KEGG   PATHWAY: leri04115
Entry
leri04115                   Pathway                                
Name
p53 signaling pathway - Leucoraja erinaceus (little skate)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
leri04115  p53 signaling pathway
leri04115

Organism
Leucoraja erinaceus (little skate) [GN:leri]
Gene
129694998  [KO:K03982]
129695062  [KO:K05868]
129695077  ccnb1; G2/mitotic-specific cyclin-B1 isoform X1 [KO:K05868]
129695247  casp3b; caspase-3b [KO:K02187] [EC:3.4.22.56]
129695693  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
129696159  ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
129696210  adgrb1a; adhesion G protein-coupled receptor B1 isoform X1 [KO:K04596]
129696887  sesn1; sestrin-1 isoform X1 [KO:K10141]
129697083  [KO:K10808] [EC:1.17.4.1]
129698126  atm; LOW QUALITY PROTEIN: serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
129698273  [KO:K10141]
129698561  [KO:K02206] [EC:2.7.11.22]
129698706  [KO:K08738]
129698796  rprma; protein reprimo A [KO:K10128]
129698865  [KO:K04398] [EC:3.4.22.61]
129699013  steap3; metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
129699432  perp; p53 apoptosis effector related to PMP-22 [KO:K10136]
129699592  ccng2; cyclin-G2 [KO:K10146]
129700287  siva1; apoptosis regulatory protein Siva [KO:K22744]
129700340  thbs1b; thrombospondin-1 [KO:K16857]
129701016  [KO:K04402]
129701086  cop1; E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
129701117  gorab; RAB6-interacting golgin isoform X1 [KO:K19748]
129701841  ccng1; cyclin-G1 [KO:K10145]
129702359  [KO:K10141]
129702442  rchy1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
129703311  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
129703639  zmat3; zinc finger matrin-type protein 3 isoform X1 [KO:K10137]
129704234  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
129704256  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
129704265  [KO:K04390]
129704860  shisa10.1; protein shisa-5 isoform X1 [KO:K10135]
129704975  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
129705015  siah1; E3 ubiquitin-protein ligase Siah1 [KO:K04506] [EC:2.3.2.27]
129705590  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
129705596  zgc:153993; apoptosis regulator BAX [KO:K02159]
129705842  pidd1; p53-induced death domain-containing protein 1 [KO:K10130]
129705897  cd82b; CD82 molecule b [KO:K06509]
129706074  [KO:K04726]
129706324  igf1; insulin-like growth factor I [KO:K05459]
129706415  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
129706968  tsc2; tuberin isoform X1 [KO:K07207]
129707227  bcl2l1; bcl-2-like protein 1 [KO:K04570]
129707730  apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
129707749  [KO:K10151]
129708784  [KO:K05459]
129708793  cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
129708916  ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10151]
129708920  mdm4; protein Mdm4 isoform X1 [KO:K10127]
129709207  chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
129709752  rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
129709936  [KO:K20394]
129710303  igfbp3; insulin-like growth factor-binding protein 3 [KO:K10138]
129710312  [KO:K02091] [EC:2.7.11.22]
129710593  ppm1da; protein phosphatase, Mg2+/Mn2+ dependent, 1Da [KO:K10147] [EC:3.1.3.16]
129711109  [KO:K04402]
129711508  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
129711578  bcl2b; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
129711636  [KO:K08738]
129711772  tp73; tumor protein p73 isoform X1 [KO:K10148]
129712428  ei24; etoposide-induced protein 2.4 homolog [KO:K10134]
129712430  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
129712431  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
129712632  ccnb2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
129712913  [KO:K22745]
129712914  [KO:K22745]
129713845  [KO:K02159]
129714694  cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
129714770  cdk4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
leri04110  Cell cycle
leri04210  Apoptosis
leri04218  Cellular senescence
KO pathway
ko04115   

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