KEGG   PATHWAY: aju04728
Entry
aju04728                    Pathway                                
Name
Dopaminergic synapse - Acinonyx jubatus (cheetah)
Description
Dopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning and memory, and endocrine regulation. Once released from presynaptic axonal terminals, DA interacts with at least five receptor subtypes in the central nervous system (CNS), which have been divided into two groups: the D1-like receptors (D1Rs), comprising D1 and D5 receptors, both positively coupled to adenylyl cyclase and cAMP production, and the D2-like receptors (D2Rs), comprising D2, D3, and D4 receptors, whose activation results in inhibition of adenylyl cyclase and suppression of cAMP production. In addition, D1Rs and D2Rs modulate intracellular Ca2+ levels and a number of Ca2+ -dependent intracellular signaling processes. Through diverse cAMP- and Ca2+-dependent and - independent mechanisms, DA influences neuronal activity, synaptic plasticity, and behavior. Presynaptically localized D2Rs regulate synthesis and release of DA as the main autoreceptor of the dopaminergic system.
Class
Organismal Systems; Nervous system
Pathway map
aju04728  Dopaminergic synapse
aju04728

Other DBs
GO: 0001963
Organism
Acinonyx jubatus (cheetah) [GN:aju]
Gene
106971078  tyrosine 3-monooxygenase [KO:K00501] [EC:1.14.16.2]
106968187  aromatic-L-amino-acid decarboxylase isoform X1 [KO:K01593] [EC:4.1.1.28 4.1.1.105]
106974109  synaptic vesicular amine transporter [KO:K08155]
106971854  chromaffin granule amine transporter [KO:K08155]
106975386  D(1A) dopamine receptor [KO:K04144]
106975633  D(1B) dopamine receptor [KO:K05840]
106987496  neuron-specific vesicular protein calcyon [KO:K15493]
106975317  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
106976431  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
106976432  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
106981698  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
106968579  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
106978946  inositol 1,4,5-trisphosphate receptor type 1 isoform X2 [KO:K04958]
106968786  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
106976077  inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
106980445  LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
106987911  calmodulin-1 [KO:K02183]
106977221  calmodulin-2 [KO:K02183]
106984637  calmodulin-like protein 6 isoform X1 [KO:K02183]
106973635  calmodulin-3 [KO:K02183]
106988136  calmodulin-like protein 3 [KO:K02183]
106988135  calmodulin-like [KO:K02183]
106977318  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
106968235  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
106970983  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
106985400  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
106970974  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
106982482  protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
106981120  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
106975306  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
106970449  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
106980855  protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
106974355  protein c-Fos [KO:K04379]
106969942  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
106969924  neuroendocrine secretory protein 55 [KO:K04632]
106981474  guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
106984082  adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
106973352  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
106985791  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
106967098  cyclic AMP-responsive element-binding protein 1 isoform X3 [KO:K05870]
106988085  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
106979942  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
106981255  cyclic AMP-responsive element-binding protein 3 [KO:K09048]
106970423  cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
106987262  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
106975473  cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
106978069  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
106987665  cyclic AMP-responsive element-binding protein 5 isoform X6 [KO:K09047]
106983500  cyclic AMP-dependent transcription factor ATF-6 beta isoform X4 [KO:K09049]
106972806  mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
106987636  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
106987637  mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
106972759  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
106969894  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
106970668  mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
106989581  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
106980464  protein phosphatase 1 regulatory subunit 1B isoform X1 [KO:K15494]
106967586  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
106967920  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
106971182  serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
106982887  sodium channel protein type 1 subunit alpha isoform X1 [KO:K04833]
106965473  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
106986998  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
106986103  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
106986735  voltage-dependent N-type calcium channel subunit alpha-1B isoform X5 [KO:K04849]
106979067  G protein-activated inward rectifier potassium channel 1 isoform X1 [KO:K04997]
106967007  G protein-activated inward rectifier potassium channel 2 [KO:K05000]
113596242  G protein-activated inward rectifier potassium channel 3 [KO:K05002]
106984374  G protein-activated inward rectifier potassium channel 4 [KO:K04999]
106977772  D(3) dopamine receptor [KO:K04146]
113596787  D(4) dopamine receptor [KO:K04147]
106977809  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
106982494  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
106973284  guanine nucleotide-binding protein G(o) subunit alpha isoform X2 [KO:K04534]
106984654  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
106987417  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
106965344  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
106973885  guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
106967264  guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
106981966  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
113593204  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3-like [KO:K04540]
106981725  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
106982557  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X3 [KO:K04541]
106970626  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
106973348  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
106989697  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
113593434  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
113592841  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
106969997  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
106985197  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
113596552  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X3 [KO:K04347]
106977369  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X1 [KO:K04547]
106969996  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
106985188  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X1 [KO:K04549]
106980600  D(2) dopamine receptor [KO:K04145]
106977969  beta-arrestin-1 isoform X5 [KO:K04439]
106972493  beta-arrestin-2 isoform X7 [KO:K04439]
106966583  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
106984892  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
106984444  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
106973000  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
106966536  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
106985785  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X2 [KO:K04354]
106984955  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
106982733  protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
106987475  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X4 [KO:K11583]
106982041  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
106987100  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
106966766  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
106975965  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X4 [KO:K11584]
106971318  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
106974042  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
106971234  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X2 [KO:K11584]
106979622  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
106975558  RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
106985046  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106987692  glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
106968274  glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
106989347  glutamate receptor ionotropic, NMDA 2A [KO:K05209]
106965657  glutamate receptor ionotropic, NMDA 2B [KO:K05210]
106967642  glutamate receptor 1 isoform X1 [KO:K05197]
106986586  glutamate receptor 2 isoform X3 [KO:K05198]
106972822  glutamate receptor 3 isoform X1 [KO:K05199]
106976499  glutamate receptor 4 isoform X1 [KO:K05200]
106977160  kinesin-1 heavy chain isoform X1 [KO:K10396]
106975864  kinesin heavy chain isoform X1 [KO:K10396]
106971520  kinesin heavy chain [KO:K10396]
106971676  circadian locomoter output cycles protein kaput isoform X2 [KO:K02223] [EC:2.3.1.48]
106971847  BMAL1; basic helix-loop-helix ARNT-like protein 1 isoform X10 [KO:K02296]
106985115  sodium-dependent dopamine transporter [KO:K05036]
106972520  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
106972743  amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
106970934  transmembrane O-methyltransferase isoform X2 [KO:K00545] [EC:2.1.1.6]
106983613  catechol O-methyltransferase isoform X1 [KO:K00545] [EC:2.1.1.6]
Compound
C00076  Calcium cation
C00082  L-Tyrosine
C00165  Diacylglycerol
C00238  Potassium cation
C00355  3,4-Dihydroxy-L-phenylalanine
C00575  3',5'-Cyclic AMP
C01161  3,4-Dihydroxyphenylacetate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C03758  Dopamine
C05582  Homovanillate
C05587  3-Methoxytyramine
Reference
PMID:21303898
  Authors
Beaulieu JM, Gainetdinov RR
  Title
The physiology, signaling, and pharmacology of dopamine receptors.
  Journal
Pharmacol Rev 63:182-217 (2011)
DOI:10.1124/pr.110.002642
Reference
PMID:15521361
  Authors
Neve KA, Seamans JK, Trantham-Davidson H
  Title
Dopamine receptor signaling.
  Journal
J Recept Signal Transduct Res 24:165-205 (2004)
DOI:10.1081/RRS-200029981
Reference
PMID:17408758
  Authors
Surmeier DJ, Ding J, Day M, Wang Z, Shen W
  Title
D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons.
  Journal
Trends Neurosci 30:228-35 (2007)
DOI:10.1016/j.tins.2007.03.008
Reference
PMID:20224735
  Authors
Knab AM, Lightfoot JT
  Title
Does the difference between physically active and couch potato lie in the dopamine system?
  Journal
Int J Biol Sci 6:133-50 (2010)
DOI:10.7150/ijbs.6.133
Reference
PMID:10433257
  Authors
Greengard P, Allen PB, Nairn AC
  Title
Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade.
  Journal
Neuron 23:435-47 (1999)
DOI:10.1016/S0896-6273(00)80798-9
Reference
PMID:15590733
  Authors
Hu XT, Dong Y, Zhang XF, White FJ
  Title
Dopamine D2 receptor-activated Ca2+ signaling modulates voltage-sensitive sodium currents in rat nucleus accumbens neurons.
  Journal
J Neurophysiol 93:1406-17 (2005)
DOI:10.1152/jn.00771.2004
Reference
PMID:17349698
  Authors
Beaulieu JM, Gainetdinov RR, Caron MG
  Title
The Akt-GSK-3 signaling cascade in the actions of dopamine.
  Journal
Trends Pharmacol Sci 28:166-72 (2007)
DOI:10.1016/j.tips.2007.02.006
Reference
PMID:19138563
  Authors
De Mei C, Ramos M, Iitaka C, Borrelli E
  Title
Getting specialized: presynaptic and postsynaptic dopamine D2 receptors.
  Journal
Curr Opin Pharmacol 9:53-8 (2009)
DOI:10.1016/j.coph.2008.12.002
Reference
PMID:15381316
  Authors
Seamans JK, Yang CR
  Title
The principal features and mechanisms of dopamine modulation in the prefrontal cortex.
  Journal
Prog Neurobiol 74:1-58 (2004)
DOI:10.1016/j.pneurobio.2004.05.006
Reference
PMID:18353279
  Authors
Yao WD, Spealman RD, Zhang J
  Title
Dopaminergic signaling in dendritic spines.
  Journal
Biochem Pharmacol 75:2055-69 (2008)
DOI:10.1016/j.bcp.2008.01.018
Reference
PMID:20727368
  Authors
Li YC, Gao WJ
  Title
GSK-3beta activity and hyperdopamine-dependent behaviors.
  Journal
Neurosci Biobehav Rev 35:645-54 (2011)
DOI:10.1016/j.neubiorev.2010.08.001
Reference
PMID:15292232
  Authors
Tang TS, Bezprozvanny I
  Title
Dopamine receptor-mediated Ca(2+) signaling in striatal medium spiny neurons.
  Journal
J Biol Chem 279:42082-94 (2004)
DOI:10.1074/jbc.M407389200
Reference
PMID:12967774
  Authors
Bergson C, Levenson R, Goldman-Rakic PS, Lidow MS
  Title
Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling.
  Journal
Trends Pharmacol Sci 24:486-92 (2003)
DOI:10.1016/S0165-6147(03)00232-3
Reference
PMID:9457173
  Authors
Missale C, Nash SR, Robinson SW, Jaber M, Caron MG
  Title
Dopamine receptors: from structure to function.
  Journal
Physiol Rev 78:189-225 (1998)
DOI:10.1152/physrev.1998.78.1.189
Reference
PMID:19251795
  Authors
Quaak M, van Schayck CP, Knaapen AM, van Schooten FJ
  Title
Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases?
  Journal
Eur Respir J 33:468-80 (2009)
DOI:10.1183/09031936.00056908
Related
pathway
aju00350  Tyrosine metabolism
aju04020  Calcium signaling pathway
aju04721  Synaptic vesicle cycle
aju04724  Glutamatergic synapse
aju05012  Parkinson disease
KO pathway
ko04728   
LinkDB

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