KEGG   PATHWAY: mcal00260
Entry
mcal00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Mus caroli (Ryukyu mouse)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
mcal00260  Glycine, serine and threonine metabolism
mcal00260

Module
mcal_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:mcal00260]
mcal_M00047  Creatine pathway [PATH:mcal00260]
mcal_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:mcal00260]
mcal_M00555  Betaine biosynthesis, choline => betaine [PATH:mcal00260]
mcal_M00621  Glycine cleavage system [PATH:mcal00260]
mcal_M00974  Betaine metabolism, animals, betaine => glycine [PATH:mcal00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Mus caroli (Ryukyu mouse) [GN:mcal]
Gene
110305962  probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]
110305224  Shmt1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
110302965  Shmt2; serine hydroxymethyltransferase, mitochondrial isoform X1 [KO:K00600] [EC:2.1.2.1]
110296726  Agxt; serine--pyruvate aminotransferase isoform X1 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
110292456  Grhpr; glyoxylate reductase/hydroxypyruvate reductase isoform X1 [KO:K00049] [EC:1.1.1.79 1.1.1.81]
110301711  Glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]
110285594  Pgam1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
110305623  Pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
110296243  Bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
110291887  Phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
110285401  Psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
110294684  Psph; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
110310366  Gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
110309767  L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
110286625  Alas2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
110300966  Alas1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
110286552  Maoa; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
110287084  Maob; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
110305720  Aoc2; retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
110305611  Aoc3; membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
110285360  Gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
110301293  Amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
110306906  Dld; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
110300227  Gcsh; glycine cleavage system H protein, mitochondrial [KO:K02437]
110295014  Dao; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
110310555  Agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
110284514  Gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
110303213  Gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
110309494  Chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
110285158  Aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase isoform X1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
110307549  Bhmt; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
110307602  Dmgdh; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
110304694  Pipox; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
110310298  Sardh; sarcosine dehydrogenase, mitochondrial isoform X2 [KO:K00314] [EC:1.5.8.3]
110284012  glycine N-methyltransferase isoform X1 [KO:K00552] [EC:2.1.1.20]
110312342  Cbs; cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]
110291304  Cth; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
110294432  Sdsl; serine dehydratase-like isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
110295099  Sds; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
110304703  Srr; serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
mcal00010  Glycolysis / Gluconeogenesis
mcal00020  Citrate cycle (TCA cycle)
mcal00230  Purine metabolism
mcal00250  Alanine, aspartate and glutamate metabolism
mcal00270  Cysteine and methionine metabolism
mcal00290  Valine, leucine and isoleucine biosynthesis
mcal00330  Arginine and proline metabolism
mcal00470  D-Amino acid metabolism
mcal00564  Glycerophospholipid metabolism
mcal00600  Sphingolipid metabolism
mcal00620  Pyruvate metabolism
mcal00630  Glyoxylate and dicarboxylate metabolism
mcal00640  Propanoate metabolism
mcal00860  Porphyrin metabolism
mcal00920  Sulfur metabolism
KO pathway
ko00260   
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