| Entry |  | 
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| Symbol | APP, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, alpha-sAPP, preA4
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| Name | (RefSeq) amyloid beta precursor protein
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| KO | | K04520 | amyloid beta A4 protein | 
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| Organism |  | 
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| Pathway | | hsa05022 | Pathways of neurodegeneration - multiple diseases | 
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| Network |  | 
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| Element | | N00996 | Mutation-caused aberrant Abeta to AGE-RAGE signaling pathway | 
 | N00997 | Mutation-caused aberrant Abeta to electron transfer in Complex I | 
 | N00999 | Mutation-caused aberrant Abeta to electron transfer in Complex IV | 
 | N01001 | Mutation-caused aberrant Abeta to mAchR-Ca2+ -apoptotic pathway | 
 | N01002 | Mutation-caused aberrant Abeta to mGluR5-Ca2+ -apoptotic pathway | 
 | N01003 | Mutation-caused aberrant Abeta to transport of calcium | 
 | N01004 | Mutation-caused aberrant Abeta to VGCC-Ca2+ -apoptotic pathway | 
 | N01005 | Mutation-caused aberrant Abeta to crosstalk between extrinsic and intrinsic apoptotic pathways | 
 | N01006 | Mutation-caused aberrant Abeta to VGCC-Ca2+ -apoptotic pathway | 
 | N01014 | Mutation-caused aberrant Abeta to IRE1a-JNK signaling pathway | 
 | N01018 | Mutation-caused aberrant Abeta to anterograde axonal transport | 
 | N01060 | Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation | 
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| Disease | | H01185 | Cerebral amyloid angiopathy | 
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| Drug target |  | 
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| Brite | KEGG Orthology (KO) [BR:hsa00001]09130 Environmental Information Processing
 09133 Signaling molecules and interaction
 04517 IgSF CAM signaling
 351 (APP)
 09150 Organismal Systems
 09156 Nervous system
 04726 Serotonergic synapse
 351 (APP)
 09160 Human Diseases
 09164 Neurodegenerative disease
 05010 Alzheimer disease
 351 (APP)
 05022 Pathways of neurodegeneration - multiple diseases
 351 (APP)
 09180 Brite Hierarchies
 09181 Protein families: metabolism
 01002 Peptidases and inhibitors [BR:hsa01002]
 351 (APP)
 09183 Protein families: signaling and cellular processes
 00535 Proteoglycans [BR:hsa00535]
 351 (APP)
 00536 Glycosaminoglycan binding proteins [BR:hsa00536]
 351 (APP)
 Peptidases and inhibitors [BR:hsa01002]
 Peptidase inhibitors
 Family I2: Kunitz - BPTI family
 351 (APP)
 Proteoglycans [BR:hsa00535]
 Cell surface proteoglycans
 Others
 351 (APP)
 Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
 Others
 351 (APP)
 
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| SSDB |  | 
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| Motif |  | 
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| Other DBs |  | 
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| Structure |  | 
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| LinkDB |  | 
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| Position | 21:complement(25880550..26171128)
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| AA seq | 770 aa MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
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| NT seq | 2313 nt   +upstreamnt  +downstreamntatgctgcccggtttggcactgctcctgctggccgcctggacggctcgggcgctggaggta
 cccactgatggtaatgctggcctgctggctgaaccccagattgccatgttctgtggcaga
 ctgaacatgcacatgaatgtccagaatgggaagtgggattcagatccatcagggaccaaa
 acctgcattgataccaaggaaggcatcctgcagtattgccaagaagtctaccctgaactg
 cagatcaccaatgtggtagaagccaaccaaccagtgaccatccagaactggtgcaagcgg
 ggccgcaagcagtgcaagacccatccccactttgtgattccctaccgctgcttagttggt
 gagtttgtaagtgatgcccttctcgttcctgacaagtgcaaattcttacaccaggagagg
 atggatgtttgcgaaactcatcttcactggcacaccgtcgccaaagagacatgcagtgag
 aagagtaccaacttgcatgactacggcatgttgctgccctgcggaattgacaagttccga
 ggggtagagtttgtgtgttgcccactggctgaagaaagtgacaatgtggattctgctgat
 gcggaggaggatgactcggatgtctggtggggcggagcagacacagactatgcagatggg
 agtgaagacaaagtagtagaagtagcagaggaggaagaagtggctgaggtggaagaagaa
 gaagccgatgatgacgaggacgatgaggatggtgatgaggtagaggaagaggctgaggaa
 ccctacgaagaagccacagagagaaccaccagcattgccaccaccaccaccaccaccaca
 gagtctgtggaagaggtggttcgagaggtgtgctctgaacaagccgagacggggccgtgc
 cgagcaatgatctcccgctggtactttgatgtgactgaagggaagtgtgccccattcttt
 tacggcggatgtggcggcaaccggaacaactttgacacagaagagtactgcatggccgtg
 tgtggcagcgccatgtcccaaagtttactcaagactacccaggaacctcttgcccgagat
 cctgttaaacttcctacaacagcagccagtacccctgatgccgttgacaagtatctcgag
 acacctggggatgagaatgaacatgcccatttccagaaagccaaagagaggcttgaggcc
 aagcaccgagagagaatgtcccaggtcatgagagaatgggaagaggcagaacgtcaagca
 aagaacttgcctaaagctgataagaaggcagttatccagcatttccaggagaaagtggaa
 tctttggaacaggaagcagccaacgagagacagcagctggtggagacacacatggccaga
 gtggaagccatgctcaatgaccgccgccgcctggccctggagaactacatcaccgctctg
 caggctgttcctcctcggcctcgtcacgtgttcaatatgctaaagaagtatgtccgcgca
 gaacagaaggacagacagcacaccctaaagcatttcgagcatgtgcgcatggtggatccc
 aagaaagccgctcagatccggtcccaggttatgacacacctccgtgtgatttatgagcgc
 atgaatcagtctctctccctgctctacaacgtgcctgcagtggccgaggagattcaggat
 gaagttgatgagctgcttcagaaagagcaaaactattcagatgacgtcttggccaacatg
 attagtgaaccaaggatcagttacggaaacgatgctctcatgccatctttgaccgaaacg
 aaaaccaccgtggagctccttcccgtgaatggagagttcagcctggacgatctccagccg
 tggcattcttttggggctgactctgtgccagccaacacagaaaacgaagttgagcctgtt
 gatgcccgccctgctgccgaccgaggactgaccactcgaccaggttctgggttgacaaat
 atcaagacggaggagatctctgaagtgaagatggatgcagaattccgacatgactcagga
 tatgaagttcatcatcaaaaattggtgttctttgcagaagatgtgggttcaaacaaaggt
 gcaatcattggactcatggtgggcggtgttgtcatagcgacagtgatcgtcatcaccttg
 gtgatgctgaagaagaaacagtacacatccattcatcatggtgtggtggaggttgacgcc
 gctgtcaccccagaggagcgccacctgtccaagatgcagcagaacggctacgaaaatcca
 acctacaagttctttgagcagatgcagaactag
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