KEGG   PATHWAY: mcf04120
Entry
mcf04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Macaca fascicularis (crab-eating macaque)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
mcf04120  Ubiquitin mediated proteolysis
mcf04120

Other DBs
GO: 0016567
Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
101864869  [KO:K02977]
101864887  UBE2E3; ubiquitin-conjugating enzyme E2 E3 [KO:K20217] [EC:2.3.2.23]
101865004  PRPF19; pre-mRNA-processing factor 19 isoform X1 [KO:K10599] [EC:2.3.2.27]
101865249  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X2 [KO:K05633] [EC:2.3.2.26]
101865547  UBE3A; ubiquitin-protein ligase E3A isoform X3 [KO:K10587] [EC:2.3.2.26]
101865827  UBE2K; ubiquitin-conjugating enzyme E2 K isoform X3 [KO:K04649] [EC:2.3.2.23]
101865841  CDC23; cell division cycle protein 23 homolog [KO:K03355]
101865932  SAE1; SUMO-activating enzyme subunit 1 isoform X1 [KO:K10684] [EC:6.2.1.45]
101866196  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
101866252  UBA52; ubiquitin-ribosomal protein eL40 fusion protein [KO:K02927]
101866254  UBE2E1; ubiquitin-conjugating enzyme E2 E1 isoform X1 [KO:K20217] [EC:2.3.2.23]
101866371  CUL3; cullin-3 isoform X1 [KO:K03869]
101866567  PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-]
101866586  UBE2C; ubiquitin-conjugating enzyme E2 C isoform X4 [KO:K06688] [EC:2.3.2.23]
101866684  UBE2N; ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
101866870  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
101867010  CUL1; cullin-1 isoform X1 [KO:K03347]
101867266  UBE2D3; ubiquitin-conjugating enzyme E2 D3 isoform X1 [KO:K06689] [EC:2.3.2.23]
101867309  UBE2G1; ubiquitin-conjugating enzyme E2 G1 isoform X1 [KO:K10575] [EC:2.3.2.23]
101867310  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
101867410  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
101867444  HERC1; probable E3 ubiquitin-protein ligase HERC1 isoform X7 [KO:K10594] [EC:2.3.2.26]
101867463  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X18 [KO:K13305] [EC:2.3.2.26]
101925095  UBE3B; ubiquitin-protein ligase E3B isoform X2 [KO:K10588] [EC:2.3.2.26]
101925102  UBE2Q1; ubiquitin-conjugating enzyme E2 Q1 [KO:K10582] [EC:2.3.2.23]
101925202  CDC20; cell division cycle protein 20 homolog [KO:K03363]
101925266  CDC27; cell division cycle protein 27 homolog isoform X5 [KO:K03350]
101925279  HUWE1; E3 ubiquitin-protein ligase HUWE1 isoform X1 [KO:K10592] [EC:2.3.2.26]
101925307  UBR5; E3 ubiquitin-protein ligase UBR5 isoform X3 [KO:K10593] [EC:2.3.2.26]
101925366  UBE3C; ubiquitin-protein ligase E3C isoform X1 [KO:K10589] [EC:2.3.2.26]
101925594  FANCL; E3 ubiquitin-protein ligase FANCL isoform X1 [KO:K10606] [EC:2.3.2.27]
101925744  RHOBTB1; rho-related BTB domain-containing protein 1 isoform X1 [KO:K07868]
101925768  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
101926258  TRIP12; E3 ubiquitin-protein ligase TRIP12 isoform X5 [KO:K10590] [EC:2.3.2.26]
101926366  ELOC; elongin-C isoform X2 [KO:K03872]
101926376  UBE2L3; ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
101926586  ELOB; elongin-B [KO:K03873]
101926775  UBB; polyubiquitin-B [KO:K04551]
101926817  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
102114869  [KO:K06688] [EC:2.3.2.23]
102114882  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
102114921  UBE2W; ubiquitin-conjugating enzyme E2 W isoform X2 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
102114949  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
102115645  SYVN1; E3 ubiquitin-protein ligase synoviolin isoform X3 [KO:K10601] [EC:2.3.2.27]
102115834  [KO:K02927]
102115875  MGRN1; E3 ubiquitin-protein ligase MGRN1 isoform X2 [KO:K10604] [EC:2.3.2.27]
102116941  [KO:K03872]
102116964  UBA3; NEDD8-activating enzyme E1 catalytic subunit isoform X2 [KO:K10686] [EC:6.2.1.64]
102118135  UBE2Q2; ubiquitin-conjugating enzyme E2 Q2 isoform X1 [KO:K10582] [EC:2.3.2.23]
102118914  CUL2; cullin-2 isoform X1 [KO:K03870]
102118939  UBOX5; RING finger protein 37 isoform X1 [KO:K10600]
102118980  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
102119440  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
102119756  FBXO4; F-box only protein 4 isoform X1 [KO:K10291]
102120287  [KO:K04552] [EC:2.3.2.23]
102120359  FBXW8; F-box/WD repeat-containing protein 8 isoform X1 [KO:K10264]
102120603  CUL4B; cullin-4B isoform X1 [KO:K10609]
102120666  [KO:K10580] [EC:2.3.2.23]
102121313  BRCA1; breast cancer type 1 susceptibility protein isoform X2 [KO:K10605] [EC:2.3.2.27]
102121569  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
102121739  BIRC7; baculoviral IAP repeat-containing protein 7 isoform X2 [KO:K16061]
102121752  UBE2J1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
102121831  [KO:K03872]
102122430  [KO:K06689] [EC:2.3.2.23]
102123009  WWP2; NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X2 [KO:K05630] [EC:2.3.2.26]
102123041  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X3 [KO:K04416] [EC:2.7.11.25]
102123469  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
102123739  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
102123991  [KO:K02977]
102124388  FBXO2; F-box only protein 2 [KO:K10099]
102124623  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
102124821  [KO:K10580] [EC:2.3.2.23]
102125306  CUL4A; cullin-4A isoform X1 [KO:K10609]
102125412  UBE2R2; ubiquitin-conjugating enzyme E2 R2 isoform X1 [KO:K02207] [EC:2.3.2.23]
102125653  DET1; DET1 homolog isoform X2 [KO:K10571]
102125991  [KO:K10580] [EC:2.3.2.23]
102126041  UBE2U; ubiquitin-conjugating enzyme E2 U [KO:K10584] [EC:2.3.2.23]
102126087  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X5 [KO:K04678] [EC:2.3.2.26]
102126089  CDC34; ubiquitin-conjugating enzyme E2 R1 isoform X1 [KO:K02207] [EC:2.3.2.23]
102126399  [KO:K04725] [EC:2.3.2.27]
102126628  UBE2H; ubiquitin-conjugating enzyme E2 H isoform X1 [KO:K10576] [EC:2.3.2.23]
102126668  [KO:K10580] [EC:2.3.2.23]
102127058  UBE2O; (E3-independent) E2 ubiquitin-conjugating enzyme isoform X1 [KO:K10581] [EC:2.3.2.24]
102128000  STUB1; E3 ubiquitin-protein ligase CHIP isoform X2 [KO:K09561] [EC:2.3.2.27]
102128144  [KO:K06688] [EC:2.3.2.23]
102128596  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
102128660  FZR1; fizzy-related protein homolog isoform X2 [KO:K03364]
102128744  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
102128933  CUL7; cullin-7 isoform X1 [KO:K10613]
102129529  HERC4; probable E3 ubiquitin-protein ligase HERC4 isoform X3 [KO:K10615] [EC:2.3.2.26]
102130085  MID1; E3 ubiquitin-protein ligase Midline-1 isoform X2 [KO:K08285] [EC:2.3.2.27]
102130620  KLHL13; kelch-like protein 13 isoform X8 [KO:K10447]
102131393  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
102131459  AIRE; autoimmune regulator isoform X6 [KO:K10603]
102132104  RNF7; RING-box protein 2 isoform X1 [KO:K10611]
102132483  RBX1; E3 ubiquitin-protein ligase RBX1 isoform X1 [KO:K03868] [EC:2.3.2.32]
102132501  UBE2S; ubiquitin-conjugating enzyme E2 S [KO:K10583] [EC:2.3.2.23]
102133040  [KO:K25228]
102133437  ANAPC15; anaphase-promoting complex subunit 15 isoform X2 [KO:K25228]
102133514  UBE2D4; ubiquitin-conjugating enzyme E2 D4 isoform X1 [KO:K06689] [EC:2.3.2.23]
102133700  CUL5; LOW QUALITY PROTEIN: cullin-5 [KO:K10612]
102134194  UBE2F; NEDD8-conjugating enzyme UBE2F isoform X2 [KO:K10687] [EC:2.3.2.34]
102134397  RHOBTB2; rho-related BTB domain-containing protein 2 isoform X2 [KO:K07868]
102134446  PRKN; E3 ubiquitin-protein ligase parkin isoform X3 [KO:K04556] [EC:2.3.2.31]
102134577  UBA6; ubiquitin-like modifier-activating enzyme 6 isoform X1 [KO:K10699] [EC:6.2.1.45]
102134859  CDC26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
102135100  COP1; E3 ubiquitin-protein ligase COP1 isoform X3 [KO:K10143] [EC:2.3.2.27]
102135339  UBE4A; ubiquitin conjugation factor E4 A [KO:K10596] [EC:2.3.2.27]
102135411  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
102135696  FBXW7; F-box/WD repeat-containing protein 7 isoform X3 [KO:K10260]
102135847  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
102135911  CBLC; E3 ubiquitin-protein ligase CBL-C isoform X2 [KO:K22518] [EC:2.3.2.27]
102136245  HERC2; E3 ubiquitin-protein ligase HERC2 isoform X1 [KO:K10595] [EC:2.3.2.26]
102136294  [KO:K02927]
102136323  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
102136325  [KO:K10580] [EC:2.3.2.23]
102136629  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1 [KO:K04553] [EC:2.3.2.23]
102136740  [KO:K04552] [EC:2.3.2.23]
102136827  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
102137660  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
102137780  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
102137853  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
102137941  [KO:K03358]
102138168  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
102138253  UBA1; ubiquitin-like modifier-activating enzyme 1 isoform X3 [KO:K03178] [EC:6.2.1.45]
102138693  UBE2E2; ubiquitin-conjugating enzyme E2 E2 [KO:K20217] [EC:2.3.2.23]
102138808  UBE2Z; ubiquitin-conjugating enzyme E2 Z [KO:K10585] [EC:2.3.2.23]
102139153  [KO:K10687] [EC:2.3.2.34]
102139281  TRIM32; E3 ubiquitin-protein ligase TRIM32 [KO:K10607] [EC:2.3.2.27]
102139788  DDB1; DNA damage-binding protein 1 [KO:K10610]
102139834  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
102139847  PIAS4; E3 SUMO-protein ligase PIAS4 isoform X6 [KO:K16065] [EC:2.3.2.27]
102139882  UBE2A; ubiquitin-conjugating enzyme E2 A isoform X1 [KO:K10573] [EC:2.3.2.23]
102140220  UBA2; SUMO-activating enzyme subunit 2 isoform X1 [KO:K10685] [EC:6.2.1.45]
102140439  UBE4B; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
102140595  UBE2D1; ubiquitin-conjugating enzyme E2 D1 [KO:K06689] [EC:2.3.2.23]
102140795  BIRC6; baculoviral IAP repeat-containing protein 6 isoform X7 [KO:K10586] [EC:2.3.2.23]
102141097  TRIM37; E3 ubiquitin-protein ligase TRIM37 isoform X14 [KO:K10608] [EC:2.3.2.27]
102141400  [KO:K02977]
102141971  ANAPC1; anaphase-promoting complex subunit 1 isoform X2 [KO:K03348]
102142514  RPS27A; ubiquitin-ribosomal protein eS31 fusion protein [KO:K02977]
102142637  SKP1; S-phase kinase-associated protein 1 isoform X2 [KO:K03094]
102142639  UBE2D2; ubiquitin-conjugating enzyme E2 D2 isoform X2 [KO:K06689] [EC:2.3.2.23]
102142834  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
102142897  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
102142968  UBE2M; NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
102143130  UBC; polyubiquitin-C [KO:K08770]
102143206  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
102143286  ERCC8; DNA excision repair protein ERCC-8 isoform X2 [KO:K10570]
102143450  KLHL9; kelch-like protein 9 [KO:K10447]
102143687  FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
102143770  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X4 [KO:K04506] [EC:2.3.2.27]
102144228  UBE2J2; ubiquitin-conjugating enzyme E2 J2 isoform X1 [KO:K04554] [EC:2.3.2.23]
102144301  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
102144800  HERC3; probable E3 ubiquitin-protein ligase HERC3 isoform X3 [KO:K10614] [EC:2.3.2.26]
102145050  NHLRC1; E3 ubiquitin-protein ligase NHLRC1 [KO:K10602] [EC:2.3.2.27]
102145093  [KO:K06688] [EC:2.3.2.23]
102145316  UBE2B; ubiquitin-conjugating enzyme E2 B isoform X1 [KO:K10574] [EC:2.3.2.23]
102145758  PPIL2; RING-type E3 ubiquitin-protein ligase PPIL2 [KO:K10598] [EC:5.2.1.8]
102145828  [KO:K03873]
102146316  [KO:K02927]
102146528  [KO:K06688] [EC:2.3.2.23]
102146750  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
102147140  [KO:K04506] [EC:2.3.2.27]
107128974  VHL; von Hippel-Lindau disease tumor suppressor isoform X1 [KO:K03871]
123573916  UBE2QL1; ubiquitin-conjugating enzyme E2Q-like protein 1 isoform X1 [KO:K10582] [EC:2.3.2.23]
123575297  [KO:K03873]
135970795  VHLL; LOW QUALITY PROTEIN: von Hippel-Lindau-like protein [KO:K03871]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
mcf03050  Proteasome
KO pathway
ko04120   

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