KEGG   PATHWAY: asao04145
Entry
asao04145                   Pathway                                
Name
Phagosome - Anolis sagrei ordinatus (Brown anole)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
asao04145  Phagosome
asao04145

Other DBs
GO: 0045335
Organism
Anolis sagrei ordinatus (Brown anole) [GN:asao]
Gene
132764688  VAMP3; vesicle-associated membrane protein 3 [KO:K13505]
132780334  STX12; syntaxin-12 [KO:K13813]
132760977  STX7; syntaxin-7 [KO:K08488]
132764636  actin, clone 302-like [KO:K05692]
132764637  actin, clone 302-like [KO:K05692]
132764638  actin, clone 302-like [KO:K05692]
132762478  actin, cytoplasmic type 5 [KO:K05692]
132762480  actin-like [KO:K05692]
132762481  actin, clone 302-like isoform X1 [KO:K05692]
132768424  ACTG1; actin, cytoplasmic 2 [KO:K05692]
132762738  actin, clone 302-like [KO:K05692]
132780002  ACTB; actin, cytoplasmic 1 [KO:K05692]
132770522  ACTRT3; actin-related protein T3 isoform X1 [KO:K05692]
132777819  CORO1A; coronin-1A [KO:K13882]
132776383  STX18; syntaxin-18 [KO:K08492]
132765713  vesicle-trafficking protein SEC22b-B-like [KO:K08517]
132774297  SEC22B; vesicle-trafficking protein SEC22b [KO:K08517]
132765326  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
132765329  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
132765334  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
132765340  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
132765342  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
132765343  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
132765344  major histocompatibility complex class I-related gene protein-like [KO:K06751]
132765814  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
132765818  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
132769747  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
132766324  RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752]
132766327  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
132766329  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
132766330  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
132766331  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
132766334  RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752]
132766337  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
132766377  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
132766777  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
132778373  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
132779134  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
132774135  class II histocompatibility antigen, M alpha chain isoform X1 [KO:K06752]
132778704  RAB5A; ras-related protein Rab-5A [KO:K07887]
132768208  RAB5B; ras-related protein Rab-5B [KO:K07888]
132778216  RAB5C; ras-related protein Rab-5C [KO:K07889]
132776100  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
132766840  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
132769784  TFRC; LOW QUALITY PROTEIN: transferrin receptor protein 1 [KO:K06503]
132768471  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
132764454  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
132767932  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
132782810  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
132777303  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
132782820  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
132775036  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
132767521  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
132775764  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
132775621  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
132765235  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
132774445  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
132763655  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
132770839  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
132768818  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
132777357  ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 isoform X1 [KO:K02154]
132778222  ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 isoform X1 [KO:K02154]
132773301  TCIRG1; V-type proton ATPase 116 kDa subunit a 3 [KO:K02154]
132781358  ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 isoform X1 [KO:K02154]
132783005  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
132772841  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
132774826  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
132781875  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
132773825  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661]
132777178  V-type proton ATPase subunit S1-like [KO:K03662]
132767872  ATP6AP1; V-type proton ATPase subunit S1 isoform X1 [KO:K03662]
132769312  RAB7A; ras-related protein Rab-7a [KO:K07897]
132767843  ras-related protein Rab-7a-like [KO:K07897]
132773614  RAB7B; ras-related protein Rab-7b [KO:K07898]
132763275  RILP; rab-interacting lysosomal protein isoform X1 [KO:K13883]
132762313  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
132772193  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
132776881  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
132778832  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
132783345  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
132778663  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
132770701  tubulin alpha-3 chain [KO:K07374]
132773286  tubulin alpha-8 chain [KO:K07374]
132768225  TUBA1B; tubulin alpha-1B chain [KO:K07374]
132768226  TUBA1A; tubulin alpha-1A chain [KO:K07374]
132768227  tubulin alpha-1C chain [KO:K07374]
132773646  tubulin alpha-1D chain-like [KO:K07374]
132773651  tubulin alpha-4A chain [KO:K07374]
132775344  tubulin alpha-3 chain [KO:K07374]
132775646  tubulin alpha-3 chain-like [KO:K07374]
132775654  tubulin alpha-3 chain-like [KO:K07374]
132775757  tubulin alpha-8 chain [KO:K07374]
132775759  tubulin alpha-4 chain-like [KO:K07374]
132765182  TUBB; tubulin beta chain [KO:K07375]
132783181  TUBB3; tubulin beta-3 chain [KO:K07375]
132773085  TUBB1; tubulin beta-1 chain [KO:K07375]
132768072  TUBB4A; tubulin beta-4A chain [KO:K07375]
132774554  tubulin beta-2 chain isoform X1 [KO:K07375]
132774705  TUBB6; tubulin beta-6 chain [KO:K07375]
132763622  TUBB4B; tubulin beta-4B chain [KO:K07375]
132771522  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
132763062  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
132778945  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
132767970  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
132781320  NOS1; nitric oxide synthase 1 [KO:K13240] [EC:1.14.13.39]
132770131  myeloperoxidase-like [KO:K10789] [EC:1.11.2.2]
132767303  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
132781038  procathepsin L-like isoform X1 [KO:K01365] [EC:3.4.22.15]
132764183  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
132769320  SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956]
132778485  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
132778523  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
132765336  antigen peptide transporter 1-like [KO:K05653] [EC:7.4.2.14]
132765811  antigen peptide transporter 1-like [KO:K05653] [EC:7.4.2.14]
132769673  antigen peptide transporter 1-like [KO:K05653] [EC:7.4.2.14]
132765338  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
132768032  CALR; calreticulin [KO:K08057]
132773917  calreticulin-like isoform X1 [KO:K08057]
132780946  CALR3; LOW QUALITY PROTEIN: calreticulin-3 [KO:K08057]
132768933  CANX; calnexin [KO:K08054]
132779199  uncharacterized protein LOC132779199 [KO:K06856]
132767515  C1R; complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
132780121  ITGB2; integrin beta-2 [KO:K06464]
132765496  complement C3-like [KO:K03990]
132765510  C3; complement C3 [KO:K03990]
132768035  A.superbus venom factor 1-like [KO:K03990]
132768036  A.superbus venom factor 1-like [KO:K03990]
132768040  venom factor-like [KO:K03990]
132783015  COLEC11; collectin-11 isoform X1 [KO:K10066]
132774750  COLEC12; collectin-12 [KO:K10062]
132771267  mannose-binding protein-like [KO:K03991]
132771268  pulmonary surfactant-associated protein D-like [KO:K03991]
132771262  pulmonary surfactant-associated protein A-like [KO:K10067]
132769935  pulmonary surfactant-associated protein A2-like [KO:K10067]
132771263  pulmonary surfactant-associated protein D-like isoform X1 [KO:K10068]
132771264  pulmonary surfactant-associated protein D-like [KO:K10068]
132771265  pulmonary surfactant-associated protein D-like isoform X1 [KO:K10068]
132771266  pulmonary surfactant-associated protein D-like isoform X1 [KO:K10068]
132771270  pulmonary surfactant-associated protein D-like [KO:K10068]
132770188  pulmonary surfactant-associated protein D-like [KO:K10068]
132768155  ITGAV; integrin alpha-V [KO:K06487]
132766978  ITGA2; integrin alpha-2 [KO:K06481]
132767747  ITGA5; integrin alpha-5 [KO:K06484]
132778950  ITGB1; integrin beta-1 [KO:K05719]
132778319  ITGB3; integrin beta-3 [KO:K06493]
132774700  ITGB5; integrin beta-5 [KO:K06588]
132765864  THBS1; thrombospondin-1 [KO:K16857]
132767040  THBS4; thrombospondin-4 [KO:K04659]
132761143  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
132781124  COMP; cartilage oligomeric matrix protein [KO:K04659]
132764123  THBS3; thrombospondin-3 [KO:K04659]
132776793  toll-like receptor 2 type-2 [KO:K10159]
132776794  toll-like receptor 2 type-2 [KO:K10159]
132776795  toll-like receptor 2 type-2 [KO:K10159]
132776321  toll-like receptor 1 [KO:K10169]
132776322  toll-like receptor 6 isoform X1 [KO:K10169]
132763647  TLR4; toll-like receptor 4 [KO:K10160]
132772739  toll-like receptor 2 [KO:K04391]
132772740  toll-like receptor 2 [KO:K04391]
132776265  PLA2R1; secretory phospholipase A2 receptor [KO:K06560]
132778396  MRC2; C-type mannose receptor 2 [KO:K06560]
132778893  MRC1; macrophage mannose receptor 1 [KO:K06560]
132778894  macrophage mannose receptor 1-like [KO:K06560]
132778895  macrophage mannose receptor 1-like [KO:K06560]
132766590  hepatic lectin-like [KO:K06563]
132766591  hepatic lectin-like isoform X1 [KO:K06563]
132768184  hepatic lectin-like [KO:K06563]
132768185  hepatic lectin-like isoform X1 [KO:K06563]
132768186  hepatic lectin-like isoform X1 [KO:K06563]
132774934  MARCO; macrophage receptor MARCO isoform X1 [KO:K13884]
132765485  OLR1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
132781367  SCARB1; scavenger receptor class B member 1 isoform X1 [KO:K13885]
132776536  CD36; platelet glycoprotein 4 [KO:K06259]
132783070  cytochrome b-245 light chain [KO:K08009]
132771762  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
132782023  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
132763907  NCF1; neutrophil cytosol factor 1 [KO:K08011]
132774401  NCF2; neutrophil cytosol factor 2 [KO:K08010]
132775905  NCF4; neutrophil cytosol factor 4 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
asao04142  Lysosome
asao04144  Endocytosis
asao04620  Toll-like receptor signaling pathway
KO pathway
ko04145   
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