KEGG   PATHWAY: alat04010
Entry
alat04010                   Pathway                                
Name
MAPK signaling pathway - Acanthopagrus latus (yellowfin seabream)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
alat04010  MAPK signaling pathway
alat04010

Other DBs
GO: 0000165
Organism
Acanthopagrus latus (yellowfin seabream) [GN:alat]
Gene
119004341  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
119004342  fosaa; proto-oncogene c-Fos [KO:K04379]
119004370  [KO:K04350]
119004376  ppm1aa; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
119004435  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
119004483  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
119004543  sos2; son of sevenless homolog 2 [KO:K03099]
119004679  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119004787  map3k9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
119004818  [KO:K04410] [EC:2.7.11.1]
119004824  [KO:K04402]
119004977  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
119005031  pgfb; placenta growth factor isoform X1 [KO:K16859]
119005040  [KO:K04453]
119005315  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
119005327  [KO:K04446]
119005364  cacng7b; voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872]
119005632  nf1a; neurofibromin isoform X1 [KO:K08052]
119005705  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
119005804  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119005818  hsc70; heat shock cognate 71 kDa protein [KO:K03283]
119006354  cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
119006356  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
119006374  cacng6b; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
119006392  cdc42l; cell division cycle 42, like [KO:K04393]
119006443  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
119006459  efna1b; ephrin-A1b [KO:K05462]
119006482  prkcg; protein kinase C alpha type isoform X1 [KO:K19663] [EC:2.7.11.13]
119006505  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
119006657  si:dkey-246i14.3; ephrin-A4 isoform X1 [KO:K05462]
119006668  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
119006720  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
119006789  efna3b; ephrin-A3b isoform X1 [KO:K05462]
119006792  [KO:K04388] [EC:2.7.11.30]
119006837  stmn1b; stathmin 1b [KO:K04381]
119006853  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
119006923  fgf18a; fibroblast growth factor 18a isoform X1 [KO:K04358]
119006924  fgf24; fibroblast growth factor 24 [KO:K04358]
119006939  fgf16; fibroblast growth factor 16 [KO:K04358]
119006992  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
119007028  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
119007045  [KO:K02187] [EC:3.4.22.56]
119007159  si:zfos-2326c3.2; misshapen-like kinase 1 isoform X1 [KO:K04407] [EC:2.7.11.1]
119007165  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
119007195  rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
119007232  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
119007245  fgf2; fibroblast growth factor 2 [KO:K18497]
119007260  cd40lg; CD40 ligand [KO:K04389]
119007321  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
119007392  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
119007415  csf1ra; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
119007531  vegfba; vascular endothelial growth factor A [KO:K05448]
119007595  [KO:K04526]
119007627  [KO:K04358]
119007650  fgf20b; fibroblast growth factor 20b [KO:K04358]
119007710  fgf1a; putative fibroblast growth factor 1 isoform X1 [KO:K18496]
119007720  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
119007900  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
119008099  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
119008149  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
119008151  atf4a; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
119008156  egf; pro-epidermal growth factor [KO:K04357]
119008355  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
119008427  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
119008429  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
119008523  map3k8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
119008591  map3k22; mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
119008592  [KO:K04361] [EC:2.7.10.1]
119008730  myca; transcriptional regulator Myc-A [KO:K04377]
119008826  arrb1; beta-arrestin-1 [KO:K04439]
119008855  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
119008972  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
119009072  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
119009115  [KO:K04674] [EC:2.7.11.30]
119009263  tgfb1a; transforming growth factor, beta 1a isoform X1 [KO:K13375]
119009268  [KO:K04466] [EC:2.7.11.25]
119009342  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
119009361  rasa2; ras GTPase-activating protein 2 [KO:K08053]
119009363  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
119009619  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119009654  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
119009685  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
119009703  [KO:K04392]
119009758  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
119009760  ppm1bb; protein phosphatase 1bb isoform X1 [KO:K04461] [EC:3.1.3.16]
119009811  ppm1na; protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative) [KO:K04457] [EC:3.1.3.16]
119009815  mapta; microtubule-associated protein tau isoform X1 [KO:K04380]
119010013  [KO:K04467] [EC:2.7.11.10]
119010026  [KO:K04723]
119010027  map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
119010077  dusp3a; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
119010094  fgf21; fibroblast growth factor 21 isoform X1 [KO:K22429]
119010225  [KO:K04870]
119010253  ngfrb; nerve growth factor receptor b [KO:K02583]
119010391  taok2b; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
119010534  [KO:K25415]
119010619  [KO:K04448]
119010646  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
119010664  [KO:K04377]
119010740  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
119010790  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
119011146  cacna1eb; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
119011205  [KO:K04449]
119011437  gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a isoform X1 [KO:K04347]
119011484  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b isoform X1 [KO:K04369] [EC:2.7.12.2]
119011561  [KO:K04345] [EC:2.7.11.11]
119011757  [KO:K25414]
119011814  [KO:K04424] [EC:2.7.11.25]
119011852  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a isoform X1 [KO:K04402]
119012066  [KO:K04379]
119012067  [KO:K04379]
119012178  max; protein max isoform X1 [KO:K04453]
119012251  [KO:K16859]
119012335  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
119012337  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
119012338  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
119012374  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
119012440  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
119012450  mecom; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
119012715  [KO:K13377]
119012997  pdgfd; platelet-derived growth factor D [KO:K05450]
119013251  [KO:K04392]
119013274  [KO:K04869]
119013310  cacng5b; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
119013387  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
119013498  [KO:K04347]
119013545  taok2a; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
119013548  [KO:K03283]
119013549  [KO:K03283]
119013554  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
119013630  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
119013820  cacna1aa; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
119013883  [KO:K04862]
119013927  grb2b; growth factor receptor-bound protein 2b isoform X1 [KO:K04364]
119014146  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
119014168  [KO:K19662] [EC:2.7.11.13]
119014173  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
119014191  cacng7a; calcium channel, voltage-dependent, gamma subunit 7a isoform X1 [KO:K04872]
119014200  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
119014275  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
119014285  [KO:K07827]
119014316  atf4b; activating transcription factor 4b [KO:K04374]
119014340  daxx; death domain-associated protein 6 [KO:K02308]
119014352  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
119014377  map3k14a; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
119014463  cacna1ia; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
119014493  [KO:K04359]
119014505  [KO:K16342] [EC:3.1.1.4]
119014508  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
119014532  [KO:K04433] [EC:2.7.12.2]
119014548  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119014564  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
119014629  [KO:K16342] [EC:3.1.1.4]
119014663  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
119014688  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
119014766  cacng3b; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
119014804  maptb; microtubule-associated protein tau [KO:K04380]
119015030  [KO:K04407] [EC:2.7.11.1]
119015032  [KO:K05085] [EC:2.7.10.1]
119015229  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
119015257  cacng6a; calcium channel, voltage-dependent, gamma subunit 6a [KO:K04871]
119015271  [KO:K04406] [EC:2.7.11.1]
119015381  [KO:K04865]
119015427  si:ch211-195b15.8; probable dual specificity protein phosphatase DDB_G0281963 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
119015428  rras; ras-related protein R-Ras [KO:K07830]
119015500  [KO:K05449]
119015892  angpt2b; angiopoietin-2b [KO:K05466]
119016568  [KO:K04393]
119016759  [KO:K03099]
119016818  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b isoform X1 [KO:K04344]
119016898  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
119017058  [KO:K04388] [EC:2.7.11.30]
119017095  angpt1; angiopoietin-1 isoform X1 [KO:K05465]
119017120  stk3; serine/threonine-protein kinase 3 [KO:K04412]
119017224  [KO:K04381]
119017234  efna1a; ephrin-A1a isoform X1 [KO:K05462]
119017235  efna3a; ephrin-A3 [KO:K05462]
119017371  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
119017431  cacng8a; calcium channel, voltage-dependent, gamma subunit 8a [KO:K04873]
119017585  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
119017686  [KO:K19662] [EC:2.7.11.13]
119017696  [KO:K04868]
119017774  [KO:K04349]
119017781  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
119017814  [KO:K05087] [EC:2.7.10.1]
119017825  rras2; ras-related protein R-Ras2 [KO:K07830]
119017935  fgf19; fibroblast growth factor 19 [KO:K22603]
119017966  fgf7; fibroblast growth factor 7 [KO:K04358]
119018128  mapk8ip1b; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
119018286  fgf3; fibroblast growth factor 3 [KO:K04358]
119018300  fgf4; fibroblast growth factor 4 [KO:K04358]
119018316  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
119018341  map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
119018496  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
119018561  vegfd; vascular endothelial growth factor D [KO:K05449]
119018725  rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
119018730  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
119018900  taok3a; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
119018948  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
119018987  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
119019038  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
119019043  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
119019048  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a isoform X1 [KO:K04849]
119019162  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
119019249  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
119019347  rasa1a; ras GTPase-activating protein 1 [KO:K04352]
119019371  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
119019478  mef2cb; myocyte enhancer factor 2cb isoform X1 [KO:K04454]
119019491  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
119019631  [KO:K05452]
119019740  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a isoform X1 [KO:K04360] [EC:2.7.10.1]
119019748  [KO:K04519]
119019754  efna5b; ephrin-A5b isoform X1 [KO:K05462]
119019813  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
119019943  traf2a; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
119020053  fgf10b; fibroblast growth factor 10b [KO:K04358]
119020102  [KO:K09784]
119020112  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119020193  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
119020234  fgf5; fibroblast growth factor 5 [KO:K04358]
119020292  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
119020431  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
119020557  angpt4; angiopoietin-1 isoform X1 [KO:K05465]
119020560  [KO:K04411]
119020732  [KO:K04444] [EC:2.7.11.1]
119020797  [KO:K04857]
119020932  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
119020999  elk4; ETS domain-containing protein Elk-4 [KO:K04376]
119021034  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
119021040  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
119021110  [KO:K04353]
119021222  [KO:K04465]
119021253  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
119021341  mapkapk2a; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
119021386  erbb3a; receptor tyrosine-protein kinase erbB-3a [KO:K05084] [EC:2.7.10.1]
119021504  ngfb; nerve growth factor [KO:K02582]
119021517  mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
119021530  [KO:K04359]
119021561  [KO:K04860]
119021652  mych; myelocytomatosis oncogene homolog [KO:K04377]
119021665  epha2a; ephrin type-A receptor 2a [KO:K05103] [EC:2.7.10.1]
119021668  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
119021699  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
119021716  [KO:K04859]
119021789  [KO:K04423] [EC:2.7.11.25]
119021965  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
119022093  [KO:K05459]
119022281  [KO:K04393]
119022303  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
119022338  nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
119022437  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
119022475  [KO:K18019] [EC:3.1.3.48]
119022646  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
119022666  [KO:K04443] [EC:2.7.11.1]
119022741  [KO:K04353]
119022797  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a isoform X1 [KO:K04864]
119022811  flna; filamin-A isoform X1 [KO:K04437]
119022925  hspa1b; heat shock 70 kDa protein 1B [KO:K03283]
119023017  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit isoform X1 [KO:K04853]
119023050  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
119023059  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
119023146  epha2b; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
119023209  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
119023270  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
119023280  [KO:K04358]
119023341  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
119023419  cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04864]
119023423  map3k12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
119023427  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
119023476  [KO:K04857]
119023513  zgc:171775; STKc_p38 domain-containing protein isoform X1 [KO:K04441] [EC:2.7.11.24]
119023514  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
119023591  erbb3b; receptor tyrosine-protein kinase erbB-3b [KO:K05084] [EC:2.7.10.1]
119023601  ngfa; neurotrophin-7 [KO:K02582]
119023684  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
119023707  kras; GTPase KRas isoform X1 [KO:K07827]
119023710  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
119023727  mapk12a; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
119024006  [KO:K22428]
119024007  [KO:K04358]
119024075  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
119024175  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
119024247  [KO:K04861]
119024334  igf2b; insulin-like growth factor 2b [KO:K13769]
119024399  [KO:K04856]
119024444  [KO:K02833]
119024676  dusp8a; dual specificity protein phosphatase 8a isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
119024688  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
119024704  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
119024744  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
119024785  [KO:K04434]
119024820  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
119024842  kitlga; kit ligand a [KO:K05461]
119024934  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
119025044  [KO:K04858]
119025110  [KO:K05460]
119025118  [KO:K17333]
119025316  [KO:K25416]
119025450  [KO:K04407] [EC:2.7.11.1]
119025486  fgf9; fibroblast growth factor 4A isoform X1 [KO:K04358]
119025558  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
119025666  zak; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
119025790  [KO:K04386]
119025841  [KO:K05085] [EC:2.7.10.1]
119026032  si:ch73-116o1.2; ras-related protein M-Ras [KO:K07831]
119026114  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
119026213  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
119026332  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
119026369  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
119026740  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
119027115  [KO:K04419] [EC:2.7.11.25]
119027261  rela; transcription factor p65 isoform X1 [KO:K04735]
119027321  [KO:K04348] [EC:3.1.3.16]
119027325  arrb2b; arrestin, beta 2b isoform X1 [KO:K04439]
119027385  [KO:K12361]
119027450  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
119027521  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
119027535  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
119027537  [KO:K04869]
119027547  [KO:K04866]
119028302  [KO:K04402]
119028306  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
119028307  kita; mast/stem cell growth factor receptor kita isoform X1 [KO:K05091] [EC:2.7.10.1]
119028330  si:ch211-79m20.1; transcription factor SPT20 homolog isoform X1 [KO:K17386]
119028360  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
119028389  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
119028451  [KO:K04867]
119028470  [KO:K04852]
119028657  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
119028674  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
119028690  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
119028723  fgf8b; fibroblast growth factor 8b [KO:K04358]
119028735  fgf22; fibroblast growth factor 22 [KO:K04358]
119028828  [KO:K25415]
119028877  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
119028898  vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
119029024  si:dkey-44g17.6; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
119029038  jun; transcription factor AP-1 [KO:K04448]
119029058  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
119029123  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
119029152  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b isoform X1 [KO:K04372] [EC:2.7.11.1]
119029184  [KO:K05462]
119029224  [KO:K04449]
119029294  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
119029295  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
119029420  gdnfa; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
119029433  kitb; KIT proto-oncogene, receptor tyrosine kinase b isoform X1 [KO:K05091] [EC:2.7.10.1]
119029448  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
119029609  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
119029635  rasgrf2a; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
119029649  crkl; crk-like protein [KO:K04438]
119029699  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
119029777  cacna1bb; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
119029894  [KO:K04454]
119029968  fgf10a; fibroblast growth factor 10a [KO:K04358]
119030068  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
119030106  [KO:K04402]
119030170  taok3b; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
119030171  [KO:K04455]
119030239  [KO:K03173] [EC:2.3.2.27]
119030334  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
119030341  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
119030380  [KO:K05462]
119030510  fgfr1b; LOW QUALITY PROTEIN: fibroblast growth factor receptor 1b [KO:K04362] [EC:2.7.10.1]
119030549  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b isoform X1 [KO:K04360] [EC:2.7.10.1]
119030658  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119030700  si:ch211-167j9.5; tyrosine kinase receptor Cad96Ca [KO:K05093] [EC:2.7.10.1]
119030725  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
119030830  [KO:K04456] [EC:2.7.11.1]
119030903  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
119030964  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
119030991  relb; transcription factor RelB isoform X1 [KO:K09253]
119030992  [KO:K04439]
119031041  crk; adapter molecule crk [KO:K04438]
119031058  taok1b; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
119031152  [KO:K05089] [EC:2.7.10.1]
119031423  rps6ka4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
119031455  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
119031507  [KO:K04438]
119031601  [KO:K04526]
119031607  [KO:K04526]
119031608  [KO:K04526]
119031674  csf1rb; macrophage colony-stimulating factor 1 receptor 2 [KO:K05090] [EC:2.7.10.1]
119031782  [KO:K18496]
119031884  hspb1; heat shock protein beta-1 [KO:K04455]
119031889  ppm1nb; protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative) [KO:K04457] [EC:3.1.3.16]
119032208  igf1; insulin-like growth factor I [KO:K05459]
119032272  ntf3; neurotrophin-3 isoform X1 [KO:K04356]
119032303  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
119032335  mapk12b; mitogen-activated protein kinase 12b isoform X1 [KO:K04441] [EC:2.7.11.24]
119032425  fgf23; fibroblast growth factor 23 [KO:K22428]
119032426  [KO:K04358]
119032485  ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
119032488  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
119032538  [KO:K07836]
119032573  cacna2d1a; voltage-dependent calcium channel subunit alpha-2/delta-1a isoform X1 [KO:K04858]
119032659  mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
119032666  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
119032717  [KO:K05461]
119032739  hgfa; hepatocyte growth factor a isoform X1 [KO:K05460]
119032898  taok1a; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
119032901  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
119033000  [KO:K06268]
119033070  fgf8a; fibroblast growth factor 8 isoform X1 [KO:K04358]
119033152  [KO:K04456] [EC:2.7.11.1]
119033225  angpt2a; angiopoietin-2a isoform X1 [KO:K05466]
119033227  [KO:K04378]
119033342  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
119033400  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
119033409  [KO:K04406] [EC:2.7.11.1]
119033469  map3k21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
119033472  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
119033529  srfb; serum response factor b isoform X1 [KO:K04378]
119033721  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
119033738  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119033746  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
119033964  [KO:K04467] [EC:2.7.11.10]
119033977  ppm1ba; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
119034075  fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
119034232  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
119034257  efna2a; ephrin-A2 isoform X1 [KO:K05462]
119034313  rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K04350]
119034443  rps6ka5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
119034485  [KO:K04427] [EC:2.7.11.25]
119034488  hspa8b; heat shock protein family A (Hsp70) member 8b [KO:K03283]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
alat04070  Phosphatidylinositol signaling system
alat04110  Cell cycle
alat04115  p53 signaling pathway
alat04210  Apoptosis
alat04310  Wnt signaling pathway
KO pathway
ko04010   

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