KEGG   PATHWAY: gvr04152
Entry
gvr04152                    Pathway                                
Name
AMPK signaling pathway - Galeopterus variegatus (Sunda flying lemur)
Description
AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose or oxygen) or that accelerate ATP consumption (eg, muscle contraction). Several upstream kinases, including liver kinase B1 (LKB1), calcium/calmodulin kinase kinase-beta (CaMKK beta), and TGF-beta-activated kinase-1 (TAK-1), can activate AMPK by phosphorylating a threonine residue on its catalytic alpha-subunit. Once activated, AMPK leads to a concomitant inhibition of energy-consuming biosynthetic pathways, such as protein, fatty acid and glycogen synthesis, and activation of ATP-producing catabolic pathways, such as fatty acid oxidation and glycolysis.
Class
Environmental Information Processing; Signal transduction
Pathway map
gvr04152  AMPK signaling pathway
gvr04152

Other DBs
GO: 2000479
Organism
Galeopterus variegatus (Sunda flying lemur) [GN:gvr]
Gene
103599396  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
103586718  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
103588278  CAB39L; calcium-binding protein 39-like [KO:K08272]
103604244  calcium-binding protein 39 [KO:K08272]
103589232  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
103597786  STRADB; STE20-related kinase adapter protein beta [KO:K17532]
103609173  LEP; leptin [KO:K05424]
103591506  LEPR; leptin receptor [KO:K05062]
103588689  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
103584608  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
103598680  ADIPOQ; adiponectin [KO:K07296]
103590236  ADIPOR2; adiponectin receptor protein 2 [KO:K07297]
103599616  ADIPOR1; adiponectin receptor protein 1 [KO:K07297]
103603598  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
103585844  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
103598955  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
103593785  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
103588852  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
103591557  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
103600242  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
103601422  PFKFB1; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1 isoform X1 [KO:K19028] [EC:2.7.1.105 3.1.3.46]
103603180  PFKFB2; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 isoform X1 [KO:K19029] [EC:2.7.1.105 3.1.3.46]
103608109  PFKFB3; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform X1 [KO:K01103] [EC:2.7.1.105 3.1.3.46]
103584917  PFKFB4; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4 [KO:K19030] [EC:2.7.1.105 3.1.3.46]
103582800  fructose-1,6-bisphosphatase 1-like [KO:K03841] [EC:3.1.3.11]
103606485  FBP2; fructose-1,6-bisphosphatase isozyme 2 isoform X1 [KO:K03841] [EC:3.1.3.11]
103603390  PFKM; 6-phosphofructokinase, muscle type [KO:K00850] [EC:2.7.1.11]
103586420  PFKL; 6-phosphofructokinase, liver type [KO:K00850] [EC:2.7.1.11]
103593933  PFKP; 6-phosphofructokinase type C [KO:K00850] [EC:2.7.1.11]
103596976  HNF4A; hepatocyte nuclear factor 4-alpha isoform X1 [KO:K07292]
103589859  G6PC; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
103605361  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
103591839  G6PC3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
103590171  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
103590981  phosphoenolpyruvate carboxykinase, cytosolic [GTP]-like [KO:K01596] [EC:4.1.1.32]
103586351  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
103586701  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
103594556  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
103588716  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
103584009  cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
103585217  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
103586347  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
103600172  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
103595172  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
103589491  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha [KO:K07202]
103581891  ELAV-like protein 1 [KO:K13088]
103596398  ELAVL1; ELAV-like protein 1 [KO:K13088]
103607082  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103602373  CCNA1; cyclin-A1 [KO:K06627]
103608004  CCNA2; cyclin-A2 [KO:K06627]
103591718  EEF2K; eukaryotic elongation factor 2 kinase isoform X1 [KO:K08292] [EC:2.7.11.20]
103600168  EEF2; elongation factor 2 [KO:K03234]
103597250  FOXO1; LOW QUALITY PROTEIN: forkhead box protein O1 [KO:K07201]
103597242  FOXO3; forkhead box protein O3 [KO:K09408]
103585976  SIRT1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
103591431  SLC2A4; solute carrier family 2, facilitated glucose transporter member 4 isoform X1 [KO:K07191]
103597614  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
103587763  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
103586114  LIPE; hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
103598511  HMGCR; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [KO:K00021] [EC:1.1.1.34]
103585311  SREBF1; sterol regulatory element-binding protein 1 [KO:K07197]
103593316  FASN; fatty acid synthase [KO:K00665] [EC:2.3.1.85]
103601428  acetyl-CoA carboxylase 1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
103588802  SCD; acyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
103587697  SCD5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
103588162  ACACB; acetyl-CoA carboxylase 2 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
103584374  MLYCD; malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
103606571  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
103591311  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
103592593  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
103598177  CIDEA; cell death activator CIDE-A [KO:K25893]
103592396  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
103606724  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
103594406  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
103592045  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
103594915  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like [KO:K04354]
103596789  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
103598404  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform-like [KO:K04354]
103592750  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
103587579  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like [KO:K04354]
103582444  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta-like [KO:K11583]
103591406  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
103606580  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
103599915  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
103596376  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
103604169  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like isoform X1 [KO:K11584]
103584018  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform-like [KO:K11584]
103585752  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
103593545  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
103600750  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
103597784  TBC1D1; TBC1 domain family member 1 [KO:K18341]
103589561  RAB2A; ras-related protein Rab-2A [KO:K07877]
103603072  RAB8A; ras-related protein Rab-8A [KO:K07901]
103597550  RAB10; ras-related protein Rab-10 [KO:K07903]
103599772  RAB11B; ras-related protein Rab-11B [KO:K07905]
103591007  RAB14; ras-related protein Rab-14 [KO:K07881]
103597253  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
103588317  CD36; platelet glycoprotein 4 [KO:K06259]
103601524  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
103595208  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
103604564  insulin receptor [KO:K04527] [EC:2.7.10.1]
103586161  IRS1; insulin receptor substrate 1 [KO:K16172]
103597238  IRS2; insulin receptor substrate 2 [KO:K07187]
103603730  IRS4; insulin receptor substrate 4 [KO:K17446]
103586572  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103586784  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103587883  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103585463  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103593683  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103608454  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103585343  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
103596384  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103590279  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103598325  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103605698  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
103597845  TSC2; tuberin isoform X1 [KO:K07207]
103582022  TSC1; hamartin [KO:K07206]
103591559  RHEB; GTP-binding protein Rheb [KO:K07208]
103601062  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
103593941  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
103606300  proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
103607895  proline-rich AKT1 substrate 1 [KO:K16184]
103595380  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
103589982  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
103606198  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
103590613  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
103592037  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
Compound
C00003  NAD+
C00008  ADP
C00020  AMP
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00085  D-Fructose 6-phosphate
C00162  Fatty acid
C00354  D-Fructose 1,6-bisphosphate
C00389  Quercetin
C00665  beta-D-Fructose 2,6-bisphosphate
C00668  alpha-D-Glucose 6-phosphate
C00698  Cl-
C00757  Berberine
C01172  beta-D-Glucose 6-phosphate
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07151  Metformin
C09731  Epigallocatechin gallate
D08351  Phenformin (BAN)
Reference
PMID:19584320
  Authors
Steinberg GR, Kemp BE
  Title
AMPK in Health and Disease.
  Journal
Physiol Rev 89:1025-78 (2009)
DOI:10.1152/physrev.00011.2008
Reference
PMID:15509864
  Authors
Hardie DG.
  Title
The AMP-activated protein kinase pathway--new players upstream and downstream.
  Journal
J Cell Sci 117:5479-87 (2004)
DOI:10.1242/jcs.01540
Reference
PMID:23747347
  Authors
Russo GL, Russo M, Ungaro P
  Title
AMP-activated protein kinase: a target for old drugs against diabetes and cancer.
  Journal
Biochem Pharmacol 86:339-50 (2013)
DOI:10.1016/j.bcp.2013.05.023
Reference
PMID:19393004
  Authors
Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Aja S
  Title
AMPK in the brain: its roles in energy balance and neuroprotection.
  Journal
J Neurochem 109 Suppl 1:17-23 (2009)
DOI:10.1111/j.1471-4159.2009.05916.x
Reference
PMID:20010958
  Authors
Li J, McCullough LD
  Title
Effects of AMP-activated protein kinase in cerebral ischemia.
  Journal
J Cereb Blood Flow Metab 30:480-92 (2010)
DOI:10.1038/jcbfm.2009.255
Reference
PMID:22700795
  Authors
Sanchez AM, Candau RB, Csibi A, Pagano AF, Raibon A, Bernardi H
  Title
The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis.
  Journal
Am J Physiol Cell Physiol 303:C475-85 (2012)
DOI:10.1152/ajpcell.00125.2012
Reference
PMID:16644802
  Authors
Viollet B, Foretz M, Guigas B, Horman S, Dentin R, Bertrand L, Hue L, Andreelli F
  Title
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders.
  Journal
J Physiol 574:41-53 (2006)
DOI:10.1113/jphysiol.2006.108506
Reference
PMID:19629071
  Authors
Shackelford DB, Shaw RJ
  Title
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.
  Journal
Nat Rev Cancer 9:563-75 (2009)
DOI:10.1038/nrc2676
Reference
PMID:22885100
  Authors
Chung JH, Manganiello V, Dyck JR
  Title
Resveratrol as a calorie restriction mimetic: therapeutic implications.
  Journal
Trends Cell Biol 22:546-54 (2012)
DOI:10.1016/j.tcb.2012.07.004
Reference
PMID:20357764
  Authors
Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
  Title
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
  Journal
Nature 464:1313-9 (2010)
DOI:10.1038/nature08991
Reference
PMID:17307971
  Authors
Towler MC, Hardie DG
  Title
AMP-activated protein kinase in metabolic control and insulin signaling.
  Journal
Circ Res 100:328-41 (2007)
DOI:10.1161/01.RES.0000256090.42690.05
Reference
PMID:23899560
  Authors
Richter EA, Hargreaves M
  Title
Exercise, GLUT4, and skeletal muscle glucose uptake.
  Journal
Physiol Rev 93:993-1017 (2013)
DOI:10.1152/physrev.00038.2012
Reference
PMID:16054041
  Authors
Kahn BB, Alquier T, Carling D, Hardie DG
  Title
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
  Journal
Cell Metab 1:15-25 (2005)
DOI:10.1016/j.cmet.2004.12.003
Reference
PMID:23565491
  Authors
Minokoshi Y, Toda C, Okamoto S
  Title
Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle.
  Journal
Indian J Endocrinol Metab 16:S562-8 (2012)
DOI:10.4103/2230-8210.105573
Reference
PMID:16723978
  Authors
Guggino WB, Stanton BA
  Title
New insights into cystic fibrosis: molecular switches that regulate CFTR.
  Journal
Nat Rev Mol Cell Biol 7:426-36 (2006)
DOI:10.1038/nrm1949
Reference
PMID:16479585
  Authors
Cheng A, Saltiel AR
  Title
More TORC for the gluconeogenic engine.
  Journal
Bioessays 28:231-4 (2006)
DOI:10.1002/bies.20375
Reference
PMID:19197243
  Authors
Herrero-Martin G, Hoyer-Hansen M, Garcia-Garcia C, Fumarola C, Farkas T, Lopez-Rivas A, Jaattela M
  Title
TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.
  Journal
EMBO J 28:677-85 (2009)
DOI:10.1038/emboj.2009.8
Reference
PMID:19724019
  Authors
Morris DL, Rui L
  Title
Recent advances in understanding leptin signaling and leptin resistance.
  Journal
Am J Physiol Endocrinol Metab 297:E1247-59 (2009)
DOI:10.1152/ajpendo.00274.2009
Reference
PMID:18725075
  Authors
Minokoshi Y, Shiuchi T, Lee S, Suzuki A, Okamoto S
  Title
Role of hypothalamic AMP-kinase in food intake regulation.
  Journal
Nutrition 24:786-90 (2008)
DOI:10.1016/j.nut.2008.06.002
Reference
PMID:23024365
  Authors
Miyamoto L, Ebihara K, Kusakabe T, Aotani D, Yamamoto-Kataoka S, Sakai T, Aizawa-Abe M, Yamamoto Y, Fujikura J, Hayashi T, Hosoda K, Nakao K
  Title
Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and alpha1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin.
  Journal
J Biol Chem 287:40441-7 (2012)
DOI:10.1074/jbc.M112.384545
Related
pathway
gvr00010  Glycolysis / Gluconeogenesis
gvr00061  Fatty acid biosynthesis
gvr00500  Starch and sucrose metabolism
gvr01040  Biosynthesis of unsaturated fatty acids
gvr04110  Cell cycle
gvr04140  Autophagy - animal
gvr04150  mTOR signaling pathway
gvr04151  PI3K-Akt signaling pathway
gvr04910  Insulin signaling pathway
gvr04920  Adipocytokine signaling pathway
KO pathway
ko04152   
LinkDB

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