KEGG   PATHWAY: apla04060
Entry
apla04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Anas platyrhynchos (mallard)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
apla04060  Cytokine-cytokine receptor interaction
apla04060

Organism
Anas platyrhynchos (mallard) [GN:apla]
Gene
101789448  TNFRSF25; tumor necrosis factor receptor superfamily member 25 [KO:K05160]
101789486  TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
101789598  CD40LG; CD40 ligand [KO:K03161]
101789606  [KO:K05068]
101789784  ACVR2A; activin receptor type-2A isoform X2 [KO:K04670] [EC:2.7.11.30]
101789810  BMP7; bone morphogenetic protein 7 [KO:K16621]
101789878  CCR7; C-C chemokine receptor type 7 [KO:K04182]
101790036  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
101790039  CCL19; C-C motif chemokine 19 precursor [KO:K05512]
101790140  CD4; T-cell surface glycoprotein CD4 precursor [KO:K06454]
101790154  TNFRSF8; tumor necrosis factor receptor superfamily member 8 isoform X1 [KO:K05145]
101790237  TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471]
101790239  CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
101790246  IL22; interleukin-22 [KO:K05445]
101790364  LEPR; leptin receptor isoform X1 [KO:K05062]
101790439  IFNG; interferon gamma precursor [KO:K04687]
101790774  IL17C; interleukin-17C [KO:K05491]
101790789  IFNGR2; interferon gamma receptor 2 [KO:K05133]
101790975  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
101790997  GH1; somatotropin precursor [KO:K05438]
101791121  [KO:K13596] [EC:2.7.11.30]
101791359  [KO:K05141]
101791678  IL23R; interleukin-23 receptor [KO:K05065]
101791719  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
101791747  CSF3R; LOW QUALITY PROTEIN: granulocyte colony-stimulating factor receptor [KO:K05061]
101791757  RELL1; RELT-like protein 1 isoform X1 [KO:K26541]
101791761  TNFRSF18; tumor necrosis factor receptor superfamily member 18 isoform X2 [KO:K05154]
101791841  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
101791874  [KO:K05064]
101791961  TNFRSF4; tumor necrosis factor receptor superfamily member 4 isoform X1 [KO:K05142]
101792120  TNFRSF13B; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 13B [KO:K05150]
101792309  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
101792342  CXCL12; stromal cell-derived factor 1 [KO:K10031]
101792740  ACKR3; atypical chemokine receptor 3 isoform X1 [KO:K04304]
101792748  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
101792805  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
101793100  IL17RA; interleukin-17 receptor A [KO:K05164]
101793135  [KO:K05066]
101793158  IL5RA; interleukin-5 receptor subunit alpha isoform X3 [KO:K05067]
101793419  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
101793561  [KO:K05439]
101793643  PRL; prolactin precursor [KO:K05439]
101793707  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
101793792  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
101793812  [KO:K05066]
101793878  [KO:K04387]
101793887  [KO:K04738]
101793918  IL17D; interleukin-17D [KO:K05492]
101794038  IL10RA; interleukin-10 receptor subunit alpha precursor [KO:K05134]
101794055  [KO:K04386]
101794065  [KO:K04183]
101794104  BMP15; bone morphogenetic protein 15 [KO:K05498]
101794111  [KO:K05066]
101794148  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
101794194  IL2RG; cytokine receptor common subunit gamma precursor [KO:K05070]
101794213  TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
101794255  GDF2; growth/differentiation factor 2 [KO:K05503]
101794299  [KO:K04738]
101794359  [KO:K05172]
101794421  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
101794439  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
101794729  IL21; interleukin-21 isoform X2 [KO:K05434]
101794795  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
101794826  ACVR1C; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
101794837  CCL22; C-C motif chemokine 22 [KO:K21083]
101794925  IL-2; interleukin-2 precursor [KO:K05429]
101795038  CX3CL1; fractalkine [KO:K05508]
101795053  [KO:K05174]
101795199  [KO:K05494]
101795383  IL18R1; interleukin-18 receptor 1 [KO:K05173]
101795384  IL17A; interleukin-17A precursor [KO:K05489]
101795406  [KO:K22669]
101795448  INHBA; inhibin beta A chain [KO:K04667]
101795572  IL1RL1; interleukin-1 receptor-like 1 isoform X3 [KO:K05171]
101795740  [KO:K04723]
101795865  RELL2; RELT-like protein 2 [KO:K26541]
101796052  [KO:K05414]
101796108  GDF10; growth/differentiation factor 10 [KO:K22674]
101796152  CCR4; C-C chemokine receptor type 4 isoform X2 [KO:K04179]
101796331  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
101796552  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
101796697  ACVR1B; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
101796903  [KO:K21283]
101796991  IL21R; interleukin-21 receptor isoform X1 [KO:K05075]
101797018  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
101797063  CCR6; C-C chemokine receptor type 6 [KO:K04181]
101797086  IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063]
101797241  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147]
101797425  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
101797713  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
101797725  TNFRSF19; tumor necrosis factor receptor superfamily member 19 isoform X1 [KO:K05155]
101798108  [KO:K04666]
101798302  BMP3; bone morphogenetic protein 3 isoform X1 [KO:K05496]
101798321  IL6; interleukin-6 [KO:K05405]
101798574  GDF9; growth/differentiation factor 9 [KO:K22673]
101798636  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
101798696  CXCR5; C-X-C chemokine receptor type 5 isoform X1 [KO:K04190]
101798837  BMP5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
101798847  [KO:K05414]
101798887  EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X3 [KO:K05162]
101799198  ACVRL1; LOW QUALITY PROTEIN: serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
101799672  IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136]
101799854  IFNGR1; LOW QUALITY PROTEIN: interferon gamma receptor 1 [KO:K05132]
101799861  [KO:K04722]
101799928  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
101800042  IL7R; interleukin-7 receptor subunit alpha isoform X2 [KO:K05072]
101800211  IL12B; LOW QUALITY PROTEIN: interleukin-12 subunit beta [KO:K05425]
101800429  [KO:K04180]
101800439  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101800483  GHR; growth hormone receptor precursor [KO:K05080]
101800492  INHBB; inhibin beta B chain [KO:K22687]
101800620  CCL26; C-C motif chemokine 26 precursor [KO:K12499]
101800742  MSTN; growth/differentiation factor 8 [KO:K05497]
101800757  [KO:K04180]
101800762  TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153]
101800880  [KO:K05073]
101800921  [KO:K12964]
101800938  [KO:K12964]
101800940  [KO:K04183]
101800964  [KO:K10032]
101801004  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101801072  IL31RA; interleukin-31 receptor subunit alpha isoform X1 [KO:K22630]
101801160  [KO:K10032]
101801227  TNFRSF6B; tumor necrosis factor receptor superfamily member 6B isoform X2 [KO:K05143]
101801232  TNFRSF21; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 21 [KO:K05157]
101801622  [KO:K22667]
101801638  XCR1; chemokine XC receptor 1 [KO:K04193]
101801641  [KO:K04388] [EC:2.7.11.30]
101801826  IL10; interleukin-10 precursor [KO:K05443]
101801842  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
101801884  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101801910  PRLR; prolactin receptor precursor [KO:K05081]
101802068  AMH; muellerian-inhibiting factor precursor [KO:K04665]
101802072  [KO:K05479]
101802159  LIFR; leukemia inhibitory factor receptor [KO:K05058]
101802224  CSF1R; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
101802287  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
101802348  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
101802521  IL15; interleukin-15 isoform X2 [KO:K05433]
101802610  CCR9; C-C chemokine receptor type 9 [KO:K04184]
101802715  IL18; interleukin-18 [KO:K05482]
101802825  [KO:K05507]
101802909  [KO:K12964]
101803013  CCL20; C-C motif chemokine 20 [KO:K14625]
101803077  BMP4; bone morphogenetic protein 4 precursor [KO:K04662]
101803147  GDF1; embryonic growth/differentiation factor 1 [KO:K05495]
101803149  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
101803671  IL17B; interleukin-17B isoform X2 [KO:K05490]
101803771  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101803777  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
101803817  [KO:K10030]
101803850  [KO:K22688]
101804010  IL8; interleukin-8 precursor [KO:K10030]
101804100  ACKR4; atypical chemokine receptor 4 [KO:K04186]
101804315  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
101804317  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
101804501  IL10RB; interleukin-10 receptor subunit beta precursor [KO:K05135]
101804730  BMP6; bone morphogenetic protein 6 [KO:K16620]
101804736  BMP8A; bone morphogenetic protein 8A isoform X1 [KO:K16622]
101805032  IL16; pro-interleukin-16 isoform X1 [KO:K22628]
101805266  GDF5; growth/differentiation factor 5 [KO:K04664]
101805328  [KO:K04674] [EC:2.7.11.30]
106014424  CCR10; C-C chemokine receptor type 10 [KO:K04185]
106014932  [KO:K10030]
106015872  [KO:K05431]
106016176  BMP2; bone morphogenetic protein 2 [KO:K21283]
106017909  [KO:K21283]
106020640  GDF6; LOW QUALITY PROTEIN: growth/differentiation factor 6 [KO:K20012]
110351183  [KO:K12964]
110351557  GDF7; growth/differentiation factor 7 [KO:K20013]
110353607  LIF; leukemia inhibitory factor isoform X2 [KO:K05419]
113839982  INHBE; inhibin beta E chain [KO:K22689]
113840022  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
113840164  [KO:K05415]
113840166  [KO:K05415]
113843142  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151]
113843481  [KO:K10032]
113843696  CNTF; ciliary neurotrophic factor [KO:K05420]
113844223  INHA; inhibin alpha chain [KO:K05500]
113844265  MPL; LOW QUALITY PROTEIN: thrombopoietin receptor [KO:K05082]
113844283  TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469]
113844483  IL12A; interleukin-12 subunit alpha [KO:K05406]
113844894  IL34; interleukin-34 isoform X1 [KO:K22633]
113845625  [KO:K05514]
119713475  [KO:K04519]
119713491  [KO:K04722]
119713563  BMP10; bone morphogenetic protein 10 [KO:K22670]
119714197  GDF15; growth/differentiation factor 15 [KO:K05504]
119714205  EBI3; interleukin-27 subunit beta [KO:K24476]
119714483  IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
119714498  [KO:K16062]
119714619  IL23A; LOW QUALITY PROTEIN: interleukin-23 subunit alpha [KO:K05426]
119714698  GDF11; growth/differentiation factor 11 [KO:K22679]
119715367  [KO:K04183]
119715550  [KO:K05066]
119715822  [KO:K13596] [EC:2.7.11.30]
119716123  [KO:K04674] [EC:2.7.11.30]
119716198  [KO:K04183]
119717223  CLCF1; LOW QUALITY PROTEIN: cardiotrophin-like cytokine factor 1 [KO:K05421]
119717570  IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
119717719  THPO; thrombopoietin [KO:K06854]
119717811  EDA2R; tumor necrosis factor receptor superfamily member 27 isoform X1 [KO:K05163]
119717893  EDA; ectodysplasin-A isoform X1 [KO:K05480]
119718219  IL17RE; interleukin-17 receptor E isoform X1 [KO:K05168]
119718220  IL17RC; interleukin-17 receptor C [KO:K05166]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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