KEGG   PATHWAY: iti04010
Entry
iti04010                    Pathway                                
Name
MAPK signaling pathway - Ictidomys tridecemlineatus (thirteen-lined ground squirrel)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
iti04010  MAPK signaling pathway
iti04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) [GN:iti]
Gene
101954284  Rasgrp1; RAS guanyl-releasing protein 1 isoform X2 [KO:K04350]
101954385  [KO:K04453]
101954451  Bdnf; brain-derived neurotrophic factor isoform X2 [KO:K04355]
101954471  Map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
101954530  Ppm1b; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
101954660  Rapgef2; rap guanine nucleotide exchange factor 2 isoform X4 [KO:K08018]
101954667  Fgf18; fibroblast growth factor 18 [KO:K04358]
101954676  Rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
101954678  Map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
101954707  Rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
101954731  Jun; transcription factor AP-1 [KO:K04448]
101954808  Hspa6; heat shock 70 kDa protein 6 [KO:K03283]
101954915  Mapkapk3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
101954956  Mknk1; LOW QUALITY PROTEIN: MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
101954974  Map4k1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X5 [KO:K04408] [EC:2.7.11.1]
101954994  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
101955098  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
101955124  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101955264  Ikbkg; NF-kappa-B essential modulator isoform X5 [KO:K07210]
101955287  Cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
101955316  Rela; transcription factor p65 [KO:K04735]
101955383  Stk4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
101955384  Vegfc; vascular endothelial growth factor C [KO:K05449]
101955436  Pla2g4b; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
101955522  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101955681  Crk; adapter molecule crk isoform X1 [KO:K04438]
101955806  Fgf8; fibroblast growth factor 8 isoform X3 [KO:K04358]
101955809  [KO:K05096] [EC:2.7.10.1]
101955831  [KO:K03283]
101955966  Map3k20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
101956072  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101956126  [KO:K03283]
101956155  Arrb1; beta-arrestin-1 isoform X3 [KO:K04439]
101956179  Cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
101956286  Nrtn; neurturin [KO:K25414]
101956312  Pla2g4d; cytosolic phospholipase A2 delta isoform X2 [KO:K16342] [EC:3.1.1.4]
101956398  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101956412  [KO:K03283]
101956463  Cacng5; voltage-dependent calcium channel gamma-5 subunit isoform X2 [KO:K04870]
101956506  Rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
101956666  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101956689  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
101956801  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X3 [KO:K04855]
101956880  Map3k8; mitogen-activated protein kinase kinase kinase 8 isoform X2 [KO:K04415] [EC:2.7.11.25]
101956898  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X14 [KO:K04851]
101956917  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101956961  Elk4; ETS domain-containing protein Elk-4 [KO:K04376]
101956975  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
101957086  Myc; myc proto-oncogene protein [KO:K04377]
101957205  Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
101957209  Kit; mast/stem cell growth factor receptor Kit isoform X4 [KO:K05091] [EC:2.7.10.1]
101957266  Rps6ka4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
101957333  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101957398  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101957564  Angpt1; angiopoietin-1 isoform X1 [KO:K05465]
101957687  Fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
101957738  Tp53; cellular tumor antigen p53 [KO:K04451]
101957826  Nlk; serine/threonine-protein kinase NLK isoform X2 [KO:K04468] [EC:2.7.11.24]
101957833  Fgf20; fibroblast growth factor 20 [KO:K04358]
101957872  Kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
101957948  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
101958010  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
101958119  [KO:K04374]
101958121  Mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
101958428  Traf2; TNF receptor-associated factor 2 isoform X6 [KO:K03173] [EC:2.3.2.27]
101958450  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
101958528  Map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X29 [KO:K04407] [EC:2.7.11.1]
101958548  Map3k21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
101958691  Dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101958796  Rasgrp2; RAS guanyl-releasing protein 2 [KO:K12361]
101958853  [KO:K04358]
101958891  Taok3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
101958947  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101958948  Map3k12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
101959100  Cdc42; cell division control protein 42 homolog isoform X2 [KO:K04393]
101959193  Artn; artemin [KO:K25415]
101959311  Map3k9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
101959359  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
101959407  Fos; proto-oncogene c-Fos [KO:K04379]
101959440  Pspn; persephin [KO:K25416]
101959621  Gdnf; glial cell line-derived neurotrophic factor isoform X2 [KO:K05452]
101959710  Cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X5 [KO:K04863]
101959879  Il1a; interleukin-1 alpha isoform X1 [KO:K04383]
101959985  Hras; GTPase HRas isoform X2 [KO:K02833]
101960092  Map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X5 [KO:K04406] [EC:2.7.11.1]
101960125  Cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
101960134  Flt3lg; fms-related tyrosine kinase 3 ligand isoform X3 [KO:K05454]
101960211  Vegfb; vascular endothelial growth factor B [KO:K16858]
101960285  Atf2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
101960354  Ppp3r1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
101960404  Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101960408  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
101960429  Flt3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
101960440  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
101960571  Araf; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
101960630  Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
101960744  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
101960867  Sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101960999  [KO:K04344]
101961072  Ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
101961192  Flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101961197  Map3k6; mitogen-activated protein kinase kinase kinase 6 isoform X2 [KO:K04425] [EC:2.7.11.25]
101961289  Rasa1; ras GTPase-activating protein 1 [KO:K04352]
101961291  Rras; ras-related protein R-Ras [KO:K07829]
101961347  Ptpn5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
101961381  Rap1a; ras-related protein Rap-1A isoform X1 [KO:K04353]
101961479  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101961610  Pgf; placenta growth factor isoform X1 [KO:K16859]
101961791  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
101961798  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101961871  Il1r1; interleukin-1 receptor type 1 [KO:K04386]
101961905  Elk1; ETS domain-containing protein Elk-1 isoform X2 [KO:K04375]
101961915  Rasa2; ras GTPase-activating protein 2 [KO:K08053]
101961937  Vegfd; vascular endothelial growth factor D [KO:K05449]
101961968  Dusp5; LOW QUALITY PROTEIN: dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101961975  Cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X2 [KO:K04862]
101962015  Mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
101962025  Fgf4; fibroblast growth factor 4 [KO:K04358]
101962074  [KO:K07836]
101962404  Mapt; microtubule-associated protein tau isoform X1 [KO:K04380]
101962416  Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101962502  Areg; amphiregulin [KO:K09782]
101962653  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X3 [KO:K04403]
101962780  Ereg; proepiregulin [KO:K09784]
101962799  Cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
101962842  Cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
101962895  Mef2c; myocyte-specific enhancer factor 2C isoform X3 [KO:K04454]
101963124  Sos2; son of sevenless homolog 2 [KO:K03099]
101963269  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101963358  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
101963371  Mapk8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
101963400  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
101963453  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101963540  Insr; insulin receptor [KO:K04527] [EC:2.7.10.1]
101963670  Il1b; interleukin-1 beta [KO:K04519]
101963720  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
101963744  Mapk12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
101963776  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101963872  Pdgfa; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
101963881  Dusp8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101963929  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
101964114  Kras; GTPase KRas isoform X1 [KO:K07827]
101964126  Efna2; ephrin-A2 [KO:K05462]
101964304  Efna4; ephrin-A4 [KO:K05462]
101964395  Ptprr; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
101964547  Pdgfrb; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
101964638  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101964669  Hspb1; heat shock protein beta-1 [KO:K04455]
101964723  Dusp9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
101964766  Efna1; ephrin-A1 [KO:K05462]
101964841  Csf1r; macrophage colony-stimulating factor 1 receptor isoform X2 [KO:K05090] [EC:2.7.10.1]
101964913  Tnf; tumor necrosis factor [KO:K03156]
101965040  Pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
101965101  Mapk13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
101965108  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101965203  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101965330  Cacng7; voltage-dependent calcium channel gamma-7 subunit isoform X2 [KO:K04872]
101965394  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101965571  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101965625  Cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
101965886  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X3 [KO:K03158]
101966058  Dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
101966144  [KO:K04393]
101966207  Ins; insulin precursor [KO:K04526]
101966264  Fgf16; fibroblast growth factor 16 [KO:K04358]
101966419  Nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
101966501  Igf2; insulin-like growth factor II isoform X2 [KO:K13769]
101966624  Mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
101966737  Mecom; histone-lysine N-methyltransferase MECOM isoform X4 [KO:K04462] [EC:2.1.1.367]
101966874  Map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
101966876  Erbb2; receptor tyrosine-protein kinase erbB-2 isoform X2 [KO:K05083] [EC:2.7.10.1]
101966977  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101967095  Cacnb3; voltage-dependent L-type calcium channel subunit beta-3 isoform X2 [KO:K04864]
101967153  Gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
101967214  [KO:K02187] [EC:3.4.22.56]
101967335  Ntf3; neurotrophin-3 [KO:K04356]
101967363  Rps6ka5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
101967418  [KO:K04855]
101967461  Ppm1a; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
101967513  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B isoform X14 [KO:K04849]
101967598  Fgf23; fibroblast growth factor 23 [KO:K22428]
101967599  Tgfb2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
101967688  Map3k11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
101967689  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101967809  [KO:K04410] [EC:2.7.11.1]
101967887  Fgf6; fibroblast growth factor 6 [KO:K04358]
101968098  Fgf10; fibroblast growth factor 10 [KO:K04358]
101968140  Rps6ka6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
101968259  Erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
101968542  Dusp3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
101968547  Mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
101968685  Relb; transcription factor RelB isoform X3 [KO:K09253]
101968856  Ntrk2; BDNF/NT-3 growth factors receptor isoform X4 [KO:K04360] [EC:2.7.10.1]
101968890  Igf1; insulin-like growth factor I isoform X2 [KO:K05459]
101968950  Cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
101969226  Fgf3; fibroblast growth factor 3 [KO:K04358]
101969240  Map3k2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
101969266  Cdc25b; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
101969273  Rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X3 [KO:K04373] [EC:2.7.11.1]
101969278  Tgfa; protransforming growth factor alpha isoform X2 [KO:K08774]
101969501  Fgf19; fibroblast growth factor 19 [KO:K22603]
101969559  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
101969595  Rap1b; ras-related protein Rap-1b [KO:K07836]
101969684  Mras; ras-related protein M-Ras isoform X1 [KO:K07831]
101969789  Fgf22; fibroblast growth factor 22 isoform X3 [KO:K04358]
101969987  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101969993  Tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
101970017  Dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101970171  Cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
101970348  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X8 [KO:K04348] [EC:3.1.3.16]
101970356  Taok1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
101970466  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101970499  Csf1; macrophage colony-stimulating factor 1 [KO:K05453]
101970645  Tgfbr1; TGF-beta receptor type-1 isoform X2 [KO:K04674] [EC:2.7.11.30]
101970651  Nf1; LOW QUALITY PROTEIN: neurofibromin [KO:K08052]
101970679  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101970700  Epha2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101970756  Ptpn7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
101970905  [KO:K12457]
101970931  Map3k3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
101971105  Mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
101971244  Braf; serine/threonine-protein kinase B-raf isoform X5 [KO:K04365] [EC:2.7.11.1]
101971356  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
101971364  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101971460  Cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
101971481  [KO:K04723]
101971730  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X2 [KO:K04431] [EC:2.7.12.2]
101971818  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101971940  Stk3; serine/threonine-protein kinase 3 isoform X2 [KO:K04412]
101971945  Arrb2; beta-arrestin-2 [KO:K04439]
101972002  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
101972098  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101972153  Pla2g4e; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
101972410  Crkl; crk-like protein isoform X1 [KO:K04438]
101972421  Pla2g4f; cytosolic phospholipase A2 zeta isoform X2 [KO:K16342] [EC:3.1.1.4]
101972544  Irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
101972573  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580]
101972668  Kitlg; kit ligand isoform X1 [KO:K05461]
101972732  Fgfr3; fibroblast growth factor receptor 3 isoform X8 [KO:K05094] [EC:2.7.10.1]
101972956  Rras2; ras-related protein R-Ras2 [KO:K07830]
101973146  Dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
101973163  Egf; pro-epidermal growth factor [KO:K04357]
101973295  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
101973345  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101973561  Rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
101973664  Dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
101973838  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101973859  Pla2g4c; cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
101973902  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101973940  Angpt2; angiopoietin-2 [KO:K05466]
101973953  Map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X7 [KO:K04463] [EC:2.7.12.2]
101974038  Mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X9 [KO:K04436]
101974157  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101974399  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
101974444  Flna; filamin-A isoform X1 [KO:K04437]
101974580  Nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X3 [KO:K04469]
101974621  Fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
101974624  Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101974749  Taok2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
101974776  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101974789  Mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
101975129  Casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101975241  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101975259  Fgf7; fibroblast growth factor 7 [KO:K04358]
101975406  Lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
101975438  Fgf21; fibroblast growth factor 21 [KO:K22429]
101975512  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101975521  Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
101975529  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
101975654  Srf; LOW QUALITY PROTEIN: serum response factor [KO:K04378]
101975730  Stmn1; stathmin isoform X2 [KO:K04381]
101975826  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
101975906  Nras; GTPase NRas [KO:K07828]
101975990  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
101976082  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101976129  Angpt4; angiopoietin-4 isoform X2 [KO:K05467]
101976396  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
101976523  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101976557  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101976716  Rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
101976910  Cd14; monocyte differentiation antigen CD14 [KO:K04391]
101976921  Dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101976957  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101977008  Hspa8; heat shock cognate 71 kDa protein [KO:K03283]
101977035  Ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
101977052  Fgf9; fibroblast growth factor 9 [KO:K04358]
101977233  Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
101977261  Cacng2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
101977403  [KO:K04460] [EC:3.1.3.16]
101977479  Ngf; beta-nerve growth factor [KO:K02582]
101977507  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
101977530  Cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X2 [KO:K04854]
101977572  Efna3; ephrin-A3 [KO:K05462]
101977815  Max; protein max isoform X4 [KO:K04453]
101977831  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
101977965  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101977970  Daxx; death domain-associated protein 6 [KO:K02308]
101978017  Cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X4 [KO:K04859]
101978392  Efna5; ephrin-A5 [KO:K05462]
101978429  Ntf4; neurotrophin-4 [KO:K12457]
101978444  Cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
101978549  Mapk9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
101978697  Map3k13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
106144716  [KO:K05450]
106145496  Cacng8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
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Reference
PMID:12191611
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Pharmacol Ther 93:193-202 (2002)
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Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
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Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
iti04070  Phosphatidylinositol signaling system
iti04110  Cell cycle
iti04115  p53 signaling pathway
iti04210  Apoptosis
iti04310  Wnt signaling pathway
iti04668  TNF signaling pathway
KO pathway
ko04010   

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