KEGG   PATHWAY: cpla04115
Entry
cpla04115                   Pathway                                
Name
p53 signaling pathway - Chiloscyllium plagiosum (whitespotted bambooshark)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
cpla04115  p53 signaling pathway
cpla04115

Organism
Chiloscyllium plagiosum (whitespotted bambooshark) [GN:cpla]
Gene
122539263  rchy1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
122539902  [KO:K02091] [EC:2.7.11.22]
122540283  casp9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
122540383  tp73; tumor protein p73 isoform X1 [KO:K10148]
122540733  ei24; etoposide-induced protein 2.4 homolog [KO:K10134]
122540735  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
122541009  ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
122541317  [KO:K10808] [EC:1.17.4.1]
122541867  [KO:K22745]
122541868  [KO:K22745]
122541966  [KO:K04503]
122542066  [KO:K02159]
122542379  [KO:K06509]
122542791  ppp1r13l; relA-associated inhibitor isoform X1 [KO:K27356]
122543267  [KO:K10128]
122543277  cdk4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
122543338  cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
122543388  tp53; cellular tumor antigen p53 [KO:K04451]
122544328  serpine1; plasminogen activator inhibitor 1 [KO:K03982]
122546714  [KO:K06625]
122547448  [KO:K10134]
122548437  sesn1; sestrin-1 isoform X1 [KO:K10141]
122548899  adgrb1a; adhesion G protein-coupled receptor B1 isoform X1 [KO:K04596]
122548983  ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
122549711  [KO:K08738]
122549716  [KO:K02161]
122549749  cdk6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
122549911  igfbp3; insulin-like growth factor-binding protein 3 [KO:K10138]
122550707  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
122551046  [KO:K10141]
122551295  [KO:K02206] [EC:2.7.11.22]
122551604  rprma; protein reprimo A [KO:K10128]
122551682  steap3; metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
122552009  [KO:K08738]
122552559  ccng2; cyclin-G2 [KO:K10146]
122552605  [KO:K10136]
122553720  thbs1b; thrombospondin-1 [KO:K16857]
122553929  siva1; apoptosis regulatory protein Siva [KO:K22744]
122554084  cop1; E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
122554442  gorab; RAB6-interacting golgin isoform X1 [KO:K19748]
122554776  [KO:K04402]
122555937  zmat3; zinc finger matrin-type protein 3 isoform X1 [KO:K10137]
122556218  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
122556551  ccng1; cyclin-G1 [KO:K10145]
122557370  [KO:K10141]
122557611  zgc:153993; apoptosis regulator BAX [KO:K02159]
122557612  ccnd1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
122557933  pidd1; p53-induced death domain-containing protein 1 isoform X1 [KO:K10130]
122558191  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
122558371  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
122558399  siah1; E3 ubiquitin-protein ligase Siah1 [KO:K04506] [EC:2.3.2.27]
122558947  [KO:K10135]
122559328  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
122559407  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
122559641  [KO:K04726]
122559649  [KO:K06625]
122559982  [KO:K04570]
122560514  tsc2; tuberin isoform X1 [KO:K07207]
122561030  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
122561054  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
122561061  [KO:K04390]
122561458  gtse1; G2 and S phase-expressed protein 1 [KO:K10129]
122561666  apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
122561684  ccnd2a; G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
122561793  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
122562547  chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
122563112  ccnd3; G1/S-specific cyclin-D3 [KO:K10151]
122563115  mdm4; protein Mdm4 [KO:K10127]
122563481  [KO:K20394]
122563659  rrm2; ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
122563887  [KO:K10147] [EC:3.1.3.16]
122565379  [KO:K05868]
122565427  [KO:K04402]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
cpla04110  Cell cycle
cpla04210  Apoptosis
cpla04218  Cellular senescence
KO pathway
ko04115   

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