KEGG   PATHWAY: alat04540
Entry
alat04540                   Pathway                                
Name
Gap junction - Acanthopagrus latus (yellowfin seabream)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
alat04540  Gap junction
alat04540

Other DBs
GO: 0005921
Organism
Acanthopagrus latus (yellowfin seabream) [GN:alat]
Gene
119004386  [KO:K07373]
119004415  [KO:K07375]
119004543  sos2; son of sevenless homolog 2 [KO:K03099]
119004923  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
119005016  [KO:K07375]
119005233  [KO:K07374]
119006147  grm5b; metabotropic glutamate receptor 5b [KO:K04604]
119006342  tubb5; tubulin beta-5 chain [KO:K07375]
119006468  adcy3a; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
119006482  prkcg; protein kinase C alpha type isoform X1 [KO:K19663] [EC:2.7.11.13]
119006711  adcy2a; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
119006750  drd2l; dopamine receptor D2 like [KO:K04145]
119006937  drd1a; D(1) dopamine receptor [KO:K04144]
119007440  adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
119007664  [KO:K12319] [EC:4.6.1.2]
119007900  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
119008149  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
119008156  egf; pro-epidermal growth factor [KO:K04357]
119008592  [KO:K04361] [EC:2.7.10.1]
119009086  tubb6; tubulin beta-5 chain isoform X1 [KO:K07375]
119009458  csnk1db; casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
119009532  gucy1a2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
119009758  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
119010163  adrb1; beta-1 adrenergic receptor [KO:K04141]
119010641  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
119010740  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
119011484  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b isoform X1 [KO:K04369] [EC:2.7.12.2]
119011561  [KO:K04345] [EC:2.7.11.11]
119011864  [KO:K08041] [EC:4.6.1.1]
119011919  [KO:K07375]
119012153  prkg3; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
119012330  [KO:K05858] [EC:3.1.4.11]
119012449  si:dkey-206f10.1; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
119012484  [KO:K08043] [EC:4.6.1.1]
119012531  grm1a; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
119012656  [KO:K07373]
119012950  gja1b; gap junction alpha-1 protein [KO:K07372]
119012997  pdgfd; platelet-derived growth factor D [KO:K05450]
119013046  [KO:K05858] [EC:3.1.4.11]
119013105  [KO:K04144]
119013313  drd2a; dopamine receptor D2a [KO:K04145]
119013628  csnk1da; casein kinase I [KO:K08959] [EC:2.7.11.1]
119013927  grb2b; growth factor receptor-bound protein 2b isoform X1 [KO:K04364]
119014168  [KO:K19662] [EC:2.7.11.13]
119014285  [KO:K07827]
119014314  [KO:K08049] [EC:4.6.1.1]
119014493  [KO:K04359]
119014548  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119014563  tubb4bl; tubulin beta-4B chain [KO:K07375]
119014564  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
119014663  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
119014993  [KO:K07374]
119014994  [KO:K07374]
119015111  si:ch211-132f19.7; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
119015229  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
119015247  [KO:K07374]
119015249  [KO:K07374]
119015250  [KO:K07374]
119015251  [KO:K07374]
119015461  gucy1b2; guanylate cyclase soluble subunit beta-2 [KO:K12319] [EC:4.6.1.2]
119016759  [KO:K03099]
119016842  [KO:K07375]
119017049  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
119017649  tjp1a; tight junction protein ZO-1 isoform X1 [KO:K05701]
119017686  [KO:K19662] [EC:2.7.11.13]
119017721  gjd6; gap junction protein delta 6 [KO:K07373]
119018341  map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
119018496  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
119018820  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
119019482  tubb2b; tubulin beta-2b chain [KO:K07375]
119019491  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
119019628  [KO:K04634]
119020112  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119020289  prkg2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
119020366  gucy1a1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
119020376  gucy1b1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
119020522  [KO:K04958]
119020663  [KO:K05704] [EC:2.7.10.2]
119021036  [KO:K04630]
119021084  [KO:K07375]
119021085  [KO:K04632]
119021190  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
119021196  [KO:K04630]
119021530  [KO:K04359]
119022136  [KO:K04145]
119022184  gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
119022214  tuba5; tubulin alpha 5 [KO:K07374]
119022303  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
119022344  [KO:K07374]
119022346  [KO:K07374]
119022347  [KO:K07374]
119022348  [KO:K07374]
119022349  [KO:K07374]
119022453  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
119022541  [KO:K08046] [EC:4.6.1.1]
119022792  [KO:K07374]
119022873  gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
119023170  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
119023298  [KO:K08046] [EC:4.6.1.1]
119023707  kras; GTPase KRas isoform X1 [KO:K07827]
119024134  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
119024323  tjp1b; tight junction protein ZO-1 isoform X1 [KO:K05701]
119024444  [KO:K02833]
119024653  [KO:K04630]
119024934  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
119025609  [KO:K07374]
119025610  [KO:K07374]
119025611  [KO:K07374]
119025914  htr2aa; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
119026094  adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
119026637  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
119027827  htr2cl1; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 [KO:K04157]
119027991  [KO:K08041] [EC:4.6.1.1]
119028220  [KO:K07375]
119028306  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
119028320  [KO:K04635]
119028330  si:ch211-79m20.1; transcription factor SPT20 homolog isoform X1 [KO:K17386]
119028360  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
119028389  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
119028627  htr2b; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
119030309  [KO:K04634]
119030342  lpar1; lysophosphatidic acid receptor 1 [KO:K04289]
119031152  [KO:K05089] [EC:2.7.10.1]
119031210  [KO:K07373]
119031317  grm5a; glutamate receptor, metabotropic 5a [KO:K04604]
119031815  [KO:K07373]
119031974  drd1b; dopamine receptor D1b [KO:K04144]
119032419  [KO:K07375]
119032662  gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
119033457  [KO:K19477] [EC:2.7.11.12]
119033936  [KO:K07376] [EC:2.7.11.12]
119034103  [KO:K05858] [EC:3.1.4.11]
119034162  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
119034234  grm1b; metabotropic glutamate receptor 1b isoform X1 [KO:K04603]
119034345  gna11b; guanine nucleotide-binding protein subunit alpha-11b isoform X1 [KO:K04635]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
PMID:14506308
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
PMID:15033580
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
PMID:10751659
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
PMID:10873290
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
PMID:12566218
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
PMID:15094344
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
PMID:15955302
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
PMID:15033579
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
PMID:15033578
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
alat04010  MAPK signaling pathway
alat04020  Calcium signaling pathway
alat04060  Cytokine-cytokine receptor interaction
alat04070  Phosphatidylinositol signaling system
alat04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   

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