KEGG   PATHWAY: mcep04010
Entry
mcep04010                   Pathway                                
Name
MAPK signaling pathway - Mugil cephalus (flathead mullet)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
mcep04010  MAPK signaling pathway
mcep04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Mugil cephalus (flathead mullet) [GN:mcep]
Gene
124995437  [KO:K05092] [EC:2.7.10.1]
124995438  [KO:K05092] [EC:2.7.10.1]
124995439  [KO:K05092] [EC:2.7.10.1]
124995576  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
124995619  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
124995666  map3k22; mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
124995915  mycA; transcriptional regulator Myc-A isoform X1 [KO:K04377]
124995917  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
124995988  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
124996063  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
124996347  rasgrf2a; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
124996417  [KO:K04362] [EC:2.7.10.1]
124996426  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
124996469  [KO:K05462]
124996560  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
124996569  mef2ca; myocyte enhancer factor 2ca isoform X1 [KO:K04454]
124996613  taok3b; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
124996614  [KO:K04455]
124996628  cacna1bb; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
124996651  erbb3b; receptor tyrosine-protein kinase ErbB-3b isoform X1 [KO:K05084] [EC:2.7.10.1]
124996666  crkL; crk-like protein [KO:K04438]
124996760  [KO:K04402]
124996807  gdnfa; glial cell line-derived neurotrophic factor [KO:K05452]
124996826  junE; JunE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
124996949  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
124997018  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
124997035  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b isoform X1 [KO:K04360] [EC:2.7.10.1]
124997044  flnA; filamin-A isoform X1 [KO:K04437]
124997147  fgf10a; fibroblast growth factor 10a [KO:K04358]
124997156  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
124997163  [KO:K03173] [EC:2.3.2.27]
124997251  cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
124997305  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
124997404  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
124997412  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
124997473  map3k14a; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
124997477  [KO:K04855]
124997478  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
124997521  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
124997528  cacng3b; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
124997541  zgc:55558; GTPase KRas [KO:K07827]
124997565  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
124997569  [KO:K04345] [EC:2.7.11.11]
124997677  cacna1ia; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
124997758  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
124997914  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
124997942  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
124997944  map3k12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
124997961  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
124998015  [KO:K16342] [EC:3.1.1.4]
124998058  cacna1aa; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
124998068  atf4b; activating transcription factor 4b [KO:K04374]
124998073  [KO:K04392]
124998162  [KO:K04364]
124998181  igf3; insulin-like growth factor 3 [KO:K05459]
124998191  [KO:K04433] [EC:2.7.12.2]
124998192  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
124998208  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
124998222  pdgfab; platelet-derived growth factor alpha polypeptide B [KO:K04359]
124998255  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
124998278  taok2a; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
124998280  [KO:K03283]
124998282  [KO:K03283]
124998283  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
124998407  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
124998489  rraS; ras-related protein R-Ras [KO:K07830]
124998785  [KO:K04443] [EC:2.7.11.1]
124998805  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
124998818  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
124998932  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
124998938  max; protein max isoform X1 [KO:K04453]
124998958  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
124999107  raf1a; raf-1 proto-oncogene, serine/threonine kinase A isoform X1 [KO:K04366] [EC:2.7.11.1]
124999138  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
124999159  [KO:K04379]
124999160  [KO:K04379]
124999177  [KO:K16859]
124999390  [KO:K13377]
124999656  [KO:K04358]
124999704  fgf23; fibroblast growth factor 23 [KO:K22428]
124999725  hgfA; hepatocyte growth factor a isoform X1 [KO:K05460]
124999775  cacna2d1a; voltage-dependent calcium channel subunit alpha-2/delta-1a isoform X1 [KO:K04858]
124999830  [KO:K05461]
124999862  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
124999867  ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
124999895  [KO:K07836]
124999916  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
124999917  [KO:K04441] [EC:2.7.11.24]
124999936  [KO:K04359]
124999979  [KO:K04870]
125000014  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
125000036  braF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
125000297  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125000330  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
125000333  ntf3; neurotrophin-3 [KO:K04356]
125000377  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
125000784  [KO:K16342] [EC:3.1.1.4]
125000785  [KO:K16342] [EC:3.1.1.4]
125000900  [KO:K05085] [EC:2.7.10.1]
125000924  [KO:K04869]
125000954  [KO:K04865]
125000989  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
125001211  [KO:K16342] [EC:3.1.1.4]
125001212  [KO:K16342] [EC:3.1.1.4]
125001218  [KO:K16342] [EC:3.1.1.4]
125001251  [KO:K04407] [EC:2.7.11.1]
125001275  [KO:K05449]
125002981  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b isoform X1 [KO:K04344]
125003436  [KO:K04345] [EC:2.7.11.11]
125003457  [KO:K25416]
125003616  [KO:K19662] [EC:2.7.11.13]
125003653  vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
125003666  kitB; KIT proto-oncogene, receptor tyrosine kinase B [KO:K05091] [EC:2.7.10.1]
125003676  [KO:K03099]
125003850  [KO:K17386]
125003854  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
125003859  atf4a; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
125003866  [KO:K04867]
125003975  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
125004095  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
125004148  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
125004219  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
125004243  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
125004257  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
125004321  cacng3a; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
125004331  [KO:K04358]
125004376  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
125004483  [KO:K04856]
125004604  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125004613  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125004667  cacng1a; calcium channel, voltage-dependent, gamma subunit 1a [KO:K04866]
125004672  fgf8b; fibroblast growth factor 8b [KO:K04358]
125004998  fgf4; fibroblast growth factor 4 [KO:K04358]
125005105  fgf7; fibroblast growth factor 7 [KO:K04358]
125005122  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
125005277  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
125005365  rras2; ras-related protein R-Ras2 [KO:K07830]
125005464  [KO:K04434]
125005499  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
125005612  fgf3; fibroblast growth factor 3 [KO:K04358]
125005650  fgf19; fibroblast growth factor 19 [KO:K22603]
125005733  map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
125005746  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
125005756  [KO:K04349]
125005788  rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
125005964  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
125006007  bdnF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
125006106  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
125006186  [KO:K04423] [EC:2.7.11.25]
125006250  [KO:K05084] [EC:2.7.10.1]
125006265  [KO:K05103] [EC:2.7.10.1]
125006269  [KO:K04353]
125006406  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
125006514  [KO:K04465]
125006555  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
125006588  [KO:K04393]
125006589  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
125006714  [KO:K04443] [EC:2.7.11.1]
125006718  [KO:K04353]
125006787  elk4; ETS domain-containing protein Elk-4 [KO:K04376]
125006852  mycH; myelocytomatosis oncogene homolog [KO:K04377]
125006895  [KO:K04857]
125006927  [KO:K04859]
125006997  dusp7; LOW QUALITY PROTEIN: dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125007007  [KO:K04444] [EC:2.7.11.1]
125007110  [KO:K04411]
125007264  ngfB; nerve growth factor [KO:K02582]
125007356  tgfA; protransforming growth factor alpha isoform X1 [KO:K08774]
125007403  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
125007441  angpt4; angiopoietin-4 [KO:K05465]
125007461  [KO:K04444] [EC:2.7.11.1]
125007528  [KO:K04419] [EC:2.7.11.25]
125007620  pdgfc; platelet-derived growth factor C [KO:K05450]
125007697  fgf16; fibroblast growth factor 16 [KO:K04358]
125007797  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
125007804  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
125007822  [KO:K04407] [EC:2.7.11.1]
125007842  [KO:K02187] [EC:3.4.22.56]
125007855  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a isoform X1 [KO:K04864]
125007867  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
125007881  cd40lg; CD40 ligand [KO:K04389]
125007942  kdrL; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
125008120  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
125008164  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
125008175  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125008184  fgf2; fibroblast growth factor 2 [KO:K18497]
125008212  egf; pro-epidermal growth factor [KO:K04357]
125008222  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
125008328  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit isoform X1 [KO:K04853]
125008332  fgf1a; putative fibroblast growth factor 1 [KO:K18496]
125008350  fgf20b; fibroblast growth factor 20b [KO:K04358]
125008365  vegfba; vascular endothelial growth factor B [KO:K05448]
125008382  csf1ra; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
125008510  [KO:K04358]
125008660  fgf18a; fibroblast growth factor 18a isoform X1 [KO:K04358]
125008677  rapgef2b; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
125008708  fgf24; fibroblast growth factor 24 isoform X1 [KO:K04358]
125008712  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
125008716  insB; preproinsulin B [KO:K04526]
125008809  irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
125008931  [KO:K04345] [EC:2.7.11.11]
125008938  fgf22; fibroblast growth factor 22 [KO:K04358]
125008988  [KO:K25415]
125009018  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b [KO:K04372] [EC:2.7.11.1]
125009089  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
125009173  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
125009234  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
125009248  [KO:K04852]
125009338  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
125009354  [KO:K18019] [EC:3.1.3.48]
125009413  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
125009453  jun; transcription factor AP-1 [KO:K04448]
125009454  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
125009551  insrb; insulin receptor B [KO:K04527] [EC:2.7.10.1]
125009643  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
125009650  kitA; mast/stem cell growth factor receptor kita isoform X1 [KO:K05091] [EC:2.7.10.1]
125009703  [KO:K16342] [EC:3.1.1.4]
125009705  [KO:K04449]
125009799  [KO:K04402]
125009811  [KO:K05462]
125009995  gadd45ab; growth arrest and DNA-damage-inducible, alpha, B [KO:K04402]
125010171  [KO:K25415]
125010175  [KO:K25414]
125010254  [KO:K04451]
125010340  [KO:K04448]
125010468  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
125010521  cacnb3b; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
125010535  [KO:K04345] [EC:2.7.11.11]
125010654  map2k2b; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
125010721  insra; insulin receptor A [KO:K04527] [EC:2.7.10.1]
125010822  cacna1eb; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
125010906  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
125010912  relA; transcription factor P65 [KO:K04735]
125011002  [KO:K04377]
125011139  [KO:K04424] [EC:2.7.11.25]
125011470  gadd45aa; growth arrest and DNA-damage-inducible, alpha, A [KO:K04402]
125011478  [KO:K04449]
125011696  [KO:K04519]
125011721  [KO:K09784]
125011773  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a isoform X1 [KO:K04360] [EC:2.7.10.1]
125011822  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
125011841  ngfA; neurotrophin-7 [KO:K02582]
125011866  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
125011880  mef2cb; myocyte enhancer factor 2cb isoform X1 [KO:K04454]
125011908  taok3a; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
125011977  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125011981  efna5b; ephrin-A5b isoform X1 [KO:K05462]
125011982  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
125011987  rasa1a; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
125012106  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
125012214  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a isoform X1 [KO:K04849]
125012267  araF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
125012364  [KO:K05452]
125012369  fgf10b; fibroblast growth factor 10b [KO:K04358]
125012370  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
125012419  fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
125012511  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
125012605  [KO:K04442] [EC:2.7.11.1]
125012733  [KO:K03173] [EC:2.3.2.27]
125012907  gadd45ga; growth arrest and DNA-damage-inducible, gamma A [KO:K04402]
125013002  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
125013008  ppm1na; protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative) [KO:K04457] [EC:3.1.3.16]
125013080  rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K04350]
125013133  pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
125013326  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
125013332  [KO:K05093] [EC:2.7.10.1]
125013339  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125013379  crk; adapter molecule crk [KO:K04438]
125013395  hspa8b; heat shock protein family A (Hsp70) member 8b [KO:K03283]
125013463  nf1a; neurofibromin isoform X1 [KO:K08052]
125013476  tgfb1a; transforming growth factor, beta 1a isoform X1 [KO:K13375]
125013490  rasa2; ras GTPase-activating protein 2 [KO:K08053]
125013554  taok1a; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
125013663  mecom; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
125013703  nlk2; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
125013951  [KO:K04723]
125013968  [KO:K04860]
125013970  relB; putative transcription factor p65 homolog isoform X1 [KO:K09253]
125014002  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
125014034  epha2b; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
125014060  arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
125014373  [KO:K22428]
125014422  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
125014536  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
125014564  [KO:K17333]
125014571  dusp8a; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125014605  [KO:K04434]
125014660  kraS; GTPase KRas [KO:K07827]
125014830  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
125014890  igf2b; insulin-like growth factor 2b [KO:K13769]
125014891  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
125014929  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
125015016  [KO:K02833]
125015058  kitlga; kit ligand A [KO:K05461]
125015166  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
125015208  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
125015268  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
125015341  [KO:K04858]
125015390  [KO:K04358]
125015404  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
125015476  [KO:K04861]
125015538  [KO:K05460]
125015712  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
125015974  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
125016076  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
125016095  hsc70; heat shock cognate 71 kDa protein [KO:K03283]
125016180  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
125016247  stmn1b; stathmin 1b [KO:K04381]
125016280  cdc42l; cell division cycle 42, like [KO:K04393]
125016388  [KO:K04388] [EC:2.7.11.30]
125016524  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
125016529  efna1b; ephrin-A1b [KO:K05462]
125016750  cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
125016834  efna3b; ephrin-A3b [KO:K05462]
125016891  [KO:K04446]
125016978  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
125016980  cacng6b; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
125017016  [KO:K05462]
125017072  cacng7b; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
125017218  tgfbr2l; LOW QUALITY PROTEIN: TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
125017327  [KO:K04407] [EC:2.7.11.1]
125017394  zak; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
125017431  [KO:K05085] [EC:2.7.10.1]
125017444  atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
125017583  [KO:K04422] [EC:2.7.11.25]
125017617  mrasa; ras-related protein M-Ras [KO:K07831]
125017774  [KO:K12361]
125017830  fgf9; fibroblast growth factor 4A [KO:K04358]
125017902  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
125018280  [KO:K04386]
125018352  [KO:K06268]
125018358  [KO:K04467] [EC:2.7.11.10]
125018405  ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
125018421  fgf8a; fibroblast growth factor 8 isoform X1 [KO:K04358]
125018476  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
125018497  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
125018547  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125018661  ppm1ba; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
125018668  [KO:K04406] [EC:2.7.11.1]
125018779  srfB; serum response factor b isoform X1 [KO:K04378]
125019058  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
125019181  angpt2a; angiopoietin-2a [KO:K05466]
125019204  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
125019214  map3k21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
125019224  rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
125019343  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125019489  daxX; death domain-associated protein 6 [KO:K02308]
125019535  stk3; serine/threonine-protein kinase 3 [KO:K04412]
125019542  [KO:K04451]
125019568  [KO:K04451]
125019584  [KO:K04451]
125020027  [KO:K04393]
125020081  angpt2b; angiopoietin-2b [KO:K05466]
125020172  tnfA; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
125020204  angpt1; angiopoietin-1 [KO:K05465]
125020267  stmn1a; stathmin 1a [KO:K04381]
125020337  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
125020371  [KO:K04388] [EC:2.7.11.30]
125020479  [KO:K04873]
125020482  cacng7a; calcium channel, voltage-dependent, gamma subunit 7a [KO:K04872]
125020484  [KO:K04871]
125020494  efna1a; ephrin-A1a [KO:K05462]
125020533  efna3a; ephrin-A3 [KO:K05462]
125020646  [KO:K04348] [EC:3.1.3.16]
125020785  [KO:K03283]
125020786  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
125020818  rps6ka4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
125020875  [KO:K04456] [EC:2.7.11.1]
125020970  [KO:K18496]
125021012  [KO:K04393]
125021033  taok1b; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
125021087  [KO:K04438]
125021226  ins; insulin [KO:K04526]
125021368  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125021494  [KO:K04439]
125021590  [KO:K05089] [EC:2.7.10.1]
125021598  hspb1; heat shock protein beta-1 [KO:K04455]
125021655  ppm1nb; protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative) [KO:K04457] [EC:3.1.3.16]
125021669  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
125021683  nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
125021699  csf1rb; macrophage colony-stimulating factor 1 receptor 2 isoform X1 [KO:K05090] [EC:2.7.10.1]
125021920  [KO:K04466] [EC:2.7.11.25]
125022013  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
125022122  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125022129  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125022147  taok2b; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
125022167  fgf21; fibroblast growth factor 21 [KO:K22429]
125022244  ppm1bb; protein phosphatase 1bb isoform X1 [KO:K04461] [EC:3.1.3.16]
125022253  erbb2; receptor tyrosine-protein kinase ErbB-2 [KO:K05083] [EC:2.7.10.1]
125022308  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
125022336  mapta; microtubule-associated protein tau isoform X1 [KO:K04380]
125022354  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
125022415  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
125022650  [KO:K04467] [EC:2.7.11.10]
125022674  map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
125022799  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
125022961  ngfrb; nerve growth factor receptor B [KO:K02583]
125023006  [KO:K04392]
125023022  dusp3a; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
125023193  fosaa; protein C-Fos [KO:K04379]
125023316  [KO:K04402]
125023326  [KO:K13377]
125023421  hspa1b; heat shock 70 kDa protein-like [KO:K03283]
125023452  sos2; son of sevenless homolog 2 [KO:K03099]
125023453  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
125023488  ppm1aa; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
125023506  pgfB; placenta growth factor [KO:K16859]
125023542  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
125023675  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125023680  rps6ka5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
125024017  [KO:K04350]
125024053  [KO:K05462]
125024058  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
125024065  [KO:K04453]
125024123  [KO:K04410] [EC:2.7.11.1]
125024209  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
125024240  lamtor3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
125024467  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
mcep04070  Phosphatidylinositol signaling system
mcep04110  Cell cycle
mcep04115  p53 signaling pathway
mcep04210  Apoptosis
mcep04310  Wnt signaling pathway
KO pathway
ko04010   

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