KEGG   PATHWAY: agen04622
Entry
agen04622                   Pathway                                
Name
RIG-I-like receptor signaling pathway - Accipiter gentilis (Northern goshawk)
Description
Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
Class
Organismal Systems; Immune system
Pathway map
agen04622  RIG-I-like receptor signaling pathway
agen04622

Organism
Accipiter gentilis (Northern goshawk) [GN:agen]
Gene
126036296  antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
126050092  interferon-induced helicase C domain-containing protein 1 isoform X1 [KO:K12647] [EC:5.6.2.6]
126050688  NFX1-type zinc finger-containing protein 1-like [KO:K27391]
126045929  NFX1-type zinc finger-containing protein 1 isoform X1 [KO:K27391]
126034148  mitochondrial antiviral-signaling protein [KO:K12648]
126038676  ATP-dependent RNA helicase DHX58 isoform X1 [KO:K12649] [EC:5.6.2.6]
126050490  TNF receptor-associated factor 3 isoform X1 [KO:K03174]
126052914  TRAF family member-associated NF-kappa-B activator [KO:K12650]
126038094  5-azacytidine-induced protein 2 isoform X1 [KO:K12651]
126038370  TANK-binding kinase 1-binding protein 1 [KO:K12652]
126035169  NF-kappa-B essential modulator-like [KO:K07210]
126034369  serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
126052261  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
126047183  interferon regulatory factor 7 isoform X1 [KO:K09447]
126036597  interferon epsilon-like [KO:K05414]
126035927  interferon-like [KO:K05415]
126035928  interferon-like [KO:K05415]
126035929  interferon type B-like [KO:K05415]
126035930  interferon-like [KO:K05415]
126035931  interferon-like [KO:K05415]
126035932  interferon-like [KO:K05415]
126035933  interferon-like [KO:K05415]
126035934  interferon-like [KO:K05415]
126035935  interferon-like [KO:K05415]
126035936  interferon-like [KO:K05415]
126035937  interferon-like [KO:K05415]
126035938  interferon-like [KO:K05415]
126035939  interferon-like [KO:K05415]
126035940  interferon-like [KO:K05415]
126035941  interferon-like [KO:K05415]
126035942  interferon-like [KO:K05415]
126035943  interferon-like [KO:K05415]
126035944  interferon-like [KO:K05415]
126035945  interferon-like [KO:K05415]
126035946  interferon-like [KO:K05415]
126035947  interferon-like [KO:K05415]
126035948  interferon-like [KO:K05415]
126035949  interferon-like [KO:K05415]
126040297  tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
126047517  FAS-associated death domain protein [KO:K02373]
126048669  receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
126048220  caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
126047422  caspase-10 [KO:K04400] [EC:3.4.22.63]
126043236  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
126051568  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
126035312  NF-kappa-B inhibitor beta [KO:K02581]
126049313  NF-kappa-B inhibitor alpha [KO:K04734]
126044906  LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
126053415  transcription factor p65 [KO:K04735]
126052119  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
126046221  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
126049491  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
126035238  mitogen-activated protein kinase kinase kinase 1-like [KO:K04416] [EC:2.7.11.25]
126036143  mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
126044892  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
126042643  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
126050836  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
126044349  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
126044350  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
126052497  mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
126052499  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
126044837  alveolar macrophage chemotactic factor-like [KO:K10030]
126044932  interleukin-8-like isoform X1 [KO:K10030]
126045009  interleukin-8-like isoform X1 [KO:K10030]
126045010  interleukin-8-like [KO:K10030]
126039801  interleukin-12 subunit alpha [KO:K05406]
126050806  interleukin-12 subunit beta isoform X1 [KO:K05425]
126040778  double-stranded RNA-specific adenosine deaminase isoform X1 [KO:K12968] [EC:3.5.4.37]
126043406  E3 ubiquitin/ISG15 ligase TRIM25 [KO:K10652] [EC:2.3.2.27]
126049530  ubiquitin carboxyl-terminal hydrolase CYLD-like isoform X1 [KO:K08601] [EC:3.4.19.12]
126041285  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
126046110  autophagy protein 5 isoform X1 [KO:K08339]
126036195  ubiquitin-like protein ATG12 [KO:K08336]
126038526  NLR family member X1 isoform X1 [KO:K12653]
126050815  stimulator of interferon genes protein isoform X1 [KO:K12654]
126035208  OTU domain-containing protein 5 isoform X1 [KO:K12655] [EC:3.4.19.12]
126052346  LOW QUALITY PROTEIN: suppressor of IKBKE 1 [KO:K12656]
126053112  ATP-dependent RNA helicase DDX3X isoform X1 [KO:K11594] [EC:5.6.2.7]
126043188  peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [KO:K09578] [EC:5.2.1.8]
126047111  triokinase/FMN cyclase isoform X1 [KO:K00863] [EC:2.7.1.28 2.7.1.29 4.6.1.15]
Compound
C00046  RNA
Reference
PMID:15208624
  Authors
Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T
  Title
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
  Journal
Nat Immunol 5:730-7 (2004)
DOI:10.1038/ni1087
Reference
PMID:18272355
  Authors
Takeuchi O, Akira S
  Title
MDA5/RIG-I and virus recognition.
  Journal
Curr Opin Immunol 20:17-22 (2008)
DOI:10.1016/j.coi.2008.01.002
Reference
PMID:19120475
  Authors
Yoneyama M, Fujita T
  Title
RNA recognition and signal transduction by RIG-I-like receptors.
  Journal
Immunol Rev 227:54-65 (2009)
DOI:10.1111/j.1600-065X.2008.00727.x
Reference
PMID:19539500
  Authors
Nakhaei P, Genin P, Civas A, Hiscott J
  Title
RIG-I-like receptors: sensing and responding to RNA virus infection.
  Journal
Semin Immunol 21:215-22 (2009)
DOI:10.1016/j.smim.2009.05.001
Reference
PMID:18549796
  Authors
Moore CB, Ting JP
  Title
Regulation of mitochondrial antiviral signaling pathways.
  Journal
Immunity 28:735-9 (2008)
DOI:10.1016/j.immuni.2008.05.005
Reference
PMID:19615405
  Authors
Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB
  Title
Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.
  Journal
Pharmacol Ther 124:219-34 (2009)
DOI:10.1016/j.pharmthera.2009.06.012
Reference
PMID:19120476
  Authors
Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G
  Title
Approaching the RNA ligand for RIG-I?
  Journal
Immunol Rev 227:66-74 (2009)
DOI:10.1111/j.1600-065X.2008.00724.x
Reference
PMID:18591413
  Authors
Saito T, Gale M Jr
  Title
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.
  Journal
J Exp Med 205:1523-7 (2008)
DOI:10.1084/jem.20081210
Reference
PMID:19076341
  Authors
Kawai T, Akira S
  Title
Toll-like receptor and RIG-I-like receptor signaling.
  Journal
Ann N Y Acad Sci 1143:1-20 (2008)
DOI:10.1196/annals.1443.020
Reference
PMID:18439848
  Authors
Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J
  Title
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
  Journal
Immunity 28:651-61 (2008)
DOI:10.1016/j.immuni.2008.03.013
Reference
PMID:18984593
  Authors
Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T
  Title
TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
  Journal
J Biol Chem 283:36211-20 (2008)
DOI:10.1074/jbc.M806576200
Reference
PMID:19224920
  Authors
Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR
  Title
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
  Journal
J Biol Chem 284:10774-82 (2009)
DOI:10.1074/jbc.M807272200
Reference
PMID:32668226
  Authors
Liu G, Gack MU
  Title
Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity.
  Journal
Immunity 53:26-42 (2020)
DOI:10.1016/j.immuni.2020.03.017
Related
pathway
agen04010  MAPK signaling pathway
agen04120  Ubiquitin mediated proteolysis
agen04210  Apoptosis
KO pathway
ko04622   
LinkDB

DBGET integrated database retrieval system