KEGG   PATHWAY: iti04720
Entry
iti04720                    Pathway                                
Name
Long-term potentiation - Ictidomys tridecemlineatus (thirteen-lined ground squirrel)
Description
Hippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippocampus induces glutamate release and activation of glutamate receptors in dendritic spines. A large increase in [Ca2+]i resulting from influx through NMDA receptors leads to constitutive activation of CaM kinase II (CaM KII) . Constitutively active CaM kinase II phosphorylates AMPA receptors, resulting in potentiation of the ionic conductance of AMPA receptors. Early-phase LTP (E-LTP) expression is due, in part, to this phosphorylation of the AMPA receptor. It is hypothesized that postsynaptic Ca2+ increases generated through NMDA receptors activate several signal transduction pathways including the Erk/MAP kinase and cAMP regulatory pathways. The convergence of these pathways at the level of the CREB/CRE transcriptional pathway may increase expression of a family of genes required for late-phase LTP (L-LTP).
Class
Organismal Systems; Nervous system
Pathway map
iti04720  Long-term potentiation
iti04720

Other DBs
GO: 0048169
Organism
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) [GN:iti]
Gene
101954421  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101954767  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101954934  Grin2b; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
101954994  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
101955221  Grm1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
101956174  Camk4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
101956506  Rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
101956838  Ep300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
101957333  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101957668  [KO:K04498] [EC:2.3.1.48]
101958119  [KO:K04374]
101958232  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
101958290  Gria1; glutamate receptor 1 isoform X1 [KO:K05197]
101958827  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
101959985  Hras; GTPase HRas isoform X2 [KO:K02833]
101960354  Ppp3r1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
101960408  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
101960571  Araf; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
101961077  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101961381  Rap1a; ras-related protein Rap-1A isoform X1 [KO:K04353]
101961510  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
101961798  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101962074  [KO:K07836]
101962301  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
101962775  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X9 [KO:K04958]
101963269  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101963322  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101963481  Grm5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
101964114  Kras; GTPase KRas isoform X1 [KO:K07827]
101964638  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101964920  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101966333  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
101967074  Calm1; calmodulin-1 [KO:K02183]
101967689  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101968140  Rps6ka6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
101968534  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X6 [KO:K04515] [EC:2.7.11.17]
101968911  Ppp1r1a; protein phosphatase 1 regulatory subunit 1A isoform X1 [KO:K08050]
101969273  Rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X3 [KO:K04373] [EC:2.7.11.1]
101969595  Rap1b; ras-related protein Rap-1b [KO:K07836]
101970348  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X8 [KO:K04348] [EC:3.1.3.16]
101970466  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101970679  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101971140  Grin2c; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
101971244  Braf; serine/threonine-protein kinase B-raf isoform X5 [KO:K04365] [EC:2.7.11.1]
101971364  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101971998  [KO:K04634]
101972436  Calml6; calmodulin-like protein 6 [KO:K02183]
101972472  Calm2; calmodulin-2 [KO:K02183]
101973345  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101973561  Rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
101973720  [KO:K08014]
101974296  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X9 [KO:K04515] [EC:2.7.11.17]
101974405  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101974776  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101975217  [KO:K02183]
101975260  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
101975335  Gria2; glutamate receptor 2 isoform X2 [KO:K05198]
101975512  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101975537  Grin2d; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
101975553  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X2 [KO:K04960]
101975906  Nras; GTPase NRas [KO:K07828]
101976082  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101976382  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X4 [KO:K05208]
101976449  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
101976513  [KO:K02183]
101976794  Calml5; calmodulin-like protein 5 [KO:K02183]
101977831  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
101978138  Calm3; calmodulin-3 isoform X2 [KO:K02183]
101978560  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00305  Magnesium cation
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
Reference
PMID:15652868
  Authors
Blitzer RD, Iyengar R, Landau EM.
  Title
Postsynaptic signaling networks: cellular cogwheels underlying long-term plasticity.
  Journal
Biol Psychiatry 57:113-9 (2005)
DOI:10.1016/j.biopsych.2004.02.031
Reference
PMID:10652548
  Authors
Soderling TR, Derkach VA.
  Title
Postsynaptic protein phosphorylation and LTP.
  Journal
Trends Neurosci 23:75-80 (2000)
DOI:10.1016/S0166-2236(99)01490-3
Reference
PMID:11378299
  Authors
Poser S, Storm DR.
  Title
Role of Ca2+-stimulated adenylyl cyclases in LTP and memory formation.
  Journal
Int J Dev Neurosci 19:387-94 (2001)
DOI:10.1016/S0736-5748(00)00094-0
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
  Authors
Purves D, Augustine GJ (ed).
  Title
Neuroscience
  Journal
Sunderland, Mass.:Sinauer Associates (2004)
Reference
PMID:14715912
  Authors
Lynch MA.
  Title
Long-term potentiation and memory.
  Journal
Physiol Rev 84:87-136 (2004)
DOI:10.1152/physrev.00014.2003
Reference
PMID:15857686
  Authors
Kelly PT, Mackinnon RL 2nd, Dietz RV, Maher BJ, Wang J.
  Title
Postsynaptic IP3 receptor-mediated Ca2+ release modulates synaptic transmission in hippocampal neurons.
  Journal
Brain Res Mol Brain Res 135:232-48 (2005)
DOI:10.1016/j.molbrainres.2004.12.018
Reference
PMID:9697848
  Authors
Berridge MJ.
  Title
Neuronal calcium signaling.
  Journal
Neuron 21:13-26 (1998)
DOI:10.1016/S0896-6273(00)80510-3
Related
pathway
iti04010  MAPK signaling pathway
iti04020  Calcium signaling pathway
iti04724  Glutamatergic synapse
KO pathway
ko04720   

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