Entry Name Folate transport and metabolism - Homo sapiens (human)
Class Organismal Systems; Digestive systemBRITE hierarchy
Pathway map hsa04981 Folate transport and metabolism
Drug D03372 Capromab pendetide (USAN)
D04525 Indium In 111 capromab pendetide (USP)
D10070 Iofolastat I 123 (USAN)
D12132 Piflufolastat F-18 (USAN)
D12257 Gallium Ga 68 gozetotide (USAN)
D12335 Lutetium Lu 177 vipivotide tetraxetan (USAN)
D12606 Flotufolastat F18 gallium (USAN)
D13129 Abefolastat tesaroxetan (USAN/INN)
Organism Homo sapiens (human) [GN:
hsa ]
Gene 10057 ABCC5; ATP binding cassette subfamily C member 5 [KO:K05668 ]
10257 ABCC4; ATP binding cassette subfamily C member 4 (PEL blood group) [KO:K05673 ]
10599 SLCO1B1; solute carrier organic anion transporter family member 1B1 [KO:K05043 ]
11309 SLCO2B1; solute carrier organic anion transporter family member 2B1 [KO:K14352 ]
113235 SLC46A1; solute carrier family 46 member 1 [KO:K14613 ]
1244 ABCC2; ATP binding cassette subfamily C member 2 [KO:K05666 ]
28234 SLCO1B3; solute carrier organic anion transporter family member 1B3 [KO:K05043 ]
4363 ABCC1; ATP binding cassette subfamily C member 1 (ABCC1 blood group) [KO:K05665 ] [EC:7.6.2.3 ]
4524 MTHFR; methylenetetrahydrofolate reductase [KO:K25004 ]
4548 MTR; 5-methyltetrahydrofolate-homocysteine methyltransferase [KO:K00548 ] [EC:2.1.1.13 ]
6573 SLC19A1; solute carrier family 19 member 1 [KO:K14609 ]
8714 ABCC3; ATP binding cassette subfamily C member 3 [KO:K05667 ]
9356 SLC22A6; solute carrier family 22 member 6 [KO:K08203 ]
9376 SLC22A8; solute carrier family 22 member 8 [KO:K08205 ]
9429 ABCG2; ATP binding cassette subfamily G member 2 (JR blood group) [KO:K05681 ]
Compound C00019 S-Adenosyl-L-methionine
C00021 S-Adenosyl-L-homocysteine
C00143 5,10-Methylenetetrahydrofolate
C00440 5-Methyltetrahydrofolate
C00445 5,10-Methenyltetrahydrofolate
Reference Authors Alam C, Kondo M, O'Connor DL, Bendayan R
Title Clinical Implications of Folate Transport in the Central Nervous System.
Journal Reference Authors Akiyama T, Kuki I, Kim K, Yamamoto N, Yamada Y, Igarashi K, Ishihara T, Hatano Y, Kobayashi K
Title Folic acid inhibits 5-methyltetrahydrofolate transport across the blood-cerebrospinal fluid barrier: Clinical biochemical data from two cases.
Journal Reference Authors Visentin M, Diop-Bove N, Zhao R, Goldman ID
Title The intestinal absorption of folates.
Journal Reference Authors Ledowsky C, Mahimbo A, Scarf V, Steel A
Title Women Taking a Folic Acid Supplement in Countries with Mandatory Food Fortification Programs May Be Exceeding the Upper Tolerable Limit of Folic Acid: A Systematic Review.
Journal Reference Authors Zarou MM, Vazquez A, Vignir Helgason G
Title Folate metabolism: a re-emerging therapeutic target in haematological cancers.
Journal Reference Authors Bekdash RA
Title Methyl Donors, Epigenetic Alterations, and Brain Health: Understanding the Connection.
Journal Reference Authors Steinfeld R, Grapp M, Kraetzner R, Dreha-Kulaczewski S, Helms G, Dechent P, Wevers R, Grosso S, Gartner J
Title Folate receptor alpha defect causes cerebral folate transport deficiency: a treatable neurodegenerative disorder associated with disturbed myelin metabolism.
Journal Reference Authors Sternbach S, West N, Singhal NK, Clements R, Basu S, Tripathi A, Dutta R, Freeman EJ, McDonough J
Title The BHMT-betaine methylation pathway epigenetically modulates oligodendrocyte maturation.
Journal Reference Authors Shulpekova Y, Nechaev V, Kardasheva S, Sedova A, Kurbatova A, Bueverova E, Kopylov A, Malsagova K, Dlamini JC, Ivashkin V
Title The Concept of Folic Acid in Health and Disease.
Journal Reference Authors Mafi S, Laroche-Raynaud C, Chazelas P, Lia AS, Derouault P, Sturtz F, Baaj Y, Froget R, Rio M, Benoist JF, Poumeaud F, Favreau F, Faye PA
Title Pharmacoresistant Epilepsy in Childhood: Think of the Cerebral Folate Deficiency, a Treatable Disease.
Journal Related KO pathway
