Entry
Name
Ribosome biogenesis in eukaryotes - Camelina sativa (false flax)
Description
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
Ortholog table
Organism
Camelina sativa (false flax) [GN:
csat ]
Gene
104732964 ribosomal RNA-processing protein 7 homolog isoform X1 [KO:K14545 ]
104719537 ribosomal RNA-processing protein 7 homolog isoform X1 [KO:K14545 ]
104722240 U3 small nucleolar RNA-associated protein 4 isoform X1 [KO:K14548 ]
104707147 U3 small nucleolar RNA-associated protein 4 isoform X1 [KO:K14548 ]
104736855 U3 small nucleolar RNA-associated protein 4-like isoform X3 [KO:K14548 ]
104762920 U3 small nucleolar ribonucleoprotein protein MPP10 isoform X1 [KO:K14559 ]
104745706 U3 small nucleolar ribonucleoprotein protein MPP10 isoform X1 [KO:K14559 ]
104727387 U3 small nucleolar ribonucleoprotein protein MPP10-like [KO:K14559 ]
104705857 U3 small nucleolar ribonucleoprotein protein IMP3-like [KO:K14560 ]
104735595 U3 small nucleolar ribonucleoprotein protein IMP3-like [KO:K14560 ]
104761256 probable mediator of RNA polymerase II transcription subunit 36b isoform X1 [KO:K14563 ] [EC:2.1.1.-]
104763405 putative rRNA 2'-O-methyltransferase fibrillarin 3 [KO:K14563 ] [EC:2.1.1.-]
104730864 mediator of RNA polymerase II transcription subunit 36a [KO:K14563 ] [EC:2.1.1.-]
104728826 putative rRNA 2'-O-methyltransferase fibrillarin 3 [KO:K14563 ] [EC:2.1.1.-]
104725758 probable mediator of RNA polymerase II transcription subunit 36b isoform X1 [KO:K14563 ] [EC:2.1.1.-]
104717697 mediator of RNA polymerase II transcription subunit 36a [KO:K14563 ] [EC:2.1.1.-]
104727478 probable mediator of RNA polymerase II transcription subunit 36b isoform X1 [KO:K14563 ] [EC:2.1.1.-]
104753322 putative rRNA 2'-O-methyltransferase fibrillarin 3 [KO:K14563 ] [EC:2.1.1.-]
104722401 mediator of RNA polymerase II transcription subunit 36a-like [KO:K14563 ] [EC:2.1.1.-]
104753342 putative rRNA 2'-O-methyltransferase fibrillarin 3 [KO:K14563 ] [EC:2.1.1.-]
104712384 H/ACA ribonucleoprotein complex subunit 4-like [KO:K11131 ] [EC:5.4.99.-]
104781619 H/ACA ribonucleoprotein complex subunit 4 isoform X2 [KO:K11131 ] [EC:5.4.99.-]
104792006 H/ACA ribonucleoprotein complex subunit 4-like [KO:K11131 ] [EC:5.4.99.-]
104769023 H/ACA ribonucleoprotein complex subunit 2-like protein [KO:K11129 ]
104734836 H/ACA ribonucleoprotein complex subunit 2-like protein [KO:K11129 ]
104708277 H/ACA ribonucleoprotein complex subunit 2-like protein [KO:K11129 ]
104791673 putative H/ACA ribonucleoprotein complex subunit 1-like protein 1 [KO:K11128 ]
104764026 putative H/ACA ribonucleoprotein complex subunit 1-like protein 1 [KO:K11128 ]
104770146 H/ACA ribonucleoprotein complex subunit 1-like protein 2 [KO:K11128 ]
104706123 H/ACA ribonucleoprotein complex subunit 1-like protein 2 isoform X1 [KO:K11128 ]
104735872 H/ACA ribonucleoprotein complex subunit 1-like protein 2 [KO:K11128 ]
104744492 putative H/ACA ribonucleoprotein complex subunit 1-like protein 1 [KO:K11128 ]
104766780 H/ACA ribonucleoprotein complex subunit 3-like protein [KO:K11130 ]
104747813 H/ACA ribonucleoprotein complex subunit 3-like protein [KO:K11130 ]
104701621 H/ACA ribonucleoprotein complex subunit 3-like protein [KO:K11130 ]
104714059 U3 small nucleolar RNA-associated protein 14-like isoform X1 [KO:K14567 ]
104772173 LOW QUALITY PROTEIN: uncharacterized protein C57A7.06-like [KO:K14567 ]
104707858 U3 small nucleolar RNA-associated protein 14 isoform X1 [KO:K14567 ]
104768922 LOW QUALITY PROTEIN: RNA cytidine acetyltransferase 1-like [KO:K14521 ] [EC:2.3.1.-]
104712479 RNA cytidine acetyltransferase 2-like isoform X1 [KO:K14521 ] [EC:2.3.1.-]
104706500 probable RNA 3'-terminal phosphate cyclase-like protein [KO:K11108 ]
104770530 probable RNA 3'-terminal phosphate cyclase-like protein [KO:K11108 ]
104736221 probable RNA 3'-terminal phosphate cyclase-like protein [KO:K11108 ]
104762833 small RNA degrading nuclease 3 isoform X1 [KO:K14570 ] [EC:3.1.-.-]
104708562 LOW QUALITY PROTEIN: small RNA degrading nuclease 2 [KO:K14570 ] [EC:3.1.-.-]
104780838 small RNA degrading nuclease 1-like isoform X1 [KO:K14570 ] [EC:3.1.-.-]
104736602 small RNA degrading nuclease 5 isoform X1 [KO:K14570 ] [EC:3.1.-.-]
104711546 small RNA degrading nuclease 1-like isoform X1 [KO:K14570 ] [EC:3.1.-.-]
104791242 small RNA degrading nuclease 1-like isoform X1 [KO:K14570 ] [EC:3.1.-.-]
104771372 5'-3' exoribonuclease 2-like isoform X1 [KO:K12619 ] [EC:3.1.13.-]
104763728 cell division control protein 48 homolog C-like isoform X1 [KO:K14571 ]
104791851 eukaryotic translation initiation factor 6-2 isoform X1 [KO:K03264 ]
Reference
Authors
Freed EF, Bleichert F, Dutca LM, Baserga SJ
Title
When ribosomes go bad: diseases of ribosome biogenesis.
Journal
Reference
Authors
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
Title
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
Journal
Reference
Authors
Strunk BS, Karbstein K
Title
Powering through ribosome assembly.
Journal
Reference
Authors
Granneman S, Baserga SJ
Title
Ribosome biogenesis: of knobs and RNA processing.
Journal
Reference
Authors
Kressler D, Hurt E, Bassler J
Title
Driving ribosome assembly.
Journal
Related pathway
KO pathway
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