KEGG   PATHWAY: mcep04150
Entry
mcep04150                   Pathway                                
Name
mTOR signaling pathway - Mugil cephalus (flathead mullet)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
mcep04150  mTOR signaling pathway
mcep04150

Organism
Mugil cephalus (flathead mullet) [GN:mcep]
Gene
124995651  atp6v1ab; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
124995767  fzd8a; frizzled-8a [KO:K02375]
124995805  tti1; TELO2-interacting protein 1 homolog [KO:K20403]
124995848  rnf152; E3 ubiquitin-protein ligase rnf152 [KO:K15705] [EC:2.3.2.27]
124995887  [KO:K15728] [EC:3.1.3.4]
124996243  clip1b; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
124996351  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
124996387  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
124996456  [KO:K00572]
124996605  tsc1b; TSC complex subunit 1b isoform X1 [KO:K07206]
124996632  ulk1b; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
124996827  slc38a9; sodium-coupled neutral amino acid transporter 9 [KO:K14995]
124996844  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
124996872  atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
124996961  atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
124997025  mapkap1; target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
124997069  [KO:K07205]
124997260  wnt9b; protein Wnt-9b [KO:K01064]
124997478  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
124997521  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
124997541  zgc:55558; GTPase KRas [KO:K07827]
124997582  strada; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
124997632  akt1s1; uncharacterized protein akt1s1 [KO:K16184]
124997679  nprl3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
124997813  dvl2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
124997961  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
124998106  fzd2; frizzled-2 [KO:K02235]
124998162  [KO:K04364]
124998181  igf3; insulin-like growth factor 3 [KO:K05459]
124998775  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
124998970  sgk1; serine/threonine-protein kinase Sgk1 [KO:K13302] [EC:2.7.11.1]
124999002  fzd3a; frizzled-3a [KO:K02329]
124999107  raf1a; raf-1 proto-oncogene, serine/threonine kinase A isoform X1 [KO:K04366] [EC:2.7.11.1]
124999262  lpin1b; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
124999669  [KO:K20411]
124999937  atp6v1e1b; V-type proton ATPase subunit E 1 [KO:K02150]
124999969  wnt5b; protein Wnt-5b isoform X1 [KO:K00444]
125000013  wnt16; protein Wnt-16 [KO:K01558]
125000036  braF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
125000121  wnt7ba; protein Wnt-7b [KO:K00572]
125000293  lrp6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
125000330  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
125000769  stradb; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
125001119  [KO:K02432]
125001256  cab39l; calcium-binding protein 39-like [KO:K08272]
125003616  [KO:K19662] [EC:2.7.11.13]
125003676  [KO:K03099]
125003808  lamtor5; ragulator complex protein LAMTOR5 [KO:K16344]
125003829  rps6; 40S ribosomal protein S6 [KO:K02991]
125004033  rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
125004237  [KO:K04688] [EC:2.7.11.1]
125004240  tsc2; tuberin isoform X1 [KO:K07207]
125004243  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
125004613  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125005026  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
125005277  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
125005318  lpin1a; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
125005555  wdr59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
125005737  [KO:K02329]
125005788  rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
125006180  mtoR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
125006336  [KO:K15728] [EC:3.1.3.4]
125006357  [KO:K00182]
125006553  eif4ba; eukaryotic translation initiation factor 4Ba isoform X1 [KO:K03258]
125006618  nprl2; GATOR complex protein NPRL2 isoform X1 [KO:K20405]
125006645  [KO:K04513]
125006978  rhebl1; ras homolog, mTORC1 binding like 1 [KO:K07208]
125007017  si:dkeyp-97e7.9; DEP domain-containing mTOR-interacting protein [KO:K20402]
125007175  sec13; protein SEC13 homolog [KO:K14004]
125007385  rhoca; ras homolog family member Ca isoform X1 [KO:K04513]
125007433  wnt7aa; wingless-type MMTV integration site family, member 7Aa [KO:K00572]
125007451  wnt4; protein Wnt-4a [KO:K00408]
125007653  [KO:K03259]
125007797  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
125008288  [KO:K00714]
125008333  cab39l1; calcium binding protein 39, like 1 [KO:K08272]
125008585  [KO:K00714]
125008716  insB; preproinsulin B [KO:K04526]
125009165  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
125009281  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) [KO:K02649]
125009384  [KO:K00922] [EC:2.7.1.153]
125009454  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
125009551  insrb; insulin receptor B [KO:K04527] [EC:2.7.10.1]
125009744  [KO:K02649]
125009876  tbc1d7; TBC1 domain family member 7 [KO:K20396]
125009969  eif4e2rs1; eukaryotic translation initiation factor 4E family member 2 related sequence 1 [KO:K03259]
125010183  wnt3a; protein Wnt-3a [KO:K00312]
125010331  eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
125010352  rheB; GTP-binding protein Rheb [KO:K07208]
125010363  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
125010445  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
125010528  [KO:K02353]
125010654  map2k2b; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
125010694  atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
125010721  insra; insulin receptor A [KO:K04527] [EC:2.7.10.1]
125010793  [KO:K00922] [EC:2.7.1.153]
125010868  depdc5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
125011166  wnt10b; protein Wnt-10b isoform X1 [KO:K01357]
125011172  wnt1; protein Wnt-1 [KO:K03209]
125011199  [KO:K02649]
125011292  lpin2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
125011383  wnt9a; protein Wnt-9a [KO:K01064]
125011444  [KO:K02375]
125011644  ulk1a; serine/threonine-protein kinase ULK1a isoform X1 [KO:K21357] [EC:2.7.11.1]
125011811  [KO:K00182]
125011866  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
125011903  [KO:K04513]
125011912  [KO:K04513]
125011991  [KO:K08267]
125012106  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
125012116  clip1a; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
125012205  [KO:K07205]
125012374  tsc1a; TSC complex subunit 1a isoform X1 [KO:K07206]
125012379  fzd10; frizzled-10 [KO:K02842]
125012522  castor1; cytosolic arginine sensor for mTORC1 subunit 1 [KO:K23080]
125012779  [KO:K02649]
125013182  cab39; calcium-binding protein 39 [KO:K08272]
125013331  ulk2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
125013336  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
125013339  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125013393  lamtor1; ragulator complex protein LAMTOR1 [KO:K20397]
125013427  rps6kb1b; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
125013584  [KO:K06519]
125013655  fzd4; frizzled-4 [KO:K02354]
125013716  [KO:K16172]
125013756  [KO:K02353]
125014012  fzd9b; frizzled-9b [KO:K02842]
125014422  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
125014660  kraS; GTPase KRas [KO:K07827]
125014677  lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
125014703  slc7a5; large neutral amino acids transporter small subunit 1 [KO:K13780]
125014842  atp6v1e1a; V-type proton ATPase subunit E 1a [KO:K02150]
125014921  prr5a; proline-rich protein 5a isoform X1 [KO:K20411]
125015016  [KO:K02833]
125015166  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
125015177  prr5l; proline-rich protein 5-like isoform X1 [KO:K20411]
125015422  wnt2; protein Wnt-2 [KO:K00182]
125015511  wnt7bb; protein Wnt-7b isoform X1 [KO:K00572]
125015966  flcN; folliculin [KO:K09594]
125015974  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
125016123  grb10b; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
125016180  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
125016263  [KO:K02376]
125016276  lamtor2; ragulator complex protein LAMTOR2 [KO:K20398]
125016398  rragca; ras-related GTP binding Ca [KO:K16186]
125016425  wnt4b; wingless-type MMTV integration site family, member 4b [KO:K00408]
125016609  mioS; GATOR complex protein MIOS isoform X1 [KO:K20407]
125016620  fzd1; frizzled-1 [KO:K02432]
125016734  deptor; DEP domain-containing mTOR-interacting protein [KO:K20402]
125016755  sgk2b; serine/threonine-protein kinase Sgk2b [KO:K13302] [EC:2.7.11.1]
125016847  seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
125016926  [KO:K02148]
125017203  wnt10a; protein Wnt-10a [KO:K01357]
125017242  wnt6b; protein Wnt-6 [KO:K00445]
125017536  fzd5; frizzled-5 [KO:K02375]
125017682  [KO:K02432]
125017729  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
125018238  [KO:K13780]
125018358  [KO:K04467] [EC:2.7.11.10]
125018547  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125018681  wnt8b; protein Wnt-8b [KO:K00714]
125018745  atp6v1ba; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
125018803  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
125018810  eif4e1c; eukaryotic translation initiation factor 4E family member 1c [KO:K03259]
125018904  [KO:K08270]
125019595  rragcb; ras-related GTP binding Cb [KO:K16186]
125019646  [KO:K20064]
125019992  [KO:K13302] [EC:2.7.11.1]
125020172  tnfA; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
125020226  sesn2; sestrin-2 isoform X1 [KO:K20394]
125020370  atp6v1c1b; V-type proton ATPase subunit C 1-B [KO:K02148]
125020689  wnt11; protein Wnt-11 [KO:K01384]
125020875  [KO:K04456] [EC:2.7.11.1]
125021007  [KO:K16172]
125021028  fnip1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
125021079  rps6kb1a; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
125021226  ins; insulin [KO:K04526]
125021254  castor2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
125021419  [KO:K02145] [EC:7.1.2.2]
125021743  rraga; ras-related GTP-binding protein A [KO:K16185]
125021939  telo2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
125022051  wnt3; proto-oncogene Wnt-3 [KO:K00312]
125022104  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
125022245  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
125022303  slc3a2a; solute carrier family 3 member 2a [KO:K06519]
125022454  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
125022627  wdr24; GATOR complex protein WDR24 [KO:K20408]
125022650  [KO:K04467] [EC:2.7.11.10]
125022850  mlst8; target of rapamycin complex subunit lst8 [KO:K08266]
125023028  dvl1a; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
125023226  eif4eb; eukaryotic translation initiation factor 4eb [KO:K03259]
125023452  sos2; son of sevenless homolog 2 [KO:K03099]
125023675  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125023858  atp6v1c2; V-type proton ATPase subunit C 1-B [KO:K02148]
125024110  [KO:K00444]
125024169  [KO:K06519]
125024209  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
125024240  lamtor3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
125024403  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
125024467  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
mcep00561  Glycerolipid metabolism
mcep04010  MAPK signaling pathway
mcep04140  Autophagy - animal
mcep04810  Regulation of actin cytoskeleton
mcep04910  Insulin signaling pathway
KO pathway
ko04150   

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