KEGG   PATHWAY: mcc05010
Entry
mcc05010                    Pathway                                
Name
Alzheimer disease - Macaca mulatta (rhesus monkey)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
mcc05010  Alzheimer disease
mcc05010

Disease
H00056  Alzheimer disease
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100192390  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
100423838  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
100423866  [KO:K02272]
100424087  AXIN1; axin-1 isoform X1 [KO:K02157]
100424587  [KO:K02268]
100425223  CYCS; cytochrome c [KO:K08738]
100425382  COX6B2; cytochrome c oxidase subunit 6B2 [KO:K02267]
100425863  TUBB4B; tubulin beta-4B chain [KO:K07375]
100426173  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
100426724  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
100427716  APP; amyloid-beta A4 protein isoform X1 [KO:K04520]
100428417  COX6C; cytochrome c oxidase subunit 6C [KO:K02268]
100428437  COX7B2; cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
100428682  PPP3R1; calcineurin subunit B type 1 isoform X3 [KO:K06268]
100429005  PSENEN; gamma-secretase subunit PEN-2 [KO:K06170]
100429280  COX7C; cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
100429880  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
100430178  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
100430704  SLC39A7; zinc transporter SLC39A7 precursor [KO:K14713]
106992278  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
106992283  [KO:K02270]
106992736  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
106993150  [KO:K02273]
106994854  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1 [KO:K03947]
106994954  [KO:K02268]
106995399  [KO:K08738]
106996000  [KO:K02273]
106996033  [KO:K07375]
106998836  [KO:K02272]
107000976  [KO:K11351]
114669847  [KO:K03938]
114669899  [KO:K03948]
114671073  [KO:K02272]
114671531  [KO:K03948]
114673005  [KO:K13241] [EC:1.14.13.39]
114673745  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
114673956  [KO:K02272]
114674848  [KO:K02270]
114675522  [KO:K03959]
114677410  [KO:K02272]
114678228  [KO:K02272]
114678786  [KO:K02272]
114679364  [KO:K02272]
114679428  [KO:K02272]
114680400  [KO:K02272]
2846621  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
2846622  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
2846623  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
2846624  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
2846625  CYTB; cytochrome b [KO:K00412]
2846626  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
2846627  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
2846628  COX2; cytochrome c oxidase subunit II [KO:K02261]
2846629  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
2846630  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
2846631  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
2846632  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
2846633  COX3; cytochrome c oxidase subunit III [KO:K02262]
574113  TUBB; tubulin beta chain [KO:K07375]
574137  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
574194  TUBA1A; tubulin alpha-1A chain [KO:K07374]
574230  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 precursor [KO:K04809]
574258  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
574260  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
574265  CTNNB1; catenin beta-1 [KO:K02105]
574327  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
574330  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
574332  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
574353  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
574362  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
574380  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
619181  RTN4; reticulon-4 [KO:K20720]
641333  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
677719  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
677864  UQCRC1; cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
692060  COX7AH; cytochrome c oxidase subunit 7AH [KO:K02270]
692061  COX5A; cytochrome c oxidase subunit 5A, mitochondrial precursor [KO:K02264]
692062  COX6B1; cytochrome c oxidase subunit 6B1 [KO:K02267]
693340  KIF5C; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
693419  WNT7A; protein Wnt-7a [KO:K00572]
693431  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial isoform X1 [KO:K03958]
693443  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
693482  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
693502  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
693506  [KO:K03938]
693554  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
693577  [KO:K03064]
693753  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
693781  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
693811  COX4I1; cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
693889  TUBB1; tubulin beta-1 chain [KO:K07375]
693918  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
693924  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
693986  SLC11A2; natural resistance-associated macrophage protein 2 [KO:K21398]
694069  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
694164  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
694260  [KO:K02128]
694318  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
694429  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 [KO:K06059] [EC:3.4.24.86]
694473  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
694520  [KO:K03949]
694544  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
694567  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
694625  FZD6; frizzled-6 precursor [KO:K02376]
694635  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
694725  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
694795  [KO:K03959]
694869  DKK2; dickkopf-related protein 2 [KO:K02165]
694996  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
695066  [KO:K03949]
695102  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
695113  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
695190  CSNK1A1L; casein kinase I isoform alpha-like [KO:K08957] [EC:2.7.11.1]
695406  SLC39A11; zinc transporter ZIP11 isoform X2 [KO:K14717]
695677  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
695843  LRP6; low-density lipoprotein receptor-related protein 6 precursor [KO:K03068]
696133  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
696144  [KO:K02128]
696200  WNT3A; protein Wnt-3a [KO:K00312]
696274  PSEN1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
696326  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
696429  NAE1; NEDD8-activating enzyme E1 regulatory subunit [KO:K04532]
696542  CYBB; cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
696652  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396] [EC:5.6.1.3]
696669  SLC39A10; zinc transporter ZIP10 precursor [KO:K14716]
696845  WNT11; protein Wnt-11 isoform X2 [KO:K01384]
696954  ATG101; autophagy-related protein 101 [KO:K19730]
696956  [KO:K02266]
696966  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
697242  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
697252  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
697409  [KO:K02264]
697633  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
697681  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X2 [KO:K03954]
697694  BACE1; beta-secretase 1 precursor [KO:K04521] [EC:3.4.23.46]
697736  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
697745  NDUFB1; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
697747  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
697756  NRBF2; nuclear receptor-binding factor 2 [KO:K21246]
697799  PSMC1; proteasome (prosome, macropain) 26S subunit, ATPase, 1 [KO:K03062]
697843  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
697950  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
697967  UQCRC2; cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
698225  [KO:K08738]
698349  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
698356  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
698435  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
698480  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
698536  IRS2; insulin receptor substrate 2 [KO:K07187]
698552  CALM1; calmodulin-1 isoform X1 [KO:K02183]
698569  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
698571  GRIN2B; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
698601  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
698640  IDE; insulin-degrading enzyme [KO:K01408] [EC:3.4.24.56]
698706  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
698712  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
698770  PSEN2; presenilin-2 [KO:K04522] [EC:3.4.23.-]
698830  HRAS; GTPase HRas [KO:K02833]
698996  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
699117  [KO:K02138]
699216  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
699231  [KO:K07375]
699575  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
699631  [KO:K02730] [EC:3.4.25.1]
699736  MAPK10; mitogen-activated protein kinase 10 isoform 1 [KO:K04440] [EC:2.7.11.24]
699810  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
699847  PSMC4; 26S protease regulatory subunit 6B [KO:K03063]
699928  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
699951  [KO:K08738]
700018  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
700087  [KO:K00411] [EC:7.1.1.8]
700193  IL1A; interleukin-1 alpha precursor [KO:K04383]
700251  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
700338  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
700518  CYC1; cytochrome c1, heme protein, mitochondrial [KO:K00413]
700565  CSNK1E; casein kinase I isoform epsilon [KO:K08960] [EC:2.7.11.1]
700573  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
700591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
700692  WNT10A; protein Wnt-10a [KO:K01357]
700718  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
700815  [KO:K02128]
700944  NDUFB3; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
701029  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
701063  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
701128  SLC39A12; zinc transporter ZIP12 isoform X3 [KO:K14718]
701174  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
701223  [KO:K00417]
701237  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
701246  [KO:K08738]
701347  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
701355  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 isoform X1 [KO:K06704] [EC:3.4.24.81]
701376  NOX1; NADPH oxidase 1 [KO:K08008]
701389  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
701661  [KO:K02265]
701683  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
701951  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
701966  [KO:K00236]
702309  [KO:K00236]
702488  [KO:K08738]
702532  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
702583  TUBA4A; tubulin alpha-4A chain isoform X1 [KO:K07374]
702781  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
702893  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
702966  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
702997  DKK1; dickkopf-related protein 1 precursor [KO:K02165]
703019  TUBB4A; tubulin beta-4A chain [KO:K07375]
703047  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
703064  FZD7; frizzled-7 [KO:K02432]
703514  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
703669  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
703685  [KO:K02268]
703751  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
703846  IRS4; insulin receptor substrate 4 [KO:K17446]
703942  FZD1; frizzled-1 [KO:K02432]
703965  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
704072  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
704137  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X2 [KO:K03937]
704257  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
704336  [KO:K00236]
704534  INS; insulin [KO:K04526]
704683  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
704701  IL1B; interleukin-1 beta precursor [KO:K04519]
704754  FZD4; frizzled-4 precursor [KO:K02354]
704867  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
704991  WNT2; protein Wnt-2 precursor [KO:K00182]
705004  [KO:K03947]
705011  DKK4; dickkopf-related protein 4 [KO:K02165]
705035  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
705112  SLC39A2; zinc transporter ZIP2 isoform X1 [KO:K14709]
705116  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
705178  [KO:K00411] [EC:7.1.1.8]
705445  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
705449  [KO:K08738]
705581  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
705609  FRAT1; proto-oncogene FRAT1 [KO:K03069]
705680  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
705692  WNT5A; protein Wnt-5a isoform X2 [KO:K00444]
705718  APH1B; gamma-secretase subunit APH-1B isoform X1 [KO:K06172]
705730  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
705773  WNT2B; protein Wnt-2b [KO:K00182]
705819  IL6; interleukin-6 precursor [KO:K05405]
705864  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
705931  NOX4; NADPH oxidase 4 isoform X5 [KO:K21423] [EC:1.6.3.-]
705944  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
705984  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
706009  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
706067  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
706099  COX7B; cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
706351  [KO:K02183]
706483  APH1A; gamma-secretase subunit APH-1A [KO:K06172]
706691  [KO:K02128]
706912  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
706921  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
706955  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X7 [KO:K04348] [EC:3.1.3.16]
706985  SNCA; alpha-synuclein isoform X1 [KO:K04528]
707169  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
707215  [KO:K07374]
707227  [KO:K02265]
707310  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
707345  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
707476  [KO:K02128]
707667  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
707768  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X3 [KO:K05853] [EC:7.2.2.10]
707864  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
707870  IRS1; insulin receptor substrate 1 [KO:K16172]
707968  UQCRH; cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
707977  KRAS; GTPase KRas [KO:K07827]
708018  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
708058  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
708233  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
708333  SLC39A4; zinc transporter ZIP4 isoform X4 [KO:K14710]
708334  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
708368  FZD8; frizzled-8 [KO:K02375]
708391  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
708396  UQCR; ubiquinol-cytochrome c reductase, 6.4kDa subunit [KO:K00420]
708411  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
708415  TUBB2B; tubulin beta-2B chain [KO:K07375]
708606  FADD; FAS-associated death domain protein [KO:K02373]
708706  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
708714  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
708821  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
708901  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
708906  WNT10B; protein Wnt-10b precursor [KO:K01357]
708912  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
708938  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
708950  UQCRQ; ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa [KO:K00418]
708952  [KO:K07375]
709009  WNT1; proto-oncogene Wnt-1 [KO:K03209]
709089  NRAS; GTPase NRas [KO:K07828]
709313  SLC39A6; zinc transporter ZIP6 isoform X1 [KO:K14712]
709331  TUBB8; tubulin beta-8 chain [KO:K07375]
709426  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
709511  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3 [KO:K04467] [EC:2.7.11.10]
709640  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
709643  TUBA1B; tubulin alpha-1B chain [KO:K07374]
709746  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
709773  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
709959  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
710028  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
710042  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
710045  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
710075  PSMA8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
710077  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
710110  [KO:K07374]
710142  SLC39A8; zinc transporter ZIP8 isoform X1 [KO:K14714]
710150  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
710242  WNT8B; protein Wnt-8b [KO:K00714]
710274  [KO:K02265]
710324  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
710330  RB1CC1; RB1-inducible coiled-coil protein 1 [KO:K17589]
710378  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
710415  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
710417  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
710521  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
710552  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
710702  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X3 [KO:K05853] [EC:7.2.2.10]
710708  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
710734  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
710775  CSNK1A1; casein kinase I isoform alpha [KO:K08957] [EC:2.7.11.1]
710796  FZD5; frizzled-5 [KO:K02375]
710822  PSMC6; 26S proteasome regulatory subunit 10B isoform X2 [KO:K03064]
710845  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
710965  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
711115  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
711212  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951]
711309  [KO:K08738]
711326  SDHD; succinate dehydrogenase complex, subunit D, integral membrane protein [KO:K00237]
711382  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
711387  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
711412  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
711417  [KO:K02128]
711564  SLC39A3; zinc transporter ZIP3 isoform a [KO:K14709]
711649  BECN1; Beclin-1 [KO:K08334]
711724  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
711936  KIF5A; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
711970  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
712131  SLC39A5; zinc transporter ZIP5 [KO:K14711]
712148  [KO:K08738]
712159  CALML5; calmodulin-like protein 5 [KO:K02183]
712193  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
712381  FZD2; frizzled-2 [KO:K02235]
712421  [KO:K04380]
712430  SLC39A9; zinc transporter ZIP9 [KO:K14715]
712455  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
712467  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
712533  [KO:K07375]
712585  APBB1; amyloid-beta A4 precursor protein-binding family B member 1 isoform X8 [KO:K04529]
712764  COX7A2L; cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
712887  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
713040  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
713095  COX4I2; cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
713114  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
713284  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
713356  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
713420  SLC39A13; zinc transporter ZIP13 precursor [KO:K14719]
713428  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
713764  WNT8A; protein Wnt-8a [KO:K00714]
713768  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
713839  FZD3; frizzled-3 precursor [KO:K02329]
713863  XBP1; X-box-binding protein 1 isoform XBP1(U) [KO:K09027]
713864  WNT7B; protein Wnt-7b isoform X2 [KO:K00572]
713995  COX6A2; cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
714274  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
714322  ATG13; autophagy-related protein 13 isoform X8 [KO:K08331]
714331  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
714381  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
714434  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
714445  CDK5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
714483  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
714623  APOE; LOW QUALITY PROTEIN: apolipoprotein E [KO:K04524]
714643  KLC2; kinesin light chain 2 [KO:K10407]
714717  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
714841  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
714901  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
715270  CALM2; calmodulin-2 [KO:K02183]
715330  BACE2; beta-secretase 2 isoform X1 [KO:K07747] [EC:3.4.23.45]
715431  BECN2; beclin-2 [KO:K08334]
715467  TNF; tumor necrosis factor [KO:K03156]
715782  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
715787  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
715807  CSNK2B; casein kinase II subunit beta [KO:K03115]
715919  RELA; transcription factor p65 isoform X1 [KO:K04735]
715994  SLC39A1; zinc transporter ZIP1 isoform X1 [KO:K14709]
716056  [KO:K08738]
716098  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
716112  SLC39A14; zinc transporter ZIP14 isoform X3 [KO:K14720]
716392  FZD9; frizzled-9 [KO:K02842]
716584  CALM3; calmodulin-3 isoform X1 [KO:K02183]
716618  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
716666  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
716671  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
716877  WNT9B; protein Wnt-9b [KO:K01064]
716909  WNT3; proto-oncogene Wnt-3 [KO:K00312]
717290  ATG2A; autophagy-related protein 2 homolog A isoform X5 [KO:K17906]
717296  AGER; advanced glycosylation end product-specific receptor precursor [KO:K19722]
717437  PSMC5; 26S protease regulatory subunit 8 [KO:K03066]
717686  [KO:K02183]
717740  BAD; bcl2-associated agonist of cell death [KO:K02158]
717751  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
717764  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
717812  FZD10; frizzled-10 [KO:K02842]
717849  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
717879  [KO:K02270]
717945  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
717953  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
718007  COX8A; cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
718012  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
718034  TUBA3E; tubulin alpha-3E chain [KO:K07374]
718040  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
718173  RTN3; reticulon-3 isoform X5 [KO:K20723]
718387  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
718418  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
718553  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
718566  AXIN2; axin-2 isoform X1 [KO:K04385]
718756  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
718945  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
719367  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
719696  NCSTN; nicastrin precursor [KO:K06171]
719811  [KO:K05863]
719935  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
719978  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
720056  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
720175  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
720636  [KO:K00419]
720677  [KO:K07375]
721259  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
721605  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
721639  [KO:K03935] [EC:7.1.1.2]
721685  WNT5B; protein Wnt-5b [KO:K00444]
721721  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X13 [KO:K04850]
721821  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
721897  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
721906  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial isoform X1 [KO:K03953]
722033  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
722117  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
722400  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
722506  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
722513  CALML3; calmodulin-like protein 3 [KO:K02183]
722862  [KO:K07375]
722929  [KO:K07375]
723069  [KO:K00234] [EC:1.3.5.1]
724039  CASP12; caspase-12 [KO:K04741] [EC:3.4.22.-]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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PMID:12805290
  Authors
Pigino G, Morfini G, Pelsman A, Mattson MP, Brady ST, Busciglio J
  Title
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport.
  Journal
J Neurosci 23:4499-508 (2003)
DOI:10.1523/JNEUROSCI.23-11-04499.2003
Reference
PMID:15645263
  Authors
Roy S, Zhang B, Lee VM, Trojanowski JQ
  Title
Axonal transport defects: a common theme in neurodegenerative diseases.
  Journal
Acta Neuropathol 109:5-13 (2005)
DOI:10.1007/s00401-004-0952-x
Reference
PMID:26074767
  Authors
Ferreira ST, Lourenco MV, Oliveira MM, De Felice FG
  Title
Soluble amyloid-beta oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease.
  Journal
Front Cell Neurosci 9:191 (2015)
DOI:10.3389/fncel.2015.00191
Reference
PMID:24529521
  Authors
De Felice FG, Lourenco MV, Ferreira ST
  Title
How does brain insulin resistance develop in Alzheimer's disease?
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Alzheimers Dement 10:S26-32 (2014)
DOI:10.1016/j.jalz.2013.12.004
Reference
PMID:26136647
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Bedse G, Di Domenico F, Serviddio G, Cassano T
  Title
Aberrant insulin signaling in Alzheimer's disease: current knowledge.
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Front Neurosci 9:204 (2015)
DOI:10.3389/fnins.2015.00204
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PMID:20101724
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Funderburk SF, Marcellino BK, Yue Z
  Title
Cell "self-eating" (autophagy) mechanism in Alzheimer's disease.
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Mt Sinai J Med 77:59-68 (2010)
DOI:10.1002/msj.20161
Related
pathway
mcc00190  Oxidative phosphorylation
mcc03050  Proteasome
mcc04020  Calcium signaling pathway
mcc04140  Autophagy - animal
mcc04141  Protein processing in endoplasmic reticulum
mcc04210  Apoptosis
mcc04310  Wnt signaling pathway
mcc04910  Insulin signaling pathway
mcc04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   

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