KEGG   PATHWAY: ehs04148
Entry
ehs04148                    Pathway                                
Name
Efferocytosis - Eurypyga helias (sunbittern)
Class
Cellular Processes; Transport and catabolism
Pathway map
ehs04148  Efferocytosis
ehs04148

Organism
Eurypyga helias (sunbittern) [GN:ehs]
Gene
104506672  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
104513561  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
104511649  PANX1; pannexin-1 [KO:K03443]
104507609  P2Y purinoceptor 2-like [KO:K04269]
104515184  P2RY6; P2Y purinoceptor 6 [KO:K04272]
104509299  P2RY12; P2Y purinoceptor 12 [KO:K04298]
104514847  S1PR1; sphingosine 1-phosphate receptor 1 [KO:K04288]
104517289  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
104507713  ATP-binding cassette sub-family A member 1-like [KO:K05641]
104510139  GPR132; probable G-protein coupled receptor 132 [KO:K08426]
104506529  ADAM10; LOW QUALITY PROTEIN: disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
104508922  flocculation protein FLO11-like [KO:K05508]
104506862  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
104516904  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
104512549  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
104511076  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
104504159  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
104505286  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
104513416  ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
104502486  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
104516204  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104510785  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
104513387  retinoic acid receptor RXR-alpha [KO:K08524]
104506327  lactadherin-like [KO:K17253]
104502786  GAS6; growth arrest-specific protein 6 [KO:K05464]
104512473  MERTK; LOW QUALITY PROTEIN: tyrosine-protein kinase Mer [KO:K05117] [EC:2.7.10.1]
104508205  platelet glycoprotein 4-like [KO:K06259]
104508725  CD36; platelet glycoprotein 4 [KO:K06259]
104508727  THBS1; thrombospondin-1 [KO:K16857]
104504125  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104509254  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104508273  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
104510905  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
104512345  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
104509438  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
104504897  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
104511150  calcium/calmodulin-dependent protein kinase type II subunit gamma-like [KO:K04515] [EC:2.7.11.17]
104503098  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
104506264  mitogen-activated protein kinase 14-like [KO:K04441] [EC:2.7.11.24]
104511199  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
104503884  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
104507758  MAP kinase-activated protein kinase 2-like [KO:K04443] [EC:2.7.11.1]
104506301  ALOX5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
104507312  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104513999  DUSP4; LOW QUALITY PROTEIN: dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104511306  dual specificity protein phosphatase 16-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104506688  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104516037  ANO6; anoctamin-6 [KO:K19500]
104503005  anoctamin-3-like [KO:K19498]
104511288  anoctamin-3-like [KO:K19498]
104516406  ANO4; anoctamin-4 [KO:K19499]
104512535  ANO5; anoctamin-5 [KO:K19480]
104513808  BSG; LOW QUALITY PROTEIN: basigin [KO:K06535]
104516971  XKR8; XK-related protein 8 [KO:K26813]
104508398  XKR9; XK-related protein 9 [KO:K26814]
104511458  XKR6; XK-related protein 6 [KO:K26811]
104509275  XKR4; XK-related protein 4 [KO:K26811]
104511487  ATP8A1; phospholipid-transporting ATPase IA [KO:K14802] [EC:7.6.2.1]
104503457  ATP11B; probable phospholipid-transporting ATPase IF [KO:K26934] [EC:7.6.2.1]
104503260  phospholipid-transporting ATPase IG-like [KO:K26934] [EC:7.6.2.1]
104510392  probable phospholipid-transporting ATPase IH [KO:K26934] [EC:7.6.2.1]
104513298  TMEM30A; cell cycle control protein 50A [KO:K26935]
104513674  cell cycle control protein 50C-like [KO:K26935]
104509463  PROS1; vitamin K-dependent protein S [KO:K03908]
104511830  ITGB3; integrin beta-3 [KO:K06493]
104505883  ITGB5; integrin beta-5 [KO:K06588]
104507552  TYRO3; tyrosine-protein kinase receptor TYRO3 [KO:K05116] [EC:2.7.10.1]
104505433  T-cell immunoglobulin and mucin domain-containing protein 4-like [KO:K26936]
104506966  STAB1; stabilin-1 [KO:K19020]
104511327  STAB2; stabilin-2 [KO:K19013]
104517369  CRKL; crk-like protein [KO:K04438]
104511028  CRK; adapter molecule crk [KO:K04438]
104507563  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
104512224  ADAM9; disintegrin and metalloproteinase domain-containing protein 9 [KO:K06834] [EC:3.4.24.-]
104504812  disintegrin and metalloproteinase domain-containing protein 9-like [KO:K06834] [EC:3.4.24.-]
104502782  calreticulin-like [KO:K08057]
104503638  C1QA; complement C1q subcomponent subunit A [KO:K03986]
104508731  C1QB; complement C1q subcomponent subunit B [KO:K03987]
104505698  C1QC; complement C1q subcomponent subunit C [KO:K03988]
104514543  MEGF11; multiple epidermal growth factor-like domains protein 11 [KO:K24068]
104515140  LOW QUALITY PROTEIN: scavenger receptor class F member 1-like [KO:K24318]
104508438  GULP1; PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
104512933  RAB17; ras-related protein Rab-17 [KO:K07909]
104504918  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
104508586  RAB5C; ras-related protein Rab-5C [KO:K07889]
104502543  TGFBRAP1; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
104516364  VPS8; vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
104504220  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
104508671  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
104517269  RAB14; ras-related protein Rab-14 [KO:K07881]
104506947  VPS39; vam6/Vps39-like protein [KO:K20183]
104513583  VPS41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
104506294  RAB7A; ras-related protein Rab-7a isoform X1 [KO:K07897]
104515267  RAB7B; ras-related protein Rab-7b [KO:K07898]
104514899  PQLC2; lysosomal amino acid transporter 1 homolog [KO:K23678]
104510386  lysosomal amino acid transporter 1 homolog [KO:K23678]
104503878  ARG2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
104503997  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
104505346  CH25H; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
104504250  NR1H3; oxysterols receptor LXR-alpha [KO:K08536]
104514998  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
104510447  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
104512442  LOW QUALITY PROTEIN: NAD-dependent protein deacetylase sirtuin-1-like [KO:K11411] [EC:2.3.1.286]
104513418  pre-B-cell leukemia transcription factor 1 [KO:K09355]
104516148  IL10; interleukin-10 [KO:K05443]
104512874  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
104503637  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
104503197  PLA2G15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
104505500  PPARD; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
104512623  SLC16A1; monocarboxylate transporter 1 [KO:K08179]
104504021  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
104509837  CD47; leukocyte surface antigen CD47 [KO:K06266]
104504817  PECAM1; LOW QUALITY PROTEIN: platelet endothelial cell adhesion molecule [KO:K06471]
104515883  signal-regulatory protein beta-1 isoform 3-like [KO:K06551]
104515693  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
104505377  PTPN11; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
104510400  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
ehs00010  Glycolysis / Gluconeogenesis
ehs04140  Autophagy - animal
ehs04145  Phagosome
KO pathway
ko04148   
LinkDB

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