KEGG   PATHWAY: daq00270
Entry
daq00270                    Pathway                                
Name
Cysteine and methionine metabolism - Dickeya aquatica
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
daq00270  Cysteine and methionine metabolism
daq00270

Module
daq_M00017  Methionine biosynthesis, aspartate => homoserine => methionine [PATH:daq00270]
daq_M00021  Cysteine biosynthesis, serine => cysteine [PATH:daq00270]
daq_M00034  Methionine salvage pathway [PATH:daq00270]
daq_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:daq00270]
Other DBs
GO: 0006534 0006555
Organism
Dickeya aquatica [GN:daq]
Gene
DAQ1742_02337  Serine acetyltransferase [KO:K00640] [EC:2.3.1.30]
DAQ1742_00241  cysE; Serine acetyltransferase [KO:K00640] [EC:2.3.1.30]
DAQ1742_03153  Cysteine synthase B [KO:K01738] [EC:2.5.1.47]
DAQ1742_00869  cysK; Cysteine synthase [KO:K01738] [EC:2.5.1.47]
DAQ1742_02410  Cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
DAQ1742_00435  metC; Cystathionine beta-lyase [KO:K01760] [EC:4.4.1.13]
DAQ1742_02409  Cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
DAQ1742_04000  metH; 5-methyltetrahydrofolate--homocysteine methyltransferase [KO:K00548] [EC:2.1.1.13]
DAQ1742_02516  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]
DAQ1742_03266  Methionine synthase II (cobalamin-independent) [KO:K00549] [EC:2.1.1.14]
DAQ1742_00243  metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]
DAQ1742_03929  metK; S-adenosylmethionine synthetase [KO:K00789] [EC:2.5.1.6]
DAQ1742_00992  speD; S-adenosylmethionine decarboxylase proenzyme, prokaryotic class 1A [KO:K01611] [EC:4.1.1.50]
DAQ1742_00993  speE; Spermidine synthase [KO:K00797] [EC:2.5.1.16]
DAQ1742_04313  Homoserine lactone synthase YpeI [KO:K22956] [EC:2.3.1.184]
DAQ1742_01021  pfs; 5'-methylthioadenosine nucleosidase / S-adenosylhomocysteine nucleosidase [KO:K01243] [EC:3.2.2.9]
DAQ1742_03465  mtnK; 5-methylthioribose kinase [KO:K00899] [EC:2.7.1.100]
DAQ1742_00976  yfiH; COG1496: Uncharacterized conserved protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
DAQ1742_03466  mtnA; Methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
DAQ1742_03469  mtnB; Methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]
DAQ1742_03468  mtnC; 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatase [KO:K09880] [EC:3.1.3.77]
DAQ1742_03467  mtnD; 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]
DAQ1742_00569  mtnD; 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]
DAQ1742_00825  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]
DAQ1742_03661  tyrB; Biosynthetic Aromatic amino acid aminotransferase alpha [KO:K00832] [EC:2.6.1.57]
DAQ1742_02534  yebR; Free methionine-(R)-sulfoxide reductase, contains GAF domain [KO:K08968] [EC:1.8.4.14]
DAQ1742_01909  macromolecule metabolism; macromolecule synthesis, modification; dna-replication, repair, restr./modif. [KO:K00558] [EC:2.1.1.37]
DAQ1742_02641  Modification methylase [KO:K00558] [EC:2.1.1.37]
DAQ1742_00960  luxS; S-ribosylhomocysteine lyase / Autoinducer-2 production protein LuxS [KO:K07173] [EC:4.4.1.21]
DAQ1742_03993  lysC; Aspartokinase [KO:K00928] [EC:2.7.2.4]
DAQ1742_03898  thrA; Aspartokinase / Homoserine dehydrogenase [KO:K12524] [EC:2.7.2.4 1.1.1.3]
DAQ1742_04289  metL; Aspartokinase / Homoserine dehydrogenase [KO:K12525] [EC:2.7.2.4 1.1.1.3]
DAQ1742_04169  asd; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
DAQ1742_04006  metA; Homoserine O-succinyltransferase [KO:K00651] [EC:2.3.1.46 2.3.1.31]
DAQ1742_04290  metB; Cystathionine gamma-synthase [KO:K01739] [EC:2.5.1.48]
DAQ1742_01036  O-acetylhomoserine sulfhydrylase / O-succinylhomoserine sulfhydrylase [KO:K01740] [EC:2.5.1.49]
DAQ1742_02416  Branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
DAQ1742_04265  ilvE; Branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
DAQ1742_00959  gshA; Glutamate--cysteine ligase [KO:K01919] [EC:6.3.2.2]
DAQ1742_03934  gshB; Glutathione synthetase [KO:K01920] [EC:6.3.2.3]
DAQ1742_02792  aspC; Aspartate aminotransferase [KO:K00813] [EC:2.6.1.1]
DAQ1742_01101  sseA; 3-mercaptopyruvate:cyanide sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]
DAQ1742_00676  mdh; Malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
DAQ1742_02447  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
DAQ1742_01160  sdaB; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
DAQ1742_03425  L-serine dehydratase, (PLP)-dependent @ Threonine dehydratase biosynthetic [KO:K17989] [EC:4.3.1.17 4.3.1.19]
DAQ1742_02336  Cysteine synthase [KO:K12339] [EC:2.5.1.144]
DAQ1742_00860  cysM; Cysteine synthase [KO:K12339] [EC:2.5.1.144]
DAQ1742_03913  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
DAQ1742_03345  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
DAQ1742_02081  serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
daq00010  Glycolysis / Gluconeogenesis
daq00250  Alanine, aspartate and glutamate metabolism
daq00260  Glycine, serine and threonine metabolism
daq00290  Valine, leucine and isoleucine biosynthesis
daq00430  Taurine and hypotaurine metabolism
daq00480  Glutathione metabolism
daq00620  Pyruvate metabolism
daq00640  Propanoate metabolism
daq00770  Pantothenate and CoA biosynthesis
daq00900  Terpenoid backbone biosynthesis
daq00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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