KEGG   PATHWAY: cdk04115
Entry
cdk04115                    Pathway                                
Name
p53 signaling pathway - Camelus dromedarius (Arabian camel)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
cdk04115  p53 signaling pathway
cdk04115

Organism
Camelus dromedarius (Arabian camel) [GN:cdk]
Gene
105096603  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
105099476  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
105086328  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
105094454  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
105092753  GORAB; RAB6-interacting golgin isoform X1 [KO:K19748]
105092872  cyclin-dependent kinase inhibitor 2A-like isoform X1 [KO:K06621]
105101086  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
105098644  MDM4; protein Mdm4 isoform X1 [KO:K10127]
105103011  TP53; cellular tumor antigen p53 [KO:K04451]
105095453  PPP1R13L; LOW QUALITY PROTEIN: relA-associated inhibitor [KO:K27356]
105101330  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
105104393  CCND1; LOW QUALITY PROTEIN: G1/S-specific cyclin-D1 [KO:K04503]
105091327  CCND2; LOW QUALITY PROTEIN: G1/S-specific cyclin-D2 [KO:K10151]
105086756  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
105100330  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
105088747  CDK6; cyclin-dependent kinase 6 isoform X2 [KO:K02091] [EC:2.7.11.22]
105085741  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
105096784  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
105086385  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
105100696  SFN; 14-3-3 protein sigma [KO:K06644]
105093721  RPRM; protein reprimo [KO:K10128]
105084760  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
105088978  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
105093852  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
105086406  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
105103609  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
105096626  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
105091976  GTSE1; G2 and S phase-expressed protein 1 [KO:K10129]
105101004  ZNF385A; LOW QUALITY PROTEIN: zinc finger protein 385A [KO:K26543]
105102832  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
105105443  PIDD1; p53-induced death domain-containing protein 1 isoform X1 [KO:K10130]
105102505  tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722]
105102515  tumor necrosis factor receptor superfamily member 10A-like isoform X1 [KO:K04722]
105099181  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
105100737  BID; LOW QUALITY PROTEIN: BH3-interacting domain death agonist [KO:K04726]
105102890  BAX; apoptosis regulator BAX [KO:K02159]
105089011  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
105104049  BBC3; LOW QUALITY PROTEIN: bcl-2-binding component 3 [KO:K10132]
105104842  SIVA1; apoptosis regulatory protein Siva isoform X2 [KO:K22744]
105100821  BCL2L1; bcl-2-like protein 1 isoform X2 [KO:K04570]
105088999  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
105100023  TP53I3; quinone oxidoreductase PIG3 [KO:K10133] [EC:1.-.-.-]
105094456  EI24; etoposide-induced protein 2.4 homolog [KO:K10134]
105087951  SHISA5; protein shisa-5 isoform X1 [KO:K10135]
105092042  PERP; p53 apoptosis effector related to PMP-22 [KO:K10136]
105085929  ZMAT3; zinc finger matrin-type protein 3 isoform X1 [KO:K10137]
105091167  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
105098528  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
105095080  cytochrome c [KO:K08738]
105092650  cytochrome c [KO:K08738]
105097442  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
105107056  CASP9; LOW QUALITY PROTEIN: caspase-9 [KO:K04399] [EC:3.4.22.62]
105084433  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105099877  AIFM2; apoptosis-inducing factor 2 isoform X1 [KO:K22745]
116150633  IGFBP3; LOW QUALITY PROTEIN: insulin-like growth factor-binding protein 3 [KO:K10138]
105097468  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
105092393  SERPINE1; plasminogen activator inhibitor 1 [KO:K03982]
105106240  ADGRB1; LOW QUALITY PROTEIN: adhesion G protein-coupled receptor B1 [KO:K04596]
105106840  CD82; CD82 antigen [KO:K06509]
105096896  THBS1; thrombospondin-1 [KO:K16857]
105089003  SERPINB5; serpin B5 isoform X1 [KO:K10139]
105106872  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
105091241  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
105090530  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
105102880  SESN3; sestrin-3 isoform X1 [KO:K10141]
105097115  SESN1; sestrin-1 isoform X1 [KO:K10141]
105103326  SESN2; sestrin-2 [KO:K20394]
105088956  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105099714  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
105088434  STEAP3; metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
105099992  COP1; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
105091452  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
105097690  CCNG1; cyclin-G1 [KO:K10145]
105091667  CCNG2; cyclin-G2 [KO:K10146]
105097840  PPM1D; protein phosphatase 1D isoform X1 [KO:K10147] [EC:3.1.3.16]
105104880  TP73; tumor protein p73 isoform X1 [KO:K10148]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
cdk04110  Cell cycle
cdk04210  Apoptosis
cdk04218  Cellular senescence
KO pathway
ko04115   
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