KEGG   PATHWAY: mcal00230
Entry
mcal00230                   Pathway                                
Name
Purine metabolism - Mus caroli (Ryukyu mouse)
Class
Metabolism; Nucleotide metabolism
Pathway map
mcal00230  Purine metabolism
mcal00230

Module
mcal_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:mcal00230]
mcal_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:mcal00230]
mcal_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:mcal00230]
mcal_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:mcal00230]
mcal_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:mcal00230]
mcal_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:mcal00230]
mcal_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:mcal00230]
Other DBs
GO: 0006163 0042278
Organism
Mus caroli (Ryukyu mouse) [GN:mcal]
Gene
110295060  Nudt9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
110305174  Adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
110289308  Nudt5; ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
110292202  Pgm1; phosphoglucomutase-1 isoform X2 [KO:K01835] [EC:5.4.2.2]
110294475  Pgm2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
110286752  Prps1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
110286493  Prps2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
110307059  Prps1l1; ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
110293931  Ppat; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
110311510  Gart; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
110306053  Pfas; phosphoribosylformylglycinamidine synthase isoform X2 [KO:K01952] [EC:6.3.5.3]
110293933  multifunctional protein ADE2 isoform X3 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
110310178  Adsl; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
110291055  Atic; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
110300366  Aprt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
110285427  Nt5c2; cytosolic purine 5'-nucleotidase isoform X2 [KO:K01081] [EC:3.1.3.5]
110304776  Nt5c; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
110293165  Nt5c1a; cytosolic 5'-nucleotidase 1A isoform X1 [KO:K01081] [EC:3.1.3.5]
110304729  Nt5m; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
110307039  cytosolic 5'-nucleotidase 1B isoform X1 [KO:K01081] [EC:3.1.3.5]
110308343  Nt5e; 5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
110309219  Pnp; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
110309665  Lacc1; laccase domain-containing protein 1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
110286595  Hprt1; hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
110296235  Impdh1; inosine-5'-monophosphate dehydrogenase 1 isoform X2 [KO:K00088] [EC:1.1.1.205]
110301086  Impdh2; inosine-5'-monophosphate dehydrogenase 2 isoform X2 [KO:K00088] [EC:1.1.1.205]
110301716  Nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
110290609  Nme7; nucleoside diphosphate kinase 7 isoform X3 [KO:K00940] [EC:2.7.4.6]
110283895  Nme4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
110283835  Nme3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
110304443  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
110304444  Nme1; nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
110308346  nucleoside diphosphate kinase B-like [KO:K00940] [EC:2.7.4.6]
110303677  Ak9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
110308986  Entpd8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
110285484  Entpd1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
110302145  Entpd3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
110305208  Cant1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
110309260  ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
110309119  ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
110306789  Entpd5; ectonucleoside triphosphate diphosphohydrolase 5 isoform X2 [KO:K01511] [EC:3.6.1.6]
110312620  Entpd6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X1 [KO:K01511] [EC:3.6.1.6]
110301710  Nudt16; U8 snoRNA-decapping enzyme isoform X1 [KO:K16855] [EC:3.6.1.62 3.6.1.64]
110301971  U8 snoRNA-decapping enzyme-like [KO:K16855] [EC:3.6.1.62 3.6.1.64]
110288733  Itpa; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
110312137  Xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
110293240  Nudt2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
110290590  Gmps; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
110307990  Gmpr; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
110309914  Gmpr2; GMP reductase 2 isoform X1 [KO:K00364] [EC:1.7.1.7]
110285477  Gda; guanine deaminase isoform X1 [KO:K01487] [EC:3.5.4.3]
110305418  Guk1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
110287923  guanylate kinase-like [KO:K00942] [EC:2.7.4.8]
110297993  Rrm1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
110310656  Rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
110306805  Rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
110303776  Hddc2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
110296277  Dguok; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
110294384  Dck; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
110298538  Hddc3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform X1 [KO:K21138] [EC:3.1.7.2]
110291088  Prune1; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
110305998  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
110307661  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
110306494  Adcy3; adenylate cyclase type 3 isoform X2 [KO:K08043] [EC:4.6.1.1]
110309267  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
110311373  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
110310126  Adcy6; adenylate cyclase type 6 isoform X5 [KO:K08046] [EC:4.6.1.1]
110299719  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
110310371  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
110311555  Adcy9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
110284653  Adcy10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
110301665  Gucy1a2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
110291186  Gucy1a1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
110291191  Gucy1b1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
110309748  guanylate cyclase soluble subunit beta-2 [KO:K12319] [EC:4.6.1.2]
110296529  Gucy2c; heat-stable enterotoxin receptor isoform X1 [KO:K12320] [EC:4.6.1.2]
110298578  olfactory guanylyl cyclase GC-D [KO:K12321] [EC:4.6.1.2]
110305918  Gucy2d; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
110286950  Gucy2f; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
110285938  guanylate cyclase 2G [KO:K22600] [EC:4.6.1.2]
110291324  Npr1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
110292276  Npr2; atrial natriuretic peptide receptor 2 isoform X1 [KO:K12324] [EC:4.6.1.2]
110310430  Pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
110285248  Pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X2 [KO:K13755] [EC:3.1.4.17]
110295911  Pde1c; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X4 [KO:K13755] [EC:3.1.4.17]
110297586  Pde2a; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X3 [KO:K18283] [EC:3.1.4.17]
110296609  Pde3a; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
110297913  Pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
110291001  Pde5a; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
110284687  Pde6a; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha isoform X1 [KO:K08718] [EC:3.1.4.35]
110294147  Pde6b; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta isoform X1 [KO:K13756] [EC:3.1.4.35]
110285619  Pde6c; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X1 [KO:K13757] [EC:3.1.4.35]
110297933  Pde6d; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X1 [KO:K13758]
110305799  Pde6g; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
110296932  Pde6h; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
110283808  Pde9a; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
110312509  Pde10a; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X5 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
110309361  Pde11a; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X1 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
110294595  Adss; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
110306945  Adssl1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
110297625  Ampd3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
110291280  Ampd1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
110291492  Ampd2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
110309688  Adk; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
110289345  Ada; adenosine deaminase isoform X1 [KO:K01488] [EC:3.5.4.4]
110291177  Ak5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
110289593  Ak1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
110292230  Ak2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
110289343  Ak8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
110312445  adenylate kinase isoenzyme 1-like isoform X1 [KO:K00939] [EC:2.7.4.3]
110292861  Ak4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
110306951  Ak7; adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
110308335  Ak6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
110285780  Ak3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
110287444  Entpd2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
110300414  Ntpcr; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
110303042  Enpp3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
110303534  Enpp1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
110292147  Pde4b; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
110301167  Pde4a; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X3 [KO:K13293] [EC:3.1.4.53]
110300097  Pde4c; cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
110307957  Pde4d; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
110290776  Pde7a; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
110303174  Pde7b; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
110297496  Pde8a; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
110308724  Pde8b; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
110309527  Fhit; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
110283825  Enpp4; bis(5'-adenosyl)-triphosphatase ENPP4 isoform X1 [KO:K18424] [EC:3.6.1.29]
110285252  Papss2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
110290754  Papss1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
110291256  uricase [KO:K00365] [EC:1.7.3.3]
110298313  5-hydroxyisourate hydrolase isoform X1 [KO:K07127] [EC:3.5.2.17]
110294570  Urad; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
110307031  Allc; probable allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mcal00030  Pentose phosphate pathway
mcal00220  Arginine biosynthesis
mcal00250  Alanine, aspartate and glutamate metabolism
mcal00260  Glycine, serine and threonine metabolism
mcal00340  Histidine metabolism
mcal00630  Glyoxylate and dicarboxylate metabolism
mcal00730  Thiamine metabolism
mcal00740  Riboflavin metabolism
mcal00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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