KEGG   PATHWAY: cide04912
Entry
cide04912                   Pathway                                
Name
GnRH signaling pathway - Ctenopharyngodon idella (grass carp)
Description
Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnRHR is coupled to Gq/11 proteins to activate phospholipase C which transmits its signal to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG activates the intracellular protein kinase C (PKC) pathway and IP3 stimulates release of intracellular calcium. In addition to the classical Gq/11, coupling of Gs is occasionally observed in a cell-specific fashion. Signaling downstream of protein kinase C (PKC) leads to transactivation of the epidermal growth factor (EGF) receptor and activation of mitogen-activated protein kinases (MAPKs), including extracellular-signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 MAPK. Active MAPKs translocate to the nucleus, resulting in activation of transcription factors and rapid induction of early genes.
Class
Organismal Systems; Endocrine system
Pathway map
cide04912  GnRH signaling pathway
cide04912

Organism
Ctenopharyngodon idella (grass carp) [GN:cide]
Gene
127503296  progonadoliberin-2 [KO:K05252]
127498435  gonadotropin-releasing hormone 3 [KO:K05252]
127499336  gonadotropin releasing hormone receptor 4 [KO:K04280]
127501656  gonadotropin releasing hormone receptor 1 [KO:K04280]
127516773  gonadotropin releasing hormone receptor 2 [KO:K04280]
127497809  gonadotropin releasing hormone receptor 3 [KO:K04280]
127513968  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
127501836  adenylate cyclase type 1b [KO:K08041] [EC:4.6.1.1]
127502168  LOW QUALITY PROTEIN: adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
127500508  adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
127497118  adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
127501758  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
127496915  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
127518999  adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
127504834  adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
127504871  adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
127515179  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
127499075  si:ch211-132f19.7; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
127495274  adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
127502320  si:dkey-206f10.1; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
127507826  adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
127520673  adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
127506489  protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
127522428  protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
127519370  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
127508471  LOW QUALITY PROTEIN: activating transcription factor 4b [KO:K04374]
127513836  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
127513346  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
127522861  guanine nucleotide-binding protein subunit alpha-11b [KO:K04635]
127520230  guanine nucleotide-binding protein subunit alpha-11a isoform X1 [KO:K04635]
127516205  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
127501913  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
127501914  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
127498080  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
127498081  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
127498831  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
127514964  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
127522689  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
127499474  inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
127517038  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
127515547  calmodulin-like protein 4a [KO:K02183]
127507638  calmodulin-like protein 4 [KO:K02183]
127494994  calmodulin 3a (phosphorylase kinase, delta) isoform X1 [KO:K02183]
127502289  calmodulin-1b [KO:K02183]
127523824  calmodulin 2b, (phosphorylase kinase, delta) [KO:K02183]
127524770  calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
127504069  calmodulin 3b (phosphorylase kinase, delta) [KO:K02183]
127498959  calmodulin-1a [KO:K02183]
127521735  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
127515592  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
127509896  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
127524192  calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
127524622  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
127503963  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
127513679  calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
127514577  protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
127508774  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
127525757  protein kinase C, beta a isoform X2 [KO:K19662] [EC:2.7.11.13]
127509047  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
127522064  protein kinase C, delta b [KO:K06068] [EC:2.7.11.13]
127514019  protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
127511476  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
127522496  calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
127516967  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
127517750  calcium channel, voltage-dependent, L type, alpha 1F subunit isoform X1 [KO:K04853]
127517829  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
127521648  calcium channel, voltage-dependent, L type, alpha 1S subunit, a [KO:K04857]
127517752  calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
127520635  mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
127514127  mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
127509155  mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
127505843  mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
127525563  mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
127524204  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
127499931  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
127522287  mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
127517001  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
127517204  mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
127510537  mitogen-activated protein kinase 12b isoform X1 [KO:K04441] [EC:2.7.11.24]
127510539  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
127505446  zgc:171775; LOW QUALITY PROTEIN: STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
127523710  mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
127502123  cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
127495782  cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
127512115  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
127512273  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
127512906  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
127512908  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
127513086  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
127513088  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
127513089  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
127513090  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
127513122  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
127513529  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
127498743  cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
127498856  cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
127498857  cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
127518267  si:ch211-168k14.2; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
127512353  LOW QUALITY PROTEIN: phospholipase D2 [KO:K01115] [EC:3.1.4.4]
127498660  phospholipase D1a [KO:K01115] [EC:3.1.4.4]
127505849  phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
127504709  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
127522841  cell division control protein 42 homolog isoform X1 [KO:K04393]
127497067  cell division cycle 42, like [KO:K04393]
127505518  cell division cycle 42 like 2 isoform X1 [KO:K04393]
127508428  dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
127523337  dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
127514659  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
127523601  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127503188  mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
127524755  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
127524923  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127503882  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
127513691  junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
127502688  transcription factor AP-1 [KO:K04448]
127524580  lutropin subunit beta [KO:K08521]
127498603  glycoprotein hormones alpha chain [KO:K08522]
127499105  protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
127502502  protein tyrosine kinase 2 beta, b [KO:K05871] [EC:2.7.10.2]
127515393  72 kDa type IV collagenase isoform X1 [KO:K01398] [EC:3.4.24.24]
127515365  matrix metalloproteinase-14a isoform X1 [KO:K07763] [EC:3.4.24.80]
127494064  matrix metalloproteinase-14b [KO:K07763] [EC:3.4.24.80]
127494596  heparin-binding EGF-like growth factor a [KO:K08523]
127503822  heparin-binding EGF-like growth factor b [KO:K08523]
127506254  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
127505760  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
127508627  growth factor receptor-bound protein 2b [KO:K04364]
127514131  growth factor receptor-bound protein 2a [KO:K04364]
127522075  son of sevenless homolog 1 isoform X1 [KO:K03099]
127525055  son of sevenless homolog 2 [KO:K03099]
127507367  HRas proto-oncogene, GTPase a [KO:K02833]
127516364  HRas proto-oncogene, GTPase b [KO:K02833]
127506985  GTPase KRas isoform X1 [KO:K07827]
127508487  zgc:55558; GTPase KRas [KO:K07827]
127517208  GTPase NRas [KO:K07828]
127522563  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
127504685  raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
127499431  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
127502256  dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
127519987  dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
127509562  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
127513496  mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
127517506  ETS domain-containing protein Elk-1 [KO:K04375]
127494067  early growth response protein 1 [KO:K09203]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00416  Phosphatidate
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:15350605
  Authors
Ruf F, Sealfon SC.
  Title
Genomics view of gonadotrope signaling circuits.
  Journal
Trends Endocrinol Metab 15:331-8 (2004)
DOI:10.1016/j.tem.2004.07.008
Reference
PMID:15613448
  Authors
Harrison GS, Wierman ME, Nett TM, Glode LM.
  Title
Gonadotropin-releasing hormone and its receptor in normal and malignant cells.
  Journal
Endocr Relat Cancer 11:725-48 (2004)
DOI:10.1677/erc.1.00777
Reference
PMID:15982836
  Authors
Pawson AJ, McNeilly AS.
  Title
The pituitary effects of GnRH.
  Journal
Anim Reprod Sci 88:75-94 (2005)
DOI:10.1016/j.anireprosci.2005.05.010
Reference
  Authors
DeGroot LJ, Jameson JL (ed).
  Title
Endocrinology (Fifth edition)
  Journal
Elsevier Saunders (2006)
Reference
PMID:10707049
  Authors
Naor Z, Benard O, Seger R.
  Title
Activation of MAPK cascades by G-protein-coupled receptors: the case of gonadotropin-releasing hormone receptor.
  Journal
Trends Endocrinol Metab 11:91-9 (2000)
DOI:10.1016/S1043-2760(99)00232-5
Reference
PMID:14596811
  Authors
Ruf F, Fink MY, Sealfon SC.
  Title
Structure of the GnRH receptor-stimulated signaling network: insights from genomics.
  Journal
Front Neuroendocrinol 24:181-99 (2003)
DOI:10.1016/S0091-3022(03)00027-X
Reference
PMID:12943720
  Authors
Farshori PQ, Shah BH, Arora KK, Martinez-Fuentes A, Catt KJ.
  Title
Activation and nuclear translocation of PKCdelta, Pyk2 and ERK1/2 by gonadotropin releasing hormone in HEK293 cells.
  Journal
J Steroid Biochem Mol Biol 85:337-47 (2003)
DOI:10.1016/S0960-0760(03)00226-7
Reference
PMID:15080147
  Authors
Shah BH, Catt KJ.
  Title
Matrix metalloproteinases in reproductive endocrinology.
  Journal
Trends Endocrinol Metab 15:47-9 (2004)
DOI:10.1016/j.tem.2004.01.004
Reference
PMID:12963732
  Authors
Roelle S, Grosse R, Aigner A, Krell HW, Czubayko F, Gudermann T.
  Title
Matrix metalloproteinases 2 and 9 mediate epidermal growth factor receptor transactivation by gonadotropin-releasing hormone.
  Journal
J Biol Chem 278:47307-18 (2003)
DOI:10.1074/jbc.M304377200
Reference
PMID:18708085
  Authors
Naor Z
  Title
Signaling by G-protein-coupled receptor (GPCR): studies on the GnRH receptor.
  Journal
Front Neuroendocrinol 30:10-29 (2009)
DOI:10.1016/j.yfrne.2008.07.001
Related
pathway
cide04010  MAPK signaling pathway
cide04020  Calcium signaling pathway
cide04060  Cytokine-cytokine receptor interaction
cide04080  Neuroactive ligand-receptor interaction
KO pathway
ko04912   
LinkDB

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