KEGG   PATHWAY: ola00600
Entry
ola00600                    Pathway                                
Name
Sphingolipid metabolism - Oryzias latipes (Japanese medaka)
Class
Metabolism; Lipid metabolism
Pathway map
ola00600  Sphingolipid metabolism
ola00600

Module
ola_M00066  Lactosylceramide biosynthesis [PATH:ola00600]
ola_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:ola00600]
ola_M00094  Ceramide biosynthesis [PATH:ola00600]
ola_M00099  Sphingosine biosynthesis [PATH:ola00600]
ola_M00100  Sphingosine degradation [PATH:ola00600]
Other DBs
GO: 0006665
Organism
Oryzias latipes (Japanese medaka) [GN:ola]
Gene
101166657  sptlc3; serine palmitoyltransferase 3 [KO:K00654] [EC:2.3.1.50]
101173642  sptlc1; serine palmitoyltransferase 1 [KO:K00654] [EC:2.3.1.50]
101165525  serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
101156930  serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]
101163276  kdsr; 3-ketodihydrosphingosine reductase [KO:K04708] [EC:1.1.1.102]
101166466  cers1; ceramide synthase 1 [KO:K04710] [EC:2.3.1.299]
101162853  ceramide synthase 2 [KO:K24621] [EC:2.3.1.297]
101155637  ceramide synthase 2 [KO:K24621] [EC:2.3.1.297]
101160439  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
101175635  ceramide synthase 2 isoform X1 [KO:K24621] [EC:2.3.1.297]
111947541  ceramide synthase 2-like [KO:K24622] [EC:2.3.1.297 2.3.1.298]
101156449  cers6; ceramide synthase 6 [KO:K23727] [EC:2.3.1.291]
101175231  cers5; ceramide synthase 5 [KO:K23727] [EC:2.3.1.291]
101166550  ceramide synthase 5 [KO:K23727] [EC:2.3.1.291]
101161703  asah1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
101165218  asah2; neutral ceramidase [KO:K12349] [EC:3.5.1.23]
101163299  acer2; alkaline ceramidase 2 [KO:K01441] [EC:3.5.1.23]
101170916  acer1; alkaline ceramidase 1 [KO:K01441] [EC:3.5.1.23]
101155496  acer3; alkaline ceramidase 3 isoform X1 [KO:K04711] [EC:3.5.1.-]
101175288  degs1; sphingolipid delta(4)-desaturase DES1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
101158246  degs2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
101173002  sgms1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27]
101170793  phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27]
101172470  sgms2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27]
101174765  smpd1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
101168943  smpd2; sphingomyelin phosphodiesterase 2 isoform X1 [KO:K12351] [EC:3.1.4.12]
101170408  smpd3; sphingomyelin phosphodiesterase 3 [KO:K12352] [EC:3.1.4.12]
101160838  sphingomyelin phosphodiesterase 5 [KO:K12352] [EC:3.1.4.12]
101161548  smpd4; sphingomyelin phosphodiesterase 4 isoform X3 [KO:K12353] [EC:3.1.4.12]
101173468  ectonucleotide pyrophosphatase/phosphodiesterase family member 7 [KO:K12354] [EC:3.1.4.12]
101166003  ectonucleotide pyrophosphatase/phosphodiesterase family member 7 [KO:K12354] [EC:3.1.4.12]
101165056  ceramide kinase [KO:K04715] [EC:2.7.1.138]
101167008  cerk; ceramide kinase [KO:K04715] [EC:2.7.1.138]
101168661  plpp2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
101172508  plpp1; phospholipid phosphatase 1 isoform X2 [KO:K01080] [EC:3.1.3.4]
101173452  plpp3; phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
101166135  phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
101159828  phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
101171943  phospholipid phosphatase 3 isoform X2 [KO:K01080] [EC:3.1.3.4]
101156966  phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
101173595  sgpp1; sphingosine-1-phosphate phosphatase 1 [KO:K04716] [EC:3.1.3.-]
101166766  sphingosine-1-phosphate phosphatase 1 [KO:K04716] [EC:3.1.3.-]
101156907  sgpp2; sphingosine-1-phosphate phosphatase 2 isoform X1 [KO:K04717] [EC:3.1.3.-]
101160322  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
101167592  sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
101160262  sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
101156524  sgpl1; sphingosine-1-phosphate lyase 1 isoform X2 [KO:K01634] [EC:4.1.2.27]
101173189  ugcg; ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
101157882  gba; glucosylceramidase precursor [KO:K01201] [EC:3.2.1.45]
101175270  gba2; non-lysosomal glucosylceramidase [KO:K17108] [EC:3.2.1.45]
101160972  beta-1,4-galactosyltransferase 6 [KO:K07553] [EC:2.4.1.274]
101162446  beta-1,4-galactosyltransferase 5 [KO:K09905] [EC:2.4.1.274 2.4.1.-]
101167424  glb1; beta-galactosidase isoform X1 [KO:K12309] [EC:3.2.1.23]
101156303  ugt8; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase [KO:K04628] [EC:2.4.1.47]
101163287  galc; galactocerebrosidase isoform X2 [KO:K01202] [EC:3.2.1.46]
101172086  gal3st1; galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
101157945  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
101159931  galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
101159667  arsa; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
101155611  neu1; sialidase-1 precursor [KO:K01186] [EC:3.2.1.18]
101163509  neu3; sialidase-3 [KO:K12357] [EC:3.2.1.18]
101160183  neu4; sialidase-4 [KO:K12357] [EC:3.2.1.18]
101164170  neu3b; sialidase-3-like [KO:K12357] [EC:3.2.1.18]
101169044  gla; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
101155420  b4galnt1; beta-1,4 N-acetylgalactosaminyltransferase 1 [KO:K00725] [EC:2.4.1.92]
101171003  beta-1,4 N-acetylgalactosaminyltransferase 1 [KO:K00725] [EC:2.4.1.92]
101172329  beta-hexosaminidase subunit alpha isoform X1 [KO:K12373] [EC:3.2.1.52]
101158618  hexb; beta-hexosaminidase subunit beta isoform X2 [KO:K12373] [EC:3.2.1.52]
101172744  gm2a; ganglioside GM2 activator [KO:K12383]
101163196  psap; prosaposin isoform X1 [KO:K12382]
101171262  prosaposin [KO:K12382]
101161410  prosaposin-like [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
ola00260  Glycine, serine and threonine metabolism
ola00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ola00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ola00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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