana (American bullfrog) [GN:acat]
Gene
141101771  NAGA; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
141102529  [KO:K01197] [EC:3.2.1.35]
141102530  [KO:K01197] [EC:3.2.1.35]
141102532  [KO:K01197] [EC:3.2.1.35]
141102613  ARL8B; ADP-ribosylation factor-like protein 8B [KO:K07955]
141102615  SUMF1; formylglycine-generating enzyme [KO:K13444] [EC:1.8.3.7]
141102711  [KO:K01197] [EC:3.2.1.35]
141102712  [KO:K01197] [EC:3.2.1.35]
141102713  [KO:K01197] [EC:3.2.1.35]
141102714  [KO:K01197] [EC:3.2.1.35]
141102753  GGA1; ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404]
141102805  CLTA; clathrin light chain A isoform X1 [KO:K04644]
141102829  RAB7A; ras-related protein Rab-7a [KO:K07897]
141102840  [KO:K05404]
141102841  [KO:K05404]
141102843  [KO:K05404]
141103001  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
141103225  BORCS8; BLOC-1-related complex subunit 8 isoform X1 [KO:K20822]
141103412  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
141103719  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
141103721  MCOLN2; mucolipin-2 [KO:K04993]
141103728  [KO:K12310] [EC:3.2.1.-]
141103729  [KO:K12310] [EC:3.2.1.-]
141103733  DNASE2B; deoxyribonuclease-2-beta [KO:K01158] [EC:3.1.22.1]
141103797  [KO:K01319] [EC:3.4.21.20]
141103901  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661]
141105610  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
141105849  KXD1; kxDL motif-containing protein 1 isoform X1 [KO:K20818]
141105860  [KO:K10089]
141105924  BORCS7; BLOC-1-related complex subunit 7 isoform X1 [KO:K20821]
141105988  [KO:K12393]
141106016  [KO:K01052] [EC:3.1.1.13]
141106017  [KO:K01052] [EC:3.1.1.13]
141106067  BLOC1S2; biogenesis of lysosome-related organelles complex 1 subunit 2 [KO:K16750]
141106074  VPS26A; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 26A [KO:K18466]
141106097  AP3D1; AP-3 complex subunit delta-1 isoform X1 [KO:K12396]
141106167  PSAP; prosaposin [KO:K12382]
141106170  SLC29A3; equilibrative nucleoside transporter 3 [KO:K15014]
141106210  AP3M1; AP-3 complex subunit mu-1 [KO:K12398]
141106357  OSBP; oxysterol-binding protein 1 [KO:K20456]
141106364  TCIRG1; V-type proton ATPase 116 kDa subunit a 3 isoform X1 [KO:K02154]
141106635  IDUA; alpha-L-iduronidase isoform X1 [KO:K01217] [EC:3.2.1.76]
141106724  [KO:K10532] [EC:2.3.1.78]
141107402  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
141107577  PPT2; lysosomal thioesterase PPT2 [KO:K01074] [EC:3.1.2.22]
141107600  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
141107602  NEU1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
141107954  BLOC1S3; biogenesis of lysosome-related organelles complex 1 subunit 3 [KO:K20186]
141107974  VAMP7; vesicle-associated membrane protein 7 [KO:K08515]
141108060  IDS; iduronate 2-sulfatase isoform X1 [KO:K01136] [EC:3.1.6.13]
141108146  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
141108251  SLC2A6; solute carrier family 2, facilitated glucose transporter member 6 [KO:K08144]
141108297  TFE3; transcription factor E3 isoform X1 [KO:K09105]
141108309  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
141108379  ABCA2; ATP-binding cassette sub-family A member 2 [KO:K05642]
141108549  [KO:K07897]
141108554  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
141108733  [KO:K16185]
141108750  [KO:K01189] [EC:3.2.1.22]
141109559  SCARB2; lysosome membrane protein 2 [KO:K12384]
141110228  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
141110358  MANBA; beta-mannosidase [KO:K01192] [EC:3.2.1.25]
141110697  AKT1S1; proline-rich AKT1 substrate 1 [KO:K16184]
141110700  [KO:K01379] [EC:3.4.23.5]
141110712  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
141110825  VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
141111240  AP5B1; AP-5 complex subunit beta-1 [KO:K19022]
141111288  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
141111311  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
141111463  [KO:K27947]
141111481  MFSD8; major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307]
141111934  OSBPL5; oxysterol-binding protein-related protein 5 isoform X1 [KO:K20464]
141111984  TPCN2; two pore channel protein 2 [KO:K14077]
141112009  ACP2; lysosomal acid phosphatase isoform X1 [KO:K14410] [EC:3.1.3.2]
141112181  [KO:K01379] [EC:3.4.23.5]
141112182  [KO:K01379] [EC:3.4.23.5]
141112215  [KO:K11824]
141112337  PLA2G15; lysosomal phospholipase A and acyltransferase isoform X1 [KO:K06129] [EC:3.1.1.5]
141112377  CTSF; cathepsin F [KO:K01373] [EC:3.4.22.41]
141112409  SLC29A2; equilibrative nucleoside transporter 2 isoform X1 [KO:K15014]
141112427  CTSW; cathepsin W [KO:K08569] [EC:3.4.22.-]
141112428  [KO:K08569] [EC:3.4.22.-]
141112518  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
141112666  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
141112688  [KO:K27947]
141112760  VPS35; vacuolar protein sorting-associated protein 35 [KO:K18468]
141112788  GALNS; N-acetylgalactosamine-6-sulfatase [KO:K01132] [EC:3.1.6.4]
141112814  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
141113256  [KO:K13289] [EC:3.4.16.5]
141113258  [KO:K13289] [EC:3.4.16.5]
141113444  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
141113497  [KO:K20402]
141113571  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform X1 [KO:K01444] [EC:3.5.1.26]
141113573  PLEKHM1; LOW QUALITY PROTEIN: pleckstrin homology domain-containing family M member 1 [KO:K23282]
141113629  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
141113670  ABCA5; cholesterol transporter ABCA5 [KO:K05648]
141113774  ARSG; arylsulfatase G [KO:K12381] [EC:3.1.6.-]
141114061  OSBPL2; oxysterol-binding protein-related protein 2 [KO:K20174]
141114089  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
141114132  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
141114288  ASAH1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
141114461  GGA3; ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404]
141114481  [KO:K12316] [EC:3.2.1.20]
141114495  GAA; lysosomal alpha-glucosidase [KO:K12316] [EC:3.2.1.20]
141114497  SGSH; N-sulphoglucosamine sulphohydrolase isoform X1 [KO:K01565] [EC:3.10.1.1]
141114537  NAGLU; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
141114593  ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 isoform X1 [KO:K02154]
141116352  NPC2; NPC intracellular cholesterol transporter 2 [KO:K13443]
141116457  GBA1; lysosomal acid glucosylceramidase isoform X1 [KO:K01201] [EC:3.2.1.45]
141116492  [KO:K02145] [EC:7.1.2.2]
141116505  [KO:K01369] [EC:3.4.22.34]
141116506  [KO:K01369] [EC:3.4.22.34]
141116507  [KO:K01369] [EC:3.4.22.34]
141116619  [KO:K01368] [EC:3.4.22.27]
141116746  SNAPIN; SNARE-associated protein Snapin [KO:K20002]
141116766  AP4S1; LOW QUALITY PROTEIN: AP-4 complex subunit sigma-1 [KO:K12403]
141116874  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
141116963  VPS39; vam6/Vps39-like protein [KO:K20183]
141117044  [KO:K01202] [EC:3.2.1.46]
141117052  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
141117053  [KO:K01371] [EC:3.4.22.38]
141117054  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
141117275  [KO:K01369] [EC:3.4.22.34]
141117276  [KO:K01369] [EC:3.4.22.34]
141117361  VPS18; vacuolar protein sorting-associated protein 18 homolog isoform X1 [KO:K20181]
141117402  LYSET; lysosomal enzyme trafficking factor [KO:K26747]
141117408  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
141117509  [KO:K01368] [EC:3.4.22.27]
141117562  [KO:K01202] [EC:3.2.1.46]
141117582  [KO:K01368] [EC:3.4.22.27]
141117615  [KO:K01369] [EC:3.4.22.34]
141117624  [KO:K01368] [EC:3.4.22.27]
141117637  [KO:K01369] [EC:3.4.22.34]
141117763  AP5M1; AP-5 complex subunit mu-1 isoform X1 [KO:K19023]
141117797  ZFYVE26; zinc finger FYVE domain-containing protein 26 [KO:K19027]
141120848  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
141126311  AP5S1; AP-5 complex subunit sigma-1 [KO:K19024]
141126679  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
141126701  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
141126732  TPP1; tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
141126905  CTSC; dipeptidyl peptidase 1 [KO:K01275] [EC:3.4.14.1]
141126926  SLC36A4; neutral amino acid uniporter 4 isoform X1 [KO:K14209]
141127369  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
141127498  CD63; CD63 antigen [KO:K06497]
141127501  BLOC1S1; biogenesis of lysosome-related organelles complex 1 subunit 1 isoform X1 [KO:K20185]
141127636  CLN5; bis(monoacylglycero)phosphate synthase CLN5 [KO:K12390]
141127720  [KO:K02155]
141127772  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
141127946  [KO:K05404]
141127947  TLR8; toll-like receptor 8 [KO:K10170]
141128054  GUSB; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
141128129  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
141128160  CLTC; clathrin heavy chain 1 [KO:K04646]
141128177  PPT1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
141128185  FUCA1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
141128294  RRAGC; ras-related GTP-binding protein C [KO:K16186]
141128334  LAPTM5; lysosomal-associated transmembrane protein 5 [KO:K12387]
141128421  AP4B1; AP-4 complex subunit beta-1 [KO:K12401]
141128522  LAMTOR5; ragulator complex protein LAMTOR5 isoform X1 [KO:K16344]
141128529  CTSE; cathepsin E [KO:K01382] [EC:3.4.23.34]
141128552  SORT1; sortilin [KO:K12388]
141128561  TFEB; transcription factor EB isoform X1 [KO:K15590]
141128585  [KO:K01368] [EC:3.4.22.27]
141128977  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [KO:K01125] [EC:3.1.4.45]
141129108  CTNS; cystinosin [KO:K12386]
141129120  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
141129422  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
141131202  SPG11; LOW QUALITY PROTEIN: spatacsin [KO:K19026]
141131217  CLN6; ceroid-lipofuscinosis neuronal protein 6 [KO:K12359]
141131332  AP3S2; AP-3 complex subunit sigma-2 isoform X1 [KO:K12399]
141131409  BLOC1S6; biogenesis of lysosome-related organelles complex 1 subunit 6 [KO:K20188]
141131427  DMXL2; dmX-like protein 2 isoform X1 [KO:K24155]
141131431  AP4E1; AP-4 complex subunit epsilon-1 isoform X1 [KO:K12400]
141131538  [KO:K01365] [EC:3.4.22.15]
141131539  [KO:K01365] [EC:3.4.22.15]
141131540  [KO:K01365] [EC:3.4.22.15]
141131555  AP3B2; AP-3 complex subunit beta-2 isoform X1 [KO:K12397]
141131625  VPS13C; intermembrane lipid transfer protein VPS13C [KO:K19525]
141131671  [KO:K01365] [EC:3.4.22.15]
141131676  ARSA; arylsulfatase A isoform X1 [KO:K01134] [EC:3.1.6.8]
141131726  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
141131934  [KO:K07955]
141131935  [KO:K01197] [EC:3.2.1.35]
141131941  [KO:K03662]
141132069  [KO:K01382] [EC:3.4.23.34]
141132091  GNS; N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
141132142  WDR7; WD repeat-containing protein 7 isoform X1 [KO:K24738]
141132205  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
141132246  CLTB; clathrin light chain B isoform X1 [KO:K04645]
141132558  GM2A; ganglioside GM2 activator [KO:K12383]
141132559  [KO:K12383]
141132560  [KO:K14209]
141132719  ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 [KO:K02154]
141132742  BORCS5; BLOC-1-related complex subunit 5 [KO:K20819]
141132757  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
141133026  VAMP8; vesicle-associated membrane protein 8 [KO:K08512]
141133086  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
141133110  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
141133147  AP3M2; AP-3 complex subunit mu-2 [KO:K12398]
141133193  MCOLN1; mucolipin-1 [KO:K04992]
141133298  AP1M2; AP-1 complex subunit mu-2 [KO:K12393]
141133340  ACP5; tartrate-resistant acid phosphatase type 5 isoform X1 [KO:K14379] [EC:3.1.3.2]
141133357  DNASE2; deoxyribonuclease-2-alpha [KO:K01158] [EC:3.1.22.1]
141133378  MAN2B1; lysosomal alpha-mannosidase [KO:K12311] [EC:3.2.1.24]
141133426  SLC38A9; neutral amino acid transporter 9 [KO:K14995]
141133463  AP1S1; AP-1 complex subunit sigma-1A [KO:K12394]
141133479  LAMTOR4; ragulator complex protein LAMTOR4 [KO:K20399]
141133490  AP4M1; AP-4 complex subunit mu-1 [KO:K12402]
141134223  ARSB; arylsulfatase B [KO:K01135] [EC:3.1.6.12]
141134268  AP3B1; AP-3 complex subunit beta-1 isoform X1 [KO:K12397]
141134725  [KO:K12373] [EC:3.2.1.52]
141134736  [KO:K12373] [EC:3.2.1.52]
141138228  AP3S1; AP-3 complex subunit sigma-1 isoform X1 [KO:K12399]
141138462  DMXL1; dmX-like protein 1 isoform X1 [KO:K24155]
141139220  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
141139330  LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387]
141139364  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
141139641  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
141139799  LAMP3; lysosome-associated membrane glycoprotein 3 isoform X1 [KO:K06562]
141139851  VPS29; vacuolar protein sorting-associated protein 29 [KO:K18467]
141139940  AP2M1; AP-2 complex subunit mu [KO:K11826]
141139954  [KO:K12307]
141139968  CLN8; protein CLN8 [KO:K12360]
141140043  SLC17A5; sialin isoform X1 [KO:K12301]
141140093  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
141140110  RRAGD; ras-related GTP-binding protein D isoform X1 [KO:K16186]
141140167  OSTM1; osteopetrosis-associated transmembrane protein 1 [KO:K23863]
141140177  CD164; sialomucin core protein 24 [KO:K06546]
141140181  FIG4; polyphosphoinositide phosphatase isoform X1 [KO:K22913] [EC:3.1.3.-]
141140256  NCOA7; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
141140346  FUCA2; plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
141140358  ABCB9; ABC-type oligopeptide transporter ABCB9 [KO:K05656]
141140431  ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 isoform X1 [KO:K02154]
141140607  SLC15A4; solute carrier family 15 member 4 isoform X1 [KO:K14638]
141140616  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
141141004  LAMP5; lysosome-associated membrane glycoprotein 5 [KO:K28774]
141141308  SLC29A1; LOW QUALITY PROTEIN: equilibrative nucleoside transporter 1 [KO:K15014]
141141477  SNAP29; synaptosomal-associated protein 29 [KO:K08509]
141141508  CLTCL1; clathrin heavy chain 2 [KO:K04646]
141144216  [KO:K12387]
141144431  OSBPL3; oxysterol-binding protein-related protein 3 [KO:K20463]
141144564  TPCN1; two pore channel protein 1 isoform X1 [KO:K16896]
141144621  VPS41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
141144682  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
141144701  GLB1; beta-galactosidase isoform X1 [KO:K12309] [EC:3.2.1.23]
141144705  STX17; syntaxin-17 isoform X1 [KO:K08491]
141144917  BLOC1S5; biogenesis of lysosome-related organelles complex 1 subunit 5 [KO:K20187]
141144950  DTNBP1; dysbindin [KO:K20189]
141144993  BLOC1S4; biogenesis of lysosome-related organelles complex 1 subunit 4 [KO:K08366]
141145115  NPC1; NPC intracellular cholesterol transporter 1 [KO:K12385]
141145120  OSBPL1A; oxysterol-binding protein-related protein 1 isoform X1 [KO:K20174]
141145168  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
141145328  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
141145389  LAPTM4B; lysosomal-associated transmembrane protein 4B [KO:K12387]
141145417  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
141145475  DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402]
141145692  AP5Z1; AP-5 complex subunit zeta-1 [KO:K19025]
141145719  AP1G2; AP-1 complex subunit gamma-like 2 [KO:K12391]
141146076  [KO:K02148]
141146678  VPS16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
141146744  [KO:K01365] [EC:3.4.22.15]
141146753  [KO:K01365] [EC:3.4.22.15]
141146765  [KO:K01365] [EC:3.4.22.15]
141146767  [KO:K01365] [EC:3.4.22.15]
141146810  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
141146953  OSBPL6; oxysterol-binding protein-related protein 6 isoform X1 [KO:K20463]
141146977  GPR155; lysosomal cholesterol signaling protein isoform X1 [KO:K28455]
141146997  VPS13A; intermembrane lipid transfer protein VPS13A isoform X1 [KO:K19525]
141147217  SLC11A1; natural resistance-associated macrophage protein 1 [KO:K12347]
141147710  [KO:K19363]
141148029  CLCN7; LOW QUALITY PROTEIN: H(+)/Cl(-) exchange transporter 7 [KO:K05016]
141148496  CLN3; battenin [KO:K12389]
141148704  ROGDI; protein rogdi homolog [KO:K24628]
141148767  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
141148830  TELO2; telomere length regulation protein TEL2 homolog [KO:K11137]
141148846  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
141148918  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087]
Compound
C00002  ATP
C00008  ADP
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 22:339-352 (2022)
DOI:10.1038/s41577-021-00626-8
Reference
PMID:19672277
  Authors
Saftig P, Klumperman J
  Title
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function.
  Journal
Nat Rev Mol Cell Biol 10:623-35 (2009)
DOI:10.1038/nrm2745
Reference
PMID:31611045
  Authors
Savini M, Zhao Q, Wang MC
  Title
Lysosomes: Signaling Hubs for Metabolic Sensing and Longevity.
  Journal
Trends Cell Biol 29:876-887 (2019)
DOI:10.1016/j.tcb.2019.08.008
Reference
PMID:33433692
  Authors
Meyer-Schwesinger C
  Title
Lysosome function in glomerular health and disease.
  Journal
Cell Tissue Res 385:371-392 (2021)
DOI:10.1007/s00441-020-03375-7
Reference
PMID:34345172
  Authors
Allemailem KS, Almatroudi A, Alrumaihi F, Almatroodi SA, Alkurbi MO, Basfar GT, Rahmani AH, Khan AA
  Title
Novel Approaches of Dysregulating Lysosome Functions in Cancer Cells by Specific Drugs and Its Nanoformulations: A Smart Approach of Modern Therapeutics.
  Journal
Int J Nanomedicine 16:5065-5098 (2021)
DOI:10.2147/IJN.S321343
Reference
PMID:36096887
  Authors
Zhang W, Yang X, Li Y, Yu L, Zhang B, Zhang J, Cho WJ, Venkatarangan V, Chen L, Burugula BB, Bui S, Wang Y, Duan C, Kitzman JO, Li M
  Title
GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway.
  Journal
Nat Commun 13:5351 (2022)
DOI:10.1038/s41467-022-33025-1
Reference
PMID:38357444
  Authors
Liu Q, Wang W, Xu L, Zhang Q, Wang H
  Title
The host mannose-6-phosphate pathway and viral infection.
  Journal
Front Cell Infect Microbiol 14:1349221 (2024)
DOI:10.3389/fcimb.2024.1349221
Reference
PMID:38711187
  Authors
He Y, Fan Y, Ahmadpoor X, Wang Y, Li ZA, Zhu W, Lin H
  Title
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases.
  Journal
Med Res Rev 44:2472-2509 (2024)
DOI:10.1002/med.22047
Reference
PMID:40759742
  Authors
Radulovic M, Yang C, Stenmark H
  Title
Lysosomal membrane homeostasis and its importance in physiology and disease.
  Journal
Nat Rev Mol Cell Biol 27:71-87 (2026)
DOI:10.1038/s41580-025-00873-w
Reference
PMID:41214333
  Authors
Watson ET, Wegeng WR, Aravani S, Ernst AM, von Blume J
  Title
Mechanistic insights into cargo sorting and export from the Golgi apparatus.
  Journal
Nat Rev Mol Cell Biol 26:940-956 (2025)
DOI:10.1038/s41580-025-00907-3
Related
pathway
acat00511  Other glycan degradation
acat00531  Glycosaminoglycan degradation
acat04130  SNARE interactions in vesicular transport
acat04140  Autophagy - animal
acat04144  Endocytosis
acat04145  Phagosome
acat04150  mTOR signaling pathway
acat04620  Toll-like receptor signaling pathway
KO pathway
ko04142   

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