KEGG   PATHWAY: mcc04010
Entry
mcc04010                    Pathway                                
Name
MAPK signaling pathway - Macaca mulatta (rhesus monkey)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
mcc04010  MAPK signaling pathway
mcc04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100424131  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
100424593  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
100424606  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100428682  PPP3R1; calcineurin subunit B type 1 isoform X3 [KO:K06268]
100429106  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
100533113  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
106992315  TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
106994852  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
114669851  [KO:K05092] [EC:2.7.10.1]
114669856  [KO:K03283]
114669860  NFKB2; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p100 subunit [KO:K04469]
114672301  [KO:K04375]
114673968  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
114675335  [KO:K04388] [EC:2.7.11.30]
574133  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
574136  FGF2; fibroblast growth factor 2 [KO:K18497]
574159  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
574209  VEGFA; vascular endothelial growth factor A isoform 1 precursor [KO:K05448]
574254  KITLG; kit ligand isoform X1 [KO:K05461]
574258  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
574304  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
574327  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
574332  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
574345  FGF7; fibroblast growth factor 7 precursor [KO:K04358]
574387  IL1RAP; interleukin-1 receptor accessory protein precursor [KO:K04723]
613027  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
613031  TGFA; protransforming growth factor alpha isoform X2 [KO:K08774]
677693  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
677710  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
692343  EPHA2; ephrin type-A receptor 2 precursor [KO:K05103] [EC:2.7.10.1]
693341  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
693356  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
693554  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
693750  [KO:K07836]
693835  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X2 [KO:K04417] [EC:2.7.11.25]
693914  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
693924  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
694085  RASA1; ras GTPase-activating protein 1 [KO:K04352]
694259  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
694473  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
694626  MYC; myc proto-oncogene protein [KO:K04377]
694725  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
694992  MEF2C; myocyte-specific enhancer factor 2C [KO:K04454]
695044  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X2 [KO:K04443] [EC:2.7.11.1]
695172  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
695250  ARRB1; beta-arrestin-1 isoform X4 [KO:K04439]
695864  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X2 [KO:K04862]
695896  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
696161  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
696294  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
696332  DUSP16; dual specificity protein phosphatase 16 isoform X2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
696494  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
696584  CRKL; crk-like protein [KO:K04438]
696709  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
696759  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
696797  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X2 [KO:K04465]
696825  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
696875  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
696936  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
697002  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
697017  ANGPT1; angiopoietin-1 precursor [KO:K05465]
697336  NRTN; neurturin [KO:K25414]
697482  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
697573  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
697747  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
697835  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
698089  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
698160  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
698178  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
698274  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
698293  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
698444  IGF1; insulin-like growth factor I precursor [KO:K05459]
698473  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
698494  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
698569  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
698585  PAK1; serine/threonine-protein kinase PAK 1 isoform X5 [KO:K04409] [EC:2.7.11.1]
698603  MECOM; histone-lysine N-methyltransferase MECOM isoform X2 [KO:K04462] [EC:2.1.1.367]
698619  EGF; pro-epidermal growth factor isoform X2 [KO:K04357]
698830  HRAS; GTPase HRas [KO:K02833]
698861  SRF; serum response factor isoform X1 [KO:K04378]
699072  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
699281  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
699331  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
699480  PSPN; persephin [KO:K25416]
699502  VEGFC; vascular endothelial growth factor C precursor [KO:K05449]
699524  FLNA; filamin-A isoform X1 [KO:K04437]
699700  RRAS2; ras-related protein R-Ras2 [KO:K07830]
699736  MAPK10; mitogen-activated protein kinase 10 isoform 1 [KO:K04440] [EC:2.7.11.24]
699798  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
699919  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
700126  FGFR1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
700193  IL1A; interleukin-1 alpha precursor [KO:K04383]
700236  PDGFC; platelet-derived growth factor C [KO:K05450]
700477  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
700568  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
700591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
700652  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
701054  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
701085  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
701185  CRK; adapter molecule crk isoform X1 [KO:K04438]
701195  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
701219  PGF; placenta growth factor isoform X2 [KO:K16859]
701226  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863]
701237  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
701245  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
701320  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
701324  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
701584  FGF10; fibroblast growth factor 10 precursor [KO:K04358]
701641  ARTN; artemin [KO:K25415]
701847  FGF20; fibroblast growth factor 20 [KO:K04358]
702041  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
702072  FGF18; fibroblast growth factor 18 [KO:K04358]
702077  FOS; proto-oncogene c-Fos [KO:K04379]
702388  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X2 [KO:K04436]
702390  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X2 [KO:K17333]
702396  AREG; amphiregulin [KO:K09782]
702429  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X7 [KO:K04859]
702502  EREG; proepiregulin [KO:K09784]
702532  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
702727  FGF22; fibroblast growth factor 22 precursor [KO:K04358]
702837  MAPK7; mitogen-activated protein kinase 7 isoform X4 [KO:K04464] [EC:2.7.11.24]
702981  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
702987  PPM1A; protein phosphatase 1A isoform X2 [KO:K04457] [EC:3.1.3.16]
703059  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
703088  TGFBR2; TGF-beta receptor type-2 precursor [KO:K04388] [EC:2.7.11.30]
703101  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
703173  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
703239  TGFB3; transforming growth factor beta-3 precursor [KO:K13377]
703409  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
703466  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
703838  RASGRP1; RAS guanyl-releasing protein 1 isoform X3 [KO:K04350]
703965  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
704310  PDGFD; platelet-derived growth factor D isoform X2 [KO:K05450]
704351  EFNA5; ephrin-A5 precursor [KO:K05462]
704404  RAP1A; ras-related protein Rap-1A [KO:K04353]
704534  INS; insulin [KO:K04526]
704562  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
704683  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
704701  IL1B; interleukin-1 beta precursor [KO:K04519]
704717  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X13 [KO:K08018]
705056  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
705195  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
705601  SOS2; son of sevenless homolog 2 [KO:K03099]
705612  FGF16; fibroblast growth factor 16 [KO:K04358]
705970  FGF1; fibroblast growth factor 1 [KO:K18496]
706009  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
706230  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
706254  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X3 [KO:K18019] [EC:3.1.3.48]
706345  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
706659  FGF17; fibroblast growth factor 17 precursor [KO:K04358]
706955  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X7 [KO:K04348] [EC:3.1.3.16]
707169  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
707225  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
707425  STK3; serine/threonine-protein kinase 3 [KO:K04412]
707455  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
707540  TGFB2; transforming growth factor beta-2 precursor [KO:K13376]
707592  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
707637  CDC42; cell division control protein 42 homolog [KO:K04393]
707690  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
707725  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
707777  TAOK2; serine/threonine-protein kinase TAO2 isoform X2 [KO:K04429] [EC:2.7.11.1]
707977  KRAS; GTPase KRas [KO:K07827]
707989  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
708091  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 [KO:K04864]
708146  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
708151  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
708215  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
708227  IGF1R; insulin-like growth factor 1 receptor precursor [KO:K05087] [EC:2.7.10.1]
708228  MAX; protein max [KO:K04453]
708233  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
708316  HGF; hepatocyte growth factor isoform X3 [KO:K05460]
708391  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
708706  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
708907  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
708918  FGF3; fibroblast growth factor 3 precursor [KO:K04358]
708938  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
709016  FGF4; fibroblast growth factor 4 [KO:K04358]
709089  NRAS; GTPase NRas [KO:K07828]
709109  FGF19; fibroblast growth factor 19 [KO:K22603]
709133  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
709399  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
709412  [KO:K03283]
709511  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3 [KO:K04467] [EC:2.7.11.10]
709728  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
709757  NTRK2; BDNF/NT-3 growth factors receptor precursor [KO:K04360] [EC:2.7.10.1]
709773  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
710061  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X3 [KO:K04372] [EC:2.7.11.1]
710077  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
710314  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
710324  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
710337  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
710360  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
710415  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
710643  FGF23; fibroblast growth factor 23 precursor [KO:K22428]
710739  FGF6; fibroblast growth factor 6 [KO:K04358]
710802  IGF2; insulin-like growth factor II isoform X2 [KO:K13769]
710979  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
711115  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
711257  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
711350  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
711353  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
711382  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
711407  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
711416  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
711512  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
711672  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X4 [KO:K04463] [EC:2.7.12.2]
711681  NGF; beta-nerve growth factor [KO:K02582]
711726  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
712421  [KO:K04380]
712610  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
712654  VEGFD; vascular endothelial growth factor D [KO:K05449]
712755  MAP3K21; mitogen-activated protein kinase kinase kinase MLK4 [KO:K17534] [EC:2.7.11.25]
712829  FGFR3; fibroblast growth factor receptor 3 isoform X10 [KO:K05094] [EC:2.7.10.1]
712911  NF1; neurofibromin isoform X1 [KO:K08052]
713521  MAPKAPK5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
713686  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
713777  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
713918  PPM1B; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
713952  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
714290  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
714677  RELB; transcription factor RelB isoform X1 [KO:K09253]
714689  [KO:K04469]
714717  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
714794  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
714805  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
714901  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
714950  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X2 [KO:K04434]
714952  TGFBR1; TGF-beta receptor type-1 isoform X2 [KO:K04674] [EC:2.7.11.30]
715074  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
715213  ANGPT4; angiopoietin-4 [KO:K05467]
715467  TNF; tumor necrosis factor [KO:K03156]
715615  HSPB1; heat shock protein beta-1 [KO:K04455]
715745  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
715782  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
715787  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
715794  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
715911  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
715919  RELA; transcription factor p65 isoform X1 [KO:K04735]
715949  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
716038  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
716170  TP53; cellular tumor antigen p53 [KO:K04451]
716214  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
716258  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
716352  MRAS; ras-related protein M-Ras [KO:K07831]
716412  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
716452  JUN; transcription factor AP-1 [KO:K04448]
716595  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
716633  [KO:K03283]
716635  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
716811  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
716899  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
716907  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
717161  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
717315  EFNA4; ephrin-A4 isoform X2 [KO:K05462]
717373  EFNA3; ephrin-A3 precursor [KO:K05462]
717399  EFNA1; ephrin-A1 [KO:K05462]
717573  CDC25B; M-phase inducer phosphatase 2 isoform X6 [KO:K05866] [EC:3.1.3.48]
717574  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
717590  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
717730  STK4; serine/threonine-protein kinase 4 [KO:K04411]
717755  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
717866  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
718092  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
718155  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
718171  RAP1B; ras-related protein Rap-1b [KO:K07836]
718288  FGF21; fibroblast growth factor 21 [KO:K22429]
718291  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X5 [KO:K04344]
718412  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
718442  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
718465  CACNG5; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
718510  [KO:K16342] [EC:3.1.1.4]
718534  NTF4; neurotrophin-4 precursor [KO:K12457]
718540  CACNG4; voltage-dependent calcium channel gamma-4 subunit isoform X2 [KO:K04869]
718582  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
718591  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
718632  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
718939  RRAS; ras-related protein R-Ras [KO:K07829]
718976  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
719085  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
719239  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X2 [KO:K05454]
719305  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
719595  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
719670  NTRK1; high affinity nerve growth factor receptor isoform X3 [KO:K03176] [EC:2.7.10.1]
719733  STMN1; stathmin isoform X1 [KO:K04381]
720001  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
720054  HSPA1A; heat shock 70 kDa protein 1A [KO:K03283]
720182  JUND; transcription factor jun-D [KO:K04449]
720263  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
720271  CACNG7; voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872]
720548  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
720708  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
720960  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
721231  EFNA2; ephrin-A2 [KO:K05462]
721324  FGF9; fibroblast growth factor 9 [KO:K04358]
721436  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
721452  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
721703  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
721712  FLT3; LOW QUALITY PROTEIN: receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
721721  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X13 [KO:K04850]
721821  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
721988  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
722033  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
722044  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
722115  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
722394  FGF8; fibroblast growth factor 8 [KO:K04358]
722407  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
mcc04070  Phosphatidylinositol signaling system
mcc04110  Cell cycle
mcc04115  p53 signaling pathway
mcc04210  Apoptosis
mcc04310  Wnt signaling pathway
mcc04668  TNF signaling pathway
KO pathway
ko04010   

DBGET integrated database retrieval system