KEGG   PATHWAY: oro04120
Entry
oro04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Odobenus rosmarus divergens (Pacific walrus)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
oro04120  Ubiquitin mediated proteolysis
oro04120

Other DBs
GO: 0016567
Organism
Odobenus rosmarus divergens (Pacific walrus) [GN:oro]
Gene
101378176  UBA52; ubiquitin-60S ribosomal protein L40 isoform X2 [KO:K02927]
101385092  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
101370294  UBA1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
101367153  SAE1; SUMO-activating enzyme subunit 1 isoform X1 [KO:K10684] [EC:6.2.1.45]
101369683  UBA2; SUMO-activating enzyme subunit 2 [KO:K10685] [EC:6.2.1.45]
101370625  UBA3; NEDD8-activating enzyme E1 catalytic subunit isoform X1 [KO:K10686] [EC:6.2.1.64]
101363321  UBA7; ubiquitin-like modifier-activating enzyme 7 [KO:K10698] [EC:6.2.1.45]
101376270  UBA6; ubiquitin-like modifier-activating enzyme 6 [KO:K10699] [EC:6.2.1.45]
101369537  UBE2A; ubiquitin-conjugating enzyme E2 A isoform X1 [KO:K10573] [EC:2.3.2.23]
101377411  UBE2B; ubiquitin-conjugating enzyme E2 B isoform X1 [KO:K10574] [EC:2.3.2.23]
101366786  ubiquitin-conjugating enzyme E2 B-like isoform X1 [KO:K10574] [EC:2.3.2.23]
101374178  ubiquitin-conjugating enzyme E2 C-like isoform X1 [KO:K06688] [EC:2.3.2.23]
101372875  ubiquitin-conjugating enzyme E2 C-like [KO:K06688] [EC:2.3.2.23]
101376634  UBE2C; ubiquitin-conjugating enzyme E2 C isoform X1 [KO:K06688] [EC:2.3.2.23]
101372286  UBE2D3; ubiquitin-conjugating enzyme E2 D3 isoform X1 [KO:K06689] [EC:2.3.2.23]
101367319  UBE2D1; ubiquitin-conjugating enzyme E2 D1 isoform X2 [KO:K06689] [EC:2.3.2.23]
101383851  UBE2D2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
101367261  UBE2E3; ubiquitin-conjugating enzyme E2 E3 isoform X1 [KO:K20217] [EC:2.3.2.23]
101372840  UBE2E2; ubiquitin-conjugating enzyme E2 E2 isoform X1 [KO:K20217] [EC:2.3.2.23]
101373789  UBE2E1; ubiquitin-conjugating enzyme E2 E1 isoform X1 [KO:K20217] [EC:2.3.2.23]
101385331  NEDD8-conjugating enzyme UBE2F-like isoform X1 [KO:K10687] [EC:2.3.2.34]
101370249  UBE2F; NEDD8-conjugating enzyme UBE2F isoform X1 [KO:K10687] [EC:2.3.2.34]
101364913  UBE2G1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
101384365  UBE2G2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
101378729  UBE2H; ubiquitin-conjugating enzyme E2 H isoform X1 [KO:K10576] [EC:2.3.2.23]
101383876  UBE2I; SUMO-conjugating enzyme UBC9 isoform X1 [KO:K10577]
101372788  UBE2J1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
101364325  UBE2J2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
101382979  UBE2K; LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 K [KO:K04649] [EC:2.3.2.23]
101386538  ubiquitin-conjugating enzyme E2 L3-like isoform X1 [KO:K04552] [EC:2.3.2.23]
101373045  ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
101381490  ubiquitin-conjugating enzyme E2 L3-like isoform X1 [KO:K04552] [EC:2.3.2.23]
101371385  UBE2L3; ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
101364334  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1 [KO:K04553] [EC:2.3.2.23]
101382819  UBE2M; NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
101363266  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
101380113  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
101374169  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
101373759  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
101363416  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
101372643  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
101374304  UBE2N; ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
101369231  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
101369061  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
101377284  ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
101380920  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
101382795  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
101376219  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
105758277  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
101362537  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
101375521  UBE2O; E2/E3 hybrid ubiquitin-protein ligase UBE2O [KO:K10581] [EC:2.3.2.24]
101377370  UBE2Q2; ubiquitin-conjugating enzyme E2 Q2 isoform X1 [KO:K10582] [EC:2.3.2.23]
101364372  UBE2QL1; ubiquitin-conjugating enzyme E2Q-like protein 1 [KO:K10582] [EC:2.3.2.23]
101375380  UBE2Q1; ubiquitin-conjugating enzyme E2 Q1 isoform X1 [KO:K10582] [EC:2.3.2.23]
101365136  UBE2R2; ubiquitin-conjugating enzyme E2 R2 [KO:K02207] [EC:2.3.2.23]
101383060  CDC34; ubiquitin-conjugating enzyme E2 R1 isoform X1 [KO:K02207] [EC:2.3.2.23]
101363237  UBE2S; ubiquitin-conjugating enzyme E2 S [KO:K10583] [EC:2.3.2.23]
101382956  UBE2U; ubiquitin-conjugating enzyme E2 U [KO:K10584] [EC:2.3.2.23]
101378002  LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 U-like [KO:K10584] [EC:2.3.2.23]
101366102  UBE2W; ubiquitin-conjugating enzyme E2 W isoform X2 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
101385053  UBE2Z; ubiquitin-conjugating enzyme E2 Z [KO:K10585] [EC:2.3.2.23]
101373264  BIRC6; baculoviral IAP repeat-containing protein 6 [KO:K10586] [EC:2.3.2.23]
101365988  UBE3A; ubiquitin-protein ligase E3A isoform X2 [KO:K10587] [EC:2.3.2.26]
101366663  UBE3B; ubiquitin-protein ligase E3B [KO:K10588] [EC:2.3.2.26]
101375860  UBE3C; ubiquitin-protein ligase E3C [KO:K10589] [EC:2.3.2.26]
101368439  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
101384945  SMURF1; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
101370748  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X2 [KO:K05632] [EC:2.3.2.26]
101374742  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
101367994  WWP2; NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1 [KO:K05630] [EC:2.3.2.26]
101367023  TRIP12; E3 ubiquitin-protein ligase TRIP12 isoform X1 [KO:K10590] [EC:2.3.2.26]
101385763  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X4 [KO:K10591] [EC:2.3.2.26]
101362864  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X2 [KO:K13305] [EC:2.3.2.26]
101369242  HUWE1; E3 ubiquitin-protein ligase HUWE1 isoform X1 [KO:K10592] [EC:2.3.2.26]
101381845  UBR5; E3 ubiquitin-protein ligase UBR5 isoform X1 [KO:K10593] [EC:2.3.2.26]
101376072  HERC1; probable E3 ubiquitin-protein ligase HERC1 [KO:K10594] [EC:2.3.2.26]
101381577  E3 ubiquitin-protein ligase HERC2 [KO:K10595] [EC:2.3.2.26]
101382845  HERC3; probable E3 ubiquitin-protein ligase HERC3 isoform X1 [KO:K10614] [EC:2.3.2.26]
101381791  HERC4; probable E3 ubiquitin-protein ligase HERC4 isoform X1 [KO:K10615] [EC:2.3.2.26]
101386558  UBE4A; ubiquitin conjugation factor E4 A [KO:K10596] [EC:2.3.2.27]
101384835  UBE4B; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
101379523  STUB1; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
101371982  PPIL2; peptidyl-prolyl cis-trans isomerase-like 2 isoform X1 [KO:K10598] [EC:5.2.1.8]
101372319  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
101362302  UBOX5; RING finger protein 37 isoform X2 [KO:K10600]
101385402  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
101377544  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
101374044  CBLB; E3 ubiquitin-protein ligase CBL-B [KO:K22517] [EC:2.3.2.27]
101362830  CBLC; E3 ubiquitin-protein ligase CBL-C [KO:K22518] [EC:2.3.2.27]
101385500  PARK2; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
101383287  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
101385058  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
101371511  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
101365827  PML; protein PML [KO:K10054] [EC:2.3.2.-]
101362953  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101366511  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
101375553  RFWD2; E3 ubiquitin-protein ligase RFWD2 isoform X1 [KO:K10143] [EC:2.3.2.27]
101382341  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
101372845  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
101373139  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
101367150  XIAP; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
101368853  BIRC7; baculoviral IAP repeat-containing protein 7 [KO:K16061]
101384284  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X2 [KO:K04706] [EC:2.3.2.-]
101383602  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
101380582  PIAS3; E3 SUMO-protein ligase PIAS3 [KO:K16064] [EC:2.3.2.-]
101377368  PIAS4; E3 SUMO-protein ligase PIAS4 [KO:K16065] [EC:2.3.2.27]
101362386  SYVN1; E3 ubiquitin-protein ligase synoviolin [KO:K10601] [EC:2.3.2.27]
101377224  NHLRC1; E3 ubiquitin-protein ligase NHLRC1 [KO:K10602] [EC:2.3.2.27]
101364632  AIRE; autoimmune regulator [KO:K10603]
101364401  MGRN1; E3 ubiquitin-protein ligase MGRN1 isoform X1 [KO:K10604] [EC:2.3.2.27]
101362868  BRCA1; breast cancer type 1 susceptibility protein isoform X3 [KO:K10605] [EC:2.3.2.27]
101376789  FANCL; E3 ubiquitin-protein ligase FANCL isoform X1 [KO:K10606] [EC:2.3.2.27]
101380716  MID1; E3 ubiquitin-protein ligase Midline-1 isoform X1 [KO:K08285] [EC:2.3.2.27]
101373417  TRIM32; E3 ubiquitin-protein ligase TRIM32 [KO:K10607] [EC:2.3.2.27]
101384405  TRIM37; E3 ubiquitin-protein ligase TRIM37 isoform X1 [KO:K10608] [EC:2.3.2.27]
101363104  RBX1; E3 ubiquitin-protein ligase RBX1 isoform X1 [KO:K03868] [EC:2.3.2.32]
101369645  CUL1; cullin-1 [KO:K03347]
101374307  S-phase kinase-associated protein 1 [KO:K03094]
101386391  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
101378003  FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
101371793  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
101383205  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
101364800  FBXW7; F-box/WD repeat-containing protein 7 isoform X1 [KO:K10260]
101365338  FBXO2; F-box only protein 2 [KO:K10099]
101370925  FBXO4; F-box only protein 4 isoform X1 [KO:K10291]
101379527  LOW QUALITY PROTEIN: cullin-2-like [KO:K03870]
101374279  CUL2; cullin-2 [KO:K03870]
101365614  TCEB1; transcription elongation factor B polypeptide 1 [KO:K03872]
101379627  TCEB2; transcription elongation factor B polypeptide 2 [KO:K03873]
101370163  VHL; von Hippel-Lindau disease tumor suppressor isoform X1 [KO:K03871]
101385818  CUL3; cullin-3 isoform X1 [KO:K03869]
101378046  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
101377917  KLHL9; kelch-like protein 9 [KO:K10447]
101375901  KLHL13; kelch-like protein 13 isoform X1 [KO:K10447]
101369145  RHOBTB1; rho-related BTB domain-containing protein 1 [KO:K07868]
101362742  RHOBTB2; rho-related BTB domain-containing protein 2 isoform X2 [KO:K07868]
101378994  cullin-4B-like [KO:K10609]
101367397  CUL4A; cullin-4A [KO:K10609]
101378186  CUL4B; cullin-4B [KO:K10609]
101369653  DDB1; DNA damage-binding protein 1 isoform X1 [KO:K10610]
101378738  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
101383073  ERCC8; DNA excision repair protein ERCC-8 [KO:K10570]
101381253  DET1; DET1 homolog [KO:K10571]
101367433  RNF7; RING-box protein 2 isoform X1 [KO:K10611]
101377109  CUL5; cullin-5 [KO:K10612]
101376722  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
101364487  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
101380028  CUL7; cullin-7 [KO:K10613]
101376493  FBXW8; F-box/WD repeat-containing protein 8 isoform X1 [KO:K10264]
101377510  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
101369715  ANAPC2; anaphase-promoting complex subunit 2 isoform X2 [KO:K03349]
101372864  CDC20; cell division cycle protein 20 homolog [KO:K03363]
101381624  FZR1; fizzy-related protein homolog isoform X1 [KO:K03364]
101362433  ANAPC1; anaphase-promoting complex subunit 1 [KO:K03348]
101370553  CDC27; cell division cycle protein 27 homolog isoform X2 [KO:K03350]
101367163  ANAPC4; anaphase-promoting complex subunit 4 isoform X2 [KO:K03351]
101367423  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
101371442  CDC16; cell division cycle protein 16 homolog [KO:K03353]
101364857  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
101368411  CDC23; cell division cycle protein 23 homolog [KO:K03355]
101382274  ANAPC10; anaphase-promoting complex subunit 10 [KO:K03357]
101363861  anaphase-promoting complex subunit 10-like isoform X1 [KO:K03357]
101365482  CDC26; anaphase-promoting complex subunit CDC26 isoform X2 [KO:K03359]
101364831  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
101368576  ANAPC16; anaphase-promoting complex subunit 16 isoform X1 [KO:K25229]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
oro03050  Proteasome
KO pathway
ko04120   
LinkDB

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