KEGG   PATHWAY: dcc04144
Entry
dcc04144                    Pathway                                
Name
Endocytosis - Dermochelys coriacea (leatherback sea turtle)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
dcc04144  Endocytosis
dcc04144

Other DBs
GO: 0006897
Organism
Dermochelys coriacea (leatherback sea turtle) [GN:dcc]
Gene
119847347  ADP-ribosylation factor 6-like isoform X1 [KO:K07941]
119857407  ARF6; ADP-ribosylation factor 6 [KO:K07941]
119847679  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X2 [KO:K00889] [EC:2.7.1.68]
119848239  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
119856234  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
119844265  PIP5KL1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
119861565  PLD1; phospholipase D1 isoform X2 [KO:K01115] [EC:3.1.4.4]
119844217  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
119860131  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
119846110  DNM2; dynamin-2 isoform X4 [KO:K23484] [EC:3.6.5.5]
119855464  CLTA; clathrin light chain A isoform X1 [KO:K04644]
119860418  CLTB; clathrin light chain B isoform X1 [KO:K04645]
119843599  clathrin heavy chain 2 isoform X1 [KO:K04646]
119844831  CLTC; LOW QUALITY PROTEIN: clathrin heavy chain 1 [KO:K04646]
119847329  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
119856968  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
119844722  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
119861253  AP2M1; AP-2 complex subunit mu isoform X1 [KO:K11826]
119847311  AP2S1; AP-2 complex subunit sigma isoform X2 [KO:K11827]
122455369  EHD2; EH domain-containing protein 2 [KO:K12469]
119850901  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
119851479  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
119863153  LOW QUALITY PROTEIN: TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
119856028  ZFYVE16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
119860010  ZFYVE9; LOW QUALITY PROTEIN: zinc finger FYVE domain-containing protein 9 [KO:K04679]
119862208  protein PML-like isoform X2 [KO:K10054] [EC:2.3.2.-]
119862209  protein PML-like isoform X1 [KO:K10054] [EC:2.3.2.-]
119855698  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
119862604  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
119861942  TFRC; transferrin receptor protein 1 isoform X2 [KO:K06503]
119851699  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
119854364  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
119858475  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
119854594  FGFR3; fibroblast growth factor receptor 3 isoform X4 [KO:K05094] [EC:2.7.10.1]
119860434  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
119862152  IGF1R; LOW QUALITY PROTEIN: insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
119848059  CBLC; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL-C [KO:K04707] [EC:2.3.2.27]
119846645  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
119858421  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
119849647  SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
119848247  SH3GL1; endophilin-A2 isoform X3 [KO:K11247]
119863017  SH3GL3; endophilin-A3 isoform X1 [KO:K11247]
119856343  SH3GL2; endophilin-A1 isoform X1 [KO:K11247]
119859777  SH3GLB1; endophilin-B1 isoform X3 [KO:K11248]
119844102  SH3GLB2; endophilin-B2 isoform X1 [KO:K21269]
119863404  BIN1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
119850564  AMPH; amphiphysin isoform X1 [KO:K12562]
119862760  EPN2; epsin-2 isoform X1 [KO:K12471]
119842919  EPN3; epsin-3 isoform X1 [KO:K12471]
119846892  EPN1; LOW QUALITY PROTEIN: epsin-1 [KO:K12471]
119848531  EPS15L1; LOW QUALITY PROTEIN: epidermal growth factor receptor substrate 15-like 1 [KO:K12472]
119860071  EPS15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
119854296  SPART; spartin isoform X1 [KO:K19366]
119862260  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
119856018  NEDD4L; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase NEDD4-like [KO:K13305] [EC:2.3.2.26]
119845581  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
119856996  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
119845681  RNF41; E3 ubiquitin-protein ligase NRDP1 isoform X1 [KO:K11981] [EC:2.3.2.27]
119841894  ITCH; E3 ubiquitin-protein ligase Itchy homolog [KO:K05632] [EC:2.3.2.26]
119862354  SMURF1; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
119843168  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
119850483  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
119845849  LDLR; low-density lipoprotein receptor [KO:K12473]
119845499  LDLRAP1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
119853231  low density lipoprotein receptor adapter protein 1-A-like isoform X4 [KO:K12474]
119855972  DAB2; disabled homolog 2 isoform X1 [KO:K12475]
119850433  C-C chemokine receptor type 5-like [KO:K04180]
119851143  C-C chemokine receptor type 5-like [KO:K04180]
119850434  C-C chemokine receptor type 5-like [KO:K04180]
119863845  C-X-C chemokine receptor type 2-like [KO:K05050]
119863218  CXCR4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
119861922  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
119849271  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
119843814  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
119857403  GRK2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
119854568  GRK4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
119848808  G protein-coupled receptor kinase 5-like isoform X1 [KO:K08291] [EC:2.7.11.16]
119858855  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
119860223  GRK6; G protein-coupled receptor kinase 6 isoform X2 [KO:K08291] [EC:2.7.11.16]
119849297  ARRB2; beta-arrestin-2 isoform X2 [KO:K04439]
119856859  ARRB1; beta-arrestin-1 isoform X2 [KO:K04439]
119859405  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
119852822  ACTR2; actin-related protein 2 isoform X2 [KO:K17260]
119859321  actin-related protein 2-B-like [KO:K17260]
119863471  ACTR3; actin-related protein 3 [KO:K18584]
119851836  ACTR3B; LOW QUALITY PROTEIN: actin-related protein 3B [KO:K18584]
119862159  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
119862952  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
119863375  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X2 [KO:K05758]
119843622  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
119858342  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
119844028  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
119859989  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
119848875  WIPF2; WAS/WASL-interacting protein family member 2 [KO:K19475]
119863257  WIPF1; WAS/WASL-interacting protein family member 1 [KO:K19475]
119850892  WIPF3; WAS/WASL-interacting protein family member 3 [KO:K19475]
119847633  heat shock cognate 71 kDa protein-like isoform X1 [KO:K03283]
119847862  heat shock 70 kDa protein 1A-like [KO:K03283]
119846639  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
119860477  DNAJC6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
119850037  WASHC4; WASH complex subunit 4 isoform X1 [KO:K18465]
119850454  WASHC5; WASH complex subunit 5 isoform X1 [KO:K18464]
119858393  WASHC2C; WASH complex subunit 2C isoform X1 [KO:K18462]
119848245  WASHC1; WASH complex subunit 1 isoform X1 [KO:K18461]
119844100  WASHC3; WASH complex subunit 3 isoform X1 [KO:K18463]
119863064  F-actin-capping protein subunit alpha-1-like [KO:K10364]
119863248  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
119856027  CAPZA3; LOW QUALITY PROTEIN: F-actin-capping protein subunit alpha-3 [KO:K10364]
119846459  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
119844944  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
119843660  VPS29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
119843932  vacuolar protein sorting-associated protein 29-like [KO:K18467]
119858858  VPS26A; vacuolar protein sorting-associated protein 26A isoform X1 [KO:K18466]
119846801  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
119841054  VPS35; vacuolar protein sorting-associated protein 35 isoform X1 [KO:K18468]
119861501  SNX12; sorting nexin-12 [KO:K17918]
119853939  SNX3; sorting nexin-3 [KO:K17918]
119862182  USP8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
119848815  STAM-binding protein [KO:K11866] [EC:3.4.19.12]
119859289  RAB7A; ras-related protein Rab-7a [KO:K07897]
119842549  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X3 [KO:K12182]
119863336  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
119851407  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
119856668  TSG101; tumor susceptibility gene 101 protein isoform X1 [KO:K12183]
119844087  MVB12B; multivesicular body subunit 12B isoform X2 [KO:K12186]
119845634  MVB12A; LOW QUALITY PROTEIN: multivesicular body subunit 12A [KO:K12186]
119852325  VPS28; vacuolar protein sorting-associated protein 28 homolog isoform X4 [KO:K12184]
119855192  VPS37A; vacuolar protein sorting-associated protein 37A isoform X1 [KO:K12185]
119843868  VPS37B; vacuolar protein sorting-associated protein 37B [KO:K12185]
119857714  VPS37C; vacuolar protein sorting-associated protein 37C [KO:K12185]
119844821  VPS37D; vacuolar protein sorting-associated protein 37D [KO:K12185]
119848997  SNF8; vacuolar-sorting protein SNF8 isoform X1 [KO:K12188]
119857770  LOW QUALITY PROTEIN: vacuolar-sorting protein SNF8-like [KO:K12188]
119842901  VPS36; vacuolar protein-sorting-associated protein 36 isoform X1 [KO:K12190]
119849001  VPS25; vacuolar protein-sorting-associated protein 25 isoform X2 [KO:K12189]
119843138  CHMP6; charged multivesicular body protein 6 [KO:K12195]
119842267  CHMP4B; charged multivesicular body protein 4b isoform X1 [KO:K12194]
119852160  CHMP4C; LOW QUALITY PROTEIN: charged multivesicular body protein 4c [KO:K24782]
119854716  charged multivesicular body protein 3 isoform X3 [KO:K12193]
119846937  CHMP2A; charged multivesicular body protein 2a [KO:K12191]
119849763  CHMP2B; charged multivesicular body protein 2b isoform X1 [KO:K12192]
119848737  CHMP7; charged multivesicular body protein 7 isoform X2 [KO:K15053]
119841311  VPS4A; vacuolar protein sorting-associated protein 4A isoform X2 [KO:K12196]
119851266  VPS4B; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
119853034  VTA1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
119841368  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
119851546  CHMP5; charged multivesicular body protein 5 [KO:K12198]
119841192  IST1; IST1 homolog isoform X1 [KO:K19476]
119850837  programmed cell death 6-interacting protein isoform X1 [KO:K12200]
119862558  SPG21; maspardin isoform X1 [KO:K19367]
119853102  IGF2R; cation-independent mannose-6-phosphate receptor isoform X1 [KO:K06564]
119862268  SNX1; sorting nexin-1 isoform X1 [KO:K17917]
119855773  SNX2; sorting nexin-2 isoform X2 [KO:K17917]
119857013  SNX6; sorting nexin-6 isoform X1 [KO:K17920]
119853329  SNX5; sorting nexin-5 isoform X3 [KO:K17920]
119859487  SNX32; sorting nexin-32 [KO:K17920]
119841751  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
119857099  HRAS; GTPase HRas [KO:K02833]
119856193  IL2RA; interleukin-2 receptor subunit alpha isoform X2 [KO:K05068]
119861146  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
119861160  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
119857324  LOW QUALITY PROTEIN: rho-related GTP-binding protein RhoC-like [KO:K04513]
119858635  RHOA; transforming protein RhoA [KO:K04513]
119847012  transforming protein RhoA-like isoform X2 [KO:K04513]
119854513  class I histocompatibility antigen, F10 alpha chain-like isoform X2 [KO:K06751]
119856428  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
119854956  LOW QUALITY PROTEIN: class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
119856331  LOW QUALITY PROTEIN: class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
119842584  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
119861599  folate receptor alpha-like [KO:K13649]
119861846  folate receptor gamma-like isoform X2 [KO:K13649]
119849619  folate receptor gamma-like isoform X2 [KO:K13649]
119845910  RTBDN; retbindin [KO:K13649]
119859763  riboflavin-binding protein-like [KO:K13649]
119863848  CAV1; caveolin-1 isoform X1 [KO:K06278]
119840925  CAV2; caveolin-2 [KO:K12958]
119858928  CAV3; caveolin-3 [KO:K12959]
119853722  EHD3; EH domain-containing protein 3 [KO:K12476]
119857127  EHD4; EH domain-containing protein 4 [KO:K12477]
119855356  EEA1; LOW QUALITY PROTEIN: early endosome antigen 1 [KO:K12478]
119852294  RAB5A; ras-related protein Rab-5A [KO:K07887]
119845688  RAB5B; ras-related protein Rab-5B [KO:K07888]
119849065  RAB5C; ras-related protein Rab-5C [KO:K07889]
119844832  RABEP1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
119858722  RBSN; rabenosyn-5 isoform X1 [KO:K12481]
119853491  RAB4A; ras-related protein Rab-4A [KO:K07879]
119860593  RUFY1; RUN and FYVE domain-containing protein 1 isoform X2 [KO:K12482]
119858887  RUFY2; RUN and FYVE domain-containing protein 2 isoform X3 [KO:K12482]
119858536  EHD1; EH domain-containing protein 1 [KO:K12483]
119847590  VPS45; vacuolar protein sorting-associated protein 45 isoform X1 [KO:K12479]
119863152  SNX4; sorting nexin-4 [KO:K17919]
119841756  RAB22A; ras-related protein Rab-22A [KO:K07891]
119851900  RAB31; ras-related protein Rab-31 isoform X1 [KO:K07891]
119851835  ras-related protein Rab-10-like isoform X1 [KO:K07903]
119852680  RAB10; ras-related protein Rab-10 [KO:K07903]
119848214  RAB8A; ras-related protein Rab-8A isoform X1 [KO:K07901]
119856751  ras-related protein Rab-35-like [KO:K07876]
119843858  RAB35; ras-related protein Rab-35 [KO:K07876]
119848104  ras-related protein Rab-11A-like [KO:K07904]
119862367  RAB11A; ras-related protein Rab-11A [KO:K07904]
119848256  RAB11B; ras-related protein Rab-11B [KO:K07905]
119859129  RAB11FIP2; rab11 family-interacting protein 2 isoform X1 [KO:K12484]
119848747  RAB11FIP1; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
119854346  RAB11FIP5; rab11 family-interacting protein 5 isoform X2 [KO:K12484]
119859246  ZFYVE27; protrudin isoform X1 [KO:K19368]
119850848  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
119863633  KIF5C; kinesin heavy chain isoform X1 [KO:K10396]
119846074  KIF5A; kinesin heavy chain isoform X2 [KO:K10396]
119862720  RAB11FIP3; LOW QUALITY PROTEIN: rab11 family-interacting protein 3 [KO:K12485]
119842839  RAB11FIP4; rab11 family-interacting protein 4 isoform X1 [KO:K12485]
119851780  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
119841001  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
119842412  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
119852239  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
119844928  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
119861159  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
119845005  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
119845339  SMAP2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
119853749  SMAP1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
119844706  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
119843524  GIT2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
119842208  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2-like isoform X2 [KO:K12488]
119850849  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X5 [KO:K12488]
119845529  ASAP3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488]
119853994  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
119861035  ACAP2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X3 [KO:K12489]
119849269  ACAP1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12489]
119845118  ACAP3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
119845582  ARAP1; LOW QUALITY PROTEIN: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 [KO:K18439]
119855186  ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
119859944  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
119863172  AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X11 [KO:K12491]
119850589  AGAP3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X3 [KO:K12491]
119846109  AGAP2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
119841798  ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 isoform X6 [KO:K12492]
119857070  ARFGAP2; ADP-ribosylation factor GTPase-activating protein 2 isoform X2 [KO:K12493]
119845277  ARFGAP3; ADP-ribosylation factor GTPase-activating protein 3 isoform X1 [KO:K12493]
119860799  PSD2; PH and SEC7 domain-containing protein 2 [KO:K12494]
119855753  LOW QUALITY PROTEIN: PH and SEC7 domain-containing protein 3-like [KO:K12494]
119848834  PSD4; LOW QUALITY PROTEIN: PH and SEC7 domain-containing protein 4 [KO:K12494]
119848231  IQSEC3; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
119858485  IQSEC1; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
119846965  IQSEC2; IQ motif and SEC7 domain-containing protein 2 isoform X1 [KO:K12495]
119862252  CYTH3; cytohesin-3 isoform X1 [KO:K18441]
119842973  CYTH1; cytohesin-1 [KO:K18441]
119863594  CYTH4; cytohesin-4 [KO:K18441]
119847131  CYTH2; cytohesin-2 [KO:K18441]
119841840  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
119850839  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
119858349  GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X5 [KO:K18443]
119849118  ADP-ribosylation factor 2 [KO:K07937]
119851140  ARF1; ADP-ribosylation factor 1 [KO:K07937]
119845773  ARF3; ADP-ribosylation factor 3 isoform X1 [KO:K07938]
119858952  ARF4; ADP-ribosylation factor 4 [KO:K07939]
119844086  ARF5; ADP-ribosylation factor 5 [KO:K07940]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
dcc04060  Cytokine-cytokine receptor interaction
dcc04070  Phosphatidylinositol signaling system
dcc04130  SNARE interactions in vesicular transport
dcc04142  Lysosome
dcc04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

DBGET integrated database retrieval system