KEGG   PATHWAY: chx04137
Entry
chx04137                    Pathway                                
Name
Mitophagy - animal - Capra hircus (goat)
Description
Mitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process called reactive oxidative species (ROS) lead to mitochondrial dysfunction. If the damage is too excessive to be repaired, such mitochondria are selectively recognized and targeted for degradation by a specific mode of autophagy, termed mitophagy. The loss of the mitochondrial membrane potential can induce mitophagy, involving the kinase PINK1 and the E3 ligase Parkin. PINK1 serves as the sensor for the mitochondrial depolarization and recruits Parkin, followed by ubiquitin-dependent recruitment of mitophagy receptors. There are also several PINK1/Parkin-independent mitophagy pathways, in which a group of LIR-containing receptors are required in response to different stimuli. Mitophagy contributes to the maintenance of a healthy mitochondrial network and the prevention of programmed cell death.
Class
Cellular Processes; Transport and catabolism
Pathway map
chx04137  Mitophagy - animal
chx04137

Other DBs
GO: 0000422
Organism
Capra hircus (goat) [GN:chx]
Gene
100860911  SP1; transcription factor Sp1 [KO:K04684]
100860953  FKBP8; peptidyl-prolyl cis-trans isomerase FKBP8 [KO:K09574] [EC:5.2.1.8]
100861034  RABGEF1; rab5 GDP/GTP exchange factor isoform X1 [KO:K20131]
100861087  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100861088  TOMM20; mitochondrial import receptor subunit TOM20 homolog [KO:K17770]
100861133  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
100861246  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
100861340  FIS1; mitochondrial fission 1 protein [KO:K17969]
100861391  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
102168620  UBA52; ubiquitin-60S ribosomal protein L40 isoform X2 [KO:K02927]
102168869  RAB7A; ras-related protein Rab-7a [KO:K07897]
102168939  CALCOCO2; calcium-binding and coiled-coil domain-containing protein 2 [KO:K21348]
102169369  TFE3; transcription factor E3 isoform X1 [KO:K09105]
102169621  TP53; cellular tumor antigen p53 [KO:K04451]
102169842  SAMM50; sorting and assembly machinery component 50 homolog [KO:K07277]
102170381  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
102170408  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102170480  TOMM7; mitochondrial import receptor subunit TOM7 homolog [KO:K17771]
102170809  PGAM5; serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1 [KO:K15637] [EC:3.1.3.16]
102172251  SQSTM1; sequestosome-1 [KO:K14381]
102172257  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
102172458  OPTN; optineurin isoform X1 [KO:K19946]
102172519  KRAS; GTPase KRas isoform X1 [KO:K07827]
102172812  PARK2; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
102173018  E2F1; transcription factor E2F1 [KO:K17454]
102173110  RAB7B; ras-related protein Rab-7b [KO:K07898]
102173325  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
102173331  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
102173423  MITF; microphthalmia-associated transcription factor isoform X2 [KO:K09455]
102173526  MARCH5; E3 ubiquitin-protein ligase MARCH5 [KO:K10660] [EC:2.3.2.27]
102173601  NBR1; next to BRCA1 gene 1 protein isoform X1 [KO:K17987]
102174096  RELA; transcription factor p65 [KO:K04735]
102174171  TFEB; transcription factor EB [KO:K15590]
102174266  CCZ1; vacuolar fusion protein CCZ1 homolog isoform X1 [KO:K27045]
102174274  TBC1D15; TBC1 domain family member 15 isoform X1 [KO:K20168]
102174419  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
102174573  USP8; ubiquitin carboxyl-terminal hydrolase 8 [KO:K11839] [EC:3.4.19.12]
102174747  TOMM20L; TOMM20-like protein 1 [KO:K17770]
102174814  RAB5B; ras-related protein Rab-5B [KO:K07888]
102174886  ATG9A; autophagy-related protein 9A isoform X1 [KO:K17907]
102174939  ARIH1; E3 ubiquitin-protein ligase ARIH1 isoform X1 [KO:K11968] [EC:2.3.2.31]
102175136  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
102175373  BCL2L13; bcl-2-like protein 13 isoform X1 [KO:K15485]
102175424  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
102175484  CITED2; cbp/p300-interacting transactivator 2 [KO:K21361]
102175496  NLRX1; NLR family member X1 isoform X1 [KO:K12653]
102175627  MON1A; vacuolar fusion protein MON1 homolog A [KO:K20195]
102176068  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
102177556  MON1B; vacuolar fusion protein MON1 homolog B [KO:K20195]
102178036  BNIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
102178199  UBC; polyubiquitin-C [KO:K08770]
102178218  MTX2; metaxin-2 isoform X1 [KO:K17776]
102178357  VCP; transitional endoplasmic reticulum ATPase [KO:K13525]
102178515  [KO:K17986]
102178662  TOMM70; mitochondrial import receptor subunit TOM70 [KO:K17768]
102178831  MTX3; metaxin-3 isoform X1 [KO:K17776]
102179131  RHOT1; mitochondrial Rho GTPase 1 isoform X1 [KO:K07870] [EC:3.6.5.-]
102179275  FUNDC1; FUN14 domain-containing protein 1 [KO:K17986]
102180219  [KO:K04506] [EC:2.3.2.27]
102180684  BCL2L1; bcl-2-like protein 1 [KO:K04570]
102181325  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
102181474  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
102182082  CSNK2B; casein kinase II subunit beta [KO:K03115]
102182224  BNIP3L; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X1 [KO:K15465]
102182439  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
102182774  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102182890  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102183091  USP30; ubiquitin carboxyl-terminal hydrolase 30 isoform X1 [KO:K11851] [EC:3.4.19.12]
102183583  HUWE1; E3 ubiquitin-protein ligase HUWE1 isoform X1 [KO:K10592] [EC:2.3.2.26]
102183607  [KO:K04570]
102184255  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
102184366  RRAS; ras-related protein R-Ras [KO:K07829]
102184456  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
102184478  RAB5A; ras-related protein Rab-5A [KO:K07887]
102184507  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
102185034  RAB5C; ras-related protein Rab-5C [KO:K07889]
102185072  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102185118  OPA1; dynamin-like 120 kDa protein, mitochondrial isoform X1 [KO:K17079] [EC:3.6.5.5]
102185423  JUN; transcription factor AP-1 [KO:K04448]
102185575  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
102185629  ATG9B; autophagy-related protein 9B [KO:K17907]
102185857  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
102185873  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
102186621  AMFR; E3 ubiquitin-protein ligase AMFR [KO:K10636] [EC:2.3.2.36]
102186625  TBC1D17; TBC1 domain family member 17 [KO:K19945]
102186668  HRAS; GTPase HRas isoform X1 [KO:K02833]
102187033  PHB2; prohibitin-2 [KO:K17081]
102187139  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
102187180  NRAS; GTPase NRas [KO:K07828]
102187800  UBB; polyubiquitin-B [KO:K04551]
102187882  BECN2; beclin-2 [KO:K08334]
102188101  RHOT2; mitochondrial Rho GTPase 2 isoform X1 [KO:K07871] [EC:3.6.5.-]
102188676  FOXO3; forkhead box protein O3 [KO:K09408]
102189360  MTX1; metaxin-1 [KO:K17776]
102189919  TOMM40L; mitochondrial import receptor subunit TOM40B [KO:K11518]
102190384  USP15; ubiquitin carboxyl-terminal hydrolase 15 isoform X1 [KO:K21343] [EC:3.4.19.12]
102190712  RRAS2; ras-related protein R-Ras2 [KO:K07830]
102190728  BECN1; beclin-1 [KO:K08334]
102190832  PINK1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
102191203  TAX1BP1; tax1-binding protein 1 isoform X1 [KO:K21347]
102191284  MUL1; mitochondrial ubiquitin ligase activator of NFKB 1 [KO:K15688] [EC:2.3.2.27]
102191461  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
106502794  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
108634445  [KO:K04506] [EC:2.3.2.27]
108634455  [KO:K04506] [EC:2.3.2.27]
Compound
C00035  GDP
C00044  GTP
Reference
PMID:25611507
  Authors
Pickrell AM, Youle RJ
  Title
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
  Journal
Neuron 85:257-73 (2015)
DOI:10.1016/j.neuron.2014.12.007
Reference
PMID:25995186
  Authors
Durcan TM, Fon EA
  Title
The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications.
  Journal
Genes Dev 29:989-99 (2015)
DOI:10.1101/gad.262758.115
Reference
PMID:25999423
  Authors
Shirihai OS, Song M, Dorn GW 2nd
  Title
How mitochondrial dynamism orchestrates mitophagy.
  Journal
Circ Res 116:1835-49 (2015)
DOI:10.1161/CIRCRESAHA.116.306374
Reference
PMID:26611876
  Authors
Hamacher-Brady A, Brady NR
  Title
Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy.
  Journal
Cell Mol Life Sci 73:775-95 (2016)
DOI:10.1007/s00018-015-2087-8
Reference
PMID:26882551
  Authors
Yamano K, Matsuda N, Tanaka K
  Title
The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation.
  Journal
EMBO Rep 17:300-16 (2016)
DOI:10.15252/embr.201541486
Reference
PMID:27021519
  Authors
Yamaguchi O, Murakawa T, Nishida K, Otsu K
  Title
Receptor-mediated mitophagy.
  Journal
J Mol Cell Cardiol 95:50-6 (2016)
DOI:10.1016/j.yjmcc.2016.03.010
Reference
PMID:27443527
  Authors
Roberts RF, Tang MY, Fon EA, Durcan TM
  Title
Defending the mitochondria: The pathways of mitophagy and mitochondrial-derived vesicles.
  Journal
Int J Biochem Cell Biol 79:427-436 (2016)
DOI:10.1016/j.biocel.2016.07.020
Reference
PMID:27701735
  Authors
Arena G, Valente EM
  Title
PINK1 in the limelight: multiple functions of an eclectic protein in human health and disease.
  Journal
J Pathol 241:251-263 (2017)
DOI:10.1002/path.4815
Related
pathway
chx04140  Autophagy - animal
chx04210  Apoptosis
KO pathway
ko04137   

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