KEGG   PATHWAY: mcoc04530
Entry
mcoc04530                   Pathway                                
Name
Tight junction - Mastomys coucha (southern multimammate mouse)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mcoc04530  Tight junction
mcoc04530

Other DBs
GO: 0005923
Organism
Mastomys coucha (southern multimammate mouse) [GN:mcoc]
Gene
116067982  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116068010  Actr2; actin-related protein 2 [KO:K17260]
116068264  Prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
116068365  Arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
116068514  [KO:K06087]
116068516  Cldn4; claudin-4 [KO:K06087]
116068520  Cldn3; claudin-3 [KO:K06087]
116068656  Micall2; MICAL-like protein 2 [KO:K21068]
116068700  Actb; actin, cytoplasmic 1 [KO:K05692]
116068714  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116068748  Arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
116068753  Arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
116068827  Arhgef18; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
116068848  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
116069258  Cldn22; claudin-22 [KO:K06087]
116069260  [KO:K06087]
116069367  Nf2; merlin isoform X1 [KO:K16684]
116069541  Rab8a; ras-related protein Rab-8A [KO:K07901]
116069698  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
116070066  Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
116070159  Marveld3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
116070446  Pard3; partitioning defective 3 homolog isoform X1 [KO:K04237]
116070458  Itgb1; integrin beta-1 [KO:K05719]
116070475  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
116070897  Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
116070957  Cldn15; claudin-15 [KO:K06087]
116071342  Cldn23; claudin-23 [KO:K06087]
116072206  Jam3; junctional adhesion molecule C isoform X1 [KO:K06785]
116072611  Cgnl1; cingulin-like protein 1 [KO:K21110]
116072668  Rdx; radixin isoform X1 [KO:K05762]
116072757  Amotl2; angiomotin-like protein 2 isoform X1 [KO:K06104]
116072929  Cldn18; claudin-18 isoform X1 [KO:K06087]
116072987  Nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
116073287  Cldn25; putative claudin-25 [KO:K06087]
116073310  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
116073799  Rab8b; ras-related protein Rab-8B [KO:K07902]
116073892  Amotl1; angiomotin-like protein 1 isoform X1 [KO:K06104]
116073981  Rhoa; transforming protein RhoA [KO:K04513]
116074273  Crb3; protein crumbs homolog 3 [KO:K06090]
116074274  Scrib; protein scribble homolog isoform X1 [KO:K16175]
116074992  Bves; blood vessel epicardial substance [KO:K21108]
116075266  Myh9; myosin-9 [KO:K10352]
116075318  Tjap1; tight junction-associated protein 1 isoform X1 [KO:K06105]
116075684  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
116076158  Tjp3; tight junction protein ZO-3 isoform X1 [KO:K06097]
116076329  [KO:K04513]
116076563  Myl6b; myosin light chain 6B isoform X1 [KO:K12751]
116076564  Myl6; myosin light polypeptide 6 isoform X1 [KO:K12751]
116076582  Stk11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
116076765  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116076804  Hspa4; heat shock 70 kDa protein 4 [KO:K09489]
116076874  Llgl1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
116076898  Ezr; ezrin [KO:K08007]
116077103  Cldn7; claudin-7 [KO:K06087]
116077263  Slc9a3r1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
116077586  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
116077605  Erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
116077675  Cldn6; claudin-6 [KO:K06087]
116077676  Cldn9; claudin-9 [KO:K06087]
116078070  Llgl2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
116078098  Cldn20; claudin-20 [KO:K06087]
116078252  Myh10; myosin-10 [KO:K10352]
116078310  Afdn; afadin isoform X1 [KO:K05702]
116078761  [KO:K06087]
116078777  Actg1; actin, cytoplasmic 2 [KO:K05692]
116079141  Rapgef6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
116079191  Prkag1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
116079262  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
116080056  Mpp5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
116080601  Rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
116080908  Prkce; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
116081192  Actn1; alpha-actinin-1 isoform X1 [KO:K05699]
116081676  Rap2c; ras-related protein Rap-2c [KO:K07839]
116082583  Tubal3; tubulin alpha chain-like 3 [KO:K07374]
116083203  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
116083458  Ocln; occludin isoform X1 [KO:K06088]
116083715  Marveld2; MARVEL domain-containing protein 2 [KO:K17291]
116083778  Map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
116084108  Cldn10; claudin-10 isoform X1 [KO:K06087]
116084337  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
116084938  Gata4; transcription factor GATA-4 isoform X1 [KO:K09183]
116085336  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116085366  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
116085607  Myh11; myosin-11 isoform X1 [KO:K10352]
116085768  Cldn1; claudin-1 [KO:K06087]
116085801  Dlg1; disks large homolog 1 isoform X1 [KO:K12076]
116085882  Hcls1; hematopoietic lineage cell-specific protein isoform X1 [KO:K06106]
116086082  Jam2; junctional adhesion molecule B [KO:K06735]
116086106  Tiam1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
116086157  Runx1; runt-related transcription factor 1 isoform X1 [KO:K08367]
116086319  Cldn5; claudin-5 [KO:K06087]
116086362  Cldn16; claudin-16 [KO:K06087]
116086505  [KO:K06106]
116086542  Cldn8; claudin-8 [KO:K06087]
116086544  Cldn17; claudin-17 [KO:K06087]
116086619  Cldn14; claudin-14 isoform X1 [KO:K06087]
116086630  Igsf5; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
116086826  Rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
116086946  Msn; moesin [KO:K05763]
116087108  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
116087114  Dlg3; disks large homolog 3 isoform X1 [KO:K21098]
116087214  Synpo; synaptopodin isoform X1 [KO:K21112]
116087270  Nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
116087400  Pard6g; partitioning defective 6 homolog gamma [KO:K06093]
116088477  Mpp4; MAGUK p55 subfamily member 4 [KO:K21109]
116088562  Arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
116088583  Prkag3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
116088889  Myl12b; myosin regulatory light chain 12B [KO:K12757]
116088890  [KO:K12757]
116088942  [KO:K07374]
116089917  Cldn34; claudin-34 [KO:K06087]
116090946  Was; wiskott-Aldrich syndrome protein [KO:K05747]
116090975  Pcna; proliferating cell nuclear antigen [KO:K04802]
116091273  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
116091289  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
116091625  Arpc5l; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
116091834  Pard6b; partitioning defective 6 homolog beta [KO:K06093]
116092927  [KO:K04353]
116093009  Rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
116093079  Cd1d; antigen-presenting glycoprotein CD1d [KO:K06448]
116093137  Arhgef2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
116093206  Rab13; ras-related protein Rab-13 isoform X1 [KO:K06109]
116093297  [KO:K06087]
116093332  [KO:K06087]
116093374  Cgn; cingulin [KO:K06102]
116093481  Prkab2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
116093571  Rap1a; ras-related protein Rap-1A isoform X1 [KO:K04353]
116093928  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116094363  [KO:K06087]
116094897  Cldn2; claudin-2 [KO:K06087]
116095033  Cldn11; claudin-11 [KO:K06087]
116095037  Prkci; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
116095540  Cldn19; claudin-19 [KO:K06087]
116095810  Prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
116096052  Epb41l4b; band 4.1-like protein 4B isoform X1 [KO:K21111]
116096175  Mpdz; multiple PDZ domain protein isoform X1 [KO:K06095]
116096245  Jun; transcription factor AP-1 [KO:K04448]
116096267  Patj; inaD-like protein isoform X1 [KO:K06092]
116096329  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
116096797  Amot; angiomotin [KO:K16819]
116096877  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
116097459  Cldn12; claudin-12 [KO:K06087]
116097568  Prkag2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
116097579  Actr3b; actin-related protein 3B isoform X1 [KO:K18584]
116097922  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
116098150  Actr3; actin-related protein 3 [KO:K18584]
116098456  [KO:K07374]
116098609  Cftr; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
116099290  [KO:K05692]
116099295  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
116099396  Arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
116099526  Tuba8; tubulin alpha-8 chain [KO:K07374]
116099610  [KO:K07374]
116099687  Ybx3; Y-box-binding protein 3 isoform X1 [KO:K06099]
116099794  [KO:K07374]
116101110  Arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
116101386  Cttn; src substrate cortactin [KO:K06106]
116101732  Sympk; symplekin [KO:K06100]
116101743  Vasp; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
116101932  Actn4; alpha-actinin-4 isoform X1 [KO:K05699]
116102138  Myh14; myosin-14 isoform X1 [KO:K10352]
116102342  Tjp1; tight junction protein ZO-1 isoform X1 [KO:K05701]
116102488  Whamm; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
116102565  Dlg2; disks large homolog 2 isoform X1 [KO:K12075]
116102923  Arhgap17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
116103147  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
116103285  Ccnd1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
116103490  F11r; junctional adhesion molecule A [KO:K06089]
116103675  Tjp2; tight junction protein ZO-2 isoform X1 [KO:K06098]
116104772  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
mcoc04520  Adherens junction
mcoc04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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