KEGG   PATHWAY: mcoc04810
Entry
mcoc04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Mastomys coucha (southern multimammate mouse)
Class
Cellular Processes; Cell motility
Pathway map
mcoc04810  Regulation of actin cytoskeleton
mcoc04810

Other DBs
GO: 0030036
Organism
Mastomys coucha (southern multimammate mouse) [GN:mcoc]
Gene
116096072  Lpar1; lysophosphatidic acid receptor 1 [KO:K04289]
116069430  Lpar2; lysophosphatidic acid receptor 2 [KO:K04291]
116088074  Lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
116099597  Lpar5; lysophosphatidic acid receptor 5 [KO:K08390]
116099458  Cxcl12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
116098629  Cxcr4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
116092238  F2; prothrombin isoform X1 [KO:K01313] [EC:3.4.21.5]
116083372  F2r; proteinase-activated receptor 1 [KO:K03914]
116101481  insulin-1 [KO:K04526]
116093773  Egf; pro-epidermal growth factor [KO:K04357]
116087087  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
116095116  Fgf2; fibroblast growth factor 2 isoform X1 [KO:K18497]
116098343  Fgf6; fibroblast growth factor 6 [KO:K04358]
116100989  Fgf3; fibroblast growth factor 3 [KO:K04358]
116100990  Fgf4; fibroblast growth factor 4 [KO:K04358]
116101280  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
116083356  Fgf10; fibroblast growth factor 10 [KO:K04358]
116093940  Fgf16; fibroblast growth factor 16 [KO:K04358]
116084437  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
116084719  Fgf9; fibroblast growth factor 9 [KO:K04358]
116076064  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
116078435  Fgf18; fibroblast growth factor 18 [KO:K04358]
116071359  Fgf20; fibroblast growth factor 20 [KO:K04358]
116090856  Fgf7; fibroblast growth factor 7 [KO:K04358]
116100991  Fgf19; fibroblast growth factor 19 [KO:K22603]
116100498  Fgf21; fibroblast growth factor 21 [KO:K22429]
116098344  Fgf23; fibroblast growth factor 23 [KO:K22428]
116068639  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116076069  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
116093026  Pdgfc; platelet-derived growth factor C [KO:K05450]
116072446  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
116093094  Insrr; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
116071392  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116069056  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
116103077  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
116069961  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
116082061  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
116071260  Pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
116087226  Pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
116088545  Fn1; fibronectin isoform X1 [KO:K05717]
116083732  Itga1; integrin alpha-1 isoform X1 [KO:K06480]
116083244  Itga2; integrin alpha-2 [KO:K06481]
116078214  Itga2b; integrin alpha-IIb [KO:K06476]
116078986  Itga3; integrin alpha-3 isoform X1 [KO:K06482]
116090371  Itga4; integrin alpha-4 [KO:K06483]
116080860  Itga5; integrin alpha-5 [KO:K06484]
116090300  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
116075887  Itga7; integrin alpha-7 isoform X1 [KO:K06583]
116089710  Itga8; integrin alpha-8 [KO:K06584]
116073780  Itga9; integrin alpha-9 isoform X1 [KO:K06585]
116093463  Itga10; integrin alpha-10 isoform X1 [KO:K06586]
116073011  Itga11; integrin alpha-11 isoform X1 [KO:K06587]
116090387  Itgav; integrin alpha-V isoform X1 [KO:K06487]
116103005  Itgal; integrin alpha-L isoform X1 [KO:K05718]
116103050  Itgam; integrin alpha-M isoform X1 [KO:K06461]
116101365  integrin alpha-D [KO:K06594]
116077294  Itgae; integrin alpha-E isoform X1 [KO:K06524]
116070458  Itgb1; integrin beta-1 [KO:K05719]
116074875  Itgb2; integrin beta-2 [KO:K06464]
116086631  integrin beta-2-like protein [KO:K06464]
116076922  Itgb3; integrin beta-3 [KO:K06493]
116077406  Itgb4; integrin beta-4 isoform X1 [KO:K06525]
116085844  Itgb5; integrin beta-5 isoform X1 [KO:K06588]
116090215  Itgb6; integrin beta-6 isoform X1 [KO:K06589]
116080371  Itgb7; integrin beta-7 isoform X1 [KO:K06590]
116080974  Itgb8; integrin beta-8 [KO:K06591]
116086252  Kng1; kininogen-1 [KO:K03898]
116086253  T-kininogen 2-like [KO:K03898]
116080412  Bdkrb1; B1 bradykinin receptor [KO:K03915]
116079827  Bdkrb2; B2 bradykinin receptor [KO:K03916]
116103504  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
116098726  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
116082298  Chrm3; muscarinic acetylcholine receptor M3 [KO:K04131]
116090486  Chrm4; muscarinic acetylcholine receptor M4 isoform X1 [KO:K04132]
116090648  Chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
116090054  complement C5 [KO:K03994]
116083233  C6; complement component C6 [KO:K03995]
116083417  C7; complement component C7 [KO:K03996]
116095470  C8a; complement component C8 alpha chain isoform X1 [KO:K03997]
116095468  C8b; complement component C8 beta chain isoform X1 [KO:K03998]
116089825  C8g; complement component C8 gamma chain isoform X1 [KO:K03999]
116083932  C9; complement component C9 isoform X1 [KO:K04000]
116068678  Gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
116076843  Gna13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
116099017  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
116069754  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
116097875  Fgd1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
116081782  Fgd3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
116073569  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
116070207  Bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
116085656  Crkl; crk-like protein [KO:K04438]
116078814  Crk; adapter molecule crk isoform X1 [KO:K04438]
116103130  Dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
116091289  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
116080813  Sos1; son of sevenless homolog 1 [KO:K03099]
116080934  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
116099791  Kras; GTPase KRas isoform X1 [KO:K07827]
116093530  Nras; GTPase NRas [KO:K07828]
116102164  Rras; ras-related protein R-Ras isoform X1 [KO:K07829]
116102825  Rras2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
116072312  Mras; ras-related protein M-Ras [KO:K07831]
116084834  Arhgef6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
116095058  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116097037  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116073929  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116096465  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
116083721  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116069491  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
116074581  Vav1; proto-oncogene vav isoform X1 [KO:K05730]
116093653  Vav3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
116089883  Vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
116086106  Tiam1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
116073820  Araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
116098774  Braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
116099433  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116089030  Mos; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
116073764  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116076013  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
116102969  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
116073648  Mapk6; mitogen-activated protein kinase 6 [KO:K04371] [EC:2.7.11.24]
116085641  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116101889  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116104026  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116079779  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116084723  Rgcc; regulator of cell cycle RGCC [KO:K26108]
116101825  Arhgef1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
116072951  Arhgef12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
116101687  Arhgap35; rho GTPase-activating protein 35 [KO:K05732]
116073981  Rhoa; transforming protein RhoA [KO:K04513]
116076329  LOW QUALITY PROTEIN: transforming protein RhoA-like [KO:K04513]
116068714  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116075508  Rac2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
116077969  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
116096877  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
116102599  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
116085808  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
116089228  Pak3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
116101918  Pak4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
116091004  Pak5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
116090694  Pak6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
116068912  Arhgef7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
116077327  Git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
116086826  Rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
116080601  Rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
116085852  Mylk; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
116069762  Mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
116091182  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
116081489  Mylk4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
116103326  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
116104637  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
116079614  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
116076104  Ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
116099596  Ppp1r12b; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
116101543  Ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
116070897  Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
116069083  Myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
116091273  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
116070956  Myl10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
116088889  Myl12b; myosin regulatory light chain 12B [KO:K12757]
116088890  myosin regulatory light chain RLC-A [KO:K12757]
116103001  Mylpf; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
116102138  Myh14; myosin-14 isoform X1 [KO:K10352]
116075266  Myh9; myosin-9 [KO:K10352]
116085607  Myh11; myosin-11 isoform X1 [KO:K10352]
116078252  Myh10; myosin-10 [KO:K10352]
116087062  Diaph1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
116093726  Diaph2; protein diaphanous homolog 2 [KO:K05741]
116096786  Slc9a1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
116103677  Pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
116093387  Pip5k1a; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
116075862  Pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
116075899  Pip4k2c; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
116077412  Pip4k2b; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
116089748  Pip4k2a; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
116088520  Pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
116068512  Limk1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
116069764  Limk2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
116084471  Diaph3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
116079073  Baiap2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
116067948  Enah; protein enabled homolog isoform X1 [KO:K05746]
116098639  Wasl; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
116096780  Wasf2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
116102295  Cyfip1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
116078900  Cyfip2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
116090377  Nckap1; nck-associated protein 1 isoform X1 [KO:K05750]
116080865  Nckap1l; nck-associated protein 1-like [KO:K05750]
116088491  Abi2; abl interactor 2 isoform X1 [KO:K05751]
116099406  Brk1; protein BRICK1 [KO:K05752]
116075370  Wasf1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
116068010  Actr2; actin-related protein 2 [KO:K17260]
116097579  Actr3b; actin-related protein 3B isoform X1 [KO:K18584]
116098150  Actr3; actin-related protein 3 [KO:K18584]
116068748  Arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
116068753  Arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
116088562  Arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
116068365  Arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
116099396  Arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
116101110  Arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
116091625  Arpc5l; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
116099290  actin-85C-like [KO:K05692]
116068700  Actb; actin, cytoplasmic 1 [KO:K05692]
116078777  Actg1; actin, cytoplasmic 2 [KO:K05692]
116092905  Pfn2; profilin-2 [KO:K05759]
116078343  Pfn1; profilin-1 [KO:K05759]
116088575  profilin-2-like [KO:K05759]
116080295  Pfn4; profilin-4 isoform X1 [KO:K05759]
116081648  Pfn3; profilin-3 [KO:K05759]
116068255  Pxn; paxillin isoform X1 [KO:K05760]
116076898  Ezr; ezrin [KO:K08007]
116072668  Rdx; radixin isoform X1 [KO:K05762]
116086946  Msn; moesin [KO:K05763]
116100927  thymosin beta-4 [KO:K05764]
116101268  Tmsb4x; thymosin beta-4 [KO:K05764]
116098022  cofilin-1 [KO:K05765]
116101393  Cfl1; cofilin-1 [KO:K05765]
116081147  Cfl2; cofilin-2 isoform X1 [KO:K05765]
116103330  Ssh3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
116068211  Ssh1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
116076986  Ssh2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
116085275  Vcl; vinculin isoform X1 [KO:K05700]
116102471  Iqgap1; ras GTPase-activating-like protein IQGAP1 isoform X1 [KO:K16848]
116083377  Iqgap2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
116093109  Iqgap3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
116090059  Gsn; gelsolin isoform X1 [KO:K05768]
116080233  Scin; adseverin [KO:K05768]
116101932  Actn4; alpha-actinin-4 isoform X1 [KO:K05699]
116081192  Actn1; alpha-actinin-1 isoform X1 [KO:K05699]
116075850  Apc2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
116086966  Apc; adenomatous polyposis coli protein isoform X1 [KO:K02085]
116084553  Spata13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
116088285  Arhgef4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
mcoc04010  MAPK signaling pathway
mcoc04510  Focal adhesion
mcoc04520  Adherens junction
KO pathway
ko04810   
LinkDB

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