KEGG ORTHOLOGY: K03174

ORTHOLOGY: K03174

Entry

K03174                      KO

Symbol

TRAF3

Name

TNF receptor-associated factor 3

Pathway

map04064

NF-kappa B signaling pathway

map04620

Toll-like receptor signaling pathway

map04621

NOD-like receptor signaling pathway

map04622

RIG-I-like receptor signaling pathway

map04657

IL-17 signaling pathway

map04668

TNF signaling pathway

map04936

Alcoholic liver disease

map05160

Hepatitis C

map05161

Hepatitis B

map05162

Measles

map05164

Influenza A

map05165

Human papillomavirus infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05168

Herpes simplex virus 1 infection

map05169

Epstein-Barr virus infection

map05171

Coronavirus disease - COVID-19

map05200

Pathways in cancer

map05203

Viral carcinogenesis

map05222

Small cell lung cancer

map05417

Lipid and atherosclerosis

Disease

H02536

Infection-induced acute encephalopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K03174  TRAF3; TNF receptor-associated factor 3
   04668 TNF signaling pathway
    K03174  TRAF3; TNF receptor-associated factor 3
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K03174  TRAF3; TNF receptor-associated factor 3
   04621 NOD-like receptor signaling pathway
    K03174  TRAF3; TNF receptor-associated factor 3
   04622 RIG-I-like receptor signaling pathway
    K03174  TRAF3; TNF receptor-associated factor 3
   04657 IL-17 signaling pathway
    K03174  TRAF3; TNF receptor-associated factor 3
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03174  TRAF3; TNF receptor-associated factor 3
   05203 Viral carcinogenesis
    K03174  TRAF3; TNF receptor-associated factor 3
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K03174  TRAF3; TNF receptor-associated factor 3
  09172 Infectious disease: viral
   05161 Hepatitis B
    K03174  TRAF3; TNF receptor-associated factor 3
   05160 Hepatitis C
    K03174  TRAF3; TNF receptor-associated factor 3
   05171 Coronavirus disease - COVID-19
    K03174  TRAF3; TNF receptor-associated factor 3
   05164 Influenza A
    K03174  TRAF3; TNF receptor-associated factor 3
   05162 Measles
    K03174  TRAF3; TNF receptor-associated factor 3
   05168 Herpes simplex virus 1 infection
    K03174  TRAF3; TNF receptor-associated factor 3
   05167 Kaposi sarcoma-associated herpesvirus infection
    K03174  TRAF3; TNF receptor-associated factor 3
   05169 Epstein-Barr virus infection
    K03174  TRAF3; TNF receptor-associated factor 3
   05165 Human papillomavirus infection
    K03174  TRAF3; TNF receptor-associated factor 3
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K03174  TRAF3; TNF receptor-associated factor 3
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K03174  TRAF3; TNF receptor-associated factor 3

Genes

HSA:	7187(TRAF3)

PTR:	453178(TRAF3)

PPS:	100980798(TRAF3)

GGO:	101136595(TRAF3)

PON:	100460079(TRAF3)

PPYG:

129013033(TRAF3)

NLE:	100606382(TRAF3)

HMH:	116485188(TRAF3)

SSYN:

129487417(TRAF3)

MCC:	693961(TRAF3)

MCF:	102141355(TRAF3)

MTHB:

126959960

MNI:	105467377(TRAF3)

CSAB:

103229744(TRAF3)

CATY:

105596732(TRAF3)

PANU:

101015482(TRAF3)

TGE:	112629252(TRAF3)

MLEU:

105547858(TRAF3)

RRO:	104654431(TRAF3)

RBB:	108514953(TRAF3)

TFN:	117071333(TRAF3)

PTEH:

111538162(TRAF3)

CANG:

105518439(TRAF3)

CJC:	100387401(TRAF3)

SBQ:	101043245(TRAF3)

CIMI:

108304024(TRAF3)

ANAN:

105730166(TRAF3)

CSYR:

103250762(TRAF3)

MMUR:

105859313 105861087(TRAF3)

LCAT:

123644162(TRAF3)

PCOQ:

105812625(TRAF3)

OGA:	100947925(TRAF3)

MMU:	22031(Traf3)

MCAL:

110306954(Traf3)

MPAH:

110324559(Traf3)

RNO:	362788(Traf3)

MCOC:

116080944(Traf3)

ANU:	117697234(Traf3)

MUN:	110553240(Traf3)

CGE:	100756323(Traf3)

MAUA:

101831388(Traf3)

PROB:

127231159(Traf3)

PLEU:

114697589 114703073(Traf3)

MORG:

121434311(Traf3)

MFOT:

126509072

AAMP:

119818887(Traf3)

NGI:	103727622(Traf3)

HGL:	101718736(Traf3)

CPOC:

100734492(Traf3)

CCAN:

109688807(Traf3)

DORD:

105983154(Traf3)

DSP:	122122592(Traf3)

PLOP:

125363299(Traf3)

NCAR:

124976672

MMMA:

107150805(Traf3)

OCU:

100359083

OPI:	101522714(TRAF3)

TUP:	102471499(TRAF3)

GVR:	103609553(TRAF3)

CFA:	490867(TRAF3)

CLUD:

112656934(TRAF3)

VVP:	112930285(TRAF3)

VLG:	121493392(TRAF3)

NPO:	129496135(TRAF3)

AML:	100466406(TRAF3)

UMR:	103656774(TRAF3)

UAH:	113267235(TRAF3)

UAR:	123779266(TRAF3)

ELK:

111148495

LLV:

125103668

MPUF:

101671223(TRAF3)

MNP:	132000278(TRAF3)

MLK:	131837014(TRAF3)

NVS:	122894215(TRAF3)

ORO:	101374855(TRAF3)

EJU:	114206264(TRAF3)

ZCA:	113908816(TRAF3)

MLX:	118002595(TRAF3)

NSU:	110571685(TRAF3)

FCA:	101096739(TRAF3)

PYU:	121032321(TRAF3)

PCOO:

112855336(TRAF3)

PBG:	122469573(TRAF3)

PVIV:

125167483(TRAF3)

LRUF:

124512500

PTG:	102952767(TRAF3)

PPAD:

109274594

PUC:

125909139

AJU:

106975974

HHV:	120244583(TRAF3)

BTA:	506182(TRAF3)

BOM:	102276392(TRAF3)

BIU:	109575564(TRAF3)

BBUB:

102402262(TRAF3)

BBIS:

104996935(TRAF3)

CHX:	102171742(TRAF3)

OAS:	100036758(TRAF3)

BTAX:

128051762 128066664(TRAF3)

ODA:	120875162(TRAF3)

CCAD:

122454978(TRAF3)

MBEZ:

129550678(TRAF3)

SSC:	100156979(TRAF3)

CFR:	102515034(TRAF3)

CBAI:

105079948(TRAF3)

CDK:	105103454(TRAF3)

VPC:	102529156(TRAF3)

BACU:

102997874(TRAF3)

BMUS:

118890316(TRAF3)

LVE:	103084510(TRAF3)

OOR:	101288184(TRAF3)

DLE:	111176049(TRAF3)

PCAD:

102974816(TRAF3)

PSIU:

116748433(TRAF3)

NASI:

112408757(TRAF3)

ECB:	100055110(TRAF3)

EPZ:	103563515(TRAF3)

EAI:	106839629(TRAF3)

MYB:	102260783(TRAF3)

MYD:	102771530(TRAF3)

MMYO:

118655021(TRAF3)

MLF:	102420724(TRAF3)

MDT:	132228750(TRAF3)

PKL:	118714100(TRAF3)

EFUS:

103301807(TRAF3)

MNA:	107538601(TRAF3)

DRO:	112311693(TRAF3)

SHON:

118976597(TRAF3)

AJM:	119037870(TRAF3)

PDIC:

114492329(TRAF3)

PHAS:

123808159(TRAF3)

MMF:	118633499(TRAF3)

PPAM:

129066167(TRAF3)

HAI:	109381072(TRAF3)

RFQ:	117023550(TRAF3)

PALE:

102881091(TRAF3)

PGIG:

120619723(TRAF3)

PVP:	105299274(TRAF3)

RAY:	107521368(TRAF3)

MJV:	108406584(TRAF3)

TOD:	119239469(TRAF3) 119250785

SARA:

101538970(TRAF3)

SETR:

126033344(TRAF3)

LAV:	100668716(TRAF3)

TMU:

101347503

ETF:	101663779(TRAF3)

DNM:	101437632(TRAF3)

MDO:	100017361(TRAF3)

GAS:	123233879(TRAF3)

SHR:	100926344(TRAF3)

AFZ:

127549887

PCW:	110197337(TRAF3)

TVP:	118843066(TRAF3)

OAA:	100075919(TRAF3)

GGA:	423471(TRAF3)

PCOC:

116228830(TRAF3)

MGP:	100549776(TRAF3)

CJO:	107315348(TRAF3)

TPAI:

128085742(TRAF3)

LMUT:

125694526(TRAF3)

NMEL:

110401083(TRAF3)

APLA:

101796752(TRAF3)

ACYG:

106046989(TRAF3)

CATA:

118250240(TRAF3)

AFUL:

116489623(TRAF3)

TGU:	100218184(TRAF3)

LSR:	110476432(TRAF3)

SCAN:

103826414(TRAF3)

PMOA:

120503731(TRAF3)

OTC:	121331801(TRAF3)

PRUF:

121358229(TRAF3)

GFR:	102033090(TRAF3)

FAB:	101807381(TRAF3)

OMA:	130254031(TRAF3)

PHI:	102110443(TRAF3)

PMAJ:

107206012(TRAF3)

CCAE:

111929794(TRAF3)

CCW:	104686673(TRAF3)

CBRC:

103612168(TRAF3)

ETL:	114062306(TRAF3)

ZAB:	102062693(TRAF3)

ZLE:	135448089(TRAF3)

ACHL:

103798530(TRAF3)

SVG:	106850535(TRAF3)

MMEA:

130573359(TRAF3)

HRT:	120753830(TRAF3)

SATI:

136362851(TRAF3)

FPG:	101918364(TRAF3)

FCH:	102057349(TRAF3)

CCRI:

104163183

NNT:	104408547(TRAF3)

SHAB:

115606790(TRAF3)

ACUN:

113480589(TRAF3)

TALA:

104364460(TRAF3)

ACHC:

115352265(TRAF3)

HALD:

104322048(TRAF3)

HLE:	104841931(TRAF3)

AGEN:

126050490

GCL:

127016708

CSTI:

104559227(TRAF3)

LDI:

104340309

MNB:	103776314(TRAF3)

DPUB:

104304250(TRAF3)

AVIT:

104277536(TRAF3)

BRHI:

104493585(TRAF3)

EGZ:	104124519(TRAF3)

NNI:	104014514(TRAF3)

PCRI:

104028508

PCAO:

104044683(TRAF3)

PADL:

103920268(TRAF3)

AFOR:

103900217(TRAF3)

FGA:	104078892(TRAF3)

GSTE:

104258337

CLV:	102085500(TRAF3)

MUI:	104537198(TRAF3)

PGUU:

104470835(TRAF3)

PLET:

104614563(TRAF3)

EHS:	104510698(TRAF3)

CMAC:

104476939(TRAF3)

CUCA:

104057729(TRAF3)

TEO:	104374816(TRAF3)

BREG:

104642394(TRAF3)

OHA:	104331522(TRAF3)

ACAR:

104527415(TRAF3)

CPEA:

104390626(TRAF3)

CVF:	104291770(TRAF3)

RTD:	128908585(TRAF3)

AAM:	106482974(TRAF3)

AROW:

112972701(TRAF3)

NPD:	112955397(TRAF3)

TGT:	104577073(TRAF3)

DNE:	112989906(TRAF3)

SCAM:

104144466(TRAF3)

ASN:	102382120(TRAF3)

AMJ:	102566882(TRAF3)

CPOO:

109321776(TRAF3)

GGN:	109298436(TRAF3)

PSS:	102461304(TRAF3)

CMY:	102941336(TRAF3)

CCAY:

125638326(TRAF3)

DCC:	119857747(TRAF3)

CPIC:

101934942(TRAF3)

TST:	117876131(TRAF3)

CABI:

116819654(TRAF3) 116822854

MRV:	120404354(TRAF3)

ACS:	100555350(traf3)

ASAO:

132762146(TRAF3)

PVT:	110078930(TRAF3)

SUND:

121927129(TRAF3)

PBI:	103062211(TRAF3)

PMUR:

107287185(TRAF3)

CTIG:

120317862(TRAF3)

TSR:	106540064(TRAF3)

PGUT:

117666012(TRAF3)

APRI:

131187938(TRAF3)

PTEX:

113435020(TRAF3)

NSS:	113420338(TRAF3)

VKO:	123026415(TRAF3)

PMUA:

114583728(TRAF3)

PRAF:

128403620(TRAF3)

ZVI:	118080386(TRAF3)

HCG:	128330317(TRAF3)

GJA:	107116596(TRAF3)

STOW:

125426382(TRAF3)

EMC:	129324633(TRAF3)

XLA:	108698786(traf3.L) 108699773(traf3.S)

XTR:	100498216(traf3)

NPR:	108790750(TRAF3)

RTEM:

120920906(TRAF3)

BBUF:

120982059(TRAF3)

BGAR:

122922026(TRAF3) 122922119

MUO:	115477870(TRAF3)

GSH:	117364101(TRAF3)

DRE:	445119(traf3)

SRX:	107719479 107733154

SANH:

107694716 107697656

SGH:	107582288 107590913

CCAR:

109051440

CAUA:

113098426 113117560

CGIB:

127976391 128031638

PTET:

122361489(traf3)

LROH:

127180150(traf3)

OMC:	131522734(traf3)

PPRM:

120477631(traf3)

RKG:	130069886(traf3)

MAMB:

125268882(traf3)

CIDE:

127499039

CERY:

137006239(traf3)

MASI:

127411039 127455466

TROS:

130560364(traf3)

TDW:	130436682(traf3)

MANU:

129417261(traf3)

IPU:

108270346

IFU:	128612897(traf3)

PHYP:

113529545(traf3)

SMEO:

124390278(traf3)

TFD:	113659586(traf3)

TVC:	132852789(traf3)

TRN:	134324995(traf3)

AMEX:

103023640(traf3)

CMAO:

118823830(traf3)

EEE:	113571406(traf3)

CHAR:

105905076(traf3)

TRU:	101069888(traf3)

TFS:	130540332(traf3)

TNG:	GSTEN00003589G001

LCO:	104936575(traf3)

TBEN:

117481345(traf3)

GACU:

117541281(traf3)

EMAC:

134863192(traf3)

ELY:	117267267(traf3)

EFO:	125900775(traf3)

PLEP:

121966080

SLUC:

116065150(traf3)

ECRA:

117940992

PFLV:

114546663(traf3)

GAT:	120832813(traf3)

PPUG:

119227245(traf3)

AFB:	129103095(traf3)

CLUM:

117751250(traf3)

PSWI:

130201334(traf3)

MSAM:

119894590 119910771

SCHU:

122861810(traf3)

CUD:	121526124(traf3)

ALAT:

119004867(traf3)

MZE:	101485974(traf3)

ONL:	100702578(traf3)

OAU:	116327980(traf3)

OLA:	101161601(traf3)

OML:	112141746(traf3)

CSAI:

133462914(traf3)

XMA:	102234631(traf3)

XCO:	114156371(traf3)

XHE:	116709290(traf3)

PRET:

103458120(traf3)

PFOR:

103153848(traf3)

PLAI:

106964477(traf3)

PMEI:

106933555(traf3)

GAF:	122846061(traf3)

PPRL:

129377262(traf3)

CVG:	107084838(traf3)

CTUL:

119793673(traf3)

GMU:	124855223(traf3)

NFU:	107391834(traf3)

KMR:

108229307

ALIM:

106527291(traf3)

NWH:	119427220(traf3)

AOCE:

111576450(traf3)

MCEP:

125023691(traf3)

CSEM:

103382287(traf3)

POV:	109642230(traf3)

SSEN:

122783372(traf3)

HHIP:

117755976(traf3)

HSP:	118116317(traf3)

PPLT:

128451556(traf3)

SMAU:

118286069(traf3)

LCF:

108891610

SDU:	111236089(traf3)

SLAL:

111659505(traf3)

XGL:	120795368(traf3)

HCQ:	109520525(traf3)

SSCV:

125981169

SBIA:

133513139(traf3)

PEE:	133413268(traf3)

PTAO:

133487956(traf3)

BPEC:

110170878(traf3)

MALB:

109972474(traf3)

BSPL:

114848462(traf3)

SJO:	128375575(traf3)

SASA:

106600975 106611198(traf3)

STRU:

115162102 115172380

OTW:	112244941(traf3) 112256827

OMY:	110497707 110505762

OGO:	124001950(traf3) 124046622

ONE:	115138681 115146031

OKI:	109894351 109904229

OKE:	118362713 118368117

SALP:

111963450 111968532

SNH:	120023505 120059926(traf3)

CCLU:

121539497 121544723

ELS:	105023593(traf3)

SFM:	108919645(traf3)

PKI:

111843185

AANG:

118214249(traf3)

LOC:	102685862(traf3)

PSPA:

121324582 121330118

ARUT:

117410328 117962601

PSEX:

120518283(traf3)

LCM:	102358156 102362986(TRAF3)

CMK:	103175325(traf3)

RTP:	109915375(traf3)

CPLA:

122542695 122553534(traf3)

HOC:	132817941(traf3) 132836696

LERI:

129700569(traf3) 129714099

PMRN:

116947765 116948469

LRJ:	133341400 133352677

BFO:	118412391 118412413 118412445

BBEL:

109462338 109465719 109465720 109466886 109468730 109479593

CIN:	100177450 100178481 100179623 100184576

SCLV:

120325943 120334915 120335171

SPU:	578197 579877 594165

LPIC:

129264539

APLC:

110975243

ARUN:

117291337

AJC:	117099897 117111939 117121421

SKO:	100370917 100372655 102802670 102807706

DPE:

6604640

DMO:	Dmoj_GI14463

DHE:

MDE:

LCQ:

BMOR:

BMAN:

MSEX:

DPL:	KGM_213331

BANY:

AAGE:

HAW:

TNL:

OFU:

ATRA:

GMW:

LGLY:

LSM:

DSV:	119431200 119431215 119431222 119431223 119431224 119431384 119431524 119445481 119463539 119464067 119464185 119464695 119465880

VDE:

VJA:

DFR:

PVUL:

PCAN:

BGT:

GAE:	121371694 121389102 121392139

HRF:

124127397

HRJ:	124267061 124267210

CRG:	105323598 105323599 105327202 105347536

CANU:

128168904 128168909 128176609 128178437

CVN:	111124729 111126076 111127917 111128592 111129069 111129814 111130375

OED:	125648915 125651421 125652594

MYI:	110450419 110453453 110455470 110460177 110465992 110465993 110466002

PMAX:

117322882 117322936 117323342 117323948 117324342 117324343 117324347 117335708

MCAF:

127698948

MMER:

123530096 123550824

RPHI:

132718605 132722147 132725427 132729208 132741048 132747473

DPOL:

127834014 127836480 127840178

MAEA:

OBI:

OSN:

LJP:

LAK:	106152129 106153620 106167915 106173469

LLON:

135485236

NVE:	5506647 5510506 5521642

EPA:	110235230 110235261 110241045 110241148 110241149 110242047 110244809 110251091

ATEN:

116290835 116300802 116303113 116304839 116306758 116308925

ADF:	107329324 107330240 107337664 107337666 107342770 107343693 107344455 107344458 107352268 107356136 107356143

AMIL:

114952985 114952991 114954431 114956421 114956444 114963345 114976293 114976512 114976656

PDAM:

113667645 113668371 113677155 113682628 113682647 113682660 113685127 113685909 113686654 113686741

SPIS:

111321168 111327454 111330591 111334112 111334113 111335560 111339228 111339472 111339473 111339678 111340651 111342724 111342792 111342957

DGT:	114517762 114530017 114530329 114531436 114532618 114534400 114534401 114534741 114539477 114539478 114539479 114539481 114540254 114541771 114541981

HSY:	130622952 130623909 130636688 130640751 130641127 130641937 130644363 130644452 130656284 130656285

RES:	135683545 135687369 135693908

AQU:	100631387 100632213 100635260 100636620 105312204 105312983 105313281 105315601

VDA:	VDAG_07731

» show all

Reference

PMID:15383523

Authors

He L, Grammer AC, Wu X, Lipsky PE

Title

TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation.

Journal

J Biol Chem 279:55855-65 (2004)
DOI:10.1074/jbc.M407284200

Reference

PMID:7527023

Authors

Hu HM, O'Rourke K, Boguski MS, Dixit VM

Title

A novel RING finger protein interacts with the cytoplasmic domain of CD40.

Journal

J Biol Chem 269:30069-72 (1994)

Sequence

[hsa:7187]

LinkDB

DBGET integrated database retrieval system