KEGG   PATHWAY: acun04144
Entry
acun04144                   Pathway                                
Name
Endocytosis - Athene cunicularia (burrowing owl)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
acun04144  Endocytosis
acun04144

Other DBs
GO: 0006897
Organism
Athene cunicularia (burrowing owl) [GN:acun]
Gene
113480759  ARF6; ADP-ribosylation factor 6 [KO:K07941]
113489462  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
113490107  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
113490878  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
113483342  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
113486607  DNM1; dynamin-1 [KO:K01528] [EC:3.6.5.5]
113483084  dynamin-3-like isoform X1 [KO:K01528] [EC:3.6.5.5]
113490501  DNM2; dynamin-2 [KO:K23484] [EC:3.6.5.5]
113489993  CLTA; clathrin light chain A isoform X1 [KO:K04644]
113485389  CLTB; clathrin light chain B [KO:K04645]
113486100  CLTCL1; clathrin heavy chain 2 isoform X1 [KO:K04646]
113487065  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
113481064  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
113487237  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
113483246  AP2M1; AP-2 complex subunit mu isoform X1 [KO:K11826]
113476683  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
113477102  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
113482298  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
113490322  ZFYVE16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
113482631  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
113483848  protein PML-like [KO:K10054] [EC:2.3.2.-]
113483936  PML; protein PML [KO:K10054] [EC:2.3.2.-]
113489639  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
113484131  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
113483383  TFRC; transferrin receptor protein 1 [KO:K06503]
113477535  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
113479434  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
113481500  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
113485394  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
113483985  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
113488489  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
113482374  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
113480332  SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
113489390  SH3GL1; endophilin-A2 isoform X1 [KO:K11247]
113484197  SH3GL3; endophilin-A3 [KO:K11247]
113490099  SH3GL2; endophilin-A1 isoform X1 [KO:K11247]
113482998  SH3GLB1; endophilin-B1 isoform X1 [KO:K11248]
113486409  SH3GLB2; endophilin-B2 isoform X1 [KO:K21269]
113477494  AMPH; amphiphysin isoform X1 [KO:K12562]
113482140  BIN1; myc box-dependent-interacting protein 1 [KO:K12562]
113486943  EPN3; epsin-3 [KO:K12471]
113485500  EPN2; epsin-2 isoform X1 [KO:K12471]
113482694  epidermal growth factor receptor substrate 15-like [KO:K12472]
113489410  EPS15L1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
113482695  EPS15; epidermal growth factor receptor substrate 15 [KO:K12472]
113477580  SPART; spartin isoform X1 [KO:K19366]
113484065  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
113489530  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
113490049  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
113481145  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
113487429  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
113486714  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
113485619  SMURF1; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
113476997  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
113478766  numb-like protein isoform X1 [KO:K12474]
113488187  LDLRAP1; low density lipoprotein receptor adapter protein 1 [KO:K12474]
113489783  DAB2; disabled homolog 2 isoform X1 [KO:K12475]
113477316  C-C chemokine receptor type 5-like [KO:K04180]
113477317  C-C chemokine receptor type 2-like [KO:K04180]
113482287  C-X-C chemokine receptor type 2-like [KO:K05050]
113482188  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
113483518  GRK7; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
113485979  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
113479265  GRK4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
113485270  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
113481464  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
113490908  beta-arrestin-1 [KO:K04439]
113491197  WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
113478064  ACTR2; actin-related protein 2 [KO:K17260]
113477058  ACTR3B; actin-related protein 3B [KO:K18584]
113482250  ACTR3; actin-related protein 3 [KO:K18584]
113485601  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
113485470  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
113482136  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
113486169  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
113482921  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
113476976  WIPF3; WAS/WASL-interacting protein family member 3 [KO:K19475]
113482101  WIPF1; WAS/WASL-interacting protein family member 1 [KO:K19475]
113488543  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
113482768  DNAJC6; putative tyrosine-protein phosphatase auxilin [KO:K09526]
113488635  WASHC4; WASH complex subunit 4 [KO:K18465]
113476954  WASHC5; WASH complex subunit 5 [KO:K18464]
113481705  WASHC2C; WASH complex subunit 2C isoform X1 [KO:K18462]
113491368  WASHC1; WASH complex subunit 1 isoform X1 [KO:K18461]
113491481  WASHC3; WASH complex subunit 3 [KO:K18463]
113488895  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
113488331  CAPZA3; LOW QUALITY PROTEIN: F-actin-capping protein subunit alpha-3 [KO:K10364]
113491008  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
113487752  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
113486211  vacuolar protein sorting-associated protein 29-like [KO:K18467]
113486241  VPS29; vacuolar protein sorting-associated protein 29 [KO:K18467]
113488436  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
113481855  VPS26A; vacuolar protein sorting-associated protein 26A isoform X1 [KO:K18466]
113484304  VPS35; vacuolar protein sorting-associated protein 35 [KO:K18468]
113480177  SNX12; sorting nexin-12 [KO:K17918]
113477694  SNX3; sorting nexin-3 [KO:K17918]
113484086  USP8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
113488024  STAMBP; STAM-binding protein [KO:K11866] [EC:3.4.19.12]
113484813  RAB7A; ras-related protein Rab-7a [KO:K07897]
113486980  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
113477245  STAM; signal transducing adapter molecule 1 [KO:K04705]
113482297  STAM2; signal transducing adapter molecule 2 [KO:K04705]
113480993  TSG101; tumor susceptibility gene 101 protein [KO:K12183]
113490921  multivesicular body subunit 12A-like [KO:K12186]
113486496  MVB12B; multivesicular body subunit 12B [KO:K12186]
113485987  VPS37B; vacuolar protein sorting-associated protein 37B [KO:K12185]
113481051  VPS37C; vacuolar protein sorting-associated protein 37C [KO:K12185]
113479156  VPS37A; vacuolar protein sorting-associated protein 37A [KO:K12185]
113489209  SNF8; vacuolar-sorting protein SNF8 [KO:K12188]
113488785  VPS36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
113486698  CHMP6; charged multivesicular body protein 6 [KO:K12195]
113487563  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
113476154  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
113479092  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
113488104  CHMP7; charged multivesicular body protein 7 [KO:K15053]
113476056  VPS4B; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 4B [KO:K12196]
113477836  VTA1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
113480201  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
113484601  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
113476420  CHMP5; charged multivesicular body protein 5 [KO:K12198]
113484636  IST1; IST1 homolog [KO:K19476]
113477505  PDCD6IP; programmed cell death 6-interacting protein [KO:K12200]
113483988  SPG21; maspardin [KO:K19367]
113477879  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
113489580  SNX2; sorting nexin-2 [KO:K17917]
113483922  SNX1; sorting nexin-1 [KO:K17917]
113480482  SNX6; sorting nexin-6 [KO:K17920]
113478671  SNX5; sorting nexin-5 isoform X1 [KO:K17920]
113487500  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
113481169  HRAS; GTPase HRas [KO:K02833]
113475946  IL15RA; LOW QUALITY PROTEIN: interleukin-15 receptor subunit alpha [KO:K05068]
113475953  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
113479902  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
113485019  RHOA; transforming protein RhoA [KO:K04513]
113490617  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
113476012  folate receptor gamma-like [KO:K13649]
113483031  riboflavin-binding protein [KO:K13649]
113491225  CAV1; caveolin-1 [KO:K06278]
113491224  CAV2; caveolin-2 [KO:K12958]
113485026  CAV3; caveolin-3 [KO:K12959]
113478520  EHD3; EH domain-containing protein 3 [KO:K12476]
113480514  EHD4; LOW QUALITY PROTEIN: EH domain-containing protein 4 [KO:K12477]
113489225  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
113476514  RAB5A; ras-related protein Rab-5A [KO:K07887]
113489175  RAB5C; ras-related protein Rab-5C [KO:K07889]
113487036  RABEP1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
113485028  RBSN; rabenosyn-5 [KO:K12481]
113478562  RAB4A; ras-related protein Rab-4A [KO:K07879]
113485222  RUFY1; RUN and FYVE domain-containing protein 1 isoform X1 [KO:K12482]
113481939  RUFY2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
113488643  VPS45; vacuolar protein sorting-associated protein 45 [KO:K12479]
113482268  SNX4; sorting nexin-4 [KO:K17919]
113476106  RAB31; ras-related protein Rab-31 [KO:K07891]
113487584  RAB22A; ras-related protein Rab-22A [KO:K07891]
113476125  ras-related protein Rab-10-like [KO:K07903]
113478815  RAB10; ras-related protein Rab-10 [KO:K07903]
113489287  RAB8A; ras-related protein Rab-8A [KO:K07901]
113486195  RAB35; ras-related protein Rab-35 [KO:K07876]
113483969  RAB11A; ras-related protein Rab-11A [KO:K07904]
113489435  RAB11B; ras-related protein Rab-11B [KO:K07905]
113488114  RAB11FIP1; rab11 family-interacting protein 1 [KO:K12484]
113481556  RAB11FIP2; rab11 family-interacting protein 2 [KO:K12484]
113479141  RAB11FIP5; rab11 family-interacting protein 5 [KO:K12484]
113481766  ZFYVE27; protrudin isoform X1 [KO:K19368]
113482170  KIF5C; kinesin heavy chain [KO:K10396]
113476642  KIF5B; kinesin-1 heavy chain [KO:K10396]
113486762  RAB11FIP4; rab11 family-interacting protein 4 isoform X1 [KO:K12485]
113485541  RAB11FIP3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
113477218  PARD3; partitioning defective 3 homolog [KO:K04237]
113484569  partitioning defective 6 homolog alpha-like [KO:K06093]
113487637  PARD6B; LOW QUALITY PROTEIN: partitioning defective 6 homolog beta [KO:K06093]
113476086  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
113487762  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
113483507  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
113487836  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
113488315  SMAP2; stromal membrane-associated protein 2 [KO:K12486]
113478184  SMAP1; stromal membrane-associated protein 1 [KO:K12486]
113490766  GIT2; ARF GTPase-activating protein GIT2 [KO:K12487]
113477430  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
113478920  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
113488363  ASAP3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
113490671  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1-like [KO:K12488]
113487764  ACAP3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
113483241  ACAP2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
113479419  ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 [KO:K18440]
113485333  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
113481995  AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
113477520  AGAP3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 [KO:K12491]
113487445  ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
113480523  ARFGAP2; ADP-ribosylation factor GTPase-activating protein 2 [KO:K12493]
113491474  ARFGAP3; ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
113490022  PSD3; PH and SEC7 domain-containing protein 3 isoform X1 [KO:K12494]
113485431  PSD2; PH and SEC7 domain-containing protein 2 [KO:K12494]
113481650  PSD; PH and SEC7 domain-containing protein 1 [KO:K12494]
113484957  IQSEC1; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
113491465  IQSEC3; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
113485753  CYTH3; cytohesin-3 [KO:K18441]
113487931  CYTH4; LOW QUALITY PROTEIN: cytohesin-4 [KO:K18441]
113487472  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 [KO:K18442]
113476540  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
113481427  GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
113476357  ARF1; ADP-ribosylation factor 1 [KO:K07937]
113485037  ARF4; ADP-ribosylation factor 4 [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
acun04060  Cytokine-cytokine receptor interaction
acun04070  Phosphatidylinositol signaling system
acun04130  SNARE interactions in vesicular transport
acun04142  Lysosome
acun04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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