KEGG   PATHWAY: cfa00600
Entry
cfa00600                    Pathway                                
Name
Sphingolipid metabolism - Canis lupus familiaris (dog)
Class
Metabolism; Lipid metabolism
Pathway map
cfa00600  Sphingolipid metabolism
cfa00600

Module
cfa_M00066  Lactosylceramide biosynthesis [PATH:cfa00600]
cfa_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:cfa00600]
cfa_M00094  Ceramide biosynthesis [PATH:cfa00600]
cfa_M00099  Sphingosine biosynthesis [PATH:cfa00600]
cfa_M00100  Sphingosine degradation [PATH:cfa00600]
Other DBs
GO: 0006665
Organism
Canis lupus familiaris (dog) [GN:cfa]
Gene
480403  SPTLC2; serine palmitoyltransferase 2 isoform X2 [KO:K00654] [EC:2.3.1.50]
484192  SPTLC1; serine palmitoyltransferase 1 isoform X8 [KO:K00654] [EC:2.3.1.50]
485766  SPTLC3; serine palmitoyltransferase 3 isoform X2 [KO:K00654] [EC:2.3.1.50]
609655  KDSR; 3-ketodihydrosphingosine reductase [KO:K04708] [EC:1.1.1.102]
609789  CERS1; ceramide synthase 1 [KO:K04710] [EC:2.3.1.299]
483187  CERS2; ceramide synthase 2 [KO:K24621] [EC:2.3.1.297]
485008  CERS4; ceramide synthase 4 isoform X2 [KO:K24621] [EC:2.3.1.297]
607925  CERS3; ceramide synthase 3 isoform X1 [KO:K24622] [EC:2.3.1.297 2.3.1.298]
488387  CERS6; ceramide synthase 6 isoform X1 [KO:K23727] [EC:2.3.1.291]
477611  CERS5; ceramide synthase 5 isoform X2 [KO:K23727] [EC:2.3.1.291]
482897  ASAH1; acid ceramidase isoform X1 [KO:K12348] [EC:3.5.1.23]
486461  ASAH2; neutral ceramidase [KO:K12349] [EC:3.5.1.23]
611739  ACER1; alkaline ceramidase 1 isoform X3 [KO:K01441] [EC:3.5.1.23]
100856386  ACER2; alkaline ceramidase 2 isoform X3 [KO:K01441] [EC:3.5.1.23]
607939  ACER3; alkaline ceramidase 3 isoform X2 [KO:K04711] [EC:3.5.1.-]
490395  DEGS1; sphingolipid delta(4)-desaturase DES1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
490854  DEGS2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
477582  SGMS1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27]
478505  SGMS2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27]
485334  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
100856377  SMPD2; sphingomyelin phosphodiesterase 2 isoform X1 [KO:K12351] [EC:3.1.4.12]
489743  SMPD3; sphingomyelin phosphodiesterase 3 isoform X1 [KO:K12352] [EC:3.1.4.12]
486434  SMPD4; sphingomyelin phosphodiesterase 4 isoform X2 [KO:K12353] [EC:3.1.4.12]
608627  ENPP7; ectonucleotide pyrophosphatase/phosphodiesterase family member 7 isoform X1 [KO:K12354] [EC:3.1.4.12]
100855615  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
474464  CERK; ceramide kinase [KO:K04715] [EC:2.7.1.138]
607962  PLPP1; phospholipid phosphatase 1 isoform X3 [KO:K01080] [EC:3.1.3.4]
479557  PLPP3; phospholipid phosphatase 3 isoform X2 [KO:K01080] [EC:3.1.3.4]
100856443  PLPP2; phospholipid phosphatase 2 isoform X1 [KO:K01080] [EC:3.1.3.4]
490728  SGPP1; sphingosine-1-phosphate phosphatase 1 [KO:K04716] [EC:3.1.3.-]
610884  SGPP2; sphingosine-1-phosphate phosphatase 2 isoform X6 [KO:K04717] [EC:3.1.3.-]
484401  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
483329  SPHK1; sphingosine kinase 1 isoform X4 [KO:K04718] [EC:2.7.1.91]
489032  SGPL1; sphingosine-1-phosphate lyase 1 [KO:K01634] [EC:4.1.2.27]
481666  UGCG; ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
612206  GBA; lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
474760  GBA2; non-lysosomal glucosylceramidase [KO:K17108] [EC:3.2.1.45]
490499  B4GALT6; beta-1,4-galactosyltransferase 6 isoform X3 [KO:K07553] [EC:2.4.1.274]
485920  B4GALT5; beta-1,4-galactosyltransferase 5 isoform X1 [KO:K09905] [EC:2.4.1.274 2.4.1.-]
403873  GLB1; beta-galactosidase precursor [KO:K12309] [EC:3.2.1.23]
487910  UGT8; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase [KO:K04628] [EC:2.4.1.47]
403916  GALC; galactocerebrosidase precursor [KO:K01202] [EC:3.2.1.46]
611960  GAL3ST1; galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
474457  ARSA; arylsulfatase A precursor [KO:K01134] [EC:3.1.6.8]
481717  NEU1; sialidase-1 isoform X2 [KO:K01186] [EC:3.2.1.18]
485195  NEU3; sialidase-3 isoform X1 [KO:K12357] [EC:3.2.1.18]
609668  NEU4; sialidase-4 isoform X1 [KO:K12357] [EC:3.2.1.18]
486166  NEU2; sialidase-2 [KO:K12357] [EC:3.2.1.18]
481129  B4GALNT1; beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X2 [KO:K00725] [EC:2.4.1.92]
478100  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
487633  HEXA; beta-hexosaminidase subunit alpha isoform X2 [KO:K12373] [EC:3.2.1.52]
100855818  GM2A; ganglioside GM2 activator [KO:K12383]
479240  PSAP; prosaposin isoform X2 [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
cfa00260  Glycine, serine and threonine metabolism
cfa00601  Glycosphingolipid biosynthesis - lacto and neolacto series
cfa00603  Glycosphingolipid biosynthesis - globo and isoglobo series
cfa00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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