Entry Name Wnt signaling pathway - Macaca mulatta (rhesus monkey)
Description Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Macaca mulatta (rhesus monkey) [GN:
mcc ]
Gene 100423838 DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353 ]
100424290 TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1 isoform X1 [KO:K04508 ]
100428013 LGR6; leucine-rich repeat-containing G-protein coupled receptor 6 isoform X1 [KO:K08399 ]
106995151 TBL1X; F-box-like/WD repeat-containing protein TBL1X isoform X2 [KO:K04508 ]
574393 SFRP4; secreted frizzled-related protein 4 precursor [KO:K02185 ]
693443 APC; adenomatous polyposis coli protein isoform X1 [KO:K02085 ]
694270 MCC; colorectal mutant cancer protein isoform X2 [KO:K26734 ]
694560 TCF7L1; transcription factor 7-like 1 isoform X2 [KO:K04490 ]
695776 LEF1; lymphoid enhancer-binding factor 1 isoform X3 [KO:K04492 ]
695843 LRP6; low-density lipoprotein receptor-related protein 6 precursor [KO:K03068 ]
696709 RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860 ]
697624 CCN4; WNT1-inducible-signaling pathway protein 1 [KO:K22471 ]
698046 TLE3; transducin-like enhancer protein 3 isoform X1 [KO:K04497 ]
698089 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446 ]
699915 SFRP2; secreted frizzled-related protein 2 [KO:K02176 ]
700760 ROR1; inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X1 [KO:K05122 ] [EC:2.7.10.1 ]
701706 DAAM1; disheveled-associated activator of morphogenesis 1 [KO:K04512 ]
701736 LGR4; leucine-rich repeat-containing G-protein coupled receptor 4 precursor [KO:K04309 ]
701759 TCF7L2; transcription factor 7-like 2 isoform X9 [KO:K04491 ]
701803 SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501 ]
701864 PRICKLE1; prickle-like protein 1 isoform X2 [KO:K04511 ]
701951 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858 ] [EC:3.1.4.11 ]
702390 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X2 [KO:K17333 ]
702504 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2 [KO:K04515 ] [EC:2.7.11.17 ]
702876 SFRP1; secreted frizzled-related protein 1 precursor [KO:K02166 ]
702997 DKK1; dickkopf-related protein 1 precursor [KO:K02165 ]
705864 DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353 ]
705980 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515 ] [EC:2.7.11.17 ]
706048 FRZB; secreted frizzled-related protein 3 precursor [KO:K25481 ]
706955 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X7 [KO:K04348 ] [EC:3.1.3.16 ]
706977 CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X11 [KO:K04515 ] [EC:2.7.11.17 ]
707345 APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085 ]
707738 SFRP5; secreted frizzled-related protein 5 [KO:K02222 ]
708169 CHD8; chromodomain-helicase-DNA-binding protein 8 isoform X5 [KO:K04494 ] [EC:5.6.2.-]
708233 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348 ] [EC:3.1.3.16 ]
708990 FBXW11; F-box/WD repeat-containing protein 11 [KO:K03362 ]
709773 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348 ] [EC:3.1.3.16 ]
710152 BAMBI; BMP and activin membrane-bound inhibitor homolog [KO:K10162 ]
710540 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
710601 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
711279 LZTS2; leucine zipper putative tumor suppressor 2 isoform X1 [KO:K26471 ]
711355 SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605 ]
711843 BTRC; F-box/WD repeat-containing protein 1A isoform X2 [KO:K03362 ]
712257 CTNNBIP1; beta-catenin-interacting protein 1 [KO:K04493 ]
714381 DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353 ]
714785 NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X2 [KO:K17334 ]
715482 ROR2; tyrosine-protein kinase transmembrane receptor ROR2 isoform X1 [KO:K05123 ] [EC:2.7.10.1 ]
715644 PRICKLE3; prickle planar cell polarity protein 3 [KO:K04511 ]
716288 CCAR2; cell cycle and apoptosis regulator protein 2 [KO:K25816 ]
717755 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
717764 PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858 ] [EC:3.1.4.11 ]
718387 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858 ] [EC:3.1.4.11 ]
718418 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858 ] [EC:3.1.4.11 ]
718632 PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345 ] [EC:2.7.11.11 ]
718661 LGR5; leucine-rich repeat-containing G-protein coupled receptor 5 isoform X1 [KO:K04308 ]
718861 PPARD; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504 ]
719305 RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
719553 DAAM2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512 ]
721262 SERPINF1; pigment epithelium-derived factor [KO:K19614 ]
721605 LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068 ]
721644 TLE2; transducin-like enhancer protein 2 isoform X2 [KO:K04497 ]
Compound Reference Authors Hatsell S, Rowlands T, Hiremath M, Cowin P.
Title Beta-catenin and Tcfs in mammary development and cancer.
Journal Reference Authors Yang Y.
Title Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
Journal Reference Authors Kalderon D.
Title Similarities between the Hedgehog and Wnt signaling pathways.
Journal Reference Authors Nusse R.
Title Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
Journal Reference Authors Jope RS, Johnson GV.
Title The glamour and gloom of glycogen synthase kinase-3.
Journal Reference Authors Veeman MT, Axelrod JD, Moon RT.
Title A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
Journal Reference Authors Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
Title PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
Journal Reference Authors Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
Title The way Wnt works: Components and mechanism.
Journal Reference Authors Carethers JM
Title Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
Journal Reference Authors Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
Title The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
Journal Reference Authors Niehrs C
Title The complex world of WNT receptor signalling.
Journal Reference Authors Abou Ziki MD, Mani A
Title Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
Journal Reference Authors He Y, Ki H, Kim H, Kim K
Title delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
Journal Reference Authors Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
Title The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
Journal Reference Authors Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
Title A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
Journal Related KO pathway
