KEGG   PATHWAY: apla04144
Entry
apla04144                   Pathway                                
Name
Endocytosis - Anas platyrhynchos (mallard)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
apla04144  Endocytosis
apla04144

Other DBs
GO: 0006897
Organism
Anas platyrhynchos (mallard) [GN:apla]
Gene
101789529  SNX3; sorting nexin-3 [KO:K17918]
101789556  RAB35; ras-related protein Rab-35 [KO:K07876]
101789606  [KO:K05068]
101789789  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
101789842  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
101789931  RAB5A; ras-related protein Rab-5A [KO:K07887]
101790068  SH3GLB2; endophilin-B2 isoform X1 [KO:K21269]
101790430  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
101790497  [KO:K06751]
101790586  CYTH4; cytohesin-4 [KO:K18441]
101790645  SNX2; sorting nexin-2 isoform X1 [KO:K17917]
101790731  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
101790801  [KO:K12474]
101791009  SPG21; maspardin [KO:K19367]
101791084  ZFYVE16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
101791340  SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X8 [KO:K12470]
101791487  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
101791489  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396] [EC:5.6.1.3]
101791510  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
101791540  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
101791620  RAB8A; ras-related protein Rab-8A [KO:K07901]
101791719  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
101791767  RAB11FIP4; rab11 family-interacting protein 4 isoform X4 [KO:K12485]
101791771  ARFGAP2; LOW QUALITY PROTEIN: ADP-ribosylation factor GTPase-activating protein 2 [KO:K12493]
101791907  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101791968  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
101792150  EPS15L1; epidermal growth factor receptor substrate 15-like 1 isoform X5 [KO:K12472]
101792193  VPS35; vacuolar protein sorting-associated protein 35 isoform X1 [KO:K18468]
101792210  IST1; IST1 homolog isoform X2 [KO:K19476]
101792227  CAV3; caveolin-3 [KO:K12959]
101792324  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
101792464  CHMP5; charged multivesicular body protein 5 [KO:K12198]
101792666  USP8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
101792760  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
101792866  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
101792870  PARD3; LOW QUALITY PROTEIN: partitioning defective 3 homolog [KO:K04237]
101793010  CHMP4C; charged multivesicular body protein 4c isoform X1 [KO:K24782]
101793125  WASHC3; WASH complex subunit 3 isoform X1 [KO:K18463]
101793138  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X5 [KO:K12488]
101793242  VPS37C; vacuolar protein sorting-associated protein 37C isoform X1 [KO:K12185]
101793265  IQSEC1; IQ motif and SEC7 domain-containing protein 1 isoform X13 [KO:K12495]
101793283  SNX6; sorting nexin-6 isoform X2 [KO:K17920]
101793361  EPS15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
101793368  EHD4; EH domain-containing protein 4 [KO:K12477]
101793376  IQSEC3; IQ motif and SEC7 domain-containing protein 3 isoform X2 [KO:K12495]
101793649  HRAS; GTPase HRas [KO:K02833]
101793731  CLTA; clathrin light chain A isoform X1 [KO:K04644]
101793808  ACAP3; LOW QUALITY PROTEIN: arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 [KO:K12489]
101793826  SNX12; sorting nexin-12 [KO:K17918]
101793881  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
101794082  RAB11FIP5; rab11 family-interacting protein 5 isoform X2 [KO:K12484]
101794093  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
101794116  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X3 [KO:K12488]
101794194  IL2RG; cytokine receptor common subunit gamma precursor [KO:K05070]
101794203  PARD6A; partitioning defective 6 homolog alpha [KO:K06093]
101794252  GRK5; G protein-coupled receptor kinase 5 isoform X3 [KO:K08291] [EC:2.7.11.16]
101794292  RBSN; rabenosyn-5 isoform X1 [KO:K12481]
101794293  PSD3; PH and SEC7 domain-containing protein 3 isoform X1 [KO:K12494]
101794415  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
101794617  RAB11FIP3; LOW QUALITY PROTEIN: rab11 family-interacting protein 3 [KO:K12485]
101794778  WASHC1; LOW QUALITY PROTEIN: WASH complex subunit 1 [KO:K18461]
101794795  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
101794803  SH3GL1; endophilin-A2 isoform X1 [KO:K11247]
101794924  [KO:K12200]
101794996  SNX5; sorting nexin-5 isoform X2 [KO:K17920]
101795353  GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
101795419  ARF4; ADP-ribosylation factor 4 [KO:K07939]
101795473  SMAP2; LOW QUALITY PROTEIN: stromal membrane-associated protein 2 [KO:K12486]
101795497  RAB10; ras-related protein Rab-10 [KO:K07903]
101795643  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X2 [KO:K05632] [EC:2.3.2.26]
101795656  ACTR3; actin-related protein 3 [KO:K18584]
101795708  IGF2R; LOW QUALITY PROTEIN: cation-independent mannose-6-phosphate receptor [KO:K06564]
101795715  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
101795826  VPS36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
101795996  SH3GLB1; endophilin-B1 isoform X1 [KO:K11248]
101796061  RAB11B; ras-related protein Rab-11B [KO:K07905]
101796105  [KO:K10054] [EC:2.3.2.-]
101796286  ACAP2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
101796455  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
101796604  EPN3; LOW QUALITY PROTEIN: epsin-3 [KO:K12471]
101796708  SNF8; vacuolar-sorting protein SNF8 isoform X1 [KO:K12188]
101796775  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
101796955  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
101796971  GRK7; rhodopsin kinase GRK7 isoform X1 [KO:K00909] [EC:2.7.11.14]
101797030  RUFY2; RUN and FYVE domain-containing protein 2 isoform X3 [KO:K12482]
101797186  SH3GL3; endophilin-A3 [KO:K11247]
101797249  SRC; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
101797285  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
101797292  AMPH; amphiphysin isoform X1 [KO:K12562]
101797303  CLTCL1; clathrin heavy chain 2 isoform X1 [KO:K04646]
101797340  WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
101797744  [KO:K08291] [EC:2.7.11.16]
101797830  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101797910  RHOA; transforming protein RhoA [KO:K04513]
101798070  SNX4; LOW QUALITY PROTEIN: sorting nexin-4 [KO:K17919]
101798072  CHMP1A; charged multivesicular body protein 1a isoform X2 [KO:K12197]
101798239  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
101798485  SMAP1; stromal membrane-associated protein 1 isoform X2 [KO:K12486]
101798491  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
101798615  [KO:K13649]
101798630  MVB12B; multivesicular body subunit 12B isoform X1 [KO:K12186]
101798639  GRK6; G protein-coupled receptor kinase 6 isoform X2 [KO:K08291] [EC:2.7.11.16]
101798755  ASAP3; LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
101798866  WIPF3; WAS/WASL-interacting protein family member 3 isoform X1 [KO:K19475]
101798987  GRK4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
101799000  EHD3; EH domain-containing protein 3 [KO:K12476]
101799051  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
101799120  AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
101799132  ARFGAP3; ADP-ribosylation factor GTPase-activating protein 3 isoform X1 [KO:K12493]
101799282  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
101799300  SNX1; sorting nexin-1 [KO:K17917]
101799340  PSD2; PH and SEC7 domain-containing protein 2 isoform X2 [KO:K12494]
101799411  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
101799870  ARF1; ADP-ribosylation factor 1 [KO:K07937]
101800112  BIN1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
101800144  VPS26A; vacuolar protein sorting-associated protein 26A [KO:K18466]
101800252  [KO:K07904]
101800429  [KO:K04180]
101800439  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101800453  RAB7A; ras-related protein Rab-7a [KO:K07897]
101800494  ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
101800570  WASHC4; WASH complex subunit 4 [KO:K18465]
101800651  ZFYVE9; zinc finger FYVE domain-containing protein 9 [KO:K04679]
101800738  KIF5C; LOW QUALITY PROTEIN: kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
101800757  [KO:K04180]
101800777  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
101800782  PSD; PH and SEC7 domain-containing protein 1 isoform X1 [KO:K12494]
101800878  SPART; spartin isoform X1 [KO:K19366]
101801089  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
101801136  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
101801184  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
101801230  SMAD3; mothers against decapentaplegic homolog 3 isoform X2 [KO:K23605]
101801257  ARF6; ADP-ribosylation factor 6 [KO:K07941]
101801259  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
101801328  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
101801367  ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
101801487  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
101801641  [KO:K04388] [EC:2.7.11.30]
101801692  EPN2; epsin-2 isoform X1 [KO:K12471]
101801705  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X4 [KO:K05633] [EC:2.3.2.26]
101801738  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101801780  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
101801848  SH3GL2; endophilin-A1 [KO:K11247]
101801854  CYTH3; cytohesin-3 isoform X1 [KO:K18441]
101801891  CAV1; caveolin-1 [KO:K06278]
101801913  WIPF1; WAS/WASL-interacting protein family member 1 isoform X1 [KO:K19475]
101802018  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
101802095  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
101802120  WASHC2C; WASH complex subunit 2C isoform X1 [KO:K18462]
101802411  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101802425  WASHC5; LOW QUALITY PROTEIN: WASH complex subunit 5 [KO:K18464]
101802528  VTA1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
101802558  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
101802747  [KO:K12488]
101802787  RAB31; ras-related protein Rab-31 [KO:K07891]
101802842  DAB2; disabled homolog 2 isoform X1 [KO:K12475]
101803031  RABEP1; rab GTPase-binding effector protein 1 [KO:K12480]
101803037  STAM; signal transducing adapter molecule 1 [KO:K04705]
101803068  TFRC; transferrin receptor protein 1 [KO:K06503]
101803197  DNAJC6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
101803298  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 [KO:K18442]
101803366  VPS37D; vacuolar protein sorting-associated protein 37D [KO:K12185]
101803787  [KO:K04500]
101803836  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
101803883  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X2 [KO:K04678] [EC:2.3.2.26]
101804056  VPS45; vacuolar protein sorting-associated protein 45 isoform X1 [KO:K12479]
101804101  AP2M1; AP-2 complex subunit mu isoform X1 [KO:K11826]
101804693  VPS37B; vacuolar protein sorting-associated protein 37B [KO:K12185]
101804698  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
101804759  RUFY1; RUN and FYVE domain-containing protein 1 isoform X2 [KO:K12482]
101804882  MVB12A; multivesicular body subunit 12A [KO:K12186]
101804916  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
101804978  RAB22A; ras-related protein Rab-22A [KO:K07891]
101804995  FGFR3; fibroblast growth factor receptor 3 isoform X7 [KO:K05094] [EC:2.7.10.1]
101805006  RAB4A; ras-related protein Rab-4A [KO:K07879]
101805076  RAB11FIP2; rab11 family-interacting protein 2 [KO:K12484]
101805150  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
101805179  EEA1; early endosome antigen 1 isoform X2 [KO:K12478]
101805247  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
101805307  CAV2; caveolin-2 [KO:K12958]
101805319  RAB11A; ras-related protein Rab-11A [KO:K07904]
101805328  [KO:K04674] [EC:2.7.11.30]
101805334  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
101805402  VPS37A; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 37A [KO:K12185]
106017617  ARF5; ADP-ribosylation factor 5 isoform X1 [KO:K07940]
110353581  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
110354206  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
113839615  VPS25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
113839618  CLTB; LOW QUALITY PROTEIN: clathrin light chain B [KO:K04645]
113840038  RAB5B; ras-related protein Rab-5B [KO:K07888]
113844857  PML; LOW QUALITY PROTEIN: protein PML [KO:K10054] [EC:2.3.2.-]
113845462  PIP5KL1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
119713043  TSG101; tumor susceptibility gene 101 protein isoform X1 [KO:K12183]
119713194  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
119713212  CHMP6; charged multivesicular body protein 6 [KO:K12195]
119713353  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
119713470  [KO:K11866] [EC:3.4.19.12]
119713509  CHMP7; charged multivesicular body protein 7 [KO:K15053]
119713577  LDLRAP1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
119714085  RAB5C; ras-related protein Rab-5C [KO:K07889]
119714633  RNF41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
119714810  GRK1; rhodopsin kinase GRK1 isoform X1 [KO:K00909] [EC:2.7.11.14]
119714986  ARAP1; LOW QUALITY PROTEIN: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 [KO:K18439]
119715258  [KO:K06751]
119715307  ARF3; ADP-ribosylation factor 3 [KO:K07938]
119715931  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
119716123  [KO:K04674] [EC:2.7.11.30]
119716851  [KO:K12193]
119717334  ZFYVE27; LOW QUALITY PROTEIN: protrudin [KO:K19368]
119717887  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
119718130  VPS4A; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 4A [KO:K12196]
119718482  VPS29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
119718506  [KO:K18467]
119718575  GRK3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
119718582  GIT2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
apla04060  Cytokine-cytokine receptor interaction
apla04070  Phosphatidylinositol signaling system
apla04130  SNARE interactions in vesicular transport
apla04142  Lysosome
apla04350  TGF-beta signaling pathway
KO pathway
ko04144   

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