Entry
Name
B cell receptor signaling pathway - Dasypus novemcinctus (nine-banded armadillo)
Description
B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
dnm04662 B cell receptor signaling pathway
Ortholog table
Other DBs
Organism
Dasypus novemcinctus (nine-banded armadillo) [GN:
dnm ]
Gene
101423469 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856 ]
101424911 CD79A; B-cell antigen receptor complex-associated protein alpha chain [KO:K06506 ]
101442017 CD79B; B-cell antigen receptor complex-associated protein beta chain [KO:K06507 ]
101414672 DAPP1; dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide [KO:K12229 ]
101446965 VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730 ]
101421086 RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392 ]
101428386 PLCG2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859 ] [EC:3.1.4.11 ]
101435854 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
101420075 PPP3CC; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348 ] [EC:3.1.3.16 ]
101427629 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
101427882 NFATC1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446 ]
101417008 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
101424450 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X2 [KO:K17333 ]
101431496 CARD11; LOW QUALITY PROTEIN: caspase recruitment domain-containing protein 11 [KO:K07367 ]
101447280 MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369 ] [EC:3.4.22.-]
101437556 NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580 ]
101412730 NFKBIA; LOW QUALITY PROTEIN: NF-kappa-B inhibitor alpha [KO:K04734 ]
101423744 phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
101435351 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
101433347 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
101444276 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
101443761 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
101426945 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
101417741 FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b [KO:K12560 ]
101446472 leukocyte immunoglobulin-like receptor subfamily A member 4 isoform X1 [KO:K06512 ]
101435306 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X1 [KO:K06512 ]
101425131 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
105744211 leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X2 [KO:K06512 ]
101426867 leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1 [KO:K06512 ]
101418535 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X2 [KO:K06512 ]
101445048 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
101413127 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
101420301 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
101446835 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
101413186 CD72; LOW QUALITY PROTEIN: B-cell differentiation antigen CD72 [KO:K06504 ]
101444386 PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Niiro H, Clark EA.
Title
Regulation of B-cell fate by antigen-receptor signals.
Journal
Reference
Authors
Kurosaki T.
Title
Genetic analysis of B cell antigen receptor signaling.
Journal
Reference
Authors
Nitschke L.
Title
The role of CD22 and other inhibitory co-receptors in B-cell activation.
Journal
Reference
Authors
Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.
Title
Complement: central to innate immunity and bridging to adaptive responses.
Journal
Reference
Authors
Kurosaki T.
Title
Regulation of B-cell signal transduction by adaptor proteins.
Journal
Reference
Authors
Nitschke L, Tsubata T.
Title
Molecular interactions regulate BCR signal inhibition by CD22 and CD72.
Journal
Reference
Authors
Jumaa H, Hendriks RW, Reth M.
Title
B cell signaling and tumorigenesis.
Journal
Reference
Authors
Rickert RC.
Title
Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.
Journal
Reference
Authors
Zouali M, Sarmay G
Title
B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.
Journal
Reference
Authors
Chiles TC.
Title
Regulation and function of cyclin D2 in B lymphocyte subsets.
Journal
Reference
Authors
Allam A, Marshall AJ
Title
Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
Journal
Reference
Authors
Gold MR
Title
To make antibodies or not: signaling by the B-cell antigen receptor.
Journal
Reference
Authors
Fu C, Turck CW, Kurosaki T, Chan AC
Title
BLNK: a central linker protein in B cell activation.
Journal
Reference
Authors
Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T
Title
BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
Journal
Reference
Authors
Shinohara H, Maeda S, Watarai H, Kurosaki T
Title
IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
Journal
Related pathway
dnm04610 Complement and coagulation cascades
dnm04810 Regulation of actin cytoskeleton
KO pathway
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