Entry
Name
Endocytosis - Anas platyrhynchos (mallard)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Other DBs
Organism
Anas platyrhynchos (mallard) [GN:
apla ]
Gene
101791084 ZFYVE16; zinc finger FYVE domain-containing protein 16 [KO:K04679 ]
101791340 SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X8 [KO:K12470 ]
101791767 RAB11FIP4; rab11 family-interacting protein 4 isoform X4 [KO:K12485 ]
101791771 ARFGAP2; LOW QUALITY PROTEIN: ADP-ribosylation factor GTPase-activating protein 2 [KO:K12493 ]
101791907 CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
101791968 VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466 ]
101792150 EPS15L1; epidermal growth factor receptor substrate 15-like 1 isoform X5 [KO:K12472 ]
101792193 VPS35; vacuolar protein sorting-associated protein 35 isoform X1 [KO:K18468 ]
101792870 PARD3; LOW QUALITY PROTEIN: partitioning defective 3 homolog [KO:K04237 ]
101793010 CHMP4C; charged multivesicular body protein 4c isoform X1 [KO:K24782 ]
101793138 ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X5 [KO:K12488 ]
101793242 VPS37C; vacuolar protein sorting-associated protein 37C isoform X1 [KO:K12185 ]
101793265 IQSEC1; IQ motif and SEC7 domain-containing protein 1 isoform X13 [KO:K12495 ]
101793361 EPS15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472 ]
101793376 IQSEC3; IQ motif and SEC7 domain-containing protein 3 isoform X2 [KO:K12495 ]
101793808 ACAP3; LOW QUALITY PROTEIN: arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 [KO:K12489 ]
101794082 RAB11FIP5; rab11 family-interacting protein 5 isoform X2 [KO:K12484 ]
101794116 ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X3 [KO:K12488 ]
101794194 IL2RG; cytokine receptor common subunit gamma precursor [KO:K05070 ]
101794293 PSD3; PH and SEC7 domain-containing protein 3 isoform X1 [KO:K12494 ]
101794617 RAB11FIP3; LOW QUALITY PROTEIN: rab11 family-interacting protein 3 [KO:K12485 ]
101795353 GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443 ]
101795473 SMAP2; LOW QUALITY PROTEIN: stromal membrane-associated protein 2 [KO:K12486 ]
101795708 IGF2R; LOW QUALITY PROTEIN: cation-independent mannose-6-phosphate receptor [KO:K06564 ]
101795826 VPS36; vacuolar protein-sorting-associated protein 36 [KO:K12190 ]
101796286 ACAP2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489 ]
101796955 ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490 ]
101797030 RUFY2; RUN and FYVE domain-containing protein 2 isoform X3 [KO:K12482 ]
101797340 WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612 ]
101798072 CHMP1A; charged multivesicular body protein 1a isoform X2 [KO:K12197 ]
101798485 SMAP1; stromal membrane-associated protein 1 isoform X2 [KO:K12486 ]
101798755 ASAP3; LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488 ]
101798866 WIPF3; WAS/WASL-interacting protein family member 3 isoform X1 [KO:K19475 ]
101799120 AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491 ]
101799132 ARFGAP3; ADP-ribosylation factor GTPase-activating protein 3 isoform X1 [KO:K12493 ]
101799282 HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182 ]
101799340 PSD2; PH and SEC7 domain-containing protein 2 isoform X2 [KO:K12494 ]
101799411 STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705 ]
101800112 BIN1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562 ]
101800144 VPS26A; vacuolar protein sorting-associated protein 26A [KO:K18466 ]
101800494 ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440 ]
101800782 PSD; PH and SEC7 domain-containing protein 1 isoform X1 [KO:K12494 ]
101801230 SMAD3; mothers against decapentaplegic homolog 3 isoform X2 [KO:K23605 ]
101801367 ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492 ]
101801913 WIPF1; WAS/WASL-interacting protein family member 1 isoform X1 [KO:K19475 ]
101802095 CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365 ]
101802528 VTA1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199 ]
101803197 DNAJC6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526 ]
101803298 ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 [KO:K18442 ]
101803366 VPS37D; vacuolar protein sorting-associated protein 37D [KO:K12185 ]
101803836 ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442 ]
101804056 VPS45; vacuolar protein sorting-associated protein 45 isoform X1 [KO:K12479 ]
101804693 VPS37B; vacuolar protein sorting-associated protein 37B [KO:K12185 ]
101804759 RUFY1; RUN and FYVE domain-containing protein 1 isoform X2 [KO:K12482 ]
101805334 SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500 ]
101805402 VPS37A; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 37A [KO:K12185 ]
110353581 ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754 ]
113839615 VPS25; vacuolar protein-sorting-associated protein 25 [KO:K12189 ]
119713043 TSG101; tumor susceptibility gene 101 protein isoform X1 [KO:K12183 ]
119713577 LDLRAP1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474 ]
119714986 ARAP1; LOW QUALITY PROTEIN: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 [KO:K18439 ]
119715931 VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196 ]
119718130 VPS4A; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 4A [KO:K12196 ]
119718482 VPS29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467 ]
Compound
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11556 1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
Authors
Acconcia F, Sigismund S, Polo S
Title
Ubiquitin in trafficking: the network at work.
Journal
Reference
Authors
Donaldson JG, Porat-Shliom N, Cohen LA
Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
Journal
Reference
Authors
Sorkin A
Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
Journal
Reference
Authors
Raiborg C, Stenmark H
Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
Journal
Reference
Authors
Scita G, Di Fiore PP
Title
The endocytic matrix.
Journal
Reference
Authors
Le Roy C, Wrana JL
Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
Journal
Reference
Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
Title
The early endosome: a busy sorting station for proteins at the crossroads.
Journal
Reference
Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
Title
Viral entry, lipid rafts and caveosomes.
Journal
Reference
Authors
Grant BD, Donaldson JG
Title
Pathways and mechanisms of endocytic recycling.
Journal
Reference
Authors
Cullen PJ, Korswagen HC
Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
Journal
Related pathway
apla04060 Cytokine-cytokine receptor interaction
apla04070 Phosphatidylinositol signaling system
apla04130 SNARE interactions in vesicular transport
KO pathway