Entry Name RIG-I-like receptor signaling pathway
Description Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map ko04622 RIG-I-like receptor signaling pathway
Orthology K02373 FADD; FAS-associated death domain protein
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K02581 NFKBIB; NF-kappa-B inhibitor beta
K02861 RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1 ]
K03156 TNF, TNFA; tumor necrosis factor superfamily, member 2
K03171 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
K03174 TRAF3; TNF receptor-associated factor 3
K04416 MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25 ]
K04427 MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25 ]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24 ]
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10 ]
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K04735 RELA; transcription factor p65
K05411 IRF3; interferon regulatory factor 3
K05442 IFNE; interferon epsilon
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10 ]
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K07211 IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10 ]
K08336 ATG12; ubiquitin-like protein ATG12
K08339 ATG5; autophagy-related protein 5
K08601 CYLD, USLP2; ubiquitin carboxyl-terminal hydrolase CYLD [EC:3.4.19.12 ]
K09447 IRF7; interferon regulatory factor 7
K09578 PIN1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [EC:5.2.1.8 ]
K10030 IL8, CXCL8; interleukin 8
K10652 TRIM25, EFP; tripartite motif-containing protein 25 [EC:2.3.2.27 ]
K12159 ISG15; ubiquitin cross-reactive protein
K12646 RIGI, DDX58; ATP-dependent RNA helicase DDX58 [EC:5.6.2.6 ]
K12647 IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1 [EC:5.6.2.6 ]
K12648 MAVS, IPS1; mitochondrial antiviral-signaling protein
K12649 DHX58, LGP2; ATP-dependent RNA helicase DHX58 [EC:5.6.2.6 ]
K12650 TANK; TRAF family member-associated NF-kappa-B activator
K12651 AZI2; 5-azacytidine-induced protein 2
K12652 TBKBP1; TANK-binding kinase 1-binding protein
K12653 NLRX1; NLR family member X1
K12654 STING1, TMEM173, MITA; stimulator of interferon genes protein
K12656 SIKE; suppressor of IKK-epsilon
K12671 CXCL10, IP10; C-X-C motif chemokine 10
K12968 ADAR, ADAR1; double-stranded RNA-specific adenosine deaminase [EC:3.5.4.37 ]
K27391 ZNFX1; NFX1-type zinc finger-containing protein 1
Compound Reference Authors Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T
Title The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
Journal Reference Authors Takeuchi O, Akira S
Title MDA5/RIG-I and virus recognition.
Journal Reference Authors Yoneyama M, Fujita T
Title RNA recognition and signal transduction by RIG-I-like receptors.
Journal Reference Authors Nakhaei P, Genin P, Civas A, Hiscott J
Title RIG-I-like receptors: sensing and responding to RNA virus infection.
Journal Reference Authors Moore CB, Ting JP
Title Regulation of mitochondrial antiviral signaling pathways.
Journal Reference Authors Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB
Title Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.
Journal Reference Authors Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G
Title Approaching the RNA ligand for RIG-I?
Journal Reference Authors Saito T, Gale M Jr
Title Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.
Journal Reference Authors Kawai T, Akira S
Title Toll-like receptor and RIG-I-like receptor signaling.
Journal Reference Authors Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J
Title TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
Journal Reference Authors Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T
Title TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
Journal Reference Authors Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR
Title RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
Journal Reference Authors Liu G, Gack MU
Title Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity.
Journal Related ko04120 Ubiquitin mediated proteolysis
