KEGG   PATHWAY: panu04151
Entry
panu04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Papio anubis (olive baboon)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
panu04151  PI3K-Akt signaling pathway
panu04151

Other DBs
GO: 0043491
Organism
Papio anubis (olive baboon) [GN:panu]
Gene
100126669  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100126695  GHR; growth hormone receptor precursor [KO:K05080]
100126735  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
100126745  PRL; prolactin isoform X2 [KO:K05439]
100126747  IL4; interleukin-4 precursor [KO:K05430]
100126754  IL2; interleukin-2 precursor [KO:K05429]
100126758  GH1; somatotropin precursor [KO:K05438]
100126764  YWHAH; 14-3-3 protein eta [KO:K16198]
100137199  IL3; interleukin-3 precursor [KO:K04736]
100137215  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
100137245  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100137475  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
100137527  IGF2; insulin-like growth factor II precursor [KO:K13769]
100137545  IFNAR2; interferon alpha/beta receptor 2 precursor [KO:K05131]
100137595  FGF1; fibroblast growth factor 1 [KO:K18496]
100379157  GHV; growth hormone variant precursor [KO:K05438]
100381179  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100381193  CSH1; chorionic somatomammotropin hormone precursor [KO:K05438]
100381195  IL6; interleukin-6 precursor [KO:K05405]
100510872  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
100510873  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X4 [KO:K02649]
100997177  PKN3; serine/threonine-protein kinase N3 isoform X3 [KO:K23692]
100997250  ANGPT2; angiopoietin-2 isoform X2 [KO:K05466]
100997339  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
100997528  [KO:K11584]
100997560  MLST8; target of rapamycin complex subunit LST8 isoform X2 [KO:K08266]
100997603  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
100997634  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100997846  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
100997854  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
100997985  INS; insulin isoform X2 [KO:K04526]
100998149  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
100998391  CD19; B-lymphocyte antigen CD19 isoform X3 [KO:K06465]
100998445  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
100998449  NGF; beta-nerve growth factor isoform X2 [KO:K02582]
100998521  PDGFA; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
100998800  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100998866  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100998877  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100999012  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X4 [KO:K03259]
100999056  [KO:K05438]
100999324  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
100999369  IRS1; insulin receptor substrate 1 [KO:K16172]
100999739  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
100999911  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101000053  [KO:K13304] [EC:2.7.11.1]
101000210  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101000289  [KO:K04737]
101000307  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
101000402  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101000592  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
101000606  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
101000613  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
101000645  MYC; myc proto-oncogene protein [KO:K04377]
101000665  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
101000688  [KO:K02991]
101000692  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
101000787  LAMB2; laminin subunit beta-2 [KO:K06243]
101000991  [KO:K04542]
101001284  PSPN; persephin [KO:K25416]
101001384  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
101001461  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
101001613  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
101001691  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
101002096  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
101002278  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101002299  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101002360  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
101002495  FGFR2; fibroblast growth factor receptor 2 isoform X12 [KO:K05093] [EC:2.7.10.1]
101002603  FGFR1; fibroblast growth factor receptor 1 isoform X6 [KO:K04362] [EC:2.7.10.1]
101002675  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
101002801  LPAR2; LOW QUALITY PROTEIN: lysophosphatidic acid receptor 2 [KO:K04291]
101002872  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
101002971  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101002992  HRAS; GTPase HRas isoform X2 [KO:K02833]
101003191  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
101003243  [KO:K06482]
101003408  FGF20; fibroblast growth factor 20 [KO:K04358]
101003425  OSM; oncostatin-M isoform X2 [KO:K05418]
101003588  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101003602  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
101003749  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101003778  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
101003812  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
101003924  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101003925  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X4 [KO:K03456]
101003935  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
101003965  FGF2; fibroblast growth factor 2 isoform X1 [KO:K18497]
101004025  FN1; fibronectin isoform X9 [KO:K05717]
101004066  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
101004074  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101004170  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
101004283  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
101004296  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
101004338  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
101004371  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101004434  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
101004461  [KO:K06856]
101004530  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
101004562  MTCP1; protein p13 MTCP-1 [KO:K16837]
101004576  IL2RA; interleukin-2 receptor subunit alpha isoform X3 [KO:K05068]
101004703  IL7; interleukin-7 isoform X1 [KO:K05431]
101004763  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
101004771  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
101004976  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101005052  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
101005084  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
101005287  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
101005361  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
101005407  SGK2; serine/threonine-protein kinase Sgk2 isoform X2 [KO:K13303] [EC:2.7.11.1]
101005414  FGF23; fibroblast growth factor 23 [KO:K22428]
101005569  YWHAG; 14-3-3 protein gamma [KO:K16198]
101005587  THBS2; thrombospondin-2 [KO:K04659]
101005612  THBS1; thrombospondin-1 [KO:K16857]
101005652  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
101005767  FGF6; fibroblast growth factor 6 [KO:K04358]
101005809  COL1A2; collagen alpha-2(I) chain [KO:K06236]
101005948  GDNF; glial cell line-derived neurotrophic factor isoform X2 [KO:K05452]
101006337  ANGPT4; angiopoietin-4 [KO:K05467]
101006375  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
101006376  LAMC3; laminin subunit gamma-3 [KO:K06247]
101006436  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
101006463  ITGA4; integrin alpha-4 [KO:K06483]
101006510  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
101006530  FGF10; fibroblast growth factor 10 [KO:K04358]
101006608  TP53; cellular tumor antigen p53 [KO:K04451]
101006669  ITGA8; integrin alpha-8 [KO:K06584]
101006756  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101006765  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
101006936  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101007023  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
101007171  JAK2; tyrosine-protein kinase JAK2 isoform X4 [KO:K04447] [EC:2.7.10.2]
101007269  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
101007274  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
101007278  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
101007358  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
101007369  EFNA4; ephrin-A4 isoform X2 [KO:K05462]
101007432  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X6 [KO:K05454]
101007514  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X4 [KO:K09047]
101007684  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
101007834  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
101007866  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
101007972  LAMC2; laminin subunit gamma-2 [KO:K06246]
101008073  EFNA1; ephrin-A1 [KO:K05462]
101008105  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
101008150  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
101008161  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
101008175  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X3 [KO:K12230]
101008264  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101008313  G6PC2; LOW QUALITY PROTEIN: glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
101008394  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101008452  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101008582  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
101008699  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101008710  CHAD; chondroadherin [KO:K06248]
101008737  OSMR; oncostatin-M-specific receptor subunit beta isoform X2 [KO:K05057]
101008905  LAMC1; laminin subunit gamma-1 isoform X1 [KO:K05635]
101008944  EPOR; erythropoietin receptor [KO:K05079]
101008957  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
101008968  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
101009029  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101009041  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
101009063  LAMA3; laminin subunit alpha-3 isoform X5 [KO:K06240]
101009064  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
101009132  ARTN; artemin [KO:K25415]
101009143  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101009359  THBS3; thrombospondin-3 isoform X3 [KO:K04659]
101009383  NTRK2; BDNF/NT-3 growth factors receptor isoform X2 [KO:K04360] [EC:2.7.10.1]
101009395  ITGA2B; integrin alpha-IIb [KO:K06476]
101009639  VEGFC; vascular endothelial growth factor C [KO:K05449]
101009907  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
101009981  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101010193  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
101010276  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
101010563  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
101010611  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
101010652  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
101010880  NTF3; neurotrophin-3 isoform X2 [KO:K04356]
101010999  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
101011004  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101011121  EIF4B; eukaryotic translation initiation factor 4B isoform X2 [KO:K03258]
101011173  FGF9; fibroblast growth factor 9 [KO:K04358]
101011174  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
101011206  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101011219  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
101011277  MYB; transcriptional activator Myb isoform X3 [KO:K09420]
101011350  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101011441  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101011528  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
101011576  VWF; von Willebrand factor isoform X1 [KO:K03900]
101011877  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
101011930  KITLG; kit ligand isoform X1 [KO:K05461]
101012041  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101012071  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
101012079  RXRA; retinoic acid receptor RXR-alpha isoform X3 [KO:K08524]
101012095  ITGB3; integrin beta-3 [KO:K06493]
101012101  [KO:K16197]
101012136  FGF16; fibroblast growth factor 16 [KO:K04358]
101012178  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
101012328  COL6A6; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
101012351  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
101012463  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
101012505  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
101012551  BAD; bcl2-associated agonist of cell death [KO:K02158]
101012673  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
101012772  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
101012779  TNN; tenascin-N isoform X1 [KO:K06252]
101012863  TCL1A; T-cell leukemia/lymphoma protein 1A isoform X2 [KO:K10167]
101012893  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
101012923  TNC; tenascin isoform X1 [KO:K06252]
101013171  EPO; erythropoietin [KO:K05437]
101013448  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
101013627  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101013728  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
101013799  ITGA1; integrin alpha-1 [KO:K06480]
101013902  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
101014095  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
101014159  ITGA2; integrin alpha-2 [KO:K06481]
101014172  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
101014456  PKN2; serine/threonine-protein kinase N2 isoform X2 [KO:K23691]
101014480  ITGA9; integrin alpha-9 [KO:K06585]
101014560  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
101014591  [KO:K06238]
101014683  IL2RB; interleukin-2 receptor subunit beta isoform X4 [KO:K05069]
101014707  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
101014878  F2R; proteinase-activated receptor 1 [KO:K03914]
101014985  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
101015041  MTOR; serine/threonine-protein kinase mTOR isoform X2 [KO:K07203] [EC:2.7.11.1]
101015152  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1 [KO:K01596] [EC:4.1.1.32]
101015176  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101015348  IBSP; bone sialoprotein 2 [KO:K06253]
101015403  HSP90B1; endoplasmin [KO:K09487]
101015443  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
101015643  TNR; tenascin-R isoform X3 [KO:K06252]
101015676  G6PC; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
101015689  SPP1; osteopontin isoform X1 [KO:K06250]
101016447  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X5 [KO:K07209] [EC:2.7.11.10]
101016516  [KO:K05414]
101016532  PRKCA; protein kinase C alpha type isoform X4 [KO:K02677] [EC:2.7.11.13]
101016586  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101016712  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
101016713  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1 [KO:K04536]
101016725  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
101016956  ITGA7; integrin alpha-7 isoform X7 [KO:K06583]
101017040  [KO:K04354]
101017078  RELA; transcription factor p65 isoform X1 [KO:K04735]
101017114  SGK1; serine/threonine-protein kinase Sgk1 isoform X3 [KO:K13302] [EC:2.7.11.1]
101017183  CRTC2; CREB-regulated transcription coactivator 2 isoform X2 [KO:K16333]
101017528  KRAS; GTPase KRas isoform X2 [KO:K07827]
101017647  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101017655  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
101017806  ITGB8; integrin beta-8 [KO:K06591]
101017891  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
101017918  [KO:K05414]
101017943  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
101017982  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101018133  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
101018141  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
101018216  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
101018226  PGF; placenta growth factor isoform X1 [KO:K16859]
101018287  [KO:K05414]
101018520  FGF3; fibroblast growth factor 3 [KO:K04358]
101018541  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101018542  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
101018652  [KO:K05414]
101019008  [KO:K05414]
101019167  [KO:K04358]
101019224  FGF4; fibroblast growth factor 4 [KO:K04358]
101019380  [KO:K05414]
101019433  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101019435  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
101019436  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
101019568  FGF19; fibroblast growth factor 19 [KO:K22603]
101019923  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101020371  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
101020406  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101020551  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
101020640  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
101020710  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
101020796  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X6 [KO:K04354]
101020904  [KO:K03258]
101020923  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
101021018  AREG; amphiregulin isoform X1 [KO:K09782]
101021050  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
101021171  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X2 [KO:K04465]
101021204  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
101021265  ITGA11; integrin alpha-11 [KO:K06587]
101021341  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
101021364  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
101021706  [KO:K05414]
101021732  EREG; proepiregulin [KO:K09784]
101021734  KIT; mast/stem cell growth factor receptor Kit isoform X5 [KO:K05091] [EC:2.7.10.1]
101021745  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101022024  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101022062  BRCA1; breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
101022081  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101022199  COMP; cartilage oligomeric matrix protein [KO:K04659]
101022229  FGF17; fibroblast growth factor 17 [KO:K04358]
101022263  YWHAQ; 14-3-3 protein theta isoform X4 [KO:K16197]
101022352  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
101022424  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
101022550  FOXO3; LOW QUALITY PROTEIN: forkhead box protein O3 [KO:K09408]
101022672  IL4R; interleukin-4 receptor subunit alpha isoform X4 [KO:K05071]
101022673  FGF18; fibroblast growth factor 18 [KO:K04358]
101022936  PTK2; focal adhesion kinase 1 isoform X25 [KO:K05725] [EC:2.7.10.2]
101023118  [KO:K05414]
101023125  VTN; vitronectin [KO:K06251]
101023802  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
101023828  [KO:K05414]
101023856  NRTN; neurturin [KO:K25414]
101024074  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
101024158  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
101024164  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
101024169  TSC1; hamartin isoform X4 [KO:K07206]
101024202  CDC37; hsp90 co-chaperone Cdc37 isoform X2 [KO:K09554]
101024204  PKN1; serine/threonine-protein kinase N1 isoform X2 [KO:K06071] [EC:2.7.11.13]
101024293  [KO:K05629]
101024356  LAMA5; laminin subunit alpha-5 [KO:K06240]
101024441  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
101024523  IFNB1; interferon beta [KO:K05415]
101024690  COL4A6; collagen alpha-6(IV) chain isoform X2 [KO:K06237]
101024761  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101024778  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 isoform X1 [KO:K16340] [EC:3.1.3.16]
101024850  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
101024880  SYK; tyrosine-protein kinase SYK isoform X6 [KO:K05855] [EC:2.7.10.2]
101024888  NOS3; LOW QUALITY PROTEIN: nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
101025020  TSC2; tuberin isoform X12 [KO:K07207]
101025143  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
101025146  [KO:K12457]
101025157  FGFR4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
101025307  CCNE2; G1/S-specific cyclin-E2 isoform X3 [KO:K06626]
101025494  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
101025814  LAMB1; LOW QUALITY PROTEIN: laminin subunit beta-1 [KO:K05636]
101025892  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
101026165  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101026183  BCL2; apoptosis regulator Bcl-2 isoform X3 [KO:K02161]
101026253  NRAS; GTPase NRas isoform X2 [KO:K07828]
101026514  LAMB4; laminin subunit beta-4 [KO:K06245]
101026665  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
101026688  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
101026781  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X6 [KO:K02580]
103884511  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
103884712  TLR2; toll-like receptor 2 [KO:K10159]
108583299  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
110741552  [KO:K05438]
116269385  FGF8; fibroblast growth factor 8 [KO:K04358]
116269767  [KO:K04659]
116270026  [KO:K05414]
116271056  [KO:K06482]
116271057  [KO:K06482]
116272742  [KO:K05637]
116272877  [KO:K02991]
116272968  [KO:K04354]
116275838  [KO:K04539]
116275849  [KO:K04358]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
panu00010  Glycolysis / Gluconeogenesis
panu04010  MAPK signaling pathway
panu04012  ErbB signaling pathway
panu04062  Chemokine signaling pathway
panu04064  NF-kappa B signaling pathway
panu04068  FoxO signaling pathway
panu04110  Cell cycle
panu04115  p53 signaling pathway
panu04150  mTOR signaling pathway
panu04210  Apoptosis
panu04370  VEGF signaling pathway
panu04510  Focal adhesion
panu04620  Toll-like receptor signaling pathway
panu04630  JAK-STAT signaling pathway
panu04662  B cell receptor signaling pathway
panu04910  Insulin signaling pathway
KO pathway
ko04151   

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