Entry Name Systemic lupus erythematosus - Dasypus novemcinctus (nine-banded armadillo)
Description Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and certain cytoplasmic components, in association with a diverse array of clinical manifestations. The primary pathological findings in patients with SLE are those of inflammation, vasculitis, immune complex deposition, and vasculopathy. Immune complexes comprising autoantibody and self-antigen is deposited particulary in the renal glomeruli and mediate a systemic inflammatory response by activating complement or via Fc{gamma}R-mediated neutrophil and macrophage activation. Activation of complement (C5) leads to injury both through formation of the membrane attack complex (C5b-9) or by generation of the anaphylatoxin and cell activator C5a. Neutrophils and macrophages cause tissue injury by the release of oxidants and proteases.
Class Human Diseases; Immune diseaseBRITE hierarchy
Pathway map Ortholog table Organism Dasypus novemcinctus (nine-banded armadillo) [GN:
dnm ]
Gene 101443856 LOW QUALITY PROTEIN: uncharacterized protein LOC101443856 [KO:K11253 ]
101417298 LOW QUALITY PROTEIN: small nuclear ribonucleoprotein-associated proteins B and B' [KO:K11086 ]
101429780 small nuclear ribonucleoprotein-associated proteins B and B' [KO:K11086 ]
111763933 small nuclear ribonucleoprotein Sm D1-like isoform X1 [KO:K11087 ]
101425252 SNRPD1; small nuclear ribonucleoprotein Sm D1 isoform X1 [KO:K11087 ]
101415145 LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752 ]
101437028 LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
101443412 LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752 ]
101438478 HLA class II histocompatibility antigen, DR alpha chain [KO:K06752 ]
101440773 HLA class II histocompatibility antigen, DQ beta 2 chain-like [KO:K06752 ]
101433781 HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752 ]
101435501 HLA class II histocompatibility antigen, DQ alpha 1 chain-like [KO:K06752 ]
101435917 HLA class II histocompatibility antigen, DQ alpha 2 chain-like isoform X1 [KO:K06752 ]
101436345 DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X1 [KO:K06752 ]
101437751 HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752 ]
101415573 HLA class II histocompatibility antigen, DP beta 1 chain-like isoform X1 [KO:K06752 ]
101417015 HLA class II histocompatibility antigen, DP alpha 1 chain isoform X1 [KO:K06752 ]
101417743 HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752 ]
101421271 HLA class II histocompatibility antigen, DM alpha chain [KO:K06752 ]
101421706 HLA class II histocompatibility antigen, DM beta chain [KO:K06752 ]
101412832 CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413 ]
101440382 CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160 ]
101423469 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856 ]
101427594 high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498 ]
Compound Reference Authors Rahman A, Isenberg DA.
Title Systemic lupus erythematosus.
Journal Reference Authors Mok CC, Lau CS.
Title Pathogenesis of systemic lupus erythematosus.
Journal Reference Authors Clatworthy MR, Smith KG.
Title B cells in glomerulonephritis: focus on lupus nephritis.
Journal Reference Authors Couser WG.
Title New insights into mechanisms of immune glomerular injury.
Journal West J Med 160:440-6 (1994)
Reference Authors Cook HT, Botto M.
Title Mechanisms of Disease: the complement system and the pathogenesis of systemic lupus erythematosus.
Journal Reference Authors Carroll MC.
Title A protective role for innate immunity in systemic lupus erythematosus.
Journal Reference Authors Sturfelt G, Truedsson L.
Title Complement and its breakdown products in SLE.
Journal Reference Authors Lu L, Kaliyaperumal A, Boumpas DT, Datta SK.
Title Major peptide autoepitopes for nucleosome-specific T cells of human lupus.
Journal Reference Authors Zieve GW, Khusial PR.
Title The anti-Sm immune response in autoimmunity and cell biology.
Journal Reference Authors Scofield RH, Farris AD, Horsfall AC, Harley JB.
Title Fine specificity of the autoimmune response to the Ro/SSA and La/SSB ribonucleoproteins.
Journal Reference Authors Hoffman RW.
Title T cells in the pathogenesis of systemic lupus erythematosus.
Journal Related dnm04060 Cytokine-cytokine receptor interaction
dnm04610 Complement and coagulation cascades
dnm04612 Antigen processing and presentation
dnm04660 T cell receptor signaling pathway
dnm04662 B cell receptor signaling pathway
dnm04670 Leukocyte transendothelial migration
KO pathway LinkDB All DBs
