KEGG   PATHWAY: panu04150
Entry
panu04150                   Pathway                                
Name
mTOR signaling pathway - Papio anubis (olive baboon)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
panu04150  mTOR signaling pathway
panu04150

Organism
Papio anubis (olive baboon) [GN:panu]
Gene
100126674  WNT2; protein Wnt-2 precursor [KO:K00182]
100126735  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
100137333  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100137461  FZD1; frizzled-1 [KO:K02432]
100137542  DEPDC5; GATOR complex protein DEPDC5 [KO:K20404]
100189542  LRP5; low-density lipoprotein receptor-related protein 5 precursor [KO:K03068]
100381179  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100510873  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X4 [KO:K02649]
100997506  WNT6; protein Wnt-6 [KO:K00445]
100997560  MLST8; target of rapamycin complex subunit LST8 isoform X2 [KO:K08266]
100997623  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform isoform X1 [KO:K02147]
100997634  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100997742  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
100997755  WNT5A; protein Wnt-5a isoform X2 [KO:K00444]
100997855  WNT10A; protein Wnt-10a [KO:K01357]
100997985  INS; insulin isoform X2 [KO:K04526]
100998800  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100998866  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100998877  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100998909  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
100999012  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X4 [KO:K03259]
100999336  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
100999369  IRS1; insulin receptor substrate 1 [KO:K16172]
100999626  WNT9A; protein Wnt-9a isoform X2 [KO:K01064]
100999712  FZD6; frizzled-6 [KO:K02376]
101000264  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
101000402  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101000590  TBC1D7; TBC1 domain family member 7 [KO:K20396]
101000688  [KO:K02991]
101000744  FZD3; frizzled-3 isoform X1 [KO:K02329]
101000859  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
101001468  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X9 [KO:K10421]
101001727  WNT3; proto-oncogene Wnt-3 isoform X2 [KO:K00312]
101001758  SLC7A5; large neutral amino acids transporter small subunit 1 isoform X1 [KO:K13780]
101002037  WNT8B; protein Wnt-8b [KO:K00714]
101002180  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
101002278  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101002314  RRAGA; ras-related GTP-binding protein A [KO:K16185]
101002458  FNIP2; folliculin-interacting protein 2 isoform X5 [KO:K20401]
101002647  SLC3A2; 4F2 cell-surface antigen heavy chain isoform X2 [KO:K06519]
101002675  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
101002971  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101002992  HRAS; GTPase HRas isoform X2 [KO:K02833]
101003212  PRR5L; proline-rich protein 5-like isoform X1 [KO:K20411]
101003749  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101004074  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101004161  NPRL2; GATOR complex protein NPRL2 isoform X2 [KO:K20405]
101004763  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
101004836  FZD10; frizzled-10 [KO:K02842]
101004880  RRAGD; ras-related GTP-binding protein D isoform X2 [KO:K16186]
101004961  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
101004976  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101005224  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
101005287  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
101005424  WNT4; protein Wnt-4 [KO:K00408]
101005652  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
101005721  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
101005753  DEPTOR; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
101005798  WNT11; protein Wnt-11 [KO:K01384]
101006008  LPIN1; phosphatidate phosphatase LPIN1 isoform X3 [KO:K15728] [EC:3.1.3.4]
101006436  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
101006580  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
101006756  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101007009  DVL1; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
101007030  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
101007271  LAMTOR4; ragulator complex protein LAMTOR4 isoform X1 [KO:K20399]
101007522  WNT9B; protein Wnt-9b [KO:K01064]
101007736  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X6 [KO:K02353]
101007756  FLCN; folliculin [KO:K09594]
101008380  RICTOR; rapamycin-insensitive companion of mTOR isoform X2 [KO:K08267]
101008394  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101008699  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101008897  WNT2B; protein Wnt-2b [KO:K00182]
101009029  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101009180  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
101009240  SESN2; sestrin-2 isoform X1 [KO:K20394]
101009789  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
101009865  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101009898  WNT7B; protein Wnt-7b [KO:K00572]
101009981  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101010034  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
101010161  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
101010276  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
101010325  FZD9; frizzled-9 [KO:K02842]
101010842  WDR59; GATOR complex protein WDR59 isoform X5 [KO:K20409]
101011059  FZD2; frizzled-2 [KO:K02235]
101011121  EIF4B; eukaryotic translation initiation factor 4B isoform X2 [KO:K03258]
101011234  STRADB; STE20-related kinase adapter protein beta [KO:K17532]
101012041  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101012071  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
101012084  GRB10; growth factor receptor-bound protein 10 isoform X3 [KO:K20064]
101012351  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
101012990  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
101013139  FZD5; frizzled-5 [KO:K02375]
101013252  WNT10B; protein Wnt-10b [KO:K01357]
101013448  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
101013533  FZD4; frizzled-4 isoform X1 [KO:K02354]
101013629  WNT1; proto-oncogene Wnt-1 [KO:K03209]
101013699  TELO2; telomere length regulation protein TEL2 homolog isoform X3 [KO:K11137]
101013835  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101014279  WNT8A; protein Wnt-8a [KO:K00714]
101015041  MTOR; serine/threonine-protein kinase mTOR isoform X2 [KO:K07203] [EC:2.7.11.1]
101015632  FZD7; frizzled-7 [KO:K02432]
101015869  [KO:K16344]
101016078  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
101016141  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
101016447  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X5 [KO:K07209] [EC:2.7.11.10]
101016532  PRKCA; protein kinase C alpha type isoform X4 [KO:K02677] [EC:2.7.11.13]
101016586  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101017114  SGK1; serine/threonine-protein kinase Sgk1 isoform X3 [KO:K13302] [EC:2.7.11.1]
101017528  KRAS; GTPase KRas isoform X2 [KO:K07827]
101018057  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
101018105  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
101018848  CAB39; calcium-binding protein 39 [KO:K08272]
101018878  MAPKAP1; LOW QUALITY PROTEIN: target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
101019087  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
101019485  DVL2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
101019776  WNT5B; protein Wnt-5b [KO:K00444]
101020411  MIOS; GATOR complex protein MIOS isoform X1 [KO:K20407]
101020686  LAMTOR3; ragulator complex protein LAMTOR3 isoform X2 [KO:K04370]
101020904  [KO:K03258]
101020923  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
101021162  TTI1; TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
101022024  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101022424  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
101022446  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
101022538  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
101022616  SEC13; protein SEC13 homolog isoform X2 [KO:K14004]
101022780  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
101022792  RPS6KA2; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
101022962  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
101023343  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
101023363  CAB39L; calcium-binding protein 39-like isoform X2 [KO:K08272]
101023443  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
101023586  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
101024001  [KO:K02149]
101024142  RRAGC; ras-related GTP-binding protein C isoform X1 [KO:K16186]
101024169  TSC1; hamartin isoform X4 [KO:K07206]
101024301  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
101024572  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X2 [KO:K04373] [EC:2.7.11.1]
101024652  ATP6V1F; V-type proton ATPase subunit F isoform X1 [KO:K02151]
101024761  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101025020  TSC2; tuberin isoform X12 [KO:K07207]
101025037  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
101025987  RRAGB; ras-related GTP-binding protein B isoform X1 [KO:K16185]
101026239  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
101026253  NRAS; GTPase NRas isoform X2 [KO:K07828]
101026312  SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
103884511  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
103888302  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X3 [KO:K23080]
103888413  PRR5; proline-rich protein 5 isoform X1 [KO:K20411]
116272877  [KO:K02991]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
panu00561  Glycerolipid metabolism
panu04010  MAPK signaling pathway
panu04140  Autophagy - animal
panu04151  PI3K-Akt signaling pathway
panu04152  AMPK signaling pathway
panu04810  Regulation of actin cytoskeleton
panu04910  Insulin signaling pathway
KO pathway
ko04150   

DBGET integrated database retrieval system