KEGG   PATHWAY: mcoc04350
Entry
mcoc04350                   Pathway                                
Name
TGF-beta signaling pathway - Mastomys coucha (southern multimammate mouse)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
mcoc04350  TGF-beta signaling pathway
mcoc04350

Other DBs
GO: 0007179
Organism
Mastomys coucha (southern multimammate mouse) [GN:mcoc]
Gene
116068447  Tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
116068599  [KO:K23910]
116068744  Smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
116068936  Tfdp1; transcription factor Dp-1 isoform X1 [KO:K04683]
116069629  Smad1; mothers against decapentaplegic homolog 1 isoform X1 [KO:K04676]
116070042  E2f4; transcription factor E2F4 [KO:K04682]
116071422  [KO:K04668]
116071432  [KO:K04668]
116072362  [KO:K14736]
116072389  Smad6; mothers against decapentaplegic homolog 6 [KO:K04677]
116072791  Bmp5; bone morphogenetic protein 5 [KO:K04663]
116072890  Neo1; neogenin isoform X1 [KO:K06766]
116073020  Acvr2b; activin receptor type-2B isoform X1 [KO:K13596] [EC:2.7.11.30]
116073193  Smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
116073264  [KO:K14736]
116073310  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
116073579  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
116073623  Sin3a; paired amphipathic helix protein Sin3a [KO:K11644]
116073648  Mapk6; mitogen-activated protein kinase 6 [KO:K04371] [EC:2.7.11.24]
116073861  Thsd4; thrombospondin type-1 domain-containing protein 4 isoform X1 [KO:K23377]
116073981  Rhoa; transforming protein RhoA [KO:K04513]
116074400  Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
116074547  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
116074735  Nodal; nodal homolog [KO:K04666]
116075853  Dcn; decorin [KO:K04660]
116075965  Amh; muellerian-inhibiting factor [KO:K04665]
116076192  Lemd3; inner nuclear membrane protein Man1 isoform X1 [KO:K19410]
116076208  Ifng; interferon gamma [KO:K04687]
116076261  Inhbe; inhibin beta E chain [KO:K22689]
116076329  [KO:K04513]
116076339  Inhbc; inhibin beta C chain [KO:K22688]
116076358  Rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
116076368  Ep300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
116077035  Rgmb; RGM domain family member B isoform X1 [KO:K06847]
116077209  Nog; noggin [KO:K04658]
116077578  Smurf2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
116077586  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
116078246  Skp1; S-phase kinase-associated protein 1 isoform X1 [KO:K03094]
116078675  Ncor1; nuclear receptor corepressor 1 [KO:K04650]
116079205  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
116079262  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
116079977  Gdf7; growth/differentiation factor 7 [KO:K20013]
116080007  Acvr1b; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
116080097  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
116080468  Sp1; transcription factor Sp1 isoform X1 [KO:K04684]
116080599  Id2; DNA-binding protein inhibitor ID-2 [KO:K17693]
116081184  Ltbp1; latent-transforming growth factor beta-binding protein 1 isoform X1 [KO:K19559]
116081312  [KO:K26168]
116081446  Smad5; mothers against decapentaplegic homolog 5 [KO:K16790]
116081930  Inhba; inhibin beta A chain [KO:K04667]
116082004  Hfe; hereditary hemochromatosis protein isoform X1 [KO:K26535]
116082103  Id4; DNA-binding protein inhibitor ID-4 [KO:K17695]
116082248  Amhr2; anti-Muellerian hormone type-2 receptor isoform X1 [KO:K04672] [EC:2.7.11.30]
116082253  Myc; myc proto-oncogene protein [KO:K04377]
116082765  Bmp6; bone morphogenetic protein 6 [KO:K16620]
116083576  Fst; follistatin isoform X1 [KO:K04661]
116083935  Zfyve16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
116084175  Crebbp; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
116084889  Bmp4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
116085235  Bmpr1a; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
116085641  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116085735  Chrd; chordin isoform X1 [KO:K04657]
116085811  Nrros; transforming growth factor beta activator LRRC33 [KO:K26317]
116085827  Tfrc; transferrin receptor protein 1 [KO:K06503]
116086794  Bambi; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
116086826  Rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
116087335  Smad4; mothers against decapentaplegic homolog 4 [KO:K04501]
116087361  Smad7; mothers against decapentaplegic homolog 7 [KO:K19631]
116087365  Smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
116088086  Gdf6; growth/differentiation factor 6 [KO:K20012]
116088482  Bmpr2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
116088885  Tgif1; homeobox protein TGIF1 isoform X1 [KO:K19383]
116090146  Acvr2a; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
116090192  Acvr1c; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
116090194  Acvr1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
116090655  Grem1; gremlin-1 [KO:K23318]
116090684  Thbs1; thrombospondin-1 isoform X1 [KO:K16857]
116090845  Fbn1; fibrillin-1 [KO:K06825]
116090993  Bmp2; bone morphogenetic protein 2 [KO:K21283]
116091178  Id1; DNA-binding protein inhibitor ID-1 isoform X1 [KO:K04680]
116091272  Tgif2; homeobox protein TGIF2 [KO:K19553]
116091283  Rbl1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
116091480  Bmp7; bone morphogenetic protein 7 [KO:K16621]
116092483  Gdf5; growth/differentiation factor 5 [KO:K04664]
116092873  Smad9; mothers against decapentaplegic homolog 9 [KO:K16791]
116093453  Hjv; hemojuvelin isoform X1 [KO:K23100]
116093770  [KO:K04686]
116093866  Bmpr1b; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
116094951  E2f5; transcription factor E2F5 isoform X1 [KO:K04682]
116095035  Skil; ski-like protein isoform X1 [KO:K18499]
116095614  Id3; DNA-binding protein inhibitor ID-3 [KO:K17694]
116095763  [KO:K16622]
116095764  [KO:K16622]
116095983  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
116096225  Cdkn2b; cyclin-dependent kinase 4 inhibitor B isoform X1 [KO:K04685]
116096378  Zfyve9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
116096498  Tmem53; transmembrane protein 53 isoform X1 [KO:K28359]
116096707  Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
116096918  [KO:K19558]
116097138  Ski; ski oncogene isoform X1 [KO:K26503]
116097773  Inhbb; inhibin beta B chain [KO:K22687]
116098531  Cul1; cullin-1 [KO:K03347]
116099414  Fmod; fibromodulin [KO:K08121]
116100454  Hamp; hepcidin [KO:K23106]
116101857  Tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
116102236  Emp3; epithelial membrane protein 3 [KO:K26257]
116102394  Rgma; repulsive guidance molecule A [KO:K23096]
116102609  Lrrc32; transforming growth factor beta activator LRRC32 isoform X1 [KO:K26316]
116102969  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
116103319  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
116103868  Grem2; gremlin-2 [KO:K23318]
116104772  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Reference
PMID:38267638
  Authors
Wu M, Wu S, Chen W, Li YP
  Title
The roles and regulatory mechanisms of TGF-beta and BMP signaling in bone and cartilage development, homeostasis and disease.
  Journal
Cell Res 34:101-123 (2024)
DOI:10.1038/s41422-023-00918-9
Related
pathway
mcoc04010  MAPK signaling pathway
mcoc04110  Cell cycle
mcoc04120  Ubiquitin mediated proteolysis
mcoc04210  Apoptosis
KO pathway
ko04350   

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