Entry Name Fc epsilon RI signaling pathway - Dasypus novemcinctus (nine-banded armadillo)
Description Fc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways are regulated both positively and negatively by the interactions of numerous signaling molecules. Mast cells that are thus activated release preformed granules which contain biogenic amines (especially histamines) and proteoglycans (especially heparin). The activation of phospholipase A2 causes the release of membrane lipids followed by development of lipid mediators such as leukotrienes (LTC4, LTD4 and LTE4) and prostaglandins (especially PDG2). There is also secretion of cytokines, the most important of which are TNF-alpha, IL-4 and IL-5. These mediators and cytokines contribute to inflammatory responses.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map dnm04664 Fc epsilon RI signaling pathway
Ortholog table Other DBs Organism Dasypus novemcinctus (nine-banded armadillo) [GN:
dnm ]
Gene 101423469 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856 ]
101432225 FCER1A; high affinity immunoglobulin epsilon receptor subunit alpha isoform X1 [KO:K08089 ]
101417880 high affinity immunoglobulin epsilon receptor subunit beta isoform X1 [KO:K08090 ]
111760411 high affinity immunoglobulin epsilon receptor subunit beta-like [KO:K08090 ]
105744140 FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983 ]
101428386 PLCG2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859 ] [EC:3.1.4.11 ]
101444276 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
101443761 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
101426945 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
101423744 phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
101435351 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
101433347 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
101421086 RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392 ]
101424799 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
101446965 VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730 ]
101417876 LAT; linker for activation of T-cells family member 1 [KO:K07362 ]
101422144 ALOX5AP; arachidonate 5-lipoxygenase-activating protein [KO:K20735 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Kawakami T, Galli SJ.
Title Regulation of mast-cell and basophil function and survival by IgE.
Journal Reference Authors Siraganian RP.
Title Mast cell signal transduction from the high-affinity IgE receptor.
Journal Reference Authors Janeway CA, Travers P, Walport M, Shlomchik MJ.
Title Immunobiology 6th edition
Journal Garland Science Publishing (2005)
Reference Authors Turner H, Kinet JP.
Title Signalling through the high-affinity IgE receptor Fc epsilonRI.
Journal Reference Authors Gilfillan AM, Tkaczyk C.
Title Integrated signalling pathways for mast-cell activation.
Journal Reference Authors Nadler MJ, Matthews SA, Turner H, Kinet JP.
Title Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: coupling form to function.
Journal Reference Authors Gu H, Saito K, Klaman LD, Shen J, Fleming T, Wang Y, Pratt JC, Lin G, Lim B, Kinet JP, Neel BG.
Title Essential role for Gab2 in the allergic response.
Journal Reference Authors Nadler MJ, Kinet JP.
Title Uncovering new complexities in mast cell signaling.
Journal Related dnm04070 Phosphatidylinositol signaling system
KO pathway LinkDB All DBs
