KEGG   PATHWAY: iti04020
Entry
iti04020                    Pathway                                
Name
Calcium signaling pathway - Ictidomys tridecemlineatus (thirteen-lined ground squirrel)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
iti04020  Calcium signaling pathway
iti04020

Other DBs
GO: 0019722
Organism
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) [GN:iti]
Gene
101954352  CUNH4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
101954361  Avpr1b; vasopressin V1b receptor [KO:K04227]
101954373  Atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
101954393  Atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X2 [KO:K05853] [EC:7.2.2.10]
101954421  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101954549  Ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
101954667  Fgf18; fibroblast growth factor 18 [KO:K04358]
101954767  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101954934  Grin2b; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
101954994  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
101955098  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
101955103  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
101955221  Grm1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
101955326  Hrc; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
101955384  Vegfc; vascular endothelial growth factor C [KO:K05449]
101955806  Fgf8; fibroblast growth factor 8 isoform X3 [KO:K04358]
101955809  [KO:K05096] [EC:2.7.10.1]
101955816  Trhr; thyrotropin-releasing hormone receptor [KO:K04282]
101956005  Mylk4; myosin light chain kinase family member 4 isoform X2 [KO:K00907] [EC:2.7.11.18]
101956072  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101956113  Cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
101956174  Camk4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
101956182  Plcz1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
101956341  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
101956525  Ryr2; ryanodine receptor 2 [KO:K04962]
101956624  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
101956689  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
101956790  P2rx2; P2X purinoceptor 2 [KO:K05216]
101956801  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X3 [KO:K04855]
101956898  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X14 [KO:K04851]
101956917  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101956975  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
101957059  Nos1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
101957148  Plcd3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X2 [KO:K05857] [EC:3.1.4.11]
101957382  Ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
101957513  Asph; aspartyl/asparaginyl beta-hydroxylase isoform X7 [KO:K00476] [EC:1.14.11.16]
101957631  F2r; proteinase-activated receptor 1 [KO:K03914]
101957687  Fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
101957833  Fgf20; fibroblast growth factor 20 [KO:K04358]
101957872  Kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
101957945  Chrm5; muscarinic acetylcholine receptor M5 [KO:K04131]
101957998  Phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
101958138  Ptk2b; LOW QUALITY PROTEIN: protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
101958232  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
101958314  Bdkrb2; B2 bradykinin receptor [KO:K03916]
101958484  Htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
101958541  Adra1a; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
101958726  Stim2; stromal interaction molecule 2 [KO:K18196]
101958827  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
101958853  [KO:K04358]
101959071  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
101959434  Orai1; calcium release-activated calcium channel protein 1 isoform X2 [KO:K16056]
101959477  Mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
101959478  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X2 [KO:K17334]
101959515  Slc8a1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
101959552  Adora2a; adenosine receptor A2a [KO:K04266]
101959621  Gdnf; glial cell line-derived neurotrophic factor isoform X2 [KO:K05452]
101959998  Orai3; protein orai-3 [KO:K16058]
101960160  Cckbr; gastrin/cholecystokinin type B receptor [KO:K04195]
101960211  Vegfb; vascular endothelial growth factor B [KO:K16858]
101960247  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
101960290  Htr5a; 5-hydroxytryptamine receptor 5A [KO:K04161]
101960354  Ppp3r1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
101960408  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
101960436  Adcy4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
101960541  Chrm3; muscarinic acetylcholine receptor M3 [KO:K04131]
101960649  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101960788  Plcd4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X5 [KO:K05857] [EC:3.1.4.11]
101960818  Ltb4r2; leukotriene B4 receptor 2 [KO:K04297]
101960863  Stim1; stromal interaction molecule 1 isoform X3 [KO:K16059]
101960960  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
101960999  [KO:K04344]
101961072  Ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
101961077  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101961192  Flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101961479  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101961488  Phkb; phosphorylase b kinase regulatory subunit beta isoform X2 [KO:K07190]
101961602  Ryr1; ryanodine receptor 1 [KO:K04961]
101961606  Adora2b; adenosine receptor A2b isoform X1 [KO:K04267]
101961921  P2rx4; P2X purinoceptor 4 isoform X2 [KO:K05218]
101961937  Vegfd; vascular endothelial growth factor D [KO:K05449]
101962025  Fgf4; fibroblast growth factor 4 [KO:K04358]
101962027  Camk1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
101962201  P2rx7; P2X purinoceptor 7 isoform X3 [KO:K05220]
101962225  Tpcn1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
101962301  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
101962317  Tpcn2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
101962448  Drd5; D(1B) dopamine receptor [KO:K05840]
101962457  [KO:K23449]
101962488  Orai2; protein orai-2 isoform X1 [KO:K16057]
101962577  Ntsr1; neurotensin receptor type 1 [KO:K04211]
101962587  Cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
101962672  Ednrb; endothelin receptor type B [KO:K04198]
101962754  Atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
101962775  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X9 [KO:K04958]
101962842  Cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
101963145  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X2 [KO:K05853] [EC:7.2.2.10]
101963269  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101963322  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101963400  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
101963481  Grm5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
101963720  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
101963823  Atp2b4; plasma membrane calcium-transporting ATPase 4 isoform X5 [KO:K05850] [EC:7.2.2.10]
101963872  Pdgfa; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
101963929  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
101963969  Atp2b3; plasma membrane calcium-transporting ATPase 3 isoform X4 [KO:K05850] [EC:7.2.2.10]
101964034  Mcoln3; mucolipin-3 isoform X1 [KO:K04994]
101964418  Slc25a6; ADP/ATP translocase 3 [KO:K05863]
101964481  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
101964547  Pdgfrb; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
101964638  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101964662  Agtr1; type-1 angiotensin II receptor [KO:K04166]
101964680  Gna11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
101964780  Itpkc; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
101964783  Grpr; gastrin-releasing peptide receptor [KO:K04169]
101964917  Cckar; cholecystokinin receptor type A [KO:K04194]
101964920  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101965148  Itpkb; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
101965203  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101965571  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101965601  Pde1c; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X8 [KO:K13755] [EC:3.1.4.17]
101965658  Oxtr; oxytocin receptor [KO:K04229]
101965694  Ntrk3; NT-3 growth factor receptor isoform X3 [KO:K05101] [EC:2.7.10.1]
101965790  Casq1; calsequestrin-1 [KO:K23468]
101966082  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
101966264  Fgf16; fibroblast growth factor 16 [KO:K04358]
101966272  Ptafr; platelet-activating factor receptor [KO:K04279]
101966598  Slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
101966876  Erbb2; receptor tyrosine-protein kinase erbB-2 isoform X2 [KO:K05083] [EC:2.7.10.1]
101967024  Bdkrb1; B1 bradykinin receptor [KO:K03915]
101967074  Calm1; calmodulin-1 [KO:K02183]
101967288  [KO:K04632]
101967418  [KO:K04855]
101967513  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B isoform X14 [KO:K04849]
101967598  Fgf23; fibroblast growth factor 23 [KO:K22428]
101967689  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101967887  Fgf6; fibroblast growth factor 6 [KO:K04358]
101967948  Lhcgr; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
101968098  Fgf10; fibroblast growth factor 10 [KO:K04358]
101968259  Erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
101968366  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
101968416  [KO:K05871] [EC:2.7.10.2]
101968425  Pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
101968534  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X6 [KO:K04515] [EC:2.7.11.17]
101968552  Tbxa2r; thromboxane A2 receptor [KO:K04264]
101968558  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
101968564  Itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
101968826  Mst1; hepatocyte growth factor-like protein [KO:K23441]
101968846  Adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
101968856  Ntrk2; BDNF/NT-3 growth factors receptor isoform X4 [KO:K04360] [EC:2.7.10.1]
101968875  Phka1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X2 [KO:K07190]
101968941  Htr7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
101968983  Adra1d; LOW QUALITY PROTEIN: alpha-1D adrenergic receptor [KO:K04137]
101969221  Sphk1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
101969226  Fgf3; fibroblast growth factor 3 [KO:K04358]
101969278  Tgfa; protransforming growth factor alpha isoform X2 [KO:K08774]
101969389  Mcu; calcium uniporter protein, mitochondrial [KO:K20858]
101969501  Fgf19; fibroblast growth factor 19 [KO:K22603]
101969789  Fgf22; fibroblast growth factor 22 isoform X3 [KO:K04358]
101969978  Ptger3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
101970163  Adrb2; beta-2 adrenergic receptor [KO:K04142]
101970266  Smim6; small integral membrane protein 6 [KO:K26468]
101970348  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X8 [KO:K04348] [EC:3.1.3.16]
101970455  Htr4; 5-hydroxytryptamine receptor 4 isoform X2 [KO:K04160]
101970466  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101970570  Mcoln2; mucolipin-2 [KO:K04993]
101970686  Ptger1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
101970752  Avpr1a; vasopressin V1a receptor [KO:K04226]
101970761  Gna15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
101971027  [KO:K04632]
101971140  Grin2c; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
101971227  Nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
101971261  Slc8a2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
101971412  [KO:K04636]
101971460  Cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
101971550  Plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X2 [KO:K05857] [EC:3.1.4.11]
101971818  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101971840  Gnal; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
101971998  [KO:K04634]
101972006  Mst1r; macrophage-stimulating protein receptor isoform X3 [KO:K05100] [EC:2.7.10.1]
101972113  Camk1g; calcium/calmodulin-dependent protein kinase type 1G isoform X2 [KO:K08794] [EC:2.7.11.17]
101972221  P2rx3; P2X purinoceptor 3 isoform X2 [KO:K05217]
101972436  Calml6; calmodulin-like protein 6 [KO:K02183]
101972472  Calm2; calmodulin-2 [KO:K02183]
101972510  Sphk2; sphingosine kinase 2 isoform X2 [KO:K04718] [EC:2.7.1.91]
101972732  Fgfr3; fibroblast growth factor receptor 3 isoform X8 [KO:K05094] [EC:2.7.10.1]
101972767  Adra1b; alpha-1B adrenergic receptor [KO:K04136]
101972951  Tnnc2; troponin C, skeletal muscle [KO:K12042]
101972961  Phkg1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X2 [KO:K00871] [EC:2.7.11.19]
101973111  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101973113  Tfeb; transcription factor EB [KO:K15590]
101973163  Egf; pro-epidermal growth factor [KO:K04357]
101973170  Grin3b; glutamate receptor ionotropic, NMDA 3B isoform X1 [KO:K05214]
101973272  Hrh2; histamine H2 receptor isoform X1 [KO:K04150]
101973319  Phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
101973345  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101973445  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
101973724  Ednra; endothelin-1 receptor [KO:K04197]
101973838  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101974101  Tacr1; substance-P receptor [KO:K04222]
101974119  P2rx6; P2X purinoceptor 6 isoform X1 [KO:K05221]
101974191  Atp2b1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
101974226  Drd1; D(1A) dopamine receptor [KO:K04144]
101974296  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X9 [KO:K04515] [EC:2.7.11.17]
101974399  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
101974424  Tnnc1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
101974427  Adrb3; beta-3 adrenergic receptor [KO:K04143]
101974517  Adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101974621  Fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
101974677  Htr2a; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
101974838  Tacr2; substance-K receptor [KO:K04223]
101975116  Pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X5 [KO:K13755] [EC:3.1.4.17]
101975217  [KO:K02183]
101975259  Fgf7; fibroblast growth factor 7 [KO:K04358]
101975260  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
101975344  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4 [KO:K05860] [EC:3.1.4.11]
101975438  Fgf21; fibroblast growth factor 21 [KO:K22429]
101975512  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101975536  [KO:K04161]
101975537  Grin2d; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
101975553  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X2 [KO:K04960]
101975565  Camk1d; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
101975826  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
101975926  Htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
101976251  Chrna7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
101976337  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
101976382  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X4 [KO:K05208]
101976449  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
101976513  [KO:K02183]
101976547  Grin3a; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
101976548  Nos3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
101976794  Calml5; calmodulin-like protein 5 [KO:K02183]
101976815  Htr2c; 5-hydroxytryptamine receptor 2C [KO:K04157]
101976824  [KO:K17332]
101976957  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101977018  Cysltr2; cysteinyl leukotriene receptor 2 isoform X1 [KO:K04323]
101977052  Fgf9; fibroblast growth factor 9 [KO:K04358]
101977054  Mylk; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
101977134  P2rx1; P2X purinoceptor 1 isoform X3 [KO:K05215]
101977214  Pln; cardiac phospholamban [KO:K05852]
101977233  Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
101977237  Cd38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
101977252  Adrb1; beta-1 adrenergic receptor [KO:K04141]
101977479  Ngf; beta-nerve growth factor [KO:K02582]
101977507  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
101977530  Cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X2 [KO:K04854]
101977831  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
101977965  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101978138  Calm3; calmodulin-3 isoform X2 [KO:K02183]
101978224  Hrh1; histamine H1 receptor [KO:K04149]
101978537  P2rx5; P2X purinoceptor 5 isoform X3 [KO:K05219]
101978560  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
101978616  Casq2; calsequestrin-2 [KO:K23445]
106144716  [KO:K05450]
106145109  Mcoln1; mucolipin-1 [KO:K04992]
106145154  Mrln; myoregulin [KO:K22643]
106145155  [KO:K22643]
110598275  [KO:K10785]
120891809  [KO:K10785]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
iti04010  MAPK signaling pathway
iti04070  Phosphatidylinositol signaling system
iti04210  Apoptosis
iti04720  Long-term potentiation
iti04730  Long-term depression
KO pathway
ko04020   

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