KEGG   PATHWAY: dmn04148
Entry
dmn04148                    Pathway                                
Name
Efferocytosis - Drosophila miranda
Class
Cellular Processes; Transport and catabolism
Pathway map
dmn04148  Efferocytosis
dmn04148

Organism
Drosophila miranda [GN:dmn]
Gene
108158700  caspase-3 [KO:K02187] [EC:3.4.22.56]
108157734  caspase-3 [KO:K04397] [EC:3.4.22.60]
108156639  caspase [KO:K04397] [EC:3.4.22.60]
108151324  sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
108159991  sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
108152862  85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
108155302  ADAM 17-like protease isoform X1 [KO:K06059] [EC:3.4.24.86]
108156102  uncharacterized protein LOC108156102 isoform X1 [KO:K06704] [EC:3.4.24.81]
108162207  disintegrin and metalloproteinase domain-containing protein 10 isoform X1 [KO:K06704] [EC:3.4.24.81]
108154915  protein similar isoform X2 [KO:K08268]
108155207  aryl hydrocarbon receptor nuclear translocator homolog [KO:K09097]
108161463  tyrosine-protein kinase hopscotch [KO:K04447] [EC:2.7.10.2]
117189168  mitogen-activated protein kinase ERK-A isoform X1 [KO:K04371] [EC:2.7.11.24]
108164991  dual specificity mitogen-activated protein kinase kinase dSOR1 [KO:K04368] [EC:2.7.12.2]
117191703  dual specificity mitogen-activated protein kinase kinase dSOR1-like [KO:K04368] [EC:2.7.12.2]
108160824  cyclic AMP response element-binding protein B isoform X1 [KO:K05870]
108158890  calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type isoform X1 [KO:K05853] [EC:7.2.2.10]
117185953  calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type-like isoform X1 [KO:K05853] [EC:7.2.2.10]
108164456  calcium/calmodulin-dependent protein kinase type II alpha chain isoform X1 [KO:K04515] [EC:2.7.11.17]
108157250  mitogen-activated protein kinase p38a-like [KO:K04441] [EC:2.7.11.24]
108157251  mitogen-activated protein kinase p38a [KO:K04441] [EC:2.7.11.24]
108162173  mitogen-activated protein kinase p38b [KO:K04441] [EC:2.7.11.24]
108152380  MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
108150925  dual specificity protein phosphatase Mpk3 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108151007  LOW QUALITY PROTEIN: anoctamin-4 [KO:K19499]
108164863  XK-related protein 6 isoform X1 [KO:K26811]
108159454  probable phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
117192552  probable phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
108164931  probable phospholipid-transporting ATPase IF [KO:K26934] [EC:7.6.2.1]
108165141  probable phospholipid-transporting ATPase IF [KO:K26934] [EC:7.6.2.1]
108152114  cell cycle control protein 50A [KO:K26935]
108160000  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
108164427  adapter molecule Crk [KO:K04438]
108161806  engulfment and cell motility protein 1 isoform X1 [KO:K12366]
108155689  dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
108154113  ras-like GTP-binding protein RhoL [KO:K04392]
108153015  ras-related protein Rac2 [KO:K04392]
108156649  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
108153146  ras-related protein Rac1 [KO:K04392]
108154154  calreticulin [KO:K08057]
108158999  prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
108152175  protein draper isoform X1 [KO:K24068]
108158729  PTB domain-containing adapter protein ced-6 isoform X1 [KO:K23285]
117193150  PTB domain-containing adapter protein ced-6-like isoform X1 [KO:K23285]
108163427  ras-related protein Rab-5B [KO:K07889]
108152008  vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
108156729  vacuolar protein-sorting-associated protein 11 homolog [KO:K20179]
108154620  vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
108150972  vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
108158250  vacuolar protein sorting-associated protein 33A [KO:K20182]
108161682  ras-related protein Rab-14 isoform X1 [KO:K07881]
108155559  vam6/Vps39-like protein [KO:K20183]
108162387  vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
108155645  ras-related protein Rab-7a [KO:K07897]
117187088  ras-related protein Rab-7a-like [KO:K07897]
117187090  ras-related protein Rab-7a-like [KO:K07897]
108157780  arginase-1 [KO:K01476] [EC:3.5.3.1]
108160300  ornithine decarboxylase 1 [KO:K01581] [EC:4.1.1.17]
108158135  carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
108163804  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
108163184  NAD-dependent histone deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
117186275  homeobox protein extradenticle isoform X1 [KO:K09355]
108164128  lipase 1-like [KO:K01052] [EC:3.1.1.13]
108156332  lipase 3-like [KO:K01052] [EC:3.1.1.13]
108164043  lipase 3-like isoform X1 [KO:K01052] [EC:3.1.1.13]
108154349  lipase 3 [KO:K01052] [EC:3.1.1.13]
108160918  lipase 3 [KO:K01052] [EC:3.1.1.13]
108158937  lipase 3 [KO:K01052] [EC:3.1.1.13]
108162635  lipase 1 [KO:K01052] [EC:3.1.1.13]
108156331  lipase 3-like [KO:K01052] [EC:3.1.1.13]
108156333  lipase 3-like isoform X1 [KO:K01052] [EC:3.1.1.13]
117188856  lipase 1-like [KO:K01052] [EC:3.1.1.13]
117188857  lipase 1-like [KO:K01052] [EC:3.1.1.13]
117192895  lipase 3-like [KO:K01052] [EC:3.1.1.13]
108163017  group XV phospholipase A2-like [KO:K06129] [EC:3.1.1.5]
108152190  LOW QUALITY PROTEIN: glucose transporter type 1 [KO:K07299]
108162535  tyrosine-protein phosphatase corkscrew isoform X1 [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
dmn00010  Glycolysis / Gluconeogenesis
dmn04140  Autophagy - animal
dmn04145  Phagosome
KO pathway
ko04148   
LinkDB

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